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     Item: 
      Title: Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Summary
       Item: 
        Title: Introduction
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Study design and sample inclusion
         Item: 
          Title: Generation of iPSC
          Children: 
           Item: 
            Title: Cell reprogramming
           Item: 
            Title: Pluripotency validation
           Item: 
            Title: Three germ layer differentiation
           Item: 
            Title: FACS analysis
           Item: 
            Title: DNA Fingerprinting analysis (Short Tandem Repeats (STR) analysis)
           Item: 
            Title: Transgene-free confirmation
           Item: 
            Title: Mycoplasma detection
           Item: 
            Title: Karyotype analysis
       Item: 
        Title: Obtaining iPSC-derived myotubes
        Children: 
         Item: 
          Title: iPSC differentiation to myotubes using growth factors
         Item: 
          Title: Characterization of iPSC-derived myotubes with qPCR and immunofluorescence of muscle-associated markers
       Item: 
        Title: Phenotyping iPSC-derived myotubes for IBM muscle hallmarks
        Children: 
         Item: 
          Title: RNA extraction and mRNA library preparation and sequencing
         Item: 
          Title: RNA-seq data processing and analysis
         Item: 
          Title: Protein detection by Western blot analysis
         Item: 
          Title: Inflammatory cytokine array
         Item: 
          Title: Immunofluorescence for autophagosome characterization
         Item: 
          Title: Autophagy protein array
         Item: 
          Title: Mitochondrial respiration
         Item: 
          Title: Total antioxidant capacity (TAC)
         Item: 
          Title: MRC enzymatic activities: cytochrome c oxidase (COX) and citrate synthase (CS) functions
         Item: 
          Title: Lactate secretion
       Item: 
        Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Clinical and epidemiological data
         Item: 
          Title: Generation of iPSC and differentiation into myotubes
         Item: 
          Title: Gene expression profile of iPSC-myotubes in IBM vs. CTL samples
         Item: 
          Title: Protein detection of IBM muscle pathological features in IBM iPSC-myotubes
         Item: 
          Title: Inflammatory Profile in IBM vs. CTL iPSC-myotubes
         Item: 
          Title: Autophagy variations in IBM vs. CTL iPSC-myotubes
         Item: 
          Title: Mitochondrial function was altered in IBM vs. CTL iPSC-myotubes
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          Title: Discussion
         Item: 
          Title: Conclusions
       Item: 
        Title: References
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