9d7133297b17ff5472278a436bde65ff  Cerebrospinal_fluid.pdf
e959a950521838e650c2259df64702db4757bd89  Cerebrospinal_fluid.pdf
771ea79b5dcf1072d135f7b204fc28a8f002b256ffde709d5c8c703d032791b5  Cerebrospinal_fluid.pdf

Title:           Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4
Subject:         Journal of Lipid Research, 66 (2025) 100865. doi:10.1016/j.jlr.2025.100865
Author:          Carla Borràs
Creator:         Elsevier
Producer:        PDFlib+PDI 10.0.2p2 (C++/Win64)
CreationDate:    Fri Aug 15 22:37:03 2025 CEST
ModDate:         Fri Aug 15 22:41:36 2025 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           16
Encrypted:       no
Page size:       612 x 792 pts (letter)
Page rot:        0
File size:       6379930 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
JBPPYH+HelveticaNeue-Roman           Type 1C           Custom           yes yes yes   2782  0
GlyphLessFont                        CID TrueType      Identity-H       yes no  yes   2784  0
WGDCWS+CharisSIL                     CID TrueType      Identity-H       yes yes yes   2786  0
TTROIP+NewBaskervilleBold            Type 1C           Custom           yes yes yes   2790  0
BRWWWZ+StixTwoExtendedRoman          Type 1C           Builtin          yes yes yes   2794  0
UCCIIX+NewBaskervilleRoman           Type 1C           Custom           yes yes yes   2798  0
SJENTX+STIX-Bold                     Type 1C           Custom           yes yes yes   2803  0
VYYYOB+STIX-Regular                  Type 1C           Custom           yes yes yes   2808  0
JDMOSY+CM_Maths_Symbols              Type 1C           Builtin          yes yes yes   2815  0
ALPSCN+HelveticaNeue-Medium          Type 1C           Custom           yes yes yes   2820  0
QLJHPK+NewBaskerville-Italic         Type 1C           Custom           yes yes yes   2824  0
SMOKIR+STIXGeneral                   Type 1C           Custom           yes yes yes     97  0
LPCAGT+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     98  0
ETRDYZ+STIXMath-Regular              Type 1C           Custom           yes yes yes    138  0
AQOUJW+ESSTIX-Ten                    Type 1C           Builtin          yes yes yes    164  0
NTMBZO+StixTwoMathItalic             Type 1C           Builtin          yes yes yes    151  0
NEBGBP+StixTwoMathSymbols            Type 1C           Builtin          yes yes yes    152  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-10-17 04:05:09 CEST
 RepresentationInformation: Cerebrospinal_fluid.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-10-16 14:50:27 CEST
  Size: 6379930
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Invalid indirect destination - referenced object 'aff11' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff2' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff4' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff3' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff6' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff10' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: Invalid indirect destination - referenced object 'aff7' cannot be found
   ID: PDF-HUL-149
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found
   ID: PDF-HUL-122
   Offset: 6304839
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 2972
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4
      Destination: titlink1
      Children: 
       Item: 
        Title: Materials and Methods
        Destination: flink1
        Children: 
         Item: 
          Title: Human samples
          Destination: slink1
         Item: 
          Title: CSF AD biomarker analysis
          Destination: slink2
         Item: 
          Title: CSF lipid-related parameters measurement
          Destination: slink3
         Item: 
          Title: Cell culture
          Destination: slink4
         Item: 
          Title: Cholesterol efflux assay
          Destination: slink5
         Item: 
          Title: Cholesterol uptake assay
          Destination: slink6
         Item: 
          Title: Quantitative Real Time-PCR
          Destination: slink7
         Item: 
          Title: Protein staining and blotting
          Destination: slink8
         Item: 
          Title: Proteomic analysis
          Destination: slink9
         Item: 
          Title: Preparation and characterization of synthetic reconstituted APOE3-and APOE4-containing lipoproteins
          Destination: slink10
         Item: 
          Title: Confocal microscopy and flow cytometry
          Destination: slink11
         Item: 
          Title: Statistical analysis
          Destination: slink12
       Item: 
        Title: Results
        Destination: flink2
        Children: 
         Item: 
          Title: CSF cholesterol and APO levels are similar in patients with AD and control individuals
          Destination: slink13
         Item: 
          Title: Astrocyte cholesterol efflux to CSF is similar in patients with AD and control individuals
          Destination: slink14
         Item: 
          Title: CSF lipoprotein-mediated cholesterol delivery to neurons is impaired in patients with AD
          Destination: slink15
         Item: 
          Title: The CSF lipoprotein proteome is modified in patients with AD
          Destination: slink16
         Item: 
          Title: APOE4-containing HDL exhibits impaired cholesterol delivery to neurons
          Destination: slink17
       Item: 
        Title: Discussion
        Destination: flink3
       Item: 
        Title: Conclusions
        Destination: flink4
        Children: 
         Item: 
          Title: Data availability
          Destination: slink18
       Item: 
        Title: Supplemental data
        Destination: flink5
       Item: 
        Title: Author contributions
        Destination: flink6
       Item: 
        Title: Funding and additional information
        Destination: flink7
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4
    Author: Carla Borràs
    Subject: Journal of Lipid Research, 66 (2025) 100865. doi:10.1016/j.jlr.2025.100865
    Creator: Elsevier
    Producer: PDFlib+PDI 10.0.2p2 (C++/Win64)
    CreationDate: Fri Aug 15 23:07:03 CEST 2025
    ModDate: Fri Aug 15 23:11:36 CEST 2025
   ID: 0x794da3ecb98befd30165d5597b703889, 0x92bd50d8ea9e1d47a916ad0b56304473
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 39
      ImageHeight: 30
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 33
      ImageHeight: 33
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 39
      ImageHeight: 30
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 33
      ImageHeight: 33
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
   Fonts: 
    Type0: 
     Font: 
      BaseFont: GlyphLessFont
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: WGDCWS+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: LPCAGT+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: SMOKIR+STIXGeneral
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: SMOKIR+STIXGeneral
       Flags: Nonsymbolic
       FontBBox: -178, -443, 2000, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: ALPSCN+HelveticaNeue-Medium
      FontSubset: true
      FirstChar: 1
      LastChar: 9
      FontDescriptor: 
       FontName: ALPSCN+HelveticaNeue-Medium
       Flags: Nonsymbolic
       FontBBox: -165, -221, 1066, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: AQOUJW+ESSTIX-Ten
      FontSubset: true
      FirstChar: 48
      LastChar: 122
      FontDescriptor: 
       FontName: AQOUJW+ESSTIX-Ten
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: TTROIP+NewBaskervilleBold
      FontSubset: true
      FirstChar: 1
      LastChar: 68
      FontDescriptor: 
       FontName: TTROIP+NewBaskervilleBold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -122, -298, 1141, 1021
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QLJHPK+NewBaskerville-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 50
      FontDescriptor: 
       FontName: QLJHPK+NewBaskerville-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -138, -274, 1347, 906
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BRWWWZ+StixTwoExtendedRoman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: BRWWWZ+StixTwoExtendedRoman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: ETRDYZ+STIXMath-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: ETRDYZ+STIXMath-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UCCIIX+NewBaskervilleRoman
      FontSubset: true
      FirstChar: 1
      LastChar: 83
      FontDescriptor: 
       FontName: UCCIIX+NewBaskervilleRoman
       Flags: Nonsymbolic
       FontBBox: -152, -296, 1116, 986
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SJENTX+STIX-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: SJENTX+STIX-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NTMBZO+StixTwoMathItalic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: NTMBZO+StixTwoMathItalic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: VYYYOB+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 11
      FontDescriptor: 
       FontName: VYYYOB+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NEBGBP+StixTwoMathSymbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: NEBGBP+StixTwoMathSymbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: JBPPYH+HelveticaNeue-Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 27
      FontDescriptor: 
       FontName: JBPPYH+HelveticaNeue-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -210, 1076, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: JDMOSY+CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: JDMOSY+CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: GlyphLessFont
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: GlyphLessFont
       Flags: FixedPitch, Symbolic
       FontBBox: 0, 0, 500, 1000
       FontFile2: true
     Font: 
      BaseFont: LPCAGT+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: LPCAGT+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
     Font: 
      BaseFont: WGDCWS+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WGDCWS+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jlr.2025.100865</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Cerebrospinal fluid lipoprotein-mediated cholesterol delivery to neurons is impaired in Alzheimer's disease and involves APOE4</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Carla Borràs</rdf:li>
               <rdf:li>Marina Canyelles</rdf:li>
               <rdf:li>David Santos</rdf:li>
               <rdf:li>Noemí Rotllan</rdf:li>
               <rdf:li>Estefanía Núñez</rdf:li>
               <rdf:li>Jesús Vázquez</rdf:li>
               <rdf:li>Daniel Maspoch</rdf:li>
               <rdf:li>Mary Cano-Sarabia</rdf:li>
               <rdf:li>Qi Zhao</rdf:li>
               <rdf:li>Maria Carmona-Iragui</rdf:li>
               <rdf:li>Sònia Sirisi</rdf:li>
               <rdf:li>Alberto Lleó</rdf:li>
               <rdf:li>Juan Fortea</rdf:li>
               <rdf:li>Daniel Alcolea</rdf:li>
               <rdf:li>Francisco Blanco-Vaca</rdf:li>
               <rdf:li>Joan Carles Escolà-Gil</rdf:li>
               <rdf:li>Mireia Tondo</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Alzheimer's disease</rdf:li>
               <rdf:li>APOE</rdf:li>
               <rdf:li>cholesterol</rdf:li>
               <rdf:li>CSF lipoprotein</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Journal of Lipid Research, 66 (2025) 100865. doi:10.1016/j.jlr.2025.100865</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Journal of Lipid Research</prism:publicationName>
         <prism:copyright>© 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.</prism:copyright>
         <prism:issn>0022-2275</prism:issn>
         <prism:volume>66</prism:volume>
         <prism:number>8</prism:number>
         <prism:coverDisplayDate>August 2025</prism:coverDisplayDate>
         <prism:pageRange>100865</prism:pageRange>
         <prism:startingPage>100865</prism:startingPage>
         <prism:doi>10.1016/j.jlr.2025.100865</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jlr.2025.100865</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jlr.2025.100865</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0.1</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jlr.2025.100865</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:EPSprocessor>PStill version 1.84.42</pdfx:EPSprocessor>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2025-08-16T02:07:03+05:30</xap:CreateDate>
         <xap:ModifyDate>2025-08-16T02:11:36+05:30</xap:ModifyDate>
         <xap:MetadataDate>2025-08-16T02:11:36+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:tdm="http://www.w3.org/ns/tdmrep/">
         <tdm:reservation>1</tdm:reservation>
         <tdm:policy>https://www.elsevier.com/tdm/tdmrep-policy.json</tdm:policy>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>PDFlib+PDI 10.0.2p2 (C++/Win64)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:c0477d19-4110-4e3f-a851-e3c3d8f9fede</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:b560dd03-5f23-4dfe-9bd2-8501545e5d8c</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 57, 693, 57, 693
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 117, 597, 119, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 121, 597, 124, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 126, 597, 129, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 227, 597, 230, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 231, 597, 235, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 236, 597, 241, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 318, 597, 321, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 597, 326, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 402, 597, 404, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 406, 597, 409, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 503, 597, 507, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 508, 597, 512, 607
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 124, 586, 128, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 129, 586, 133, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 225, 586, 228, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 230, 586, 234, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 235, 586, 239, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 586, 337, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 338, 586, 342, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 386, 586, 388, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 390, 586, 393, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 514, 586, 517, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 518, 586, 525, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 526, 586, 532, 596
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 110, 575, 113, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 114, 575, 121, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 122, 575, 128, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 194, 575, 197, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 198, 575, 205, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 206, 575, 212, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 272, 575, 275, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 276, 575, 283, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 284, 575, 290, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 291, 575, 298, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 372, 575, 375, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 376, 575, 383, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 384, 575, 390, 585
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 163, 564, 166, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 167, 564, 171, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 172, 564, 176, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 177, 564, 181, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 182, 564, 186, 574
       Flags: Print
       Destination: 2698
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 307, 564, 310, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 311, 564, 315, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 316, 564, 320, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 321, 564, 325, 574
       Flags: Print
       Destination: 2698
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 326, 564, 330, 574
       Flags: Print
       Destination: 2698
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 432, 564, 434, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 436, 564, 439, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 441, 564, 445, 574
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 446, 564, 450, 574
       Flags: Print
       Destination: 2698
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 451, 564, 455, 574
       Flags: Print
       Destination: 2698
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 347, 146, 351, 156
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 553, 122, 558, 132
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 117, 598, 117, 600
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 227, 598, 227, 600
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 318, 598, 318, 600
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 402, 598, 402, 600
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 503, 598, 503, 600
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 124, 587, 124, 589
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 225, 587, 225, 589
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 587, 333, 589
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 386, 587, 386, 589
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 514, 587, 514, 589
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 110, 576, 110, 578
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 194, 576, 194, 578
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 272, 576, 272, 578
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 372, 576, 372, 578
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 163, 565, 163, 567
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 307, 565, 307, 567
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 432, 565, 432, 567
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 194, 63, 270, 71
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 359, 63, 430, 71
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 541, 758, 563, 780
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 251, 24, 388, 30
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 421, 32, 563, 40
       Flags: Print
    Page: 
     Label: 2
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 50, 708, 55, 718
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 50, 685, 56, 694
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 172, 673, 187, 682
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 141, 625, 146, 634
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 50, 541, 55, 551
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 151, 493, 156, 503
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 217, 481, 222, 491
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 254, 445, 263, 455
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 267, 445, 275, 455
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 107, 410, 116, 419
       Flags: Print
       Destination: 49
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 147, 326, 169, 336
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 207, 290, 216, 300
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 223, 290, 232, 300
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 261, 266, 270, 276
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 278, 266, 287, 276
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 163, 182, 173, 192
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 163, 147, 172, 156
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 432, 515, 441, 524
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 309, 484, 543, 493
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 380, 442, 389, 451
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 349, 369, 358, 377
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 510, 179, 519, 188
       Flags: Print
       Destination: 53
    Page: 
     Label: 3
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 511, 219, 520, 228
       Flags: Print
       Destination: 53
    Page: 
     Label: 4
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 339, 536, 348, 545
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 354, 536, 363, 545
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 526, 321, 534
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 329, 526, 339, 534
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 443, 484, 452, 492
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 419, 345, 428, 354
       Flags: Print
       Destination: 53
    Page: 
     Label: 5
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 410, 556, 443, 565
       Flags: Print
       Destination: 13
    Page: 
     Label: 6
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 708, 76, 718
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 230, 613, 291, 622
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 601, 76, 611
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 152, 553, 250, 563
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 77, 493, 171, 503
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 261, 410, 285, 419
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 205, 302, 228, 312
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 140, 194, 162, 204
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 90, 123, 187, 132
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 132, 87, 228, 96
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 151, 63, 258, 73
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 339, 661, 362, 670
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 637, 338, 646
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 613, 367, 622
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 359, 577, 396, 587
       Flags: Print
       Destination: 25
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 493, 335, 503
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 495, 326, 523, 336
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 290, 338, 300
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 428, 266, 452, 276
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 194, 336, 204
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 418, 99, 523, 108
       Flags: Print
       Destination: 57
    Page: 
     Label: 7
     Sequence: 7
    Page: 
     Label: 8
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 132, 527, 160, 537
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 50, 480, 74, 489
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 101, 420, 196, 429
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 234, 319, 260, 329
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 212, 283, 238, 293
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 50, 271, 76, 281
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 211, 200, 250, 209
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 412, 732, 437, 742
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 492, 708, 531, 718
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 491, 661, 520, 670
       Flags: Print
       Destination: 37
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 421, 601, 448, 611
       Flags: Print
       Destination: 41
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 476, 553, 500, 563
       Flags: Print
       Destination: 41
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 457, 440, 466, 450
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 472, 440, 481, 450
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 488, 440, 513, 450
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 349, 273, 358, 283
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 365, 273, 376, 283
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 356, 213, 367, 223
       Flags: Print
       Destination: 53
    Page: 
     Label: 9
     Sequence: 9
    Page: 
     Label: 10
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 243, 708, 253, 718
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 153, 625, 164, 634
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 116, 577, 125, 587
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 258, 529, 267, 539
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 276, 529, 287, 539
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 189, 481, 198, 491
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 198, 206, 208, 216
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 356, 732, 367, 742
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 455, 649, 466, 658
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 496, 505, 507, 515
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 447, 362, 457, 371
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 373, 314, 384, 324
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 312, 266, 323, 276
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 528, 254, 539, 264
       Flags: Print
       Destination: 53
    Page: 
     Label: 11
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 177, 163, 198, 171
       Flags: Print
       Destination: 21
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 415, 143, 435, 152
       Flags: Print
       Destination: 21
    Page: 
     Label: 12
     Sequence: 12
    Page: 
     Label: 13
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 145, 685, 155, 694
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 255, 661, 264, 670
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 98, 613, 107, 622
       Flags: Print
       Destination: 53
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 135, 290, 145, 300
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 102, 218, 112, 228
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 106, 194, 116, 204
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 224, 170, 234, 180
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 548, 577, 559, 587
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 416, 63, 492, 72
       Flags: Print
       Destination: 57
    Page: 
     Label: 14
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 113, 600, 272, 608
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 589, 291, 598
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 578, 282, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 567, 277, 576
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 556, 253, 565
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 545, 291, 554
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 534, 66, 543
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 523, 291, 532
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 512, 67, 521
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 47, 501, 277, 510
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 309, 462, 470, 471
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 411, 553, 419
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 403, 458, 410
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 394, 553, 402
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 385, 553, 393
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 376, 351, 384
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 367, 553, 375
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 358, 553, 366
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 349, 553, 357
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 340, 343, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 331, 553, 339
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 322, 553, 330
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 313, 553, 321
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 304, 553, 312
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 295, 553, 303
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 286, 515, 294
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 277, 553, 285
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 268, 507, 276
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 259, 553, 267
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 250, 553, 258
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 241, 553, 249
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 232, 439, 240
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 223, 553, 231
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 214, 462, 222
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 205, 553, 213
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 196, 553, 204
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 187, 550, 195
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 178, 553, 186
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 169, 553, 177
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 160, 553, 168
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 151, 553, 159
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 142, 492, 150
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 321, 134, 553, 142
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 321, 125, 553, 133
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 321, 116, 553, 124
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 321, 107, 503, 115
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 98, 553, 106
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 89, 553, 97
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 80, 553, 88
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 322, 71, 357, 79
       Flags: Print
    Page: 
     Label: 15
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 746, 301, 754
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 737, 301, 745
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 728, 301, 736
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 719, 160, 727
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 710, 301, 718
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 701, 301, 709
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 692, 301, 700
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 683, 168, 691
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 674, 301, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 665, 301, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 656, 252, 664
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 647, 301, 655
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 638, 301, 646
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 629, 301, 637
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 620, 196, 628
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 611, 301, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 602, 301, 610
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 594, 259, 602
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 585, 301, 593
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 576, 301, 584
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 567, 301, 575
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 558, 238, 566
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 549, 301, 557
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 540, 301, 548
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 531, 301, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 522, 301, 530
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 513, 108, 521
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 504, 301, 512
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 495, 301, 503
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 486, 301, 494
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 477, 222, 485
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 468, 301, 476
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 459, 301, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 450, 301, 458
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 441, 301, 449
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 432, 89, 440
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 423, 301, 431
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 414, 301, 422
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 405, 301, 413
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 396, 301, 404
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 387, 230, 395
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 378, 301, 386
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 369, 301, 377
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 360, 301, 368
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 351, 301, 359
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 342, 301, 350
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 333, 301, 341
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 325, 301, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 316, 119, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 307, 301, 315
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 298, 301, 306
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 289, 301, 297
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 280, 257, 288
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 271, 301, 279
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 262, 301, 270
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 253, 301, 261
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 244, 301, 252
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 235, 114, 243
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 226, 301, 234
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 217, 301, 225
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 208, 301, 216
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 199, 301, 207
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 190, 107, 198
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 181, 301, 189
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 172, 301, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 163, 300, 171
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 154, 301, 162
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 145, 301, 153
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 136, 301, 144
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 127, 301, 135
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 118, 209, 126
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 109, 301, 117
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 100, 301, 108
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 91, 301, 99
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 71, 82, 230, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 73, 301, 81
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 70, 65, 301, 72
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 746, 563, 754
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 737, 444, 745
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 728, 563, 736
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 719, 563, 727
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 710, 563, 718
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 701, 493, 709
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 692, 563, 700
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 683, 563, 691
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 674, 563, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 665, 563, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 656, 563, 664
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 647, 363, 655
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 638, 563, 646
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 629, 563, 637
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 620, 563, 628
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 611, 563, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 602, 479, 610
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 594, 563, 602
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 585, 563, 593
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 576, 537, 584
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 567, 564, 575
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 558, 564, 566
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 549, 564, 557
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 540, 564, 548
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 531, 363, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 522, 563, 530
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 513, 563, 521
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 504, 563, 512
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 495, 354, 503
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 486, 563, 494
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 477, 563, 485
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 468, 563, 476
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 459, 454, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 450, 563, 458
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 441, 563, 449
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 432, 563, 440
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 423, 563, 431
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 414, 527, 422
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 405, 563, 413
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 396, 563, 404
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 387, 563, 395
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 378, 414, 386
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 369, 563, 377
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 360, 563, 368
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 351, 563, 359
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 342, 563, 350
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 332, 333, 390, 341
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 325, 563, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 316, 563, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 307, 519, 315
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 298, 563, 306
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 289, 563, 297
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 280, 563, 288
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 271, 361, 279
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 262, 563, 270
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 253, 563, 261
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 244, 563, 252
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 235, 529, 243
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 226, 563, 234
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 217, 563, 225
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 208, 563, 216
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 199, 563, 207
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 190, 403, 198
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 181, 564, 189
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 172, 564, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 163, 564, 171
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 154, 564, 162
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 334, 145, 356, 153
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 136, 563, 144
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 127, 553, 135
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 118, 563, 126
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 109, 563, 117
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 100, 563, 108
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 91, 367, 99
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 82, 563, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 73, 563, 81
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 333, 65, 466, 72
       Flags: Print
    Page: 
     Label: 16
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 746, 291, 754
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 737, 291, 745
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 728, 250, 736
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 60, 719, 291, 727
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 60, 710, 291, 718
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 60, 701, 291, 709
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 60, 692, 224, 700
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 683, 291, 691
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 674, 291, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 665, 265, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 656, 291, 664
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 61, 647, 257, 655
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 746, 553, 754
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 737, 553, 745
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 728, 553, 736
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 719, 385, 727
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 710, 553, 718
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 701, 553, 709
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 692, 553, 700
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 683, 553, 691
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 674, 367, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 665, 553, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 656, 553, 664
       Flags: Print
      Annotation: 
       Subtype: Link
       Contents: 
       Rect: 323, 647, 537, 655
       Flags: Print
  Checksum: 0b3664c0
   Type: CRC32
  Checksum: 9d7133297b17ff5472278a436bde65ff
   Type: MD5
  Checksum: e959a950521838e650c2259df64702db4757bd89
   Type: SHA-1
  Checksum: 771ea79b5dcf1072d135f7b204fc28a8f002b256ffde709d5c8c703d032791b5
   Type: SHA-256