d9d04d3621e22672443c6f7f46685246 jcm-14-04720.pdf 4be05b80b6e18766cd6f18b5f4773f17b7a5b6cb jcm-14-04720.pdf 97104d4dbef46c63051d2c83ae24cc2db6a993365bd4e0fc46afdd11b550c0c6 jcm-14-04720.pdf Title: A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population Subject: Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies. Keywords: Abdominal Aortic Aneurysm (AAA); risk prediction models; AAA screening; risk factors Author: Olga Peypoch, Laura Calsina Juscafresa, Antón Vega-Méndez, Bárbara Lobato-Delgado, Joan Fité, Begoña Soto, Lluis Nieto, Mireia de la Rosa Estadella, Ager Uribezubia, Jose-María Romero, Emma Plana, Manuel Miralles, Albert Clarà, Jaume Dilmé, José Manuel Soria, Mercedes Camacho, Angel Martinez-Perez and Maria Sabater-Lleal Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Thu Jul 3 14:35:28 2025 CEST ModDate: Thu Jul 3 14:39:51 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1079680 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 DMTLJA+VnURWPalladioL Type 1 Custom yes yes yes 16 0 XPCQFA+URWPalladioL-Roma Type 1 Custom yes yes yes 21 0 BJOQNS+URWPalladioL-Bold Type 1 Custom yes yes yes 27 0 CLJYXX+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 KWKPAT+CMSY10 Type 1 Builtin yes yes yes 61 0 JEGDHL+PalatinoLinotype TrueType WinAnsi yes yes no 80 0 JEGDHL+PalatinoLinotype TrueType WinAnsi yes yes no 99 0 JEGDHJ+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 116 0 JEGDHL+PalatinoLinotype TrueType WinAnsi yes yes no 119 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-18 03:08:19 CEST RepresentationInformation: jcm-14-04720.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-17 19:55:08 CEST Size: 1079680 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 280 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Sample Inclusion Destination: subsection.2.1 Item: Title: Data Cleaning Destination: subsection.2.2 Item: Title: Statistical Modeling and Selection of Main Factors Associated with Aortic Diameter Destination: subsection.2.3 Item: Title: Statistical Modeling and Selection of Main Factors Associated with Aortic Diameter Growth Destination: subsection.2.4 Item: Title: Results Destination: section.3 Children: Item: Title: Cohort Description Destination: subsection.3.1 Item: Title: Growth Rate by Aortic Diameter Intervals Destination: subsection.3.2 Item: Title: Selection of Best Variables Influencing AAA Diameter Destination: subsection.3.3 Item: Title: Selection of Best Variables Influencing AAA Growth Rate Destination: subsection.3.4 Item: Title: Models to Predict Estimated Time to Surgery Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Children: Item: Title: Clinical Determinants of Aortic Diameter in Individuals with AAA Destination: subsection.4.1 Item: Title: AAA Expansion Rates per Diameter Interval and Clinical Determinants of Expansion Destination: subsection.4.2 Item: Title: Optimization of Surveillance Intervals Destination: subsection.4.3 Item: Title: Strengths and Limitations Destination: subsection.4.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population Author: Olga Peypoch, Laura Calsina Juscafresa, Antón Vega-Méndez, Bárbara Lobato-Delgado, Joan Fité, Begoña Soto, Lluis Nieto, Mireia de la Rosa Estadella, Ager Uribezubia, Jose-María Romero, Emma Plana, Manuel Miralles, Albert Clarà, Jaume Dilmé, José Manuel Soria, Mercedes Camacho, Angel Martinez-Perez and Maria Sabater-Lleal Subject: Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies. 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