1f732c80253e53c0bcdddcd13a292993 blooda_adv-2025-016180-main.pdf 7e1dc5dc4a2663e8cadf057b0e6a39e6f265e9f4 blooda_adv-2025-016180-main.pdf 657ec9519161683bb91226bd86fe3a9d25727f709e70f1f441c6be63cb493c88 blooda_adv-2025-016180-main.pdf Title: The role of miR-150-5p/E2F3/survivin axis in the pathogenesis of plasmablastic lymphoma and its therapeutic potential Subject: BLOOD ADVANCES, 9 (2025) 2953-2967. doi:10.1182/bloodadvances.2025016180 Author: Miriam Verdú-Bou Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Thu Jun 19 00:53:55 2025 CEST ModDate: Mon Oct 20 19:35:22 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 4298362 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HKPFCL+AdvOTee8bf91a Type 1C WinAnsi yes yes no 64 0 HKPFCM+AdvstixtSym Type 1C Custom yes yes yes 65 0 HKPEPB+AdvTT51434264 Type 1C WinAnsi yes yes no 1042 0 HKPEPC+AdvOT333dc5e5 Type 1C WinAnsi yes yes no 67 0 HKPEPD+Advstixtexrm Type 1C Custom yes yes yes 552 0 HKPEPE+AdvOT333dc5e5+fb Type 1C Custom yes yes yes 68 0 HKPFAF+AdvOT333dc5e5+20 Type 1C WinAnsi yes yes no 69 0 HKPFAG+AdvOT5921cb55.B Type 1C WinAnsi yes yes no 70 0 HKPFAH+AdvOT5921cb55.B+20 Type 1C WinAnsi yes yes no 71 0 HKPFAI+AdvOT702dc698.I Type 1C WinAnsi yes yes no 72 0 HKPFAJ+AdvTT51434264+fb Type 1C Custom yes yes yes 1043 0 HKPFAK+AdvTT51434264+20 Type 1C WinAnsi yes yes no 1044 0 HKPFAL+AdvTTb753ee21.I Type 1C WinAnsi yes yes no 1045 0 OJJCEB+ArialMT TrueType WinAnsi yes yes no 1 0 HKPFDN+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 66 0 HKPFHM+AkzidenzGroteskBE-Bold Type 1C WinAnsi yes yes no 90 0 HKPFJM+AkzidenzGroteskBE-Regular Type 1C WinAnsi yes yes no 91 0 HKPFJN+AkzidenzGroteskBE-It Type 1C WinAnsi yes yes no 92 0 HKPFJO+SymbolMT Type 1C Custom yes yes no 93 0 HKPHBG+AkzidenzGroteskBE-Cn Type 1C WinAnsi yes yes no 94 0 HKPIGP+AdvOT5921cb55.B+fb Type 1C Custom yes yes yes 133 0 HKPIHA+AdvOT28113c6d.BI Type 1C WinAnsi yes yes no 134 0 HKPIHB+AdvOT28113c6d.BI+20 Type 1C WinAnsi yes yes no 135 0 HKPLAC+AkzidenzGroteskBE-Regular Type 1C WinAnsi yes yes no 300 0 HKPLDC+AkzidenzGroteskBE-Cn Type 1C WinAnsi yes yes no 301 0 HKPLED+AkzidenzGroteskBE-It Type 1C WinAnsi yes yes no 302 0 HKPMBP+AkzidenzGroteskBE-Bold Type 1C WinAnsi yes yes no 303 0 HKPFHM+AkzidenzGroteskBE-Bold Type 1C WinAnsi yes yes no 483 0 HKPFJM+AkzidenzGroteskBE-Regular Type 1C WinAnsi yes yes no 484 0 HKPPEO+AkzidenzGroteskBE-Md Type 1C WinAnsi yes yes no 485 0 HKPHBG+AkzidenzGroteskBE-Cn Type 1C WinAnsi yes yes no 486 0 HKPPOM+AdvOT702dc698.I+fb Type 1C Custom yes yes yes 551 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-21 03:48:55 CEST RepresentationInformation: blooda_adv-2025-016180-main.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-20 19:38:19 CEST Size: 4298362 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1138 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: The role of miR-150-5p/E2F3/survivin axis in the pathogenesis of plasmablastic lymphoma and its therapeutic potential Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Patients’ samples Destination: slink1 Item: Title: RNA-seq Destination: slink2 Item: Title: Microarrays Destination: slink3 Item: Title: CAM assay Destination: slink4 Item: Title: Results Destination: flink3 Children: Item: Title: Clinical features of the PBL cohort Destination: slink5 Item: Title: E2F-mediated cell cycle disruption in PBL Destination: slink6 Item: Title: miRNA expression profile in PBL Destination: slink7 Children: Item: Title: miRNA expression pattern is associated with MYC-t Destination: thirlink1 Item: Title: miRNAs regulate cell cycle control and tumor progression–associated pathways Destination: thirlink2 Item: Title: miR-150-5p acts as a tumor suppressor in PBL Destination: slink8 Item: Title: E2F3 drives lymphomagenesis in PBL Destination: slink9 Item: Title: miR-150-5p/E2F3–negative regulatory loop Destination: slink10 Item: Title: E2F3 is an essential target of miR-150-5p in the regulation of the cell cycle and apoptosis Destination: slink11 Item: Title: E2F3 and survivin as potential therapeutic targets of PBL-1 Destination: slink12 Item: Title: Discussion Destination: flink4 Item: Title: Authorship Destination: flink5 Item: Title: References Destination: blink1 Info: Title: The role of miR-150-5p/E2F3/survivin axis in the pathogenesis of plasmablastic lymphoma and its therapeutic potential Author: Miriam Verdú-Bou Subject: BLOOD ADVANCES, 9 (2025) 2953-2967. doi:10.1182/bloodadvances.2025016180 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Thu Jun 19 01:23:55 CEST 2025 ModDate: Mon Oct 20 19:35:22 CEST 2025 ID: 0x5bf605fd190a92bdae003f2e467eeac4, 0x9847dff583ad95fb37cb0abe09bcf314 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 296 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 296 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 36 ImageHeight: 171 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 42 ImageHeight: 201 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 100 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 3 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 517 ImageHeight: 588 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 53 ImageHeight: 258 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 30 ImageHeight: 18 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 354 ImageHeight: 355 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 354 ImageHeight: 354 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 233 ImageHeight: 91 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 233 ImageHeight: 66 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 233 ImageHeight: 122 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 91 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 96 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 180 ImageHeight: 180 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 228 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 180 ImageHeight: 3 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 230 ImageHeight: 228 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 83 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 230 ImageHeight: 224 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 110 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 228 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 79 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 181 ImageHeight: 180 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 98 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 180 ImageHeight: 180 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 58 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 180 ImageHeight: 181 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 231 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 80 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3 ImageHeight: 180 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 231 ImageHeight: 228 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 78 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 54 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 180 ImageHeight: 180 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 278 ImageHeight: 70 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 180 ImageHeight: 3 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 180 ImageHeight: 181 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 93 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 100 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 93 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 268 ImageHeight: 268 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 270 ImageHeight: 270 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 100 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 269 ImageHeight: 269 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 199 ImageHeight: 90 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 198 ImageHeight: 115 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 82 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 49 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 108 ImageHeight: 80 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 60 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 754 ImageHeight: 570 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 111 ImageHeight: 88 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 251 ImageHeight: 49 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 112 ImageHeight: 88 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 148 ImageHeight: 147 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 146 ImageHeight: 146 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 147 ImageHeight: 146 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png CompressionScheme: uncompressed ImageWidth: 18 ImageHeight: 17 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 113 ImageHeight: 87 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 148 ImageHeight: 147 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 97 ImageHeight: 76 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: HKPFCL+AdvOTee8bf91a FontSubset: true FirstChar: 44 LastChar: 218 FontDescriptor: FontName: HKPFCL+AdvOTee8bf91a Flags: Nonsymbolic FontBBox: -41, -250, 1010, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFCM+AdvstixtSym FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HKPFCM+AdvstixtSym Flags: Symbolic FontBBox: -20, -1114, 1135, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPFDN+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HKPFDN+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPEPC+AdvOT333dc5e5 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: HKPEPC+AdvOT333dc5e5 Flags: Nonsymbolic FontBBox: -31, -250, 1010, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPEPE+AdvOT333dc5e5+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HKPEPE+AdvOT333dc5e5+fb Flags: Symbolic FontBBox: 0, 0, 416, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPFAF+AdvOT333dc5e5+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: HKPFAF+AdvOT333dc5e5+20 Flags: Nonsymbolic FontBBox: -145, -145, 1218, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPIGP+AdvOT5921cb55.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKPIGP+AdvOT5921cb55.B+fb Flags: Symbolic FontBBox: 0, 0, 572, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPFAG+AdvOT5921cb55.B FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HKPFAG+AdvOT5921cb55.B Flags: Nonsymbolic FontBBox: -62, -250, 1104, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPIHA+AdvOT28113c6d.BI FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: HKPIHA+AdvOT28113c6d.BI Flags: Nonsymbolic FontBBox: -114, -250, 1062, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFAH+AdvOT5921cb55.B+20 FontSubset: true FirstChar: 129 LastChar: 150 FontDescriptor: FontName: HKPFAH+AdvOT5921cb55.B+20 Flags: Nonsymbolic FontBBox: -156, -166, 1218, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPIHB+AdvOT28113c6d.BI+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: HKPIHB+AdvOT28113c6d.BI+20 Flags: Nonsymbolic FontBBox: -208, -166, 1145, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFAI+AdvOT702dc698.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HKPFAI+AdvOT702dc698.I Flags: Nonsymbolic FontBBox: -93, -250, 1104, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPEPB+AdvTT51434264 FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HKPEPB+AdvTT51434264 Flags: Serif, Nonsymbolic FontBBox: -10, -239, 1031, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFAJ+AdvTT51434264+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKPFAJ+AdvTT51434264+fb Flags: Symbolic FontBBox: 19, 0, 979, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPFAK+AdvTT51434264+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: HKPFAK+AdvTT51434264+20 Flags: Nonsymbolic FontBBox: -177, -197, 1239, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFAL+AdvTTb753ee21.I FontSubset: true FirstChar: 44 LastChar: 89 FontDescriptor: FontName: HKPFAL+AdvTTb753ee21.I Flags: Nonsymbolic FontBBox: -156, -239, 1125, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFHM+AkzidenzGroteskBE-Bold FontSubset: true FirstChar: 32 LastChar: 72 FontDescriptor: FontName: HKPFHM+AkzidenzGroteskBE-Bold Flags: Nonsymbolic, ForceBold FontBBox: -166, -250, 1222, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFJM+AkzidenzGroteskBE-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: HKPFJM+AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFJN+AkzidenzGroteskBE-It FontSubset: true FirstChar: 45 LastChar: 89 FontDescriptor: FontName: HKPFJN+AkzidenzGroteskBE-It Flags: Nonsymbolic, Italic FontBBox: -123, -250, 1303, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFJO+SymbolMT FontSubset: true FirstChar: 2 LastChar: 4 FontDescriptor: FontName: HKPFJO+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: HKPHBG+AkzidenzGroteskBE-Cn FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: HKPHBG+AkzidenzGroteskBE-Cn Flags: Nonsymbolic FontBBox: -134, -250, 875, 901 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFHM+AkzidenzGroteskBE-Bold FontSubset: true FirstChar: 65 LastChar: 74 FontDescriptor: FontName: HKPFHM+AkzidenzGroteskBE-Bold Flags: Nonsymbolic, ForceBold FontBBox: -166, -250, 1222, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPFJM+AkzidenzGroteskBE-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: HKPFJM+AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPPEO+AkzidenzGroteskBE-Md FontSubset: true FirstChar: 43 LastChar: 83 FontDescriptor: FontName: HKPPEO+AkzidenzGroteskBE-Md Flags: Nonsymbolic, ForceBold FontBBox: -145, -250, 1225, 963 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPHBG+AkzidenzGroteskBE-Cn FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HKPHBG+AkzidenzGroteskBE-Cn Flags: Nonsymbolic FontBBox: -134, -250, 875, 901 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPPOM+AdvOT702dc698.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HKPPOM+AdvOT702dc698.I+fb Flags: Symbolic FontBBox: 51, 0, 552, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPEPD+Advstixtexrm FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: HKPEPD+Advstixtexrm Flags: Symbolic FontBBox: -385, -229, 1041, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HKPLAC+AkzidenzGroteskBE-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: HKPLAC+AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPLDC+AkzidenzGroteskBE-Cn FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: HKPLDC+AkzidenzGroteskBE-Cn Flags: Nonsymbolic FontBBox: -134, -250, 875, 901 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPLED+AkzidenzGroteskBE-It FontSubset: true FirstChar: 50 LastChar: 109 FontDescriptor: FontName: HKPLED+AkzidenzGroteskBE-It Flags: Nonsymbolic, Italic FontBBox: -123, -250, 1303, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HKPMBP+AkzidenzGroteskBE-Bold FontSubset: true FirstChar: 32 LastChar: 73 FontDescriptor: FontName: HKPMBP+AkzidenzGroteskBE-Bold Flags: Nonsymbolic, ForceBold FontBBox: -166, -250, 1222, 927 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: OJJCEB+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: OJJCEB+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1182/bloodadvances.2025016180 The role of miR-150-5p/E2F3/survivin axis in the pathogenesis of plasmablastic lymphoma and its therapeutic potential Miriam Verdú-Bou Maria Joao Baptista Marcelo Lima Ribeiro Aleix Méndez-López Núria Profitós-Pelejà Fabian Frontzek Gaël Roué José Luís Mate Mireia Pellicer Pau Abrisqueta Josep Castellví Mariana Bastos-Oreiro Javier Menárguez Miguel Alcoceba Eva González-Barca Fina Climent Antonio Salar Juan-Manuel Sancho Annette M. Staiger German Ott Ioannis Anagnostopoulos Manel Esteller Georg Lenz Gustavo Tapia∗ José-Tomás Navarro∗ BLOOD ADVANCES, 9 (2025) 2953-2967. doi:10.1182/bloodadvances.2025016180 The American Society of Hematology journal BLOOD ADVANCES © 2025 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. 2473-9529 9 12 24 June 2025 2025-06-24 2953-2967 2953 2967 10.1182/bloodadvances.2025016180 https://doi.org/10.1182/bloodadvances.2025016180 VoR 7.0.1 10.1182/bloodadvances.2025016180 noindex Elsevier 2025-06-19T04:23:55+05:30 2025-10-20T17:35:22+00:00 2025-10-20T17:35:22+00:00 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 uuid:d97ba1b3-2e27-415f-a762-deb4ca0eea6b uuid:c9ccc291-e7d6-484b-800e-a8e85335faab https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode Pages: Page: Label: 2953 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 105, 619, 105, 621 Annotation: Subtype: Link Rect: 107, 622, 111, 631 Destination: 962 Annotation: Subtype: Link Rect: 113, 622, 117, 631 Destination: 962 Annotation: Subtype: Link Rect: 195, 619, 195, 621 Annotation: Subtype: Link Rect: 197, 622, 201, 631 Destination: 962 Annotation: Subtype: Link Rect: 285, 619, 285, 621 Annotation: Subtype: Link Rect: 287, 622, 291, 631 Destination: 962 Annotation: Subtype: Link Rect: 370, 619, 370, 621 Annotation: Subtype: Link Rect: 371, 622, 375, 631 Destination: 962 Annotation: Subtype: Link Rect: 456, 619, 456, 621 Annotation: Subtype: Link Rect: 458, 622, 462, 631 Destination: 962 Annotation: Subtype: Link Rect: 525, 619, 525, 621 Annotation: Subtype: Link Rect: 527, 622, 531, 631 Destination: 962 Annotation: Subtype: Link Rect: 533, 622, 537, 631 Destination: 962 Annotation: Subtype: Link Rect: 78, 607, 78, 609 Annotation: Subtype: Link Rect: 80, 610, 83, 619 Destination: 962 Annotation: Subtype: Link Rect: 144, 607, 144, 609 Annotation: Subtype: Link Rect: 146, 610, 150, 619 Destination: 962 Annotation: Subtype: Link Rect: 206, 607, 206, 609 Annotation: Subtype: Link Rect: 208, 610, 212, 619 Destination: 962 Annotation: Subtype: Link Rect: 273, 607, 273, 609 Annotation: Subtype: Link Rect: 275, 610, 279, 619 Destination: 962 Annotation: Subtype: Link Rect: 339, 607, 339, 609 Annotation: Subtype: Link Rect: 341, 610, 345, 619 Destination: 962 Annotation: Subtype: Link Rect: 434, 607, 434, 609 Annotation: Subtype: Link Rect: 436, 610, 443, 619 Destination: 962 Annotation: Subtype: Link Rect: 512, 607, 512, 609 Annotation: Subtype: Link Rect: 514, 610, 522, 619 Destination: 962 Annotation: Subtype: Link Rect: 99, 595, 99, 597 Annotation: Subtype: Link Rect: 101, 598, 109, 607 Destination: 962 Annotation: Subtype: Link Rect: 187, 595, 187, 597 Annotation: Subtype: Link Rect: 189, 598, 197, 607 Destination: 962 Annotation: Subtype: Link Rect: 246, 595, 246, 597 Annotation: Subtype: Link Rect: 248, 598, 256, 607 Destination: 962 Annotation: Subtype: Link Rect: 309, 595, 309, 597 Annotation: Subtype: Link Rect: 311, 598, 319, 607 Destination: 962 Annotation: Subtype: Link Rect: 399, 595, 399, 597 Annotation: Subtype: Link Rect: 401, 598, 405, 607 Destination: 962 Annotation: Subtype: Link Rect: 407, 598, 411, 607 Destination: 962 Annotation: Subtype: Link Rect: 484, 595, 484, 597 Annotation: Subtype: Link Rect: 486, 598, 493, 607 Destination: 962 Annotation: Subtype: Link Rect: 541, 595, 541, 597 Annotation: Subtype: Link Rect: 543, 598, 550, 607 Destination: 962 Annotation: Subtype: Link Rect: 132, 583, 132, 585 Annotation: Subtype: Link Rect: 134, 586, 142, 595 Destination: 962 Annotation: Subtype: Link Rect: 199, 583, 199, 585 Annotation: Subtype: Link Rect: 200, 586, 208, 595 Destination: 962 Annotation: Subtype: Link Rect: 256, 583, 256, 585 Annotation: Subtype: Link Rect: 258, 586, 262, 595 Destination: 962 Annotation: Subtype: Link Rect: 320, 583, 320, 585 Annotation: Subtype: Link Rect: 322, 586, 326, 595 Destination: 962 Annotation: Subtype: Link Rect: 429, 583, 429, 585 Annotation: Subtype: Link Rect: 429, 586, 432, 595 Destination: 962 Annotation: Subtype: Link Rect: 434, 586, 438, 595 Destination: 962 Annotation: Subtype: Link Rect: 439, 586, 443, 595 Destination: 962 Annotation: Subtype: Link Rect: 56, 106, 216, 113 Annotation: Subtype: Link Rect: 305, 104, 556, 111 Annotation: Subtype: Link Rect: 305, 95, 368, 102 Annotation: Subtype: Link Rect: 493, 762, 586, 782 Page: Label: 2954 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 150, 663, 154, 672 Destination: 501 Annotation: Subtype: Link Rect: 174, 641, 178, 650 Destination: 501 Annotation: Subtype: Link Rect: 179, 641, 183, 650 Destination: 501 Annotation: Subtype: Link Rect: 219, 630, 223, 639 Destination: 501 Annotation: Subtype: Link Rect: 146, 608, 150, 617 Destination: 501 Annotation: Subtype: Link Rect: 233, 586, 237, 595 Destination: 501 Annotation: Subtype: Link Rect: 231, 537, 241, 546 Destination: 501 Annotation: Subtype: Link Rect: 214, 515, 224, 524 Destination: 501 Annotation: Subtype: Link Rect: 261, 460, 265, 469 Destination: 501 Annotation: Subtype: Link Rect: 98, 428, 102, 436 Destination: 501 Annotation: Subtype: Link Rect: 274, 406, 281, 415 Destination: 501 Annotation: Subtype: Link Rect: 260, 323, 268, 332 Destination: 501 Annotation: Subtype: Link Rect: 59, 225, 66, 234 Destination: 501 Annotation: Subtype: Link Rect: 68, 225, 76, 234 Destination: 501 Annotation: Subtype: Link Rect: 392, 229, 423, 238 Destination: 83 Annotation: Subtype: Link Rect: 417, 152, 452, 161 Destination: 83 Annotation: Subtype: Link Rect: 348, 97, 381, 106 Destination: 83 Page: Label: 2955 Sequence: 3 Page: Label: 2956 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 230, 678, 262, 687 Destination: 83 Annotation: Subtype: Link Rect: 131, 655, 139, 664 Destination: 501 Annotation: Subtype: Link Rect: 55, 567, 63, 576 Destination: 501 Annotation: Subtype: Link Rect: 65, 567, 72, 576 Destination: 607 Annotation: Subtype: Link Rect: 191, 470, 224, 479 Destination: 83 Annotation: Subtype: Link Rect: 36, 393, 69, 402 Destination: 83 Annotation: Subtype: Link Rect: 132, 322, 164, 331 Destination: 83 Annotation: Subtype: Link Rect: 515, 711, 548, 720 Destination: 145 Annotation: Subtype: Link Rect: 382, 656, 414, 665 Destination: 145 Annotation: Subtype: Link Rect: 389, 623, 421, 632 Destination: 145 Annotation: Subtype: Link Rect: 321, 562, 329, 571 Destination: 607 Annotation: Subtype: Link Rect: 330, 562, 338, 571 Destination: 607 Annotation: Subtype: Link Rect: 352, 434, 384, 443 Destination: 145 Annotation: Subtype: Link Rect: 475, 347, 508, 356 Destination: 145 Annotation: Subtype: Link Rect: 334, 286, 352, 295 Destination: 607 Annotation: Subtype: Link Rect: 549, 286, 556, 295 Destination: 607 Annotation: Subtype: Link Rect: 324, 264, 331, 273 Destination: 607 Page: Label: 2957 Sequence: 5 Page: Label: 2958 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 145, 715, 153, 724 Destination: 607 Annotation: Subtype: Link Rect: 220, 678, 252, 687 Destination: 145 Annotation: Subtype: Link Rect: 235, 546, 243, 555 Destination: 607 Annotation: Subtype: Link Rect: 142, 520, 175, 529 Destination: 291 Annotation: Subtype: Link Rect: 39, 394, 72, 403 Destination: 291 Annotation: Subtype: Link Rect: 114, 383, 145, 392 Destination: 291 Annotation: Subtype: Link Rect: 188, 350, 222, 359 Destination: 291 Annotation: Subtype: Link Rect: 66, 278, 74, 287 Destination: 607 Annotation: Subtype: Link Rect: 142, 252, 175, 261 Destination: 291 Annotation: Subtype: Link Rect: 369, 700, 401, 709 Destination: 291 Annotation: Subtype: Link Rect: 346, 678, 379, 687 Destination: 291 Annotation: Subtype: Link Rect: 510, 667, 544, 676 Destination: 291 Annotation: Subtype: Link Rect: 503, 545, 536, 554 Destination: 353 Annotation: Subtype: Link Rect: 377, 501, 411, 510 Destination: 353 Annotation: Subtype: Link Rect: 455, 469, 492, 477 Destination: 353 Annotation: Subtype: Link Rect: 398, 414, 431, 423 Destination: 353 Annotation: Subtype: Link Rect: 385, 353, 417, 362 Destination: 353 Annotation: Subtype: Link Rect: 408, 342, 440, 351 Destination: 353 Annotation: Subtype: Link Rect: 394, 257, 402, 266 Destination: 607 Page: Label: 2959 Sequence: 7 Page: Label: 2960 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 235, 700, 267, 709 Destination: 353 Annotation: Subtype: Link Rect: 243, 689, 277, 698 Destination: 433 Annotation: Subtype: Link Rect: 124, 667, 157, 676 Destination: 433 Annotation: Subtype: Link Rect: 243, 645, 276, 654 Destination: 433 Annotation: Subtype: Link Rect: 39, 532, 73, 541 Destination: 433 Annotation: Subtype: Link Rect: 65, 510, 98, 519 Destination: 433 Annotation: Subtype: Link Rect: 180, 499, 214, 508 Destination: 433 Annotation: Subtype: Link Rect: 60, 321, 91, 330 Destination: 466 Annotation: Subtype: Link Rect: 191, 288, 224, 297 Destination: 466 Annotation: Subtype: Link Rect: 39, 227, 71, 236 Destination: 466 Annotation: Subtype: Link Rect: 371, 689, 402, 698 Destination: 466 Annotation: Subtype: Link Rect: 308, 569, 339, 578 Destination: 466 Annotation: Subtype: Link Rect: 494, 525, 525, 534 Destination: 466 Annotation: Subtype: Link Rect: 439, 503, 471, 512 Destination: 466 Annotation: Subtype: Link Rect: 511, 367, 518, 376 Destination: 501 Annotation: Subtype: Link Rect: 520, 367, 527, 376 Destination: 607 Annotation: Subtype: Link Rect: 529, 367, 546, 376 Destination: 607 Annotation: Subtype: Link Rect: 393, 263, 401, 272 Destination: 607 Annotation: Subtype: Link Rect: 403, 263, 410, 272 Destination: 607 Annotation: Subtype: Link Rect: 410, 241, 418, 250 Destination: 607 Annotation: Subtype: Link Rect: 419, 241, 427, 250 Destination: 607 Annotation: Subtype: Link Rect: 511, 230, 529, 239 Destination: 607 Page: Label: 2961 Sequence: 9 Page: Label: 2962 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 253, 666, 261, 675 Destination: 607 Annotation: Subtype: Link Rect: 263, 666, 271, 675 Destination: 607 Annotation: Subtype: Link Rect: 241, 655, 249, 664 Destination: 501 Annotation: Subtype: Link Rect: 251, 655, 259, 664 Destination: 607 Annotation: Subtype: Link Rect: 261, 655, 268, 664 Destination: 607 Annotation: Subtype: Link Rect: 113, 578, 121, 587 Destination: 607 Annotation: Subtype: Link Rect: 128, 545, 135, 554 Destination: 607 Annotation: Subtype: Link Rect: 174, 485, 181, 494 Destination: 607 Annotation: Subtype: Link Rect: 183, 485, 191, 494 Destination: 607 Annotation: Subtype: Link Rect: 197, 463, 204, 472 Destination: 607 Annotation: Subtype: Link Rect: 206, 463, 213, 472 Destination: 607 Annotation: Subtype: Link Rect: 210, 364, 218, 373 Destination: 607 Annotation: Subtype: Link Rect: 486, 638, 494, 647 Destination: 725 Annotation: Subtype: Link Rect: 325, 616, 333, 625 Destination: 725 Annotation: Subtype: Link Rect: 372, 584, 380, 593 Destination: 725 Annotation: Subtype: Link Rect: 389, 487, 397, 496 Destination: 725 Annotation: Subtype: Link Rect: 399, 487, 407, 496 Destination: 725 Annotation: Subtype: Link Rect: 442, 487, 450, 496 Destination: 725 Annotation: Subtype: Link Rect: 413, 465, 421, 474 Destination: 725 Annotation: Subtype: Link Rect: 423, 465, 431, 474 Destination: 725 Annotation: Subtype: Link Rect: 497, 465, 505, 474 Destination: 725 Annotation: Subtype: Link Rect: 507, 465, 515, 474 Destination: 725 Annotation: Subtype: Link Rect: 397, 410, 405, 419 Destination: 725 Annotation: Subtype: Link Rect: 407, 410, 414, 419 Destination: 725 Page: Label: 2963 Sequence: 11 Page: Label: 2964 Sequence: 12 Page: Label: 2965 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 412, 508, 502, 517 Annotation: Subtype: Link Rect: 533, 508, 556, 517 Annotation: Subtype: Link Rect: 305, 497, 372, 506 Annotation: Subtype: Link Rect: 406, 497, 497, 506 Annotation: Subtype: Link Rect: 533, 497, 556, 506 Annotation: Subtype: Link Rect: 305, 486, 373, 495 Annotation: Subtype: Link Rect: 402, 486, 492, 495 Annotation: Subtype: Link Rect: 533, 486, 556, 495 Annotation: Subtype: Link Rect: 305, 475, 372, 484 Annotation: Subtype: Link Rect: 409, 475, 499, 484 Annotation: Subtype: Link Rect: 533, 475, 556, 484 Annotation: Subtype: Link Rect: 305, 465, 372, 474 Annotation: Subtype: Link Rect: 414, 465, 504, 474 Annotation: Subtype: Link Rect: 533, 465, 556, 474 Annotation: Subtype: Link Rect: 305, 454, 372, 463 Annotation: Subtype: Link Rect: 408, 454, 498, 463 Annotation: Subtype: Link Rect: 533, 454, 556, 463 Annotation: Subtype: Link Rect: 305, 443, 372, 452 Annotation: Subtype: Link Rect: 405, 443, 496, 452 Annotation: Subtype: Link Rect: 478, 404, 550, 413 Annotation: Subtype: Link Rect: 54, 345, 556, 353 Annotation: Subtype: Link Rect: 54, 335, 173, 343 Annotation: Subtype: Link Rect: 54, 321, 550, 329 Annotation: Subtype: Link Rect: 54, 311, 319, 319 Annotation: Subtype: Link Rect: 54, 297, 110, 305 Annotation: Subtype: Link Rect: 114, 297, 551, 305 Annotation: Subtype: Link Rect: 54, 287, 138, 295 Annotation: Subtype: Link Rect: 54, 273, 470, 281 Annotation: Subtype: Link Rect: 54, 259, 556, 267 Annotation: Subtype: Link Rect: 54, 249, 243, 257 Annotation: Subtype: Link Rect: 54, 236, 541, 244 Annotation: Subtype: Link Rect: 54, 226, 202, 234 Annotation: Subtype: Link Rect: 54, 212, 556, 220 Annotation: Subtype: Link Rect: 54, 202, 122, 210 Annotation: Subtype: Link Rect: 54, 188, 556, 196 Annotation: Subtype: Link Rect: 54, 178, 196, 186 Annotation: Subtype: Link Rect: 54, 164, 549, 172 Annotation: Subtype: Link Rect: 54, 154, 230, 162 Annotation: Subtype: Link Rect: 54, 140, 556, 148 Annotation: Subtype: Link Rect: 54, 130, 132, 138 Annotation: Subtype: Link Rect: 54, 116, 556, 124 Annotation: Subtype: Link Rect: 54, 106, 109, 114 Annotation: Subtype: Link Rect: 54, 92, 556, 100 Annotation: Subtype: Link Rect: 54, 82, 109, 90 Annotation: Subtype: Link Rect: 54, 68, 406, 76 Page: Label: 2966 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 54, 712, 512, 720 Annotation: Subtype: Link Rect: 54, 698, 556, 706 Annotation: Subtype: Link Rect: 54, 688, 250, 696 Annotation: Subtype: Link Rect: 54, 674, 547, 682 Annotation: Subtype: Link Rect: 54, 664, 145, 672 Annotation: Subtype: Link Rect: 54, 650, 556, 658 Annotation: Subtype: Link Rect: 54, 640, 104, 648 Annotation: Subtype: Link Rect: 54, 626, 553, 634 Annotation: Subtype: Link Rect: 54, 616, 299, 624 Annotation: Subtype: Link Rect: 54, 602, 542, 610 Annotation: Subtype: Link Rect: 54, 593, 200, 601 Annotation: Subtype: Link Rect: 54, 579, 556, 587 Annotation: Subtype: Link Rect: 54, 569, 114, 577 Annotation: Subtype: Link Rect: 54, 555, 556, 563 Annotation: Subtype: Link Rect: 54, 545, 321, 553 Annotation: Subtype: Link Rect: 54, 531, 556, 539 Annotation: Subtype: Link Rect: 54, 521, 208, 529 Annotation: Subtype: Link Rect: 54, 507, 556, 515 Annotation: Subtype: Link Rect: 54, 497, 102, 505 Annotation: Subtype: Link Rect: 54, 483, 556, 491 Annotation: Subtype: Link Rect: 54, 473, 178, 481 Annotation: Subtype: Link Rect: 54, 459, 556, 467 Annotation: Subtype: Link Rect: 54, 449, 190, 457 Annotation: Subtype: Link Rect: 54, 435, 447, 443 Annotation: Subtype: Link Rect: 54, 421, 545, 429 Annotation: Subtype: Link Rect: 54, 407, 556, 415 Annotation: Subtype: Link Rect: 54, 397, 144, 405 Annotation: Subtype: Link Rect: 54, 383, 556, 391 Annotation: Subtype: Link Rect: 54, 373, 181, 381 Annotation: Subtype: Link Rect: 54, 359, 66, 367 Annotation: Subtype: Link Rect: 70, 359, 555, 367 Annotation: Subtype: Link Rect: 54, 349, 140, 357 Annotation: Subtype: Link Rect: 54, 335, 545, 343 Annotation: Subtype: Link Rect: 54, 326, 388, 333 Annotation: Subtype: Link Rect: 54, 312, 556, 320 Annotation: Subtype: Link Rect: 54, 302, 235, 310 Annotation: Subtype: Link Rect: 54, 288, 532, 296 Annotation: Subtype: Link Rect: 54, 274, 553, 282 Annotation: Subtype: Link Rect: 54, 264, 299, 272 Annotation: Subtype: Link Rect: 54, 250, 549, 258 Annotation: Subtype: Link Rect: 54, 240, 178, 248 Annotation: Subtype: Link Rect: 54, 226, 555, 234 Annotation: Subtype: Link Rect: 54, 212, 556, 220 Annotation: Subtype: Link Rect: 54, 202, 254, 210 Annotation: Subtype: Link Rect: 54, 188, 556, 196 Annotation: Subtype: Link Rect: 54, 178, 301, 186 Annotation: Subtype: Link Rect: 54, 164, 532, 172 Annotation: Subtype: Link Rect: 54, 154, 164, 162 Annotation: Subtype: Link Rect: 54, 140, 418, 148 Annotation: Subtype: Link Rect: 54, 126, 556, 134 Annotation: Subtype: Link Rect: 54, 116, 93, 124 Annotation: Subtype: Link Rect: 54, 102, 539, 110 Annotation: Subtype: Link Rect: 54, 88, 506, 96 Page: Label: 2967 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 54, 712, 556, 720 Annotation: Subtype: Link Rect: 54, 702, 154, 710 Annotation: Subtype: Link Rect: 54, 688, 556, 696 Annotation: Subtype: Link Rect: 54, 678, 111, 686 Annotation: Subtype: Link Rect: 54, 664, 520, 672 Annotation: Subtype: Link Rect: 54, 650, 505, 658 Annotation: Subtype: Link Rect: 54, 636, 556, 644 Annotation: Subtype: Link Rect: 54, 626, 67, 634 Annotation: Subtype: Link Rect: 54, 612, 556, 620 Annotation: Subtype: Link Rect: 54, 602, 292, 610 Annotation: Subtype: Link Rect: 54, 589, 537, 596 Annotation: Subtype: Link Rect: 54, 579, 93, 587 Annotation: Subtype: Link Rect: 54, 565, 447, 573 Annotation: Subtype: Link Rect: 54, 551, 555, 559 Annotation: Subtype: Link Rect: 54, 537, 496, 545 Checksum: 58d17971 Type: CRC32 Checksum: 1f732c80253e53c0bcdddcd13a292993 Type: MD5 Checksum: 7e1dc5dc4a2663e8cadf057b0e6a39e6f265e9f4 Type: SHA-1 Checksum: 657ec9519161683bb91226bd86fe3a9d25727f709e70f1f441c6be63cb493c88 Type: SHA-256