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Title:           LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria
Subject:         Journal of Lipid Research, 66 (2025) 100783. doi:10.1016/j.jlr.2025.100783
Author:          A. Benitez-Amaro
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     Item: 
      Title: LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria
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       Item: 
        Title: Material and methods
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        Children: 
         Item: 
          Title: Ethics statement, study design, and animal model description
          Destination: slink1
         Item: 
          Title: Serum NT-proBNP determinations
          Destination: slink2
         Item: 
          Title: Peptide synthesis and conjugation
          Destination: slink3
         Item: 
          Title: Transmission electron microscopy
          Destination: slink4
         Item: 
          Title: Isolation, purification, and characterization of mitochondrial fraction isolated from heart
          Destination: slink5
         Item: 
          Title: Western blot analysis
          Destination: slink6
         Item: 
          Title: TLC analysis of neutral lipid content in cardiac mitochondria
          Destination: slink7
         Item: 
          Title: Determination of gene expression by real-time PCR
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         Item: 
          Title: Confocal microscopy studies
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         Item: 
          Title: Respiration in frozen samples
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         Item: 
          Title: Determination of mitochondrial content in heart homogenates
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          Title: Statistical analysis
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        Title: Results
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          Title: Mitochondrial fraction isolated from the rabbit heart is not contaminated by lysosomes or LDs but retains MAM components
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         Item: 
          Title: HFHC triggers CE buildup in cardiac mitochondria and disrupts cristae mitochondrial architecture
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         Item: 
          Title: Anti-P3 Abs effectively inhibit CE accumulation in mitochondria and help to mitigate architectural alterations in cardiomyo ...
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         Item: 
          Title: Bioenergetic benefits of Anti-P3 aAbs: promoting mitochondria-LD interactions in cardiomyocytes
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         Item: 
          Title: Blocking mitochondrial CE accumulation restores complex II activity in the hearts of anti-P3–treated rabbits
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         Item: 
          Title: Mitochondrial CE accumulation is strongly associated with ECM expansion in rabbit hearts
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        Title: Discussion
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          Title: Limitations of this study
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               <rdf:li>E. Garcia</rdf:li>
               <rdf:li>M.T. LaChica Lhoëst</rdf:li>
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