925d48c05cac7eff52ec05546315773b  12974_2025_Article_3347.pdf
e812db064d5c4ac6a7ae7cc4f42e8bd290a77a15  12974_2025_Article_3347.pdf
7763049ab16cda6c43506997fd7388b845052d19b227c197e52e4e74b1a6abcb  12974_2025_Article_3347.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Tue Jan 21 11:19:37 2025 CET
ModDate:         Thu Jan 23 12:07:47 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           14
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       3014640 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     26  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     23  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     25  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     27  0
MyriadPro-It                         Type 1C           Custom           yes no  yes    934  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes     86  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes    988  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     24  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     30  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     33  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     47  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    208  0
MyriadPro-It                         Type 1C           Custom           yes no  yes    209  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes     73  0
HSYDQA+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     85  0
HSYDQA+STIX-Regular                  Type 1C           Custom           yes yes yes    117  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-11-21 04:25:02 CET
 RepresentationInformation: 12974_2025_Article_3347.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-11-20 18:01:01 CET
  Size: 3014640
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1034
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study participants
         Item: 
          Title: PBMC isolation
         Item: 
          Title: Single-cell RNA sequencing
         Item: 
          Title: Data processing
         Item: 
          Title: Differential gene expression and cell-type proportions
         Item: 
          Title: Inference of cell-cell communication
         Item: 
          Title: Flow cytometry
         Item: 
          Title: A model for predicting plasma NfL levels
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Expansion of peripheral immune cells in the blood of ALS patients
         Item: 
          Title: Extensive gene expression alterations in NK_2 and other immune cell populations in ALS
         Item: 
          Title: Inference of cell-cell communication patterns
         Item: 
          Title: Validation of alterations in cell type proportions using flow cytometry
         Item: 
          Title: Regression modeling implicates CD56bright NK cells in neurodegeneration
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Tue Jan 21 11:19:37 CET 2025
    ModDate: Thu Jan 23 12:07:47 CET 2025
   ID: 0x7b967d550177a0bec9d48e20dc4dc6e1, 0x3c75d27f10bef683b6ec202579a04197
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1866
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1391
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 599
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1431
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2008
      ImageHeight: 1283
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: HSYDQA+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: HSYDQA+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -175, -250, 1007, 933
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -153, -250, 1046, 935
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: HSYDQA+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: HSYDQA+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:InstanceID>uuid:d8889c1a-bc99-423b-b823-58079fb8dc1d</xmpMM:InstanceID>
         <xmpMM:OriginalDocumentID>adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31</xmpMM:OriginalDocumentID>
         <xmpMM:DocumentID>xmp.id:4cda0deb-e5d1-9646-9c5a-707349f08ee5</xmpMM:DocumentID>
         <xmpMM:RenditionClass>proof:pdf</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:DerivedFrom rdf:parseType="Resource">
            <stRef:instanceID>xmp.iid:d531cb6d-5cff-7249-b7d7-927c691b28c2</stRef:instanceID>
            <stRef:documentID>xmp.did:e8ec9483-60a6-9f4b-8371-d1f18938f337</stRef:documentID>
            <stRef:renditionClass>default</stRef:renditionClass>
         </xmpMM:DerivedFrom>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:parameters>from application/x-indesign to application/pdf</stEvt:parameters>
                  <stEvt:softwareAgent>Adobe InDesign 18.3 (Windows)</stEvt:softwareAgent>
                  <stEvt:when>2025-01-21T11:19:37+01:00</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:ffc418b8-67e4-4eb9-bb96-423eea615720</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2025-01-21T14:25:58+01:00</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <xmp:CreateDate>2025-01-21T11:19:37+01:00</xmp:CreateDate>
         <xmp:ModifyDate>2025-01-23T12:07:47+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2025-01-23T12:07:47+01:00</xmp:MetadataDate>
         <xmp:CreatorTool>Adobe InDesign 18.3 (Windows)</xmp:CreatorTool>
         <prism:aggregationType>journal</prism:aggregationType>
         <crossmark:DOI>10.1186/s12974-025-03347-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12974-025-03347-0</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <dc:format>application/pdf</dc:format>
         <pdf:Producer>Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>An unordered array of references to resources that were incorporated, by inclusion or reference, into this document.</pdfaProperty:description>
                           <pdfaProperty:name>Ingredients</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 508, 73, 538, 65
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 65, 279, 57
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 206, 575, 211, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 59, 551, 64, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 216, 515, 221, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 105, 479, 110, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 116, 479, 121, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 283, 479, 288, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 56, 467, 61, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 159, 359, 163, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 265, 71, 270, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 425, 407, 435, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 307, 287, 317, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 347, 575, 356, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 404, 563, 414, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 451, 563, 461, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 370, 467, 379, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 505, 395, 514, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 95, 683, 105, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 118, 623, 128, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 213, 575, 218, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 56
      Annotation: 
       Subtype: Link
       Rect: 273, 491, 278, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 166, 455, 171, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 78, 347, 83, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 198, 263, 203, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 159, 215, 164, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 360, 683, 365, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 504, 491, 509, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 325, 407, 329, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 521, 227, 526, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 496, 83, 501, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 131, 86, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 521, 119, 526, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 97
     Thumb: true
    Page: 
     Sequence: 7
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 151, 299, 156, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 266, 215, 271, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 194, 155, 199, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 110
      Annotation: 
       Subtype: Link
       Rect: 78, 71, 83, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 347, 215, 352, 202
       Flags: Print
       AppearanceDictionary: true
       Destination: 110
      Annotation: 
       Subtype: Link
       Rect: 437, 71, 442, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 110
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 179, 133, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 139, 179, 149, 166
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 180, 671, 184, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 189, 671, 194, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 139, 563, 144, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 150, 563, 155, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 227, 491, 232, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 239, 491, 244, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 248, 347, 258, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 138, 335, 148, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 195, 287, 200, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 205, 287, 215, 274
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 275, 155, 285, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 76, 83, 86, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 361, 527, 371, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 441, 443, 451, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 383, 395, 393, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 399, 395, 409, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 307, 275, 317, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 176, 707, 185, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 202, 623, 211, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 80, 587, 90, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 118, 467, 128, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 184, 443, 194, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 104, 227, 114, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 248, 191, 258, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 275, 119, 285, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 307, 683, 317, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 330, 587, 340, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 361, 443, 370, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 376, 443, 386, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 391, 443, 401, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 406, 443, 416, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 369, 299, 379, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 175
      Annotation: 
       Subtype: Link
       Rect: 384, 299, 393, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 527, 69, 514
       Flags: Print
       AppearanceDictionary: true
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 496, 695, 535, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 686, 398, 677
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Thumb: true
    Page: 
     Sequence: 14
     Thumb: true
  Checksum: ff02c6e3
   Type: CRC32
  Checksum: 925d48c05cac7eff52ec05546315773b
   Type: MD5
  Checksum: e812db064d5c4ac6a7ae7cc4f42e8bd290a77a15
   Type: SHA-1
  Checksum: 7763049ab16cda6c43506997fd7388b845052d19b227c197e52e4e74b1a6abcb
   Type: SHA-256