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Title:           Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum
Subject:         DOI: 10.1093/braincomms/fcaf173; Brain Communications, 7, 3, 2025-05-06.; Abstract: Dementia with Lewy bodies often presents with cholinergic degeneration and varying degrees of cerebrovascular disease. There is a lack of radiological methods for evaluating cholinergic degeneration in dementia with Lewy bodies. We investigated the potential of the Cholinergic Pathway Hyperintensities Scale (CHIPS) in identifying cerebrovascular disease–related disruptions in cholinergic white matter pathways, offering a practical and accessible method for assessing cholinergic integrity in neurodegenerative diseases. We assessed the associations of CHIPS with regional brain atrophy, Alzheimer’s disease co-pathology and clinical phenotype. Additionally, we compared its diagnostic performance to that of other manual and automated evaluation methods. We included 82 individuals (41 patients in the Lewy body continuum with either probable dementia with Lewy bodies or mild cognitive impairment with Lewy bo
Keywords:        dementia with Lewy bodies; cholinergic white matter pathways; CHIPS; white matter signal abnormalities
Author:          Cene Jerele
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     Item: 
      Title: Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum
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      Children: 
       Item: 
        Title: Introduction
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       Item: 
        Title: Methods
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         Item: 
          Title: Study population
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         Item: 
          Title: MRI scanning
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         Item: 
          Title: Global and regional manual measures of WMSA
          Destination: secfcaf173-s2.3
         Item: 
          Title: Automated segmentation of global WMSA assessed with FreeSurfer
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         Item: 
          Title: Tractography analysis of cholinergic white matter pathways
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         Item: 
          Title: Measures of regional brain atrophy
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         Item: 
          Title: CSF biomarkers
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         Item: 
          Title: Statistical analysis
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       Item: 
        Title: Results
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         Item: 
          Title: Cohort characteristics
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         Item: 
          Title: Interrater agreement
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         Item: 
          Title: Associations with age, sex, and education for selection of covariates
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         Item: 
          Title: Aim 1 part 1 group differences in WMSA markers and white matter cholinergic pathways (tractography)
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         Item: 
          Title: Aim 1 part 2 associations among WMSA markers and white matter cholinergic pathways (tractography)
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          Title: Aim 1 part 3 diagnostic performance of CHIPS and other MRI markers for discriminating LB patients from controls
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          Title: Aim 2 part 1 associations with regional brain atrophy
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          Title: Aim 2 part 2 associations with CSF biomarkers, clinical features, and cognitive performance
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        Title: Discussion
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        Title: Conclusion
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        Title: Supplementary material
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        Title: Funding
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        Title: Data availability
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   Type: MD5
  Checksum: f82e272b397d55792ddaeb356d48fe8f9e84255c
   Type: SHA-1
  Checksum: b57baa636983dd8b7dec844effd77003cb7bcf42b488f7a729f6cb6911b8206c
   Type: SHA-256