0ab9e512d2e6b50d66e54ce5a4a7826d ProtSci_Dallinger_Exper_recombi_rep_motifs.pdf 8510f2544b040fb3a36905652135a8b68b701b0d ProtSci_Dallinger_Exper_recombi_rep_motifs.pdf f319f3485a0a060ec9675abc69b42dfa932d3343ad9f93d4da350eb0efec8899 ProtSci_Dallinger_Exper_recombi_rep_motifs.pdf Title: Experimental recombining of repetitive motifs leads to large functional metallothioneins and demonstrates their modular evolvability potential Subject: Protein Science 2025.34:e5247 Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 24.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Thu Dec 12 18:45:18 2024 CET ModDate: Fri Nov 7 11:46:39 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 8805850 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JCBBEM+AdvOTc022ae45.B Type 1C WinAnsi yes yes no 48 0 JCBBNJ+AdvOT569473da Type 1C WinAnsi yes yes no 49 0 JCBBOK+AdvP4C4E59 Type 1C Custom yes yes yes 175 0 JCBBOL+AdvOTf2679e53.I Type 1C WinAnsi yes yes no 50 0 JCBBOM+AdvOT8608a8d1+03 Type 1C Custom yes yes yes 51 0 JCBDBG+AdvOT569473da+20 Type 1C WinAnsi yes yes no 52 0 Times-Roman Type 1 WinAnsi no no no 5 0 JCBDPC+AdvOT03676dda.BI Type 1C WinAnsi yes yes no 105 0 JCBEAC+AdvOTc022ae45.B+20 Type 1C WinAnsi yes yes no 106 0 JCBFBO+AdvP4C4E74 Type 1C Custom yes yes no 142 0 JCBFBP+AdvP4C4E40 Type 1C WinAnsi yes yes no 143 0 JCBFBN+AdvOT8608a8d1+20 Type 1C WinAnsi yes yes no 144 0 JCDHOK+AdvOT8608a8d1+22 Type 1C Custom yes yes yes 237 0 JCDHPK+AdvOTdd3b7348.I+03 Type 1C Custom yes yes yes 238 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-08 03:12:07 CET RepresentationInformation: ProtSci_Dallinger_Exper_recombi_rep_motifs.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-07 12:17:30 CET Size: 8805850 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Experimental recombining of repetitive motifs leads to large functional metallothioneins and demonstrates their modular evo... Destination: atl_PRO_5247_ Children: Item: Title: Abstract Destination: HeadingPRO_5247ABSid_1 Item: Title: 1 | INTRODUCTION Destination: HeadingPRO_5247pro5247-sec-0001 Item: Title: 2 | RESULTS Destination: HeadingPRO_5247pro5247-sec-0002 Children: Item: Title: 2.1 | The multidomain MT of Alinda biplicata as a model system Destination: HeadingPRO_5247pro5247-sec-0003 Item: Title: 2.2 | Chemical characterization of the metal–protein complexes Destination: HeadingPRO_5247pro5247-sec-0004 Item: Title: 2.3 | Metal tolerance in living cells Destination: HeadingPRO_5247pro5247-sec-0005 Item: Title: 3 | DISCUSSION Destination: HeadingPRO_5247pro5247-sec-0006 Children: Item: Title: 3.1 | Functional properties of multidomain MTs Destination: HeadingPRO_5247pro5247-sec-0007 Item: Title: 3.2 | Evolutionary implications of the modular architecture of MTs Destination: HeadingPRO_5247pro5247-sec-0008 Item: Title: 4 | MATERIALS AND METHODS Destination: HeadingPRO_5247pro5247-sec-0009 Children: Item: Title: 4.1 | Production and purification of recombinant metal–MT complexes Destination: HeadingPRO_5247pro5247-sec-0010 Item: Title: 4.2 | Analysis of metal–MT complexes Destination: HeadingPRO_5247pro5247-sec-0011 Item: Title: 4.3 | Metal tolerance assays in bacteria Destination: HeadingPRO_5247pro5247-sec-0012 Item: Title: 4.4 | Cloning AbiMTs in yeast expression vector and metal tolerance assays in yeast MT‐knockout cells Destination: HeadingPRO_5247pro5247-sec-0013 Item: Title: AUTHOR CONTRIBUTIONS Destination: HeadingPRO_5247pro5247-sec-0018 Item: Title: ACKNOWLEDGMENTS Destination: HeadingPRO_5247pro5247-sec-0014 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: HeadingPRO_5247pro5247-sec-0015 Item: Title: DATA AVAILABILITY STATEMENT Destination: HeadingPRO_5247pro5247-sec-0017 Item: Title: ORCID Destination: HeadingPRO_5247ORCid Item: Title: REFERENCES Destination: HeadingPRO_5247pro5247-bibl-00011 Item: Title: SUPPORTING INFORMATION Destination: HeadingPRO_5247SUPPid 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