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library preparation and sequencing Destination: s2_3 Item: Title: RNA-seq bioinformatic analysis Destination: s2_4 Item: Title: Inflammasome and innate immune memory assay Destination: s2_5 Item: Title: Western blot analysis Destination: s2_6 Item: Title: Virus infection of macrophages Destination: s2_7 Item: Title: Time-lapse microscopy of viral infection kinetics in macrophage populations Destination: s2_8 Item: Title: Phagocytosis assay using pHrodo Cell labeling kit Destination: s2_9 Item: Title: Flow cytometry and sorting Destination: s2_10 Item: Title: Statistical analyses Destination: s2_11 Item: Title: Results Destination: s3 Children: Item: Title: Rothia nasimurium stimulates cytokine production in various porcine immune cells Destination: s3_1 Item: Title: Heat-inactivated Rothia nasimurium fully activates the inflammasome Destination: s3_2 Item: Title: Antimicrobial properties of HI-Ro-treated macrophages Destination: s3_3 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 ID: 0x230d9ff93f4212584c0ac7df663e52bf, 0x7e8f4afd6e92e44c8588d77cd3fd7398 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2012 ImageHeight: 1560 BitsPerSample: 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Flags: Nonsymbolic FontBBox: -52, -208, 958, 875 FontFile3: true Encoding: MacRomanEncoding XMP: Aida Tort-Miró Uxía Alonso Beatriz Martín-Mur Jordana Muñoz-Basagoiti Yan Zeng David Marín-Moraleda Enrique Ezcurra Sergio Montaner-Tarbes María J. Navas Marta Muñoz Paula Monleón Judith González-Oliver Esmeralda Cano Carles Vilalta Marc Caballé Lourdes Criado Karl Kochanowski Francesc Accensi Virginia Aragón Florencia Correa-Fiz Anna Esteve-Codina Fernando Rodríguez Jordi Argilaguet Tort-Miró A, Alonso U, Martín-Mur B, Muñoz-Basagoiti J, Zeng Y, Marín-Moraleda D, Ezcurra E, Montaner-Tarbes S, Navas MJ, Muñoz M, Monleón P, González-Oliver J, Cano E, Vilalta C, Caballé M, Criado L, Kochanowski K, Accensi F, Aragón V, Correa-Fiz F, Esteve-Codina A, Rodríguez F and Argilaguet J (2025) Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages. Front. Immunol. 16:1584092. doi: 10.3389/fimmu.2025.1584092 Copyright © 2025 Tort-Miró, Alonso, Martín-Mur, Muñoz-Basagoiti, Zeng, Marín-Moraleda, Ezcurra, Montaner-Tarbes, Navas, Muñoz, Monleón, González-Oliver, Cano, Vilalta, Caballé, Criado, Kochanowski, Accensi, Aragón, Correa-Fiz, Esteve-Codina, Rodríguez and Argilaguet. 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Rothia nasimurium immunostimulant adjuvants antivirals innate immune memory porcine alveolar macrophages Inactivated Rothia nasimurium promotes a persistent antiviral immune status in porcine alveolar macrophages Rothia nasimurium; immunostimulant; adjuvants; antivirals; innate immune memory; porcine alveolar macrophages True https://www.frontiersin.org/legal/copyright-statement Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 221, 685, 515, 706 Annotation: Subtype: Link Rect: 221, 660, 515, 681 Annotation: Subtype: Link Rect: 221, 635, 468, 656 Annotation: Subtype: Link Rect: 221, 610, 434, 631 Annotation: Subtype: Link Rect: 403, 495, 412, 504 Annotation: Subtype: Link Rect: 49, 33, 129, 40 Annotation: Subtype: Link Rect: 500, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 690, 125, 705 Annotation: Subtype: Link Rect: 60, 546, 147, 553 Annotation: Subtype: Link Rect: 60, 526, 134, 533 Annotation: Subtype: Link Rect: 49, 318, 159, 325 Annotation: Subtype: Link Rect: 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