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      Title: Next-generation BCMA-targeted chimeric antigen receptor CARTemis-1: the impact of manufacturing procedure on CAR T-cell features
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        Title: Abstract
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        Title: 1 Background
       Item: 
        Title: 2 Methods
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          Title: 2.1 CAR gene construct and design
         Item: 
          Title: 2.2 In vitro studies with CARTemis-1
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          Title: 2.3 In vivo studies with CARTemis-1
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          Title: 2.4 GMP-manufacture of CARTemis-1
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          Title: 2.5 Statistical analysis
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        Title: 3 Results
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          Title: 3.1 Rationally designed next-generation anti-BCMA CAR-T (CARTemis-1) shows potent target recognition and no susceptibility to soluble BCMA inhibition
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          Title: 3.2 CARTemis-1 shows potent efficacy against myeloma cells both in vitro and in vivo
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          Title: 3.3 Characterization and optimization of the manufacturing protocol
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          Title: 3.4 CARTemis-1 cells can be successfully manufactured under GMP conditions with increased memory subpopulations and reduced exhaustion markers
         Item: 
          Title: 3.5 CARTemis-1 produced under GMP conditions shows potent and selective antitumor efficacy against MM cell lines and primary myeloma cells
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          Title: 3.6 CARTemis-1 has a potent antitumor effect in mouse models with no signs of GvHD or tissue damage
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        Title: 4 Discussion
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        Title: 5 Conclusions
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        Title: References
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