77e190bfc708064837db5cb23dccdc5c  320378.pdf
2ae48ffc5ff72303700a1e15842e88414884de08  320378.pdf
08b20f0096c849645f8ddcf848a3d909bb4bafb1eef38f316142e933b9e07bbe  320378.pdf

Title:           
Subject:         
Keywords:        The JAMA Network
Author:          American Medical Association
Creator:         XPP
Producer:        ; modified using iTextSharp.LGPLv2.Core 3.7.4.0
CreationDate:    Fri Dec 27 15:37:28 2024 CET
ModDate:         Mon Oct  6 13:38:10 2025 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       612 x 792 pts (letter)
Page rot:        0
File size:       1146846 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
NGLCKI+GuardianSans-Semibold         Type 1C           Custom           yes yes yes     33  0
NGLCKK+GuardianSans-Medium           Type 1C           Custom           yes yes yes     34  0
NGLCKM+GuardianSansGR-Regular        Type 1C           Custom           yes yes yes     35  0
NGLCLD+GuardianSans-RegularIt        Type 1C           Custom           yes yes yes     36  0
PBCKFH+ArialMT                       TrueType          WinAnsi          yes yes no       1  0
NGLDAC+MathematicalPi-One            Type 1C           Custom           yes yes no      77  0
NGLDDH+GuardianAgateSansGR-Medium    Type 1C           Custom           yes yes yes     96  0
NGLDDJ+GuardianAgateSans1GR-Regular  Type 1C           Custom           yes yes yes     97  0
NGLDGH+GuardianAgateSans1D-Bold      Type 1C           WinAnsi          yes yes no     114  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-10-07 03:58:13 CEST
 RepresentationInformation: 320378.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-10-06 14:58:14 CEST
  Size: 1146846
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 235
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
   Info: 
    Title: 
    Author: American Medical Association
    Subject: 
    Keywords: The JAMA Network
    Creator: XPP
    Producer: ; modified using iTextSharp.LGPLv2.Core 3.7.4.0
    CreationDate: Fri Dec 27 15:37:28 CET 2024
    ModDate: Mon Oct 06 13:38:10 CEST 2025
   ID: 0x324677fe156437ba92f99510a877a4c1, 0xb34061bdfc2b68c8a2019771d42aa8c7
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 111
      ImageHeight: 112
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: NGLDDH+GuardianAgateSansGR-Medium
      FontSubset: true
      FirstChar: 37
      LastChar: 121
      FontDescriptor: 
       FontName: NGLDDH+GuardianAgateSansGR-Medium
       Flags: Symbolic
       FontBBox: -260, -204, 1070, 1036
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLCKI+GuardianSans-Semibold
      FontSubset: true
      FirstChar: 43
      LastChar: 124
      FontDescriptor: 
       FontName: NGLCKI+GuardianSans-Semibold
       Flags: Symbolic
       FontBBox: -185, -222, 1277, 1082
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLDDJ+GuardianAgateSans1GR-Regular
      FontSubset: true
      FirstChar: 2
      LastChar: 133
      FontDescriptor: 
       FontName: NGLDDJ+GuardianAgateSans1GR-Regular
       Flags: Symbolic
       FontBBox: -250, -204, 1063, 1036
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLCKK+GuardianSans-Medium
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: NGLCKK+GuardianSans-Medium
       Flags: Symbolic
       FontBBox: -180, -219, 1240, 1072
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLDGH+GuardianAgateSans1D-Bold
      FontSubset: true
      FirstChar: 65
      LastChar: 67
      FontDescriptor: 
       FontName: NGLDGH+GuardianAgateSans1D-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -271, -226, 1072, 1036
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: NGLCKM+GuardianSansGR-Regular
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: NGLCKM+GuardianSansGR-Regular
       Flags: Symbolic
       FontBBox: -175, -217, 1194, 1061
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLCLD+GuardianSans-RegularIt
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: NGLCLD+GuardianSans-RegularIt
       Flags: Symbolic, Italic
       FontBBox: -217, -217, 1106, 1061
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: NGLDAC+MathematicalPi-One
      FontSubset: true
      FirstChar: 2
      LastChar: 2
      FontDescriptor: 
       FontName: NGLDAC+MathematicalPi-One
       Flags: Symbolic
       FontBBox: -30, -210, 1000, 779
       FontFile3: true
      EncodingDictionary: 
       Differences: true
    TrueType: 
     Font: 
      BaseFont: PBCKFH+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: PBCKFH+ArialMT
       Flags: Nonsymbolic
       FontBBox: -664, -324, 2000, 1039
       FontFile2: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.2.1-c043 52.372728, 2009/01/18-13:18:53        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreateDate>2024-12-27T14:37:28Z</xmp:CreateDate>
         <xmp:ModifyDate>2024-12-27T14:37:28Z</xmp:ModifyDate>
         <xmp:CreatorTool>XPP</xmp:CreatorTool>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Keywords>The JAMA Network</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:creator>
            <rdf:Seq>
               <rdf:li>American Medical Association</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 430, 163, 499, 173
      Annotation: 
       Subtype: Link
       Rect: 430, 144, 504, 154
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 182, 581, 298, 590
      Annotation: 
       Subtype: Link
       Rect: 86, 184, 134, 195
      Annotation: 
       Subtype: Link
       Rect: 347, 158, 378, 169
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 236, 684, 285, 695
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 650, 188, 662
      Annotation: 
       Subtype: Link
       Rect: 85, 586, 134, 597
    Page: 
     Label: 5
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 283, 554, 332, 566
      Annotation: 
       Subtype: Link
       Rect: 46, 308, 95, 319
      Annotation: 
       Subtype: Link
       Rect: 338, 152, 387, 164
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 91, 541, 140, 553
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 342, 606, 391, 618
    Page: 
     Label: 9
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 149, 699, 274, 709
      Annotation: 
       Subtype: Link
       Rect: 285, 685, 330, 695
      Annotation: 
       Subtype: Link
       Rect: 88, 638, 161, 648
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 124, 208, 168, 218
      Annotation: 
       Subtype: Link
       Rect: 139, 194, 184, 204
      Annotation: 
       Subtype: Link
       Rect: 139, 127, 193, 137
      Annotation: 
       Subtype: Link
       Rect: 58, 92, 155, 102
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 214, 713, 322, 723
      Annotation: 
       Subtype: Link
       Rect: 299, 688, 386, 698
      Annotation: 
       Subtype: Link
       Rect: 46, 677, 75, 687
      Annotation: 
       Subtype: Link
       Rect: 312, 652, 378, 662
      Annotation: 
       Subtype: Link
       Rect: 46, 641, 75, 651
      Annotation: 
       Subtype: Link
       Rect: 280, 605, 332, 615
      Annotation: 
       Subtype: Link
       Rect: 109, 569, 162, 579
      Annotation: 
       Subtype: Link
       Rect: 265, 545, 349, 555
      Annotation: 
       Subtype: Link
       Rect: 171, 509, 276, 519
      Annotation: 
       Subtype: Link
       Rect: 179, 484, 259, 494
      Annotation: 
       Subtype: Link
       Rect: 120, 459, 223, 469
      Annotation: 
       Subtype: Link
       Rect: 105, 434, 211, 444
      Annotation: 
       Subtype: Link
       Rect: 256, 395, 322, 405
      Annotation: 
       Subtype: Link
       Rect: 109, 359, 214, 369
      Annotation: 
       Subtype: Link
       Rect: 58, 323, 140, 333
      Annotation: 
       Subtype: Link
       Rect: 278, 298, 389, 308
      Annotation: 
       Subtype: Link
       Rect: 156, 262, 237, 272
      Annotation: 
       Subtype: Link
       Rect: 336, 237, 380, 247
      Annotation: 
       Subtype: Link
       Rect: 46, 226, 93, 236
      Annotation: 
       Subtype: Link
       Rect: 58, 190, 146, 200
      Annotation: 
       Subtype: Link
       Rect: 273, 165, 385, 175
    Page: 
     Label: 13
  Checksum: b3b4112f
   Type: CRC32
  Checksum: 77e190bfc708064837db5cb23dccdc5c
   Type: MD5
  Checksum: 2ae48ffc5ff72303700a1e15842e88414884de08
   Type: SHA-1
  Checksum: 08b20f0096c849645f8ddcf848a3d909bb4bafb1eef38f316142e933b9e07bbe
   Type: SHA-256