c02e5feb97f2ddd7a5f111d1599398dc 320381.pdf 3437e8ab9fbb82d9f9e10b0a4eb53bc7b7e56d7c 320381.pdf aee635de278574030f5cfe4270167ff87a136ae768c43aaaa9bf628eccb991fb 320381.pdf Title: Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease Subject: Probiotics are gaining recognition as a viable strategy for mitigating cardiovascular risk factors. Specifically, recent studies highlight their potential benefits in managing cholesterol levels, blood pressure, and inflammation, which are critical components in the prevention of cardiovascular diseases (CVD). This comprehensive review aims to elucidate the impact of probiotic consumption on major cardiovascular risk factors, including individuals with hypertension, type II diabetes mellitus, metabolic syndrome, hypercholesterolemia, and in secondary prevention in coronary artery disease. Scientific evidence based on human studies suggests that probiotic consumption is associated with positive effects on anthropometric measures, inflammation markers, blood pressure, glucose metabolism markers, lipid profiles, and endothelial function. However, these findings should be interpreted pragmatically and acknowledge the significant variability in results. This variability may be attributed to factors such as probiotic composition (single strain or multiple strains), the characteristics of the delivery matrix (food, capsules, and sachets), the duration of the intervention, the dosage regimen, and baseline health profiles of the participants. Incorporating probiotics as part of a comprehensive and healthy lifestyle approach can be considered a feasible strategy for both the prevention and management of CVD. However, further research is needed on factors influencing the effect of probiotics, such as: (i) optimal probiotic strain(s), (ii) appropriate dosage, (iii) duration of treatment, (iv) optimal delivery vehicle, and (v) sex-specific differences. Keywords: inflammation; lipid profile; functional foods; blood pressure Author: Anallely López-Yerena, Victoria de Santisteban Villaplana, Lina Badimon, Gemma Vilahur and Teresa Padro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Dec 27 10:33:42 2024 CET ModDate: Fri Dec 27 10:43:50 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1307307 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SOZKOC+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 SYIGNM+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 KLTEEX+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 PQALZP+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 DIGKIO+VnURWPalladioL Type 1 Custom yes yes yes 32 0 ITUPXD+CMSY10 Type 1 Builtin yes yes yes 62 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 71 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 75 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 79 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 83 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 90 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 110 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 114 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 118 0 BCDHEE+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 122 0 BCDIEE+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 129 0 BCDJEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 136 0 QDULQU+EURM10 Type 1 Builtin yes yes yes 148 0 URYLRZ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 153 0 GIZSCG+EURM7 Type 1 Builtin yes yes yes 161 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-08 03:52:10 CEST RepresentationInformation: 320381.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-07 12:22:34 CEST Size: 1307307 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 723 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Probiotics Destination: section.2 Item: Title: The Health-Promoting Properties of Probiotics in the Management and Prevention of CVD Destination: section.3 Children: Item: Title: Hypertension Destination: subsection.3.1 Item: Title: Type 2 Diabetes Mellitus (T2DM) Destination: subsection.3.2 Item: Title: Metabolic Syndrome Destination: subsection.3.3 Item: Title: Hypercholesterolemia Destination: subsection.3.4 Item: Title: Secondary Prevention in Coronary Artery Disease Destination: subsection.3.5 Item: Title: Final Remarks/Conclusions Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Probiotics: A Potential Strategy for Preventing and Managing Cardiovascular Disease Author: Anallely López-Yerena, Victoria de Santisteban Villaplana, Lina Badimon, Gemma Vilahur and Teresa Padro Subject: Probiotics are gaining recognition as a viable strategy for mitigating cardiovascular risk factors. Specifically, recent studies highlight their potential benefits in managing cholesterol levels, blood pressure, and inflammation, which are critical components in the prevention of cardiovascular diseases (CVD). This comprehensive review aims to elucidate the impact of probiotic consumption on major cardiovascular risk factors, including individuals with hypertension, type II diabetes mellitus, metabolic syndrome, hypercholesterolemia, and in secondary prevention in coronary artery disease. Scientific evidence based on human studies suggests that probiotic consumption is associated with positive effects on anthropometric measures, inflammation markers, blood pressure, glucose metabolism markers, lipid profiles, and endothelial function. However, these findings should be interpreted pragmatically and acknowledge the significant variability in results. This variability may be attributed to factors such as probiotic composition (single strain or multiple strains), the characteristics of the delivery matrix (food, capsules, and sachets), the duration of the intervention, the dosage regimen, and baseline health profiles of the participants. Incorporating probiotics as part of a comprehensive and healthy lifestyle approach can be considered a feasible strategy for both the prevention and management of CVD. However, further research is needed on factors influencing the effect of probiotics, such as: (i) optimal probiotic strain(s), (ii) appropriate dosage, (iii) duration of treatment, (iv) optimal delivery vehicle, and (v) sex-specific differences. 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