be7635ea24a5f9b6ee7247916f5f8843 320384.pdf 39d61ba200788230105f9eb3e903947b25a5b062 320384.pdf aeb8acddcaad92a41ddfa3bac36d8c189100848581fc7ade5bbe532ee27341b6 320384.pdf Title: Secukinumab for Treatment of Plaque Psoriasis in Real-World Clinical Practice in Spain: A Literature Review Subject: Background/Objectives: Secukinumab was shown to be effective in treating moderate-to-severe plaque psoriasis in adults and pediatric patients 6 years. Methods: A literature review was conducted to identify studies published in the preceding 5 years assessing the effectiveness and/or survival (safety in the second instance) associated with secukinumab treatment for moderate-to-severe plaque psoriasis with/without psoriatic arthritis (PsA) in real-world clinical practice in Spain. Results: 11 references were included, corresponding to seven studies (six retrospective and one prospective) (n = 1050). Baseline characteristics were mean age 46.5–53.0 years; 28.7–55.0% women; 30.0–53.1% patients with PsA; 27.9–47.4% naïve to biologic treatments; mean Psoriasis Area and Severity Index (PASI) score 12.5 (standard deviation [SD]: 6.9)–18.1 (SD: 10.3). PASI 90 response rates were 54–65% at Week 24 and 46–63% at Week 52; 43–47% of patients showed PASI 1 at Week 12 and 47–56% at Week 52. Treatment persistence at Week 52 was 72–89%, being 74.5% in the larger cohort series (n = 384) at 2 years. Adverse-event-related treatment discontinuation was rare. Conclusions: Secukinumab demonstrated long-term safety and efficacy in treating adult patients with moderate-to-severe plaque psoriasis in actual clinical practice, with survival rates of up to two years and consistent efficacy in Spain. Keywords: psoriasis; real-world evidence; secukinumab; Spain Author: Esteban Daudén, José María Ortiz-Salvador, Jaime Notario, Lluís Puig, Jorge Santos-Juanes, Enrique Herrera-Acosta, Lara Gómez-Labrador and Ricardo Ruiz-Villaverde Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Jan 13 17:52:39 2025 CET ModDate: Mon Jan 13 17:57:06 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 816967 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CSFKSW+URWPalladioL-Roma Type 1 Custom yes yes yes 10 0 HOHUJQ+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 IYHVUB+URWPalladioL-Ital Type 1 Custom yes yes yes 21 0 JLGPER+CMSY10 Type 1 Builtin yes yes yes 26 0 HBEPKG+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 65 0 HBEPKH+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 71 0 HBEPKI+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 77 0 HBEPLJ+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 83 0 HBEPLK+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 86 0 HBEPLL+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 89 0 HBEPPK+PalatinoLinotype-Roman TrueType MacRoman yes yes no 92 0 HBEPKG+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 106 0 HBEPKH+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 112 0 HBEPKI+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 118 0 HBEPLJ+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 124 0 HBEPLK+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 127 0 HBEPLL+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 130 0 HBEPPK+PalatinoLinotype-Roman TrueType MacRoman yes yes no 133 0 HQBQWV+VnURWPalladioL Type 1 Custom yes yes yes 156 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-08 03:51:59 CEST RepresentationInformation: 320384.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-07 13:59:33 CEST Size: 816967 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 331 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Children: Item: Title: Literature Review Destination: subsection.3.1 Item: Title: Baseline Patient Characteristics Destination: subsection.3.2 Item: Title: Secukinumab Dosage Destination: subsection.3.3 Item: Title: PASI Severity Assessment Destination: subsection.3.4 Item: Title: Survival with Secukinumab Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: appendix.A. Info: Title: Secukinumab for Treatment of Plaque Psoriasis in Real-World Clinical Practice in Spain: A Literature Review Author: Esteban Daudén, José María Ortiz-Salvador, Jaime Notario, Lluís Puig, Jorge Santos-Juanes, Enrique Herrera-Acosta, Lara Gómez-Labrador and Ricardo Ruiz-Villaverde Subject: Background/Objectives: Secukinumab was shown to be effective in treating moderate-to-severe plaque psoriasis in adults and pediatric patients 6 years. Methods: A literature review was conducted to identify studies published in the preceding 5 years assessing the effectiveness and/or survival (safety in the second instance) associated with secukinumab treatment for moderate-to-severe plaque psoriasis with/without psoriatic arthritis (PsA) in real-world clinical practice in Spain. Results: 11 references were included, corresponding to seven studies (six retrospective and one prospective) (n = 1050). Baseline characteristics were mean age 46.5 53.0 years; 28.7 55.0% women; 30.0 53.1% patients with PsA; 27.9 47.4% naïve to biologic treatments; mean Psoriasis Area and Severity Index (PASI) score 12.5 (standard deviation [SD]: 6.9) 18.1 (SD: 10.3). PASI 90 response rates were 54 65% at Week 24 and 46 63% at Week 52; 43 47% of patients showed PASI 1 at Week 12 and 47 56% at Week 52. Treatment persistence at Week 52 was 72 89%, being 74.5% in the larger cohort series (n = 384) at 2 years. Adverse-event-related treatment discontinuation was rare. Conclusions: Secukinumab demonstrated long-term safety and efficacy in treating adult patients with moderate-to-severe plaque psoriasis in actual clinical practice, with survival rates of up to two years and consistent efficacy in Spain. 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