56c827bab95e5d89db40e75119240e17 320396.pdf dc040877e459ce7f2501106e2133321db7b33a32 320396.pdf 68e7b334442471b536d48d70ca53089f8d1f700f40fc73e21f0eb8f911135bbb 320396.pdf Title: KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary Subject: Life Sciences [q-bio] Keywords: NPHP, nephronophthisis, HLRCC, hereditary leiomyomatosis and renal cell cancer, HIPKD, hyperinsulinemic hypoglycemia and polycystic kidney disease, HANAC, hereditary angiopathy with nephropathy, aneurysms, and muscle cramps, COL, collagen, CGS, contiguous gene syndrome, AR, autosomal recessive, ADPKD, autosomal dominant polycystic kidney disease, AD, autosomal dominant, PLD, polycystic liver disease ACD, acquired cystic disease, PKD, polycystic kidney disease, KF, kidney failure, ICA, intracranial aneurysm, CKD, chronic kidney disease, ADTKD, autosomal dominant tubulointerstitial kidney disease, ADPLD, autosomal dominant polycystic liver disease, nomenclature ADPKD, autosomal dominant polycystic kidney disease, monogenic disease, guideline, evidence-based, ADPKD, ADPKD evidence-based guideline monogenic disease nomenclature ADPKD, autosomal dominant polycystic kidney disease ADPLD, autosomal dominant polycystic liver disease ADTKD, autosomal dominant tubulointerstitial kidney disease CKD, chronic kidney disease ICA, intracranial aneurysm KF, kidney failure PKD, polycystic kidney disease PLD, polycystic liver disease ACD, acquired cystic disease AD, autosomal dominant ADPKD, autosomal dominant polycystic kidney disease AR, autosomal recessive CGS, contiguous gene syndrome COL, collagen HANAC, hereditary angiopathy with nephropathy, aneurysms, and muscle cramps HIPKD, hyperinsulinemic hypoglycemia and polycystic kidney disease HLRCC, hereditary leiomyomatosis and renal cell cancer NPHP, nephronophthisis Author: Vicente E Torres, Curie Ahn, Thijs R M Barten, Godela Brosnahan, Melissa A Cadnapaphornchai, Arlene B Chapman, Emilie Cornec-Le Gall, Joost P H Drenth, Ron T Gansevoort, Peter C Harris, Tess Harris, Shigeo Horie, Max C Liebau, Michele Liew, Andrew J Mallett, Changlin Mei, Djalila Mekahli, Dwight Odland, Albert C.M. Ong, Luiz F Onuchic, Null- C Pei, Ronald D Perrone, Gopala K Rangan, Brian Rayner, Roser Torra, Ethan M Balk, Craig E Gordon, Amy Earley, Reem A Mustafa, Olivier Devuyst Creator: HAL Producer: PDFLaTeX CreationDate: Sun Oct 5 09:05:31 2025 CEST ModDate: Fri Jan 10 20:45:51 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.28 x 841.89 pts (A4) Page rot: 0 File size: 1462495 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- ENRWBZ+LMRoman12-Bold-Identity-H CID Type 0C Identity-H yes yes yes 592 0 FTTCQO+LMRoman10-Regular-Identity-H CID Type 0C Identity-H yes yes yes 593 0 AAESAN+LMRoman10-Bold-Identity-H CID Type 0C Identity-H yes yes yes 594 0 IRUWLC+LMRoman12-Regular-Identity-H CID Type 0C Identity-H yes yes yes 595 0 JHOFFF+AdvOT9974ba86.B Type 1C WinAnsi yes yes no 806 0 JHOEPM+AdvOTb99cb1f1.B Type 1C WinAnsi yes yes no 807 0 JHOEPN+AdvOTce3d9a73 Type 1C WinAnsi yes yes no 808 0 JHOEPO+AdvMYRLIGHT Type 1C WinAnsi yes yes no 809 0 JHOEPP+AdvP4C4E74 Type 1C Custom yes yes yes 810 0 JHOFAA+AdvOTe8296edf.I Type 1C WinAnsi yes yes no 811 0 JHOFAB+AdvOTe8296edf.I+20 Type 1C WinAnsi yes yes no 812 0 JHOFAC+AdvOTe8296edf.I+fb Type 1C Custom yes yes yes 813 0 JHOFBC+AdvOT56309c18.I Type 1C WinAnsi yes yes no 814 0 JHOFBD+AdvOTce3d9a73+fb Type 1C Custom yes yes yes 815 0 JHOFFD+AdvOT15e8cdec Type 1C WinAnsi yes yes no 816 0 JHOFFE+AdvMYRLIGIT Type 1C WinAnsi yes yes no 817 0 JHOFGF+AdvPSSym Type 1C WinAnsi yes yes no 823 0 JHOFGG+AdvOT46dcae81 Type 1C WinAnsi yes yes no 824 0 JHOFGH+AdvOT77db9845 Type 1C WinAnsi yes yes no 825 0 JHOFHI+AdvOT77db9845+fb Type 1C Custom yes yes yes 826 0 JHOFHJ+AdvOT77db9845+20 Type 1C WinAnsi yes yes no 827 0 JHOFHK+AdvOT255b5711.I Type 1C WinAnsi yes yes no 828 0 JHOFIL+AdvOT56309c18.I+fb Type 1C Custom yes yes yes 829 0 JHOFIM+AdvP4C4E51 Type 1C WinAnsi yes yes no 830 0 JHOFLM+MyriadPro-Semibold Type 1C WinAnsi yes yes no 831 0 JHOFMM+MyriadPro-Regular Type 1C WinAnsi yes yes no 832 0 JHOFMN+MyriadPro-It Type 1C WinAnsi yes yes no 833 0 JHOFNO+AdvOT15e8cdec+20 Type 1C WinAnsi yes yes no 837 0 JHOFNP+AdvPS3FDD77 Type 1C WinAnsi yes yes no 838 0 JHOFOA+AdvOT9974ba86.B+fb Type 1C Custom yes yes yes 839 0 JHOFOB+AdvOT15e8cdec+fb Type 1C Custom yes yes yes 840 0 JHOGCA+AdvOT8817665d Type 1C WinAnsi yes yes no 842 0 JHOGGP+MyriadPro-Regular Type 1C Custom yes yes yes 845 0 JHOGJA+MyriadPro-Semibold Type 1C Custom yes yes yes 846 0 JHOGKA+AdvOT9632b9fb.BI Type 1C WinAnsi yes yes no 849 0 JHOHAA+Arial-BoldMT CID TrueType Identity-H yes yes yes 850 0 JHOGOP+MyriadPro-It Type 1C WinAnsi yes yes no 851 0 JHOHHO+AdvOT9974ba86.B+20 Type 1C WinAnsi yes yes no 852 0 JHOIAM+MyriadPro-Bold Type 1C WinAnsi yes yes no 855 0 JHOIDM+MyriadPro-Regular Type 1C Custom yes yes yes 858 0 JHOIEM+MyriadPro-Semibold Type 1C Custom yes yes yes 859 0 JHOIGM+MyriadPro-Regular Type 1C Custom yes yes yes 860 0 JHOIML+MyriadPro-Regular Type 1C Custom yes yes yes 865 0 JHOFMM+MyriadPro-Regular Type 1C WinAnsi yes yes no 868 0 JHOFLM+MyriadPro-Semibold Type 1C WinAnsi yes yes no 869 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-11 03:58:57 CEST RepresentationInformation: 320396.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-10 08:18:17 CEST Size: 1462495 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'aff2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'dtbl3fna' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fn1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'dtbl4fna' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl2fna' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib28' cannot be found ID: PDF-HUL-149 InfoMessage: File header gives version as 1.4, but catalog dictionary gives version as 1.7 ID: PDF-HUL-87 ErrorMessage: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tbl4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'fig10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bib33' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-122 Offset: 30795 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff2' cannot be found ID: PDF-HUL-122 Offset: 30930 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-122 Offset: 31065 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff4' cannot be found ID: PDF-HUL-122 Offset: 31200 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff5' cannot be found ID: PDF-HUL-122 Offset: 31335 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff6' cannot be found ID: PDF-HUL-122 Offset: 31470 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff7' cannot be found ID: PDF-HUL-122 Offset: 31605 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff8' cannot be found ID: PDF-HUL-122 Offset: 31739 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff9' cannot be found ID: PDF-HUL-122 Offset: 31873 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff3' cannot be found ID: PDF-HUL-122 Offset: 32008 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found ID: PDF-HUL-122 Offset: 32147 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff1' cannot be found ID: PDF-HUL-122 Offset: 32282 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found ID: PDF-HUL-122 Offset: 32420 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fn1' cannot be found ID: PDF-HUL-122 Offset: 32550 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found ID: PDF-HUL-122 Offset: 32689 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found ID: PDF-HUL-122 Offset: 32827 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found ID: PDF-HUL-122 Offset: 32966 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found ID: PDF-HUL-122 Offset: 33101 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found ID: PDF-HUL-122 Offset: 33240 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found ID: PDF-HUL-122 Offset: 33379 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found ID: PDF-HUL-122 Offset: 33518 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff19' cannot be found ID: PDF-HUL-122 Offset: 33657 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found ID: PDF-HUL-122 Offset: 33796 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found ID: PDF-HUL-122 Offset: 33935 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found ID: PDF-HUL-122 Offset: 34074 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found ID: PDF-HUL-122 Offset: 34213 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff24' cannot be found ID: PDF-HUL-122 Offset: 34352 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff25' cannot be found ID: PDF-HUL-122 Offset: 34491 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-122 Offset: 34629 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff27' cannot be found ID: PDF-HUL-122 Offset: 34768 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff28' cannot be found ID: PDF-HUL-122 Offset: 34906 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff29' cannot be found ID: PDF-HUL-122 Offset: 35045 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff30' cannot be found ID: PDF-HUL-122 Offset: 35184 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff26' cannot be found ID: PDF-HUL-122 Offset: 35323 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff30' cannot be found ID: PDF-HUL-122 Offset: 35462 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff31' cannot be found ID: PDF-HUL-122 Offset: 35601 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff32' cannot be found ID: PDF-HUL-122 Offset: 35740 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff33' cannot be found ID: PDF-HUL-122 Offset: 35879 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff34' cannot be found ID: PDF-HUL-122 Offset: 36014 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff34' cannot be found ID: PDF-HUL-122 Offset: 36380 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib1' cannot be found ID: PDF-HUL-122 Offset: 53401 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 53549 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 53695 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib2' cannot be found ID: PDF-HUL-122 Offset: 54056 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib3' cannot be found ID: PDF-HUL-122 Offset: 54192 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib4' cannot be found ID: PDF-HUL-122 Offset: 54328 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig1' cannot be found ID: PDF-HUL-122 Offset: 54464 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl1' cannot be found ID: PDF-HUL-122 Offset: 54600 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib5' cannot be found ID: PDF-HUL-122 Offset: 78281 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig2' cannot be found ID: PDF-HUL-122 Offset: 78417 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 78565 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig3' cannot be found ID: PDF-HUL-122 Offset: 88863 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2' cannot be found ID: PDF-HUL-122 Offset: 88997 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib6' cannot be found ID: PDF-HUL-122 Offset: 89131 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig4' cannot be found ID: PDF-HUL-122 Offset: 89267 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2fna' cannot be found ID: PDF-HUL-122 Offset: 96580 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib9' cannot be found ID: PDF-HUL-122 Offset: 99725 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found ID: PDF-HUL-122 Offset: 99863 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib4' cannot be found ID: PDF-HUL-122 Offset: 151236 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found ID: PDF-HUL-122 Offset: 151375 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found ID: PDF-HUL-122 Offset: 151750 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib8' cannot be found ID: PDF-HUL-122 Offset: 151885 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found ID: PDF-HUL-122 Offset: 152494 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig5' cannot be found ID: PDF-HUL-122 Offset: 152627 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found ID: PDF-HUL-122 Offset: 152764 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found ID: PDF-HUL-122 Offset: 162110 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found ID: PDF-HUL-122 Offset: 162486 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found ID: PDF-HUL-122 Offset: 162626 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found ID: PDF-HUL-122 Offset: 170396 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 170536 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 170676 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 170816 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 170956 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 171096 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 171235 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 171375 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 171515 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig6' cannot be found ID: PDF-HUL-122 Offset: 180596 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 180736 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 180876 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig7' cannot be found ID: PDF-HUL-122 Offset: 181011 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 181147 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found ID: PDF-HUL-122 Offset: 189020 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found ID: PDF-HUL-122 Offset: 189160 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib4' cannot be found ID: PDF-HUL-122 Offset: 189295 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib6' cannot be found ID: PDF-HUL-122 Offset: 189431 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found ID: PDF-HUL-122 Offset: 189571 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3' cannot be found ID: PDF-HUL-122 Offset: 189707 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib4' cannot be found ID: PDF-HUL-122 Offset: 189843 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found ID: PDF-HUL-122 Offset: 189983 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig8' cannot be found ID: PDF-HUL-122 Offset: 190119 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'dtbl3fna' cannot be found ID: PDF-HUL-122 Offset: 199331 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found ID: PDF-HUL-122 Offset: 205003 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl4' cannot be found ID: PDF-HUL-122 Offset: 210820 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'dtbl4fna' cannot be found ID: PDF-HUL-122 Offset: 216948 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'dtbl4fna' cannot be found ID: PDF-HUL-122 Offset: 217100 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found ID: PDF-HUL-122 Offset: 222382 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found ID: PDF-HUL-122 Offset: 222522 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found ID: PDF-HUL-122 Offset: 222662 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig9' cannot be found ID: PDF-HUL-122 Offset: 222798 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib27' cannot be found ID: PDF-HUL-122 Offset: 222937 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib28' cannot be found ID: PDF-HUL-122 Offset: 233081 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found ID: PDF-HUL-122 Offset: 233221 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found ID: PDF-HUL-122 Offset: 258408 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found ID: PDF-HUL-122 Offset: 258548 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'fig10' cannot be found ID: PDF-HUL-122 Offset: 258686 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found ID: PDF-HUL-122 Offset: 258826 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found ID: PDF-HUL-122 Offset: 258966 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found ID: PDF-HUL-122 Offset: 259102 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib32' cannot be found ID: PDF-HUL-122 Offset: 259239 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib33' cannot be found ID: PDF-HUL-122 Offset: 259377 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 274233 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1079 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Language: en Outlines: Item: Title: KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidne ... Destination: titlink1 Children: Item: Title: 1: Nomenclature, prevalence, diagnosis, and prognosis Destination: flink1 Children: Item: Title: Definition and nomenclature Destination: slink1 Item: Title: Prevalence Destination: slink2 Item: Title: Diagnosis Destination: slink3 Item: Title: Prognosis Destination: slink4 Item: Title: 2: Kidney manifestations Destination: flink2 Children: Item: Title: High blood pressure (BP) Destination: slink5 Item: Title: Kidney pain Destination: slink6 Item: Title: Nephrolithiasis Destination: slink7 Item: Title: Gout Destination: slink8 Item: Title: Hematuria Destination: slink9 Item: Title: Urinary tract infections Destination: slink10 Item: Title: Renal cell carcinoma Destination: slink11 Item: Title: 3: CKD management and progression, KF, and kidney replacement therapy Destination: flink3 Children: Item: Title: CKD management and progression Destination: slink12 Item: Title: Kidney transplantation Destination: slink13 Item: Title: Chronic dialysis Destination: slink14 Item: Title: 4: Therapies to delay the progression of ADPKD Destination: flink4 Children: Item: Title: Tolvaptan Destination: slink15 Item: Title: Water intake in the absence of tolvaptan Destination: slink16 Item: Title: Other pharmacologic interventions Destination: slink17 Item: Title: 5: Polycystic liver disease Destination: flink5 Children: Item: Title: Diagnosis and staging of PLD Destination: slink18 Item: Title: Risk factors Destination: slink19 Item: Title: Nutrition and lifestyle Destination: slink20 Item: Title: Management of PLD Destination: slink21 Item: Title: Liver cyst infections Destination: slink22 Item: Title: 6: Intracranial aneurysms (ICAs) and other extrarenal manifestations Destination: flink6 Children: Item: Title: ICAs Destination: slink23 Item: Title: Other vascular associations Destination: slink24 Item: Title: Cardiac associations Destination: slink25 Item: Title: Abdominal wall hernia Destination: slink26 Item: Title: Other extrarenal manifestations Destination: slink27 Item: Title: 7: Lifestyle and psychosocial aspects Destination: flink7 Children: Item: Title: Nutrition Destination: slink28 Item: Title: Physical activity Destination: slink29 Item: Title: Lifestyle management Destination: slink30 Item: Title: Psychosocial care Destination: slink31 Item: Title: 8: Pregnancy and reproductive issues Destination: flink8 Children: Item: Title: Contraceptive measures in women Destination: slink32 Item: Title: Preconception counseling Destination: slink33 Item: Title: Pregnant women with ADPKD Destination: slink34 Item: Title: 9: Pediatric issues Destination: flink9 Children: Item: Title: Diagnosis of ADPKD in children Destination: slink35 Item: Title: BP control in children and adolescents with ADPKD Destination: slink36 Item: Title: Follow-up assessment in children with ADPKD Destination: slink37 Item: Title: Diet and lifestyle in children with ADPKD Destination: slink38 Item: Title: Optimal models of care for children with ADPKD Destination: slink39 Item: Title: 10: Approaches to the management of people with ADPKD Destination: flink10 Item: Title: Conclusions Destination: flink11 Item: Title: Disclosure Destination: flink12 Item: Title: Acknowledgments Destination: acklink1 Item: Title: Additional Information Destination: flink13 Item: Title: Supplementary Material Destination: flink14 Item: Title: References Destination: blink2 Info: Title: KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary Author: Vicente E Torres, Curie Ahn, Thijs R M Barten, Godela Brosnahan, Melissa A Cadnapaphornchai, Arlene B Chapman, Emilie Cornec-Le Gall, Joost P H Drenth, Ron T Gansevoort, Peter C Harris, Tess Harris, Shigeo Horie, Max C Liebau, Michele Liew, Andrew J Mallett, Changlin Mei, Djalila Mekahli, Dwight Odland, Albert C.M. Ong, Luiz F Onuchic, Null- C Pei, Ronald D Perrone, Gopala K Rangan, Brian Rayner, Roser Torra, Ethan M Balk, Craig E Gordon, Amy Earley, Reem A Mustafa, Olivier Devuyst Subject: Life Sciences [q-bio] Keywords: NPHP, nephronophthisis, HLRCC, hereditary leiomyomatosis and renal cell cancer, HIPKD, hyperinsulinemic hypoglycemia and polycystic kidney disease, HANAC, hereditary angiopathy with nephropathy, aneurysms, and muscle cramps, COL, collagen, CGS, contiguous gene syndrome, AR, autosomal recessive, ADPKD, autosomal dominant polycystic kidney disease, AD, autosomal dominant, PLD, polycystic liver disease ACD, acquired cystic disease, PKD, polycystic kidney disease, KF, kidney failure, ICA, intracranial aneurysm, CKD, chronic kidney disease, ADTKD, autosomal dominant tubulointerstitial kidney disease, ADPLD, autosomal dominant polycystic liver disease, nomenclature ADPKD, autosomal dominant polycystic kidney disease, monogenic disease, guideline, evidence-based, ADPKD, ADPKD evidence-based guideline monogenic disease nomenclature ADPKD, autosomal dominant polycystic kidney disease ADPLD, autosomal dominant polycystic liver disease ADTKD, autosomal dominant tubulointerstitial kidney disease CKD, chronic kidney disease ICA, intracranial aneurysm KF, kidney failure PKD, polycystic kidney disease PLD, polycystic liver disease ACD, acquired cystic disease AD, autosomal dominant ADPKD, autosomal dominant polycystic kidney disease AR, autosomal recessive CGS, contiguous gene syndrome COL, collagen HANAC, hereditary angiopathy with nephropathy, aneurysms, and muscle cramps HIPKD, hyperinsulinemic hypoglycemia and polycystic kidney disease HLRCC, hereditary leiomyomatosis and renal cell cancer NPHP, nephronophthisis Creator: HAL Producer: PDFLaTeX CreationDate: Sun Oct 05 09:05:31 CEST 2025 ModDate: Fri Jan 10 21:15:51 CET 2025 ID: 0x905f884994365e80f789b63969fbd0fe, 0x905f884994365e80f789b63969fbd0fe Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 229 ImageHeight: 265 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 975 ImageHeight: 547 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 64 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 878 ImageHeight: 335 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 732 ImageHeight: 272 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 878 ImageHeight: 336 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 149 ImageHeight: 677 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 732 ImageHeight: 407 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: Separation Fonts: Type0: Font: BaseFont: ENRWBZ+LMRoman12-Bold-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: FTTCQO+LMRoman10-Regular-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: AAESAN+LMRoman10-Bold-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: JHOHAA+Arial-BoldMT Encoding: Identity-H ToUnicode: true Font: BaseFont: IRUWLC+LMRoman12-Regular-Identity-H Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: JHOFMM+MyriadPro-Regular FontSubset: true FirstChar: 32 LastChar: 177 FontDescriptor: FontName: JHOFMM+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFMN+MyriadPro-It FontSubset: true FirstChar: 49 LastChar: 80 FontDescriptor: FontName: JHOFMN+MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFNO+AdvOT15e8cdec+20 FontSubset: true FirstChar: 134 LastChar: 151 FontDescriptor: FontName: JHOFNO+AdvOT15e8cdec+20 Flags: Nonsymbolic FontBBox: 0, -114, 1125, 687 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFNP+AdvPS3FDD77 FontSubset: true FirstChar: 119 LastChar: 119 FontDescriptor: FontName: JHOFNP+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFOA+AdvOT9974ba86.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHOFOA+AdvOT9974ba86.B+fb Flags: Symbolic FontBBox: 9, 0, 520, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFOB+AdvOT15e8cdec+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JHOFOB+AdvOT15e8cdec+fb Flags: Symbolic FontBBox: 9, 0, 447, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOGCA+AdvOT8817665d FontSubset: true FirstChar: 35 LastChar: 36 FontDescriptor: FontName: JHOGCA+AdvOT8817665d Flags: Nonsymbolic FontBBox: -20, -208, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOGGP+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: JHOGGP+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOGJA+MyriadPro-Semibold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: JHOGJA+MyriadPro-Semibold Flags: Symbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOGKA+AdvOT9632b9fb.BI FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JHOGKA+AdvOT9632b9fb.BI Flags: Nonsymbolic FontBBox: -93, -250, 927, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOGOP+MyriadPro-It FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: JHOGOP+MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOHHO+AdvOT9974ba86.B+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: JHOHHO+AdvOT9974ba86.B+20 Flags: Nonsymbolic FontBBox: -10, -93, 1250, 687 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOIAM+MyriadPro-Bold FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: JHOIAM+MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOIDM+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 128 FontDescriptor: FontName: JHOIDM+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOIEM+MyriadPro-Semibold FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: JHOIEM+MyriadPro-Semibold Flags: Symbolic, ForceBold FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOIGM+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: JHOIGM+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOIML+MyriadPro-Regular FontSubset: true FirstChar: 2 LastChar: 176 FontDescriptor: FontName: JHOIML+MyriadPro-Regular Flags: Symbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFMM+MyriadPro-Regular FontSubset: true FirstChar: 32 LastChar: 129 FontDescriptor: FontName: JHOFMM+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFLM+MyriadPro-Semibold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JHOFLM+MyriadPro-Semibold Flags: Nonsymbolic, ForceBold FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFFF+AdvOT9974ba86.B FontSubset: true FirstChar: 40 LastChar: 124 FontDescriptor: FontName: JHOFFF+AdvOT9974ba86.B Flags: Nonsymbolic FontBBox: -31, -250, 875, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOEPM+AdvOTb99cb1f1.B FontSubset: true FirstChar: 69 LastChar: 80 FontDescriptor: FontName: JHOEPM+AdvOTb99cb1f1.B Flags: Nonsymbolic FontBBox: -41, -250, 968, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOEPN+AdvOTce3d9a73 FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: JHOEPN+AdvOTce3d9a73 Flags: Nonsymbolic FontBBox: -41, -250, 854, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOEPO+AdvMYRLIGHT FontSubset: true FirstChar: 40 LastChar: 150 FontDescriptor: FontName: JHOEPO+AdvMYRLIGHT Flags: Nonsymbolic FontBBox: -41, -239, 1072, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOEPP+AdvP4C4E74 FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: JHOEPP+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFAA+AdvOTe8296edf.I FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: JHOFAA+AdvOTe8296edf.I Flags: Nonsymbolic FontBBox: -104, -250, 885, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFAB+AdvOTe8296edf.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: JHOFAB+AdvOTe8296edf.I+20 Flags: Nonsymbolic FontBBox: -52, -114, 1083, 687 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFAC+AdvOTe8296edf.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHOFAC+AdvOTe8296edf.I+fb Flags: Symbolic FontBBox: 30, 0, 510, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFBC+AdvOT56309c18.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: JHOFBC+AdvOT56309c18.I Flags: Nonsymbolic FontBBox: -93, -250, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFBD+AdvOTce3d9a73+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHOFBD+AdvOTce3d9a73+fb Flags: Symbolic FontBBox: 0, 0, 791, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFFD+AdvOT15e8cdec FontSubset: true FirstChar: 37 LastChar: 233 FontDescriptor: FontName: JHOFFD+AdvOT15e8cdec Flags: Nonsymbolic FontBBox: -41, -250, 833, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFFE+AdvMYRLIGIT FontSubset: true FirstChar: 73 LastChar: 121 FontDescriptor: FontName: JHOFFE+AdvMYRLIGIT Flags: Nonsymbolic FontBBox: -114, -239, 1031, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFGF+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: JHOFGF+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFGG+AdvOT46dcae81 FontSubset: true FirstChar: 65 LastChar: 65 FontDescriptor: FontName: JHOFGG+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFGH+AdvOT77db9845 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: JHOFGH+AdvOT77db9845 Flags: Serif, Nonsymbolic FontBBox: -41, -250, 937, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFHI+AdvOT77db9845+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: JHOFHI+AdvOT77db9845+fb Flags: Symbolic FontBBox: 19, 0, 531, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFHJ+AdvOT77db9845+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: JHOFHJ+AdvOT77db9845+20 Flags: Nonsymbolic FontBBox: -135, -135, 1093, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFHK+AdvOT255b5711.I FontSubset: true FirstChar: 44 LastChar: 121 FontDescriptor: FontName: JHOFHK+AdvOT255b5711.I Flags: Nonsymbolic FontBBox: -93, -250, 989, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFIL+AdvOT56309c18.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JHOFIL+AdvOT56309c18.I+fb Flags: Symbolic FontBBox: 0, 0, 833, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JHOFIM+AdvP4C4E51 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: JHOFIM+AdvP4C4E51 Flags: Nonsymbolic FontBBox: -31, -239, 1041, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JHOFLM+MyriadPro-Semibold FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: JHOFLM+MyriadPro-Semibold Flags: Nonsymbolic, ForceBold FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding CIDFontType0: Font: BaseFont: IRUWLC+LMRoman12-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IRUWLC+LMRoman12-Regular Flags: Serif, Symbolic FontBBox: -422, -280, 1394, 1127 FontFile3: true Font: BaseFont: ENRWBZ+LMRoman12-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ENRWBZ+LMRoman12-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -476, -289, 1577, 1137 FontFile3: true Font: BaseFont: FTTCQO+LMRoman10-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FTTCQO+LMRoman10-Regular Flags: Serif, Symbolic FontBBox: -430, -290, 1417, 1127 FontFile3: true Font: BaseFont: AAESAN+LMRoman10-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAESAN+LMRoman10-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -486, -295, 1607, 1133 FontFile3: true CIDFontType2: Font: BaseFont: JHOHAA+Arial-BoldMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JHOHAA+Arial-BoldMT Flags: Symbolic FontBBox: -628, -376, 2000, 1056 FontFile2: true XMP: application/pdf doi:10.1016/j.kint.2024.07.010 KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary Vicente E. Torres Curie Ahn Thijs R.M. Barten Godela Brosnahan Melissa A. Cadnapaphornchai Arlene B. Chapman Emilie Cornec-Le Gall Joost P.H. Drenth Ron T. Gansevoort Peter C. Harris Tess Harris Shigeo Horie Max C. Liebau Michele Liew Andrew J. Mallett Changlin Mei Djalila Mekahli Dwight Odland Albert C.M. Ong Luiz F. Onuchic York P-C. Pei Ronald D. Perrone Gopala K. Rangan Brian Rayner Roser Torra Ethan M. Balk Craig E. Gordon Amy Earley Reem A. Mustafa Olivier Devuyst ADPKD evidence-based guideline monogenic disease nomenclature Kidney International, 107 (2025) 234-254. doi:10.1016/j.kint.2024.07.010 Kidney Disease: Improving Global Outcomes (KDIGO) journal Kidney International © 2024, Kidney Disease: Improving Global Outcomes (KDIGO). Published by Elsevier Inc. on behalf of the International Society of Nephrology. 0085-2538 107 2 February 2025 234-254 234 254 10.1016/j.kint.2024.07.010 https://doi.org/10.1016/j.kint.2024.07.010 2010-04-23 true 10.1016/j.kint.2024.07.010 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.kint.2024.07.010 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2025-01-11T01:13:50+05:30 2025-01-11T01:15:51+05:30 2025-01-11T01:15:51+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat Distiller 8.1.0 (Windows) uuid:2e54a07d-5b81-4881-a3a1-17287e2328c3 uuid:e0e74d58-44f1-4a09-82e0-df0665fe5812 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 233 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 173, 237, 421, 257 Annotation: Subtype: Link Rect: 249, 59, 345, 83 Annotation: Subtype: Link Rect: 82, 42, 512, 58 Annotation: Subtype: Link Rect: 245, 29, 345, 44 Annotation: Subtype: Link Rect: 192, 660, 433, 795 Page: Label: 234 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 126, 622, 130, 634 Destination: null Annotation: Subtype: Link Rect: 186, 622, 190, 634 Destination: null Annotation: Subtype: Link Rect: 278, 622, 283, 634 Destination: null Annotation: Subtype: Link Rect: 379, 622, 384, 634 Destination: null Annotation: Subtype: Link Rect: 536, 622, 540, 634 Destination: null Annotation: Subtype: Link Rect: 542, 622, 547, 634 Destination: null Annotation: Subtype: Link Rect: 139, 608, 144, 620 Destination: null Annotation: Subtype: Link Rect: 255, 608, 259, 620 Destination: null Annotation: Subtype: Link Rect: 261, 608, 265, 620 Destination: null Annotation: Subtype: Link Rect: 357, 608, 361, 620 Destination: null Annotation: Subtype: Link Rect: 458, 608, 467, 620 Destination: null Annotation: Subtype: Link Rect: 542, 608, 547, 620 Destination: null Annotation: Subtype: Link Rect: 96, 594, 105, 606 Destination: null Annotation: Subtype: Link Rect: 107, 596, 111, 603 Destination: null Annotation: Subtype: Link Rect: 181, 594, 190, 606 Destination: null Annotation: Subtype: Link Rect: 266, 594, 275, 606 Destination: null Annotation: Subtype: Link Rect: 277, 594, 286, 606 Destination: null Annotation: Subtype: Link Rect: 288, 594, 296, 606 Destination: null Annotation: Subtype: Link Rect: 298, 594, 307, 606 Destination: null Annotation: Subtype: Link Rect: 378, 594, 387, 606 Destination: null Annotation: Subtype: Link Rect: 480, 594, 489, 606 Destination: null Annotation: Subtype: Link Rect: 110, 580, 119, 592 Destination: null Annotation: Subtype: Link Rect: 196, 580, 205, 592 Destination: null Annotation: Subtype: Link Rect: 207, 580, 216, 592 Destination: null Annotation: Subtype: Link Rect: 298, 580, 307, 592 Destination: null Annotation: Subtype: Link Rect: 393, 580, 402, 592 Destination: null Annotation: Subtype: Link Rect: 484, 580, 493, 592 Destination: null Annotation: Subtype: Link Rect: 106, 566, 115, 578 Destination: null Annotation: Subtype: Link Rect: 209, 566, 218, 578 Destination: null Annotation: Subtype: Link Rect: 311, 566, 320, 578 Destination: null Annotation: Subtype: Link Rect: 387, 566, 396, 578 Destination: null Annotation: Subtype: Link Rect: 457, 566, 466, 578 Destination: null Annotation: Subtype: Link Rect: 538, 566, 547, 578 Destination: null Annotation: Subtype: Link Rect: 122, 552, 131, 564 Destination: null Annotation: Subtype: Link Rect: 133, 552, 142, 564 Destination: null Annotation: Subtype: Link Rect: 203, 552, 212, 564 Destination: null Annotation: Subtype: Link Rect: 302, 552, 311, 564 Destination: null Annotation: Subtype: Link Rect: 412, 552, 421, 564 Destination: null Annotation: Subtype: Link Rect: 423, 552, 432, 564 Destination: null Annotation: Subtype: Link Rect: 471, 704, 549, 719 Annotation: Subtype: Link Rect: 159, 77, 257, 85 Annotation: Subtype: Link Rect: 44, 67, 47, 72 Destination: null Annotation: Subtype: Link Rect: 446, 748, 549, 756 Page: Label: 235 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 183, 632, 260, 640 Annotation: Subtype: Link Rect: 44, 622, 100, 630 Annotation: Subtype: Link Rect: 71, 554, 237, 561 Annotation: Subtype: Link Rect: 198, 472, 202, 482 Destination: null Annotation: Subtype: Link Rect: 172, 109, 267, 119 Destination: null Annotation: Subtype: Link Rect: 139, 73, 236, 83 Destination: null Annotation: Subtype: Link Rect: 44, 61, 287, 71 Annotation: Subtype: Link Rect: 44, 49, 133, 59 Annotation: Subtype: Link Rect: 136, 53, 139, 63 Destination: null Annotation: Subtype: Link Rect: 388, 557, 392, 567 Destination: null Annotation: Subtype: Link Rect: 394, 557, 397, 567 Destination: null Annotation: Subtype: Link Rect: 502, 493, 533, 503 Destination: null Annotation: Subtype: Link Rect: 366, 433, 393, 443 Destination: null Page: Label: 236 Sequence: 4 Rotate: 90 Page: Label: 237 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 234, 639, 237, 649 Destination: null Annotation: Subtype: Link Rect: 401, 551, 435, 561 Destination: null Annotation: Subtype: Link Rect: 441, 551, 543, 561 Destination: null Page: Label: 238 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 152, 161, 185, 171 Destination: null Annotation: Subtype: Link Rect: 229, 53, 259, 63 Destination: null Annotation: Subtype: Link Rect: 265, 58, 276, 68 Destination: null Annotation: Subtype: Link Rect: 510, 198, 543, 208 Destination: null Page: Label: 239 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 522, 671, 525, 679 Destination: null Page: Label: 240 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 281, 63, 284, 71 Destination: null Annotation: Subtype: Link Rect: 146, 53, 152, 62 Destination: null Page: Label: 241 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 229, 699, 232, 709 Destination: null Annotation: Subtype: Link Rect: 218, 591, 226, 601 Destination: null Annotation: Subtype: Link Rect: 433, 551, 549, 561 Annotation: Subtype: Link Rect: 303, 539, 518, 549 Annotation: Subtype: Link Rect: 520, 543, 527, 553 Destination: null Annotation: Subtype: Link Rect: 388, 459, 392, 469 Destination: null Annotation: Subtype: Link Rect: 471, 383, 549, 393 Annotation: Subtype: Link Rect: 303, 371, 549, 381 Annotation: Subtype: Link Rect: 303, 359, 549, 369 Annotation: Subtype: Link Rect: 303, 347, 406, 357 Annotation: Subtype: Link Rect: 338, 328, 345, 338 Destination: null Annotation: Subtype: Link Rect: 368, 72, 404, 82 Destination: null Annotation: Subtype: Link Rect: 410, 77, 417, 87 Destination: null Page: Label: 242 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 77, 125, 95, 135 Destination: null Annotation: Subtype: Link Rect: 303, 123, 549, 133 Annotation: Subtype: Link Rect: 303, 111, 396, 121 Annotation: Subtype: Link Rect: 398, 115, 405, 125 Destination: null Annotation: Subtype: Link Rect: 317, 356, 323, 365 Destination: null Page: Label: 243 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 79, 316, 86, 326 Destination: null Annotation: Subtype: Link Rect: 456, 699, 463, 709 Destination: null Annotation: Subtype: Link Rect: 465, 699, 472, 709 Destination: null Annotation: Subtype: Link Rect: 436, 483, 444, 493 Destination: null Annotation: Subtype: Link Rect: 445, 483, 452, 493 Destination: null Annotation: Subtype: Link Rect: 452, 352, 460, 362 Destination: null Annotation: Subtype: Link Rect: 461, 352, 468, 362 Destination: null Annotation: Subtype: Link Rect: 515, 292, 522, 302 Destination: null Annotation: Subtype: Link Rect: 524, 292, 531, 302 Destination: null Page: Label: 244 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 176, 534, 214, 544 Destination: null Annotation: Subtype: Link Rect: 220, 538, 227, 548 Destination: null Annotation: Subtype: Link Rect: 229, 538, 236, 548 Destination: null Annotation: Subtype: Link Rect: 508, 378, 543, 388 Destination: null Annotation: Subtype: Link Rect: 61, 61, 68, 69 Destination: null Page: Label: 245 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 220, 483, 227, 493 Destination: null Annotation: Subtype: Link Rect: 228, 483, 236, 493 Destination: null Annotation: Subtype: Link Rect: 145, 113, 148, 123 Destination: null Annotation: Subtype: Link Rect: 150, 113, 154, 123 Destination: null Annotation: Subtype: Link Rect: 155, 113, 163, 123 Destination: null Annotation: Subtype: Link Rect: 346, 443, 375, 453 Destination: null Annotation: Subtype: Link Rect: 381, 447, 385, 457 Destination: null Annotation: Subtype: Link Rect: 386, 447, 394, 457 Destination: null Annotation: Subtype: Link Rect: 436, 108, 472, 118 Destination: null Page: Label: 246 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 449, 583, 452, 591 Destination: null Page: Label: 247 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 194, 214, 201, 224 Destination: null Page: Label: 248 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 516, 335, 543, 345 Destination: null Page: Label: 249 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 410, 506, 412, 514 Destination: null Annotation: Subtype: Link Rect: 389, 497, 392, 505 Destination: null Page: Label: 250 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 264, 556, 272, 566 Destination: null Annotation: Subtype: Link Rect: 334, 663, 341, 673 Destination: null Annotation: Subtype: Link Rect: 338, 436, 345, 446 Destination: null Annotation: Subtype: Link Rect: 509, 408, 543, 418 Destination: null Annotation: Subtype: Link Rect: 359, 305, 366, 315 Destination: null Page: Label: 251 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 77, 376, 84, 386 Destination: null Annotation: Subtype: Link Rect: 515, 304, 522, 314 Destination: null Page: Label: 252 Sequence: 20 Annotations: Annotation: Subtype: Link Rect: 202, 651, 209, 661 Destination: null Annotation: Subtype: Link Rect: 392, 567, 400, 577 Destination: null Annotation: Subtype: Link Rect: 307, 443, 345, 453 Destination: null Annotation: Subtype: Link Rect: 351, 447, 358, 457 Destination: null Annotation: Subtype: Link Rect: 360, 447, 367, 457 Destination: null Annotation: Subtype: Link Rect: 85, 53, 91, 61 Destination: null Annotation: Subtype: Link Rect: 131, 53, 137, 61 Destination: null Annotation: Subtype: Link Rect: 177, 53, 184, 61 Destination: null Page: Label: 253 Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 48, 622, 145, 632 Destination: null Page: Label: 254 Sequence: 22 Annotations: Annotation: Subtype: Link Rect: 209, 395, 255, 403 Annotation: Subtype: Link Rect: 44, 384, 103, 393 Annotation: Subtype: Link Rect: 61, 350, 279, 357 Annotation: Subtype: Link Rect: 61, 341, 271, 348 Annotation: Subtype: Link Rect: 61, 332, 283, 339 Annotation: Subtype: Link Rect: 61, 323, 224, 330 Annotation: Subtype: Link Rect: 61, 314, 272, 321 Annotation: Subtype: Link Rect: 61, 305, 267, 312 Annotation: Subtype: Link Rect: 61, 296, 287, 303 Annotation: Subtype: Link Rect: 61, 287, 207, 294 Annotation: Subtype: Link Rect: 61, 278, 273, 285 Annotation: Subtype: Link Rect: 61, 269, 181, 276 Annotation: Subtype: Link Rect: 61, 260, 283, 267 Annotation: Subtype: Link Rect: 61, 251, 191, 258 Annotation: Subtype: Link Rect: 61, 242, 258, 250 Annotation: Subtype: Link Rect: 61, 233, 284, 241 Annotation: Subtype: Link Rect: 61, 224, 210, 232 Annotation: Subtype: Link Rect: 61, 215, 265, 223 Annotation: Subtype: Link Rect: 61, 206, 281, 214 Annotation: Subtype: Link Rect: 61, 197, 287, 205 Annotation: Subtype: Link Rect: 61, 188, 140, 196 Annotation: Subtype: Link Rect: 61, 179, 281, 187 Annotation: Subtype: Link Rect: 61, 170, 282, 178 Annotation: Subtype: Link Rect: 61, 161, 245, 169 Annotation: Subtype: Link Rect: 61, 152, 258, 160 Annotation: Subtype: Link Rect: 61, 143, 273, 151 Annotation: Subtype: Link Rect: 61, 134, 272, 142 Annotation: Subtype: Link Rect: 61, 125, 283, 133 Annotation: Subtype: Link Rect: 60, 117, 287, 124 Annotation: Subtype: Link Rect: 60, 108, 287, 115 Annotation: Subtype: Link Rect: 60, 99, 133, 106 Annotation: Subtype: Link Rect: 60, 90, 282, 97 Annotation: Subtype: Link Rect: 60, 81, 252, 88 Annotation: Subtype: Link Rect: 320, 709, 544, 716 Annotation: Subtype: Link Rect: 320, 700, 369, 707 Annotation: Subtype: Link Rect: 320, 691, 531, 698 Annotation: Subtype: Link Rect: 320, 682, 546, 689 Annotation: Subtype: Link Rect: 320, 673, 408, 680 Annotation: Subtype: Link Rect: 320, 664, 546, 671 Annotation: Subtype: Link Rect: 320, 655, 545, 662 Annotation: Subtype: Link Rect: 320, 646, 546, 653 Annotation: Subtype: Link Rect: 320, 637, 546, 644 Annotation: Subtype: Link Rect: 320, 628, 515, 635 Annotation: Subtype: Link Rect: 320, 619, 529, 626 Annotation: Subtype: Link Rect: 320, 610, 542, 617 Annotation: Subtype: Link Rect: 320, 601, 485, 608 Annotation: Subtype: Link Rect: 320, 592, 546, 599 Annotation: Subtype: Link Rect: 320, 583, 524, 590 Annotation: Subtype: Link Rect: 320, 574, 542, 581 Annotation: Subtype: Link Rect: 320, 565, 531, 572 Annotation: Subtype: Link Rect: 320, 556, 382, 564 Annotation: Subtype: Link Rect: 320, 547, 536, 555 Annotation: Subtype: Link Rect: 320, 538, 539, 546 Annotation: Subtype: Link Rect: 320, 529, 542, 537 Annotation: Subtype: Link Rect: 320, 520, 355, 528 Annotation: Subtype: Link Rect: 320, 511, 533, 519 Annotation: Subtype: Link Rect: 320, 502, 540, 510 Annotation: Subtype: Link Rect: 320, 493, 449, 501 Annotation: Subtype: Link Rect: 320, 484, 546, 492 Annotation: Subtype: Link Rect: 320, 475, 546, 483 Annotation: Subtype: Link Rect: 320, 466, 449, 474 Annotation: Subtype: Link Rect: 320, 457, 541, 465 Annotation: Subtype: Link Rect: 320, 448, 535, 456 Annotation: Subtype: Link Rect: 320, 439, 543, 447 Annotation: Subtype: Link Rect: 320, 431, 377, 438 Annotation: Subtype: Link Rect: 320, 422, 523, 429 Annotation: Subtype: Link Rect: 320, 413, 527, 420 Annotation: Subtype: Link Rect: 320, 404, 408, 411 Annotation: Subtype: Link Rect: 320, 395, 546, 402 Annotation: Subtype: Link Rect: 320, 386, 546, 393 Annotation: Subtype: Link Rect: 320, 377, 527, 384 Annotation: Subtype: Link Rect: 320, 368, 540, 375 Annotation: Subtype: Link Rect: 320, 359, 511, 366 Annotation: Subtype: Link Rect: 320, 350, 546, 357 Annotation: Subtype: Link Rect: 320, 341, 516, 348 Annotation: Subtype: Link Rect: 320, 332, 517, 339 Annotation: Subtype: Link Rect: 320, 323, 530, 330 Annotation: Subtype: Link Rect: 320, 314, 374, 321 Annotation: Subtype: Link Rect: 320, 305, 546, 313 Annotation: Subtype: Link Rect: 320, 296, 545, 303 Annotation: Subtype: Link Rect: 320, 287, 534, 295 Annotation: Subtype: Link Rect: 320, 278, 400, 286 Annotation: Subtype: Link Rect: 320, 269, 520, 277 Annotation: Subtype: Link Rect: 320, 260, 496, 268 Annotation: Subtype: Link Rect: 320, 251, 530, 259 Annotation: Subtype: Link Rect: 320, 242, 527, 250 Annotation: Subtype: Link Rect: 320, 233, 408, 241 Annotation: Subtype: Link Rect: 320, 224, 546, 232 Annotation: Subtype: Link Rect: 320, 215, 534, 223 Annotation: Subtype: Link Rect: 320, 206, 457, 214 Annotation: Subtype: Link Rect: 320, 197, 541, 205 Annotation: Subtype: Link Rect: 320, 188, 542, 196 Annotation: Subtype: Link Rect: 320, 180, 546, 187 Annotation: Subtype: Link Rect: 320, 170, 372, 178 Annotation: Subtype: Link Rect: 320, 162, 543, 169 Annotation: Subtype: Link Rect: 320, 153, 520, 160 Annotation: Subtype: Link Rect: 320, 144, 520, 151 Annotation: Subtype: Link Rect: 320, 135, 529, 142 Annotation: Subtype: Link Rect: 320, 126, 374, 133 Annotation: Subtype: Link Rect: 320, 117, 546, 124 Annotation: Subtype: Link Rect: 320, 108, 521, 115 Annotation: Subtype: Link Rect: 320, 99, 546, 106 Annotation: Subtype: Link Rect: 320, 90, 530, 97 Annotation: Subtype: Link Rect: 320, 81, 384, 88 Checksum: 904b822f Type: CRC32 Checksum: 56c827bab95e5d89db40e75119240e17 Type: MD5 Checksum: dc040877e459ce7f2501106e2133321db7b33a32 Type: SHA-1 Checksum: 68e7b334442471b536d48d70ca53089f8d1f700f40fc73e21f0eb8f911135bbb Type: SHA-256