f8b7e8676fb4d1f013083acf7e02587e 320625.pdf 2e064d0271637abcfa8a31ecdc71462a4c7744a7 320625.pdf d7e1b89a290555176a8e130a02b1bdf4ae71befb99c5feca3af236bb34697c6b 320625.pdf Title: Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses: Main Results Subject: (1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients’ mean age was 44.2 20.8 years. Primary surgeries were performed on the femur (n = 404; 69.1%), tibia (n = 79; 13.5%), humerus (n = 74; 12.6%), pelvis (n = 20; 3.4%), and scapula (n = 4; 0.7%). Survival following primary surgery was 73.3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0.194), between the different etiologies (p = 0.540), or between the lower and the upper limb (p = 0.618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0.001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors. Keywords: megaprostheses; tumor; prostheses; survival; orthopedics; fixation; coating; neoplasm; osteosarcoma Author: Israel Pérez Muñoz, Fausto González Lizán, María del Carmen Sanz Pascual, Pau Machado Granados, Ana Peiró, Manuel Angulo Sánchez, Carolina de la Calva Ceinos, Paula González Rojo, Libe Asua Mentxaka, Iraia Arteagoitia, Nerea Hernández González, Josu Merino Pérez, Víctor Manuel Zarzuela, Pablo Puertas García-Sandoval, Gregorio Valero Cifuentes, Antonio Valcárcel Díaz, Amparo Godoy Montijano, Francisco Fernández Serrano, Javier González Acha, Pello Esnaloa, Iván Chaves Dorta, Luis Coll Mesa, Caleb Baz Figueroa, Álvaro Álvarez Garma, Aida Orce, Juan Luis Cebrián Parra, Roberto García Maroto, Óscar Pablos González, Míriam Maireles Pérez, María Luisa Fontalva Guerrero, Carlos Garcés Zarzalejo, Luis Roberto Estellés Marcos de León and Isidro Gracia Alegría Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sat Dec 28 09:40:57 2024 CET ModDate: Sat Dec 28 09:43:23 2024 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 752516 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XLIESF+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 FVPOSW+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 XBKMIT+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 CUNRHN+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 LGTZLE+CMSY10 Type 1 Builtin yes yes yes 32 0 RTXECF+VnURWPalladioL Type 1 Custom yes yes yes 37 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-14 03:50:44 CEST RepresentationInformation: 320625.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-13 14:27:17 CEST Size: 752516 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 256 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Overview Destination: subsection.2.1 Item: Title: Inclusion and Exclusion: Study Variables Destination: subsection.2.2 Item: Title: Statistical Analysis Destination: subsection.2.3 Item: Title: Results Destination: section.3 Children: Item: Title: Sample Size, Participating Sites, and Time Distribution Destination: subsection.3.1 Item: Title: Demographic and Etiologic Data Destination: subsection.3.2 Item: Title: Surgical Data Destination: subsection.3.3 Item: Title: Status at the End of Follow-Up Destination: subsection.3.4 Item: Title: Prosthesis Survival Destination: subsection.3.5 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses: Main Results Author: Israel Pérez Muñoz, Fausto González Lizán, María del Carmen Sanz Pascual, Pau Machado Granados, Ana Peiró, Manuel Angulo Sánchez, Carolina de la Calva Ceinos, Paula González Rojo, Libe Asua Mentxaka, Iraia Arteagoitia, Nerea Hernández González, Josu Merino Pérez, Víctor Manuel Zarzuela, Pablo Puertas García-Sandoval, Gregorio Valero Cifuentes, Antonio Valcárcel Díaz, Amparo Godoy Montijano, Francisco Fernández Serrano, Javier González Acha, Pello Esnaloa, Iván Chaves Dorta, Luis Coll Mesa, Caleb Baz Figueroa, Álvaro Álvarez Garma, Aida Orce, Juan Luis Cebrián Parra, Roberto García Maroto, Óscar Pablos González, Míriam Maireles Pérez, María Luisa Fontalva Guerrero, Carlos Garcés Zarzalejo, Luis Roberto Estellés Marcos de León and Isidro Gracia Alegría Subject: (1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients’ mean age was 44.2 20.8 years. Primary surgeries were performed on the femur (n = 404; 69.1%), tibia (n = 79; 13.5%), humerus (n = 74; 12.6%), pelvis (n = 20; 3.4%), and scapula (n = 4; 0.7%). Survival following primary surgery was 73.3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0.194), between the different etiologies (p = 0.540), or between the lower and the upper limb (p = 0.618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0.001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors. 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