ff818dd4fc35ddfb9f4e23bdad27e3db 320634.pdf a90957229f573d1946e7964b36010bb52ee7a738 320634.pdf b3eac5025af39da586134be80c79637f18eec4faf2b291b3ae38c18064cceafe 320634.pdf Title: Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations Subject: Background: Exposure time to a tuberculosis (TB) index case may be a marker of a recent latent tuberculosis infection (LTBI) risk. The aim of this study was to determine the LTBI risk involved in immigrant contact based on exposure time to pulmonary TB index cases. Methods: We conducted a 30-month LTBI prevalence study of pulmonary TB immigrant contacts in Catalonia (1 January 2019–30 June 2021). Contacts with LTBI were identified by means of the tuberculin skin test and/or interferon gamma release assay. Variables associated with LTBI in contacts were analysed using adjusted OR (aOR) and 95% confidence interval (CI) values. Results: LTBI prevalence was 37.4% (939/2509). Prevalence was higher in men than women (40.6% versus 33.5%; p < 0.001), and in all age groups, relative to children <5 years (12.2%; p < 0.001)). Prevalence increased with exposure time to the index case; relative to <6 h/week exposure, LTBI risk was greater for both 6 h/day (aOR = 2.0; 95% CI: 1.5–2.6) and <6 h/day but 6 h/week (aOR = 1.6; 95% CI: 1.1–2.2). Conclusions: The LTBI risk in immigrant contacts increases with recent exposure time to the index case, and may suggest recent LTBI in immigrants. Keywords: latent tuberculosis infection; immigrant; tuberculosis; contact tracing; epidemiology; transmission; exposure time Author: Sofia Godoy, Miquel Alsedà, Ignasi Parrón, Joan-Pau Millet, Joan A. Caylà, Núria Follia, Monica Carol, Angels Orcau, Diana Toledo, Gloria Ferrús, Pere Plans, Irene Barrabeig, Laura Clotet, Angela Domínguez, Jaume March-Llanes, Pere Godoy and on behalf of the Transmission of Tuberculosis in Catalonia (Spain) Working Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Mon Feb 10 12:55:30 2025 CET ModDate: Mon Feb 10 13:04:09 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 266045 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 AEKUJT+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 UDFSUB+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 GGBUVT+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 PDTLUH+CMSY10 Type 1 Builtin yes yes yes 32 0 DMTLJA+VnURWPalladioL Type 1 Custom yes yes yes 37 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 72 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-28 04:27:19 CET RepresentationInformation: 320634.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-23 08:46:34 CEST Size: 266045 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 247 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Item: Title: Results Destination: section.3 Item: Title: Discussion Destination: section.4 Item: Title: References Destination: appendix.A. Info: Title: Exposure Time to a Tuberculosis Index Case as a Marker of Infection in Immigrant Populations Author: Sofia Godoy, Miquel Alsedà, Ignasi Parrón, Joan-Pau Millet, Joan A. Caylà, Núria Follia, Monica Carol, Angels Orcau, Diana Toledo, Gloria Ferrús, Pere Plans, Irene Barrabeig, Laura Clotet, Angela Domínguez, Jaume March-Llanes, Pere Godoy and on behalf of the Transmission of Tuberculosis in Catalonia (Spain) Working Group Subject: Background: Exposure time to a tuberculosis (TB) index case may be a marker of a recent latent tuberculosis infection (LTBI) risk. The aim of this study was to determine the LTBI risk involved in immigrant contact based on exposure time to pulmonary TB index cases. Methods: We conducted a 30-month LTBI prevalence study of pulmonary TB immigrant contacts in Catalonia (1 January 2019 30 June 2021). Contacts with LTBI were identified by means of the tuberculin skin test and/or interferon gamma release assay. Variables associated with LTBI in contacts were analysed using adjusted OR (aOR) and 95% confidence interval (CI) values. Results: LTBI prevalence was 37.4% (939/2509). Prevalence was higher in men than women (40.6% versus 33.5%; p < 0.001), and in all age groups, relative to children <5 years (12.2%; p < 0.001)). Prevalence increased with exposure time to the index case; relative to <6 h/week exposure, LTBI risk was greater for both 6 h/day (aOR = 2.0; 95% CI: 1.5 2.6) and <6 h/day but 6 h/week (aOR = 1.6; 95% CI: 1.1 2.2). Conclusions: The LTBI risk in immigrant contacts increases with recent exposure time to the index case, and may suggest recent LTBI in immigrants. 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