e9c6f6b548877678126826abf033c5f1  NatCom_a2025v16p2020.pdf
24e7bd205c7fc24bef93679ec82148003b9f539d  NatCom_a2025v16p2020.pdf
601a635bfaa4119984b49e8b461aa35afa267182dc225e12fb7f1b1bf8a3f660  NatCom_a2025v16p2020.pdf

Title:           Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
Subject:         Nature Communications, doi:10.1038/s41467-025-57034-y
Keywords:        
Author:          David Aranda-García
Creator:         Springer
Producer:        iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:    Thu Feb 27 12:54:36 2025 CET
ModDate:         Thu Feb 27 15:32:59 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           17
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       3766296 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
EKFBOA+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes     68  0
EKFCCP+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no     555  0
EKFCDA+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      70  0
EKFBML+AdvOT13119950                 Type 1C           WinAnsi          yes yes no      71  0
EKFBMM+AdvOT89719618                 Type 1C           WinAnsi          yes yes no      72  0
EKFBMN+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no    1314  0
EKFBMO+AdvOT13119950+fb              Type 1C           Custom           yes yes yes    626  0
EKFBMP+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no      76  0
EKFBNP+AdvOTdd63dae3+20              Type 1C           WinAnsi          yes yes no      78  0
EKFCEB+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no      67  0
EKFCEC+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no      69  0
EKFCFF+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      73  0
EKFCFG+AdvOTdd63dae3+22              Type 1C           Custom           yes yes no      74  0
EKFCFD+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes     75  0
EKFCFE+AdvOT70e1938e+fb              Type 1C           Custom           yes yes yes     77  0
EKFILA+AdvOT8608a8d1                 Type 1C           WinAnsi          yes yes no     197  0
EKFLBC+AdvOT3d287b35.B+fb            Type 1C           Custom           yes yes yes    292  0
EKGMCK+AdvOT3d287b35.B+20            Type 1C           WinAnsi          yes yes no     516  0
EKGMEK+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes    556  0
EKGMKK+AdvOT0c200bf0+20              Type 1C           WinAnsi          yes yes no     587  0
EKGMKJ+AdvOT0c200bf0+22              Type 1C           Custom           yes yes no     588  0
EKGMNK+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no     625  0
EKGMPK+AdvOT0c200bf0+03              Type 1C           Custom           yes yes yes    637  0
EKGMPL+AdvOT0c200bf0+01              Type 1C           Custom           yes yes yes    638  0
EKGNDL+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     969  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2025-12-13 04:14:56 CET
 RepresentationInformation: NatCom_a2025v16p2020.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2025-12-12 16:53:30 CET
  Size: 3766296
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 1390
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: A comprehensive dataset with a large diversity in receptor and ligand types
          Destination: B1
         Item: 
          Title: GPCRs are flexible molecules with local breathing motions at the nano- to microsecond timescale
          Destination: B2
         Item: 
          Title: Lipid insertion into the receptor core is a persistent phenomenon in GPCRs
          Destination: B3
         Item: 
          Title: Computer simulations recover lipid insertions observed in experimental structure
          Destination: B4
         Item: 
          Title: Lipid insertion sites are hotspots for allosteric modulation of GPCRs
          Destination: B5
         Item: 
          Title: Lipids dynamics reveal lateral gateways into the receptor core
          Destination: B6
         Item: 
          Title: Allosteric sites and lateral channels are often hidden but can be disclosed by lipid dynamics
          Destination: B7
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Structure selection and curation
          Destination: B8
         Item: 
          Title: Simulation protocol
          Destination: B9
         Item: 
          Title: Conformational sampling
          Destination: B10
         Item: 
          Title: Estimation of state transition rates between closed, intermediate, and open GPCR states
          Destination: B11
         Item: 
          Title: Lipid insertions
          Destination: B12
         Item: 
          Title: Reporting summary
          Destination: B13
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: Code availability
        Destination: M2
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Competing interests
        Destination: A7
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
    Author: David Aranda-García
    Subject: Nature Communications, doi:10.1038/s41467-025-57034-y
    Keywords: 
    Creator: Springer
    Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Feb 27 13:24:36 CET 2025
    ModDate: Thu Feb 27 15:32:59 CET 2025
   ID: 0xe936b56c641c67805ad56fe9cd0ed06f, 0x7531f25cfb426da688e3bc5dd20f17ca
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 275
      ImageHeight: 36
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 298
      ImageHeight: 707
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 149
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 149
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 298
      ImageHeight: 566
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 41
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 42
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 742
      ImageHeight: 284
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 594
      ImageHeight: 284
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 96
      ImageHeight: 42
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 41
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 131
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 128
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 96
      ImageHeight: 42
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 128
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 131
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 128
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 275
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 95
      ImageHeight: 42
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 131
      ImageHeight: 40
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 446
      ImageHeight: 425
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 298
      ImageHeight: 707
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 446
      ImageHeight: 425
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 446
      ImageHeight: 425
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 98
      ImageHeight: 49
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 98
      ImageHeight: 49
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 578
      ImageHeight: 374
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 578
      ImageHeight: 250
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 98
      ImageHeight: 49
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 98
      ImageHeight: 50
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 75
      ImageHeight: 50
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 107
      ImageHeight: 53
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 107
      ImageHeight: 53
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 107
      ImageHeight: 53
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 99
      ImageHeight: 48
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 290
      ImageHeight: 735
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 114
      ImageHeight: 57
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 107
      ImageHeight: 53
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 145
      ImageHeight: 882
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 114
      ImageHeight: 57
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 146
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 104
      ImageHeight: 51
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 104
      ImageHeight: 52
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 145
      ImageHeight: 1468
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 290
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 352
      ImageHeight: 442
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 114
      ImageHeight: 57
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1441
      ImageHeight: 148
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 434
      ImageHeight: 295
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 866
      ImageHeight: 148
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 114
      ImageHeight: 57
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 114
      ImageHeight: 57
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 290
      ImageHeight: 735
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 114
      ImageHeight: 47
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 442
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 114
      ImageHeight: 57
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 146
      ImageHeight: 1468
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 434
      ImageHeight: 441
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 114
      ImageHeight: 57
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 290
      ImageHeight: 735
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 107
      ImageHeight: 54
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 114
      ImageHeight: 57
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2000
      ImageHeight: 1468
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1057
      ImageHeight: 445
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: EKFCEB+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 44
      LastChar: 124
      FontDescriptor: 
       FontName: EKFCEB+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBOA+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EKFBOA+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKGMCK+AdvOT3d287b35.B+20
      FontSubset: true
      FirstChar: 145
      LastChar: 145
      FontDescriptor: 
       FontName: EKGMCK+AdvOT3d287b35.B+20
       Flags: Nonsymbolic
       FontBBox: -187, -145, 1395, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFCEC+AdvOT70e1938e
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: EKFCEC+AdvOT70e1938e
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFILA+AdvOT8608a8d1
      FontSubset: true
      FirstChar: 181
      LastChar: 181
      FontDescriptor: 
       FontName: EKFILA+AdvOT8608a8d1
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFCDA+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 48
      LastChar: 57
      FontDescriptor: 
       FontName: EKFCDA+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBML+AdvOT13119950
      FontSubset: true
      FirstChar: 38
      LastChar: 241
      FontDescriptor: 
       FontName: EKFBML+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBMM+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: EKFBMM+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFCFF+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: EKFCFF+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKGNDL+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: EKGNDL+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFCFG+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: EKFCFG+AdvOTdd63dae3+22
       Flags: Nonsymbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: EKFCFD+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: EKFCFD+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKGMKK+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: EKGMKK+AdvOT0c200bf0+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBMP+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 37
      LastChar: 215
      FontDescriptor: 
       FontName: EKFBMP+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKGMKJ+AdvOT0c200bf0+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: EKGMKJ+AdvOT0c200bf0+22
       Flags: Nonsymbolic
       FontBBox: -10, -250, 645, 885
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: EKFCFE+AdvOT70e1938e+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EKFCFE+AdvOT70e1938e+fb
       Flags: Symbolic
       FontBBox: 9, 0, 854, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKFBNP+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 129
      LastChar: 151
      FontDescriptor: 
       FontName: EKFBNP+AdvOTdd63dae3+20
       Flags: Nonsymbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBMN+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 67
      LastChar: 121
      FontDescriptor: 
       FontName: EKFBMN+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFLBC+AdvOT3d287b35.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EKFLBC+AdvOT3d287b35.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 875, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKFCCP+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: EKFCCP+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKGMEK+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: EKGMEK+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKGMNK+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: EKGMNK+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: EKFBMO+AdvOT13119950+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EKFBMO+AdvOT13119950+fb
       Flags: Symbolic
       FontBBox: 9, 0, 666, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKGMPK+AdvOT0c200bf0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EKGMPK+AdvOT0c200bf0+03
       Flags: Symbolic
       FontBBox: -156, -177, 802, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EKGMPL+AdvOT0c200bf0+01
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: EKGMPL+AdvOT0c200bf0+01
       Flags: Symbolic
       FontBBox: -41, -218, 947, 1104
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2020/06/23-02:37:56        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1038/s41467-025-57034-y</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>David Aranda-García</rdf:li>
               <rdf:li>Tomasz Maciej Stepniewski</rdf:li>
               <rdf:li>Mariona Torrens-Fontanals</rdf:li>
               <rdf:li>Adrian García-Recio</rdf:li>
               <rdf:li>Marta Lopez-Balastegui</rdf:li>
               <rdf:li>Brian Medel-Lacruz</rdf:li>
               <rdf:li>Adrián Morales-Pastor</rdf:li>
               <rdf:li>Alejandro Peralta-García</rdf:li>
               <rdf:li>Miguel Dieguez-Eceolaza</rdf:li>
               <rdf:li>David Sotillo-Nuñez</rdf:li>
               <rdf:li>Tianyi Ding</rdf:li>
               <rdf:li>Matthäus Drabek</rdf:li>
               <rdf:li>Célien Jacquemard</rdf:li>
               <rdf:li>Jakub Jakowiecki</rdf:li>
               <rdf:li>Willem Jespers</rdf:li>
               <rdf:li>Mireia Jiménez-Rosés</rdf:li>
               <rdf:li>Víctor Jun-Yu-Lim</rdf:li>
               <rdf:li>Alessandro Nicoli</rdf:li>
               <rdf:li>Urszula Orzel</rdf:li>
               <rdf:li>Aida Shahraki</rdf:li>
               <rdf:li>Johanna K. S. Tiemann</rdf:li>
               <rdf:li>Vicente Ledesma-Martin</rdf:li>
               <rdf:li>Francho Nerín-Fonz</rdf:li>
               <rdf:li>Sergio Suárez-Dou</rdf:li>
               <rdf:li>Oriol Canal</rdf:li>
               <rdf:li>Gáspár Pándy-Szekeres</rdf:li>
               <rdf:li>Jiafei Mao</rdf:li>
               <rdf:li>David E. Gloriam</rdf:li>
               <rdf:li>Esther Kellenberger</rdf:li>
               <rdf:li>Dorota Latek</rdf:li>
               <rdf:li>Ramon Guixà-González</rdf:li>
               <rdf:li>Hugo Gutiérrez-de-Terán</rdf:li>
               <rdf:li>Irina G. Tikhonova</rdf:li>
               <rdf:li>Peter W. Hildebrand</rdf:li>
               <rdf:li>Marta Filizola</rdf:li>
               <rdf:li>M. Madan Babu</rdf:li>
               <rdf:li>Antonella Di Pizio</rdf:li>
               <rdf:li>Slawomir Filipek</rdf:li>
               <rdf:li>Peter Kolb</rdf:li>
               <rdf:li>Arnau Cordomi</rdf:li>
               <rdf:li>Toni Giorgino</rdf:li>
               <rdf:li>Maria Marti-Solano</rdf:li>
               <rdf:li>Jana Selent</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Springer US</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:subject>
            <rdf:Bag></rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-025-57034-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <prism:doi>10.1038/s41467-025-57034-y</prism:doi>
         <prism:url>http://dx.doi.org/10.1038/s41467-025-57034-y</prism:url>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Nature Communications</prism:publicationName>
         <prism:copyright>© 2025, The Author(s)</prism:copyright>
         <prism:issn>2041-1723</prism:issn>
         <pdfx:doi>10.1038/s41467-025-57034-y</pdfx:doi>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>True</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1038/s41467-025-57034-y</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2025-02-27T15:32:59+01:00</xmp:ModifyDate>
         <xmp:CreateDate>2025-02-27T17:24:36+05:30</xmp:CreateDate>
         <xmp:MetadataDate>2025-02-27T15:32:59+01:00</xmp:MetadataDate>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Keywords></pdf:Keywords>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:fb2571e7-4c77-4144-8576-1cc78d6ec327</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:e675d5e4-66c3-4b15-b379-42c3b09b76e2</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:bb73c1a3-f52f-41d1-af53-5d7d3174856c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2025-02-27T17:26:23+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <sn:authorInfo>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Mariona Torrens-Fontanals</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6233-8945</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Adrian García-Recio</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7143-9075</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Brian Medel-Lacruz</author:name>
                  <author:orcid>http://orcid.org/0000-0003-2831-7731</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Miguel Dieguez-Eceolaza</author:name>
                  <author:orcid>http://orcid.org/0009-0008-9169-6416</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>David Sotillo-Nuñez</author:name>
                  <author:orcid>http://orcid.org/0009-0006-6414-8970</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Tianyi Ding</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1989-3705</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Célien Jacquemard</author:name>
                  <author:orcid>http://orcid.org/0000-0002-9633-3429</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Willem Jespers</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4951-9220</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Mireia Jiménez-Rosés</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4049-8670</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Alessandro Nicoli</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6177-9749</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Johanna K. S. Tiemann</author:name>
                  <author:orcid>http://orcid.org/0000-0001-7551-6245</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Francho Nerín-Fonz</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5548-7608</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Sergio Suárez-Dou</author:name>
                  <author:orcid>http://orcid.org/0000-0002-7929-9468</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Oriol Canal</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6292-5947</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>David E. Gloriam</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4299-7561</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Esther Kellenberger</author:name>
                  <author:orcid>http://orcid.org/0000-0002-9320-4840</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Dorota Latek</author:name>
                  <author:orcid>http://orcid.org/0000-0002-0429-0637</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Ramon Guixà-González</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0397-9800</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Hugo Gutiérrez-de-Terán</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0459-3491</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Irina G. Tikhonova</author:name>
                  <author:orcid>http://orcid.org/0000-0002-6228-9431</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Peter W. Hildebrand</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0063-1104</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Marta Filizola</author:name>
                  <author:orcid>http://orcid.org/0000-0002-4382-8276</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>M. Madan Babu</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0556-6196</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Antonella Di Pizio</author:name>
                  <author:orcid>http://orcid.org/0000-0002-8520-5165</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Slawomir Filipek</author:name>
                  <author:orcid>http://orcid.org/0000-0003-3147-3858</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Peter Kolb</author:name>
                  <author:orcid>http://orcid.org/0000-0003-4089-614X</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Arnau Cordomi</author:name>
                  <author:orcid>http://orcid.org/0000-0002-5793-2947</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Toni Giorgino</author:name>
                  <author:orcid>http://orcid.org/0000-0001-6449-0596</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Maria Marti-Solano</author:name>
                  <author:orcid>http://orcid.org/0000-0003-0373-8927</author:orcid>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <author:name>Jana Selent</author:name>
                  <author:orcid>http://orcid.org/0000-0002-1844-4449</author:orcid>
               </rdf:li>
            </rdf:Bag>
         </sn:authorInfo>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>pdfx</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was published.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      <pdf:Producer>iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer></rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 253, 202, 255, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 188, 191, 191, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 252, 159, 255, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 426, 208, 561, 216
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 197, 364, 206
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 448, 197, 561, 206
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 187, 339, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 169, 444, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 556, 137, 559, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 341, 116, 344, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 347, 116, 350, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 472, 116, 477, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 478, 116, 483, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 389, 105, 394, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 396, 105, 400, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: -2, 479, 50, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 486, 50, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 74, 48, 143, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 234, 737, 239, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 245, 733, 294, 741
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 722, 87, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 202, 384, 206, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 209, 384, 214, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 272, 373, 276, 378
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 60, 262, 63, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 185, 255, 190, 260
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 187, 240, 191, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 284, 219, 287, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 173, 169, 178, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 199, 165, 202, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 198, 144, 201, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 86, 133, 150, 141
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 209, 52, 214, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 536, 722, 540, 730
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 516, 551, 520, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 351, 519, 355, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 547, 508, 552, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 448, 497, 561, 505
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 486, 322, 495
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 497, 444, 501, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 450, 427, 454, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 493, 427, 498, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 407, 405, 413, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 500, 347, 505, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 433, 101, 437, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 176, 99, 180, 104
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 554, 109, 559, 114
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 230, 701, 292, 709
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 451, 722, 561, 730
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 711, 318, 720
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 343, 711, 347, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 79, 508, 84, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 210, 444, 214, 452
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 181, 251, 185, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 237, 202, 241, 207
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 138, 176, 142, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 207, 95, 212, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 230, 95, 235, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 289, 95, 294, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 144, 84, 149, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 242, 73, 247, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 452, 555, 457, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 459, 555, 464, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 408, 476, 413, 484
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 458, 422, 462, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 383, 347, 387, 355
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 377, 337, 381, 345
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 376, 304, 380, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 550, 294, 554, 302
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 367, 262, 371, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 553, 223, 559, 228
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 418, 112, 422, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 405, 684, 511, 691
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 417, 664, 524, 671
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 113, 690, 118, 698
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 467, 679, 561, 687
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 669, 341, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 441, 669, 445, 677
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 104, 519, 230, 527
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 236, 523, 241, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 242, 523, 248, 528
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 181, 422, 294, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 412, 57, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 135, 412, 263, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 124, 251, 250, 259
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 282, 251, 286, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 86, 219, 91, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 136, 176, 141, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 110, 169, 116, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 71, 90, 197, 98
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 396, 566, 400, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 501, 480, 506, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 416, 465, 542, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 326, 454, 453, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 407, 433, 538, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 308, 422, 435, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 483, 422, 561, 430
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 412, 354, 420
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 553, 405, 559, 410
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 536, 262, 541, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 420, 240, 424, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 541, 208, 545, 216
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 321, 197, 325, 206
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 476, 176, 480, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 375, 69, 379, 77
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 359, 654, 466, 661
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 449, 733, 454, 741
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 215, 594, 278, 602
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 57, 551, 61, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 247, 551, 294, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 540, 118, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 152, 501, 157, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 160, 501, 166, 506
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 57, 433, 121, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 211, 379, 215, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 147, 330, 152, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 141, 287, 147, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 148, 287, 153, 292
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 171, 219, 175, 227
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 135, 112, 140, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 120, 73, 126, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 206, 62, 211, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 212, 62, 218, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 519, 555, 524, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 358, 497, 362, 505
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 461, 480, 467, 485
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 547, 358, 552, 366
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 466, 304, 470, 313
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 476, 262, 480, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 228, 664, 294, 671
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 654, 80, 661
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 361, 714, 468, 721
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 368, 201, 478, 208
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 384, 191, 491, 198
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 181, 509, 188
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 427, 171, 535, 178
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 435, 161, 542, 168
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 446, 151, 557, 158
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 454, 141, 550, 148
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 307, 131, 322, 138
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 56, 694, 60, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 61, 694, 67, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 154, 647, 159, 655
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 60, 615, 64, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 214, 379, 219, 388
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 73, 330, 77, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 79, 330, 84, 335
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 251, 298, 257, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 124, 266, 128, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 250, 180, 256, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 257, 180, 262, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 263, 180, 269, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 271, 180, 277, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 115, 101, 119, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 57, 73, 62, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 137, 52, 141, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 143, 52, 148, 57
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 448, 716, 453, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 551, 630, 557, 635
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 486, 587, 491, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 514, 544, 519, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 520, 544, 525, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 528, 544, 533, 549
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 547, 508, 552, 516
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 330, 433, 333, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 519
      Annotation: 
       Subtype: Link
       Rect: 541, 272, 561, 281
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 262, 349, 270
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 356, 191, 361, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 429, 127, 435, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 366, 116, 371, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 421, 105, 426, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 85, 47, 90, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 557
      Annotation: 
       Subtype: Link
       Rect: 491, 212, 496, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 553, 159, 559, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 328, 137, 333, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 335, 137, 340, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 393, 122, 397, 131
       Flags: Print
       AppearanceDictionary: true
       Destination: 557
      Annotation: 
       Subtype: Link
       Rect: 551, 101, 556, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 557
      Annotation: 
       Subtype: Link
       Rect: 537, 73, 542, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 627
      Annotation: 
       Subtype: Link
       Rect: 543, 73, 549, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 186, 524, 190, 531
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 259, 368, 263, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 279, 368, 283, 375
       Flags: Print
       AppearanceDictionary: true
       Destination: 420
      Annotation: 
       Subtype: Link
       Rect: 280, 284, 298, 291
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 158, 276, 196, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 129, 247, 177, 253
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 222, 277, 228, 281
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 187, 240, 294, 248
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 229, 110, 238
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 61, 144, 66, 152
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 248, 90, 294, 98
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 79, 139, 88
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 221, 47, 226, 56
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 522, 615, 526, 623
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 384, 561, 388, 570
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 450, 212, 456, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 406, 137, 412, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 296, 663, 448, 670
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 193, 566, 198, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 257, 465, 261, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 230
      Annotation: 
       Subtype: Link
       Rect: 195, 240, 200, 248
       Flags: Print
       AppearanceDictionary: true
       Destination: 595
      Annotation: 
       Subtype: Link
       Rect: 384, 469, 389, 474
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 516, 465, 520, 473
       Flags: Print
       AppearanceDictionary: true
       Destination: 364
      Annotation: 
       Subtype: Link
       Rect: 306, 369, 496, 377
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 534, 219, 561, 227
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 208, 457, 216
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 457, 212, 462, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 645
      Annotation: 
       Subtype: Link
       Rect: 448, 58, 545, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 47, 344, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 113, 631, 116, 637
       Flags: Print
       AppearanceDictionary: true
       Destination: 145
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 251, 369, 291, 377
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 358, 152, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 58, 238, 66
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 669, 199, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 551, 155, 559
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 530, 594, 554, 602
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 583, 470, 591
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 470, 394, 480
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 470, 394, 480
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 469, 402, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 392, 469, 401, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 469, 402, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 503, 470, 505, 480
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 503, 470, 505, 480
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 512, 469, 513, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 503, 469, 512, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 512, 469, 514, 478
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 238, 458, 240, 467
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 238, 458, 240, 467
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 456, 248, 465
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 238, 456, 247, 465
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 247, 456, 249, 465
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 78, 445, 79, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 78, 445, 79, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 87, 443, 88, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 78, 443, 87, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 87, 443, 88, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 445, 189, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 445, 189, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 443, 197, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 443, 196, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 443, 198, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 254, 445, 255, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 254, 445, 255, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 263, 443, 264, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 254, 443, 263, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 263, 443, 264, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 445, 441, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 445, 441, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 449, 443, 450, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 443, 449, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 449, 443, 450, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 432, 106, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 432, 106, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 431, 115, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 105, 431, 114, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 114, 431, 115, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 221, 432, 222, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 221, 432, 222, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 230, 431, 231, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 221, 431, 230, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 230, 431, 231, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 432, 414, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 412, 432, 414, 441
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 421, 431, 422, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 431, 421, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 421, 431, 423, 440
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 206, 419, 208, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 206, 419, 208, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 215, 418, 216, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 206, 418, 215, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 215, 418, 217, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 427, 419, 428, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 427, 419, 428, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 418, 437, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 427, 418, 436, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 436, 418, 437, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 419, 527, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 419, 527, 429
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 418, 536, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 526, 418, 535, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 535, 418, 536, 427
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 88, 407, 90, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 88, 407, 90, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 97, 405, 98, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 89, 405, 97, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 97, 405, 99, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 407, 358, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 407, 358, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 405, 367, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 357, 405, 366, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 366, 405, 367, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 466, 407, 467, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 466, 407, 467, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 405, 476, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 466, 405, 475, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 475, 405, 476, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 407, 542, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 407, 542, 416
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 549, 405, 550, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 541, 405, 549, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 549, 405, 551, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 140, 394, 141, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 140, 394, 141, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 149, 393, 150, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 140, 393, 149, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 149, 393, 150, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 394, 272, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 394, 272, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 393, 280, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 270, 393, 279, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 279, 393, 281, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 394, 383, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 394, 383, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 393, 392, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 382, 393, 391, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 391, 393, 392, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 489, 394, 491, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 489, 394, 491, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 498, 393, 499, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 490, 393, 498, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 498, 393, 500, 402
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 97, 381, 98, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 97, 381, 98, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 106, 380, 107, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 97, 380, 106, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 106, 380, 107, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 381, 188, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 381, 188, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 380, 197, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 187, 380, 196, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 196, 380, 197, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 381, 287, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 381, 287, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 380, 296, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 286, 380, 295, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 380, 296, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 389, 381, 391, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 389, 381, 391, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 398, 380, 399, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 380, 398, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 398, 380, 400, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 454, 381, 456, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 454, 381, 456, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 380, 464, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 454, 380, 463, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 380, 465, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 381, 541, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 381, 541, 391
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 549, 380, 550, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 540, 380, 549, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 549, 380, 550, 389
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 98, 369, 99, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 98, 369, 99, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 107, 367, 108, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 98, 367, 107, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 107, 367, 108, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 213, 369, 215, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 213, 369, 215, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 222, 367, 223, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 214, 367, 222, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 222, 367, 224, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 369, 295, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 369, 295, 378
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 367, 303, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 294, 367, 302, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 367, 304, 376
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 74, 138, 144, 145
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 0b65cb57
   Type: CRC32
  Checksum: e9c6f6b548877678126826abf033c5f1
   Type: MD5
  Checksum: 24e7bd205c7fc24bef93679ec82148003b9f539d
   Type: SHA-1
  Checksum: 601a635bfaa4119984b49e8b461aa35afa267182dc225e12fb7f1b1bf8a3f660
   Type: SHA-256