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Introduction Destination: flink1 Item: Title: 2. Materials and methods Destination: flink2 Children: Item: Title: 2.1. Generation of CaMKII-CB1-RS and Ati-CB1-RS mice Destination: slink1 Item: Title: 2.2. Generation of reporter mouse lines: CaMKII-nuGFP and Ati-nuGFP mice Destination: slink2 Item: Title: 2.3. Mice Destination: slink3 Item: Title: 2.4. Drugs and treatments Destination: slink4 Item: Title: 2.5. Glucose tolerance test Destination: slink5 Item: Title: 2.6. Binge-eating Destination: slink6 Item: Title: 2.7. Experimental sequence Destination: slink7 Item: Title: 2.8. Self-administration Destination: slink8 Children: Item: Title: 2.8.1. Self-administration session Destination: tlink9 Item: Title: 2.8.2. Persistence to response Destination: tlink10 Item: Title: 2.8.3. Motivation Destination: tlink11 Item: Title: 2.8.4. Compulsivity Destination: tlink12 Item: Title: 2.9. Behavioral tests Destination: slink13 Children: Item: Title: 2.9.1. Novelty-suppressed feeding test Destination: tlink14 Item: Title: 2.9.2. Light-dark box test Destination: tlink15 Item: Title: 2.9.3. Elevated plus maze test Destination: tlink16 Item: Title: 2.9.4. Tail suspension test Destination: tlink17 Item: Title: 2.9.5. Forced swimming test Destination: tlink18 Item: Title: 2.9.6. Sucrose preference test Destination: tlink19 Item: Title: 2.9.7. Locomotor activity Destination: tlink20 Item: Title: 2.10. Statistical analysis Destination: slink21 Item: Title: 3. Results Destination: flink3 Children: Item: Title: 3.1. Rescue of CB1 in CaMKII + neurons or in adipocytes Destination: slink22 Item: Title: 3.2. Rescue of CB1 in CaMKII + neurons drives feeding behavior in mice Destination: slink23 Item: Title: 3.3. CaMKII-CB1-RS mice develop obesity but not glucose intolerance in obesogenic conditions Destination: slink24 Item: Title: 3.4. CaMKII-CB1-RS mice develop metabolic syndrome in a model of stress-related obesity Destination: slink25 Item: Title: 3.5. CB1 expression in CaMKII neurons was sufficient to promote binge-eating behavior and food addictive-like behavior Destination: slink26 Item: Title: 3.6. The expression of CB1 in CaMKII + neurons enhances cognitive flexibility and rescues anxiety-like behavior but not depressi ... Destination: slink27 Item: Title: 4. Discussion Destination: flink4 Item: Title: flink5 Destination: flink5 Item: Title: flink6 Destination: flink6 Item: Title: flink7 Destination: flink7 Item: Title: flink8 Destination: flink8 Item: Title: flink9 Destination: flink9 Item: Title: References Destination: blink1 Info: Title: Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior Author: Elena Martin-Garcia Subject: Molecular Metabolism, 92 (2025) 102096. doi:10.1016/j.molmet.2025.102096 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Jan 29 03:52:59 CET 2025 ModDate: Wed Jan 29 03:54:54 CET 2025 ID: 0xd49dce312f1faa381b3b8f7d3d181491, 0x44472bab193f2442915aa5f4dba1d9db Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 103 ImageHeight: 102 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: 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Azua Endocannabinoid system Cannabinoid type 1 receptor (CB1) Impulsivity Feeding behavior Obesity Metabolic syndrome Food addiction Molecular Metabolism, 92 (2025) 102096. doi:10.1016/j.molmet.2025.102096 The Authors journal Molecular Metabolism © 2025 The Authors. 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