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PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Gut IgA functionally interacts with systemic IgG to enhance antipneumococcal vaccine responses Children: Item: Title: INTRODUCTION Item: Title: RESULTS Children: Item: Title: IgA augments IgG responses to TD immunogens Item: Title: IgA enhances IgG responses to TI immunogens Item: Title: IgA restrains IgG responses to gut commensal antigens Item: Title: IgA could affect IgG responses via gut commensals Item: Title: IgA controls FO B cell differentiation to PCs Item: Title: IgA constrains T cell expression of the immune inhibitor PD-1 Item: Title: IgA limits anergic B cells and gut permeability in humans Item: Title: DISCUSSION Item: Title: MATERIALS AND METHODS Children: Item: Title: Study design Item: Title: Human subjects Children: Item: Title: Analysis of human blood and stool samples Item: Title: Mice Item: Title: Analysis of murine blood and stool samples Item: Title: Colonization of GF mice Item: Title: Isolation and identification of translocated gut bacteria Item: Title: Culture of bacteria Item: Title: Immunizations Item: Title: Bacteria isolation from mouse feces Item: Title: Flow cytometry and cell sorting Item: Title: Enzyme-linked immunosorbent assay Item: Title: RNA sequencing Item: Title: 16S rRNA gene sequencing and analysis Item: Title: 16S rRNA gene quantitative PCR Item: Title: Mouse B cell cultures Item: Title: Histology and immunofluorescence Item: Title: Statistical analysis Item: Title: Supplementary Materials Children: Item: Title: The PDF file includes: Item: Title: Other Supplementary Material for this manuscript includes the following: Item: Title: REFERENCES AND NOTES Item: Title: Acknowledgments Info: Title: Science Journals   AAAS Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Wed Feb 05 21:08:12 CET 2025 ModDate: Wed Feb 12 13:08:47 CET 2025 ID: 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