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Title:           Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
Subject:         EMBO Reports 0.0:1-35
Keywords:        Autoimmunity; Autophagy; Condensates; Metacaspases; Proteostasis
Author:          Jose Salguero-Linares
Creator:         Springer
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     Item: 
      Title: Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Absence of AtMC1 results in autoimmunity dependent on SA synthesis and signalling through the EDS1-PAD4 immune node
          Destination: B1
         Item: 
          Title: Overexpression of a catalytically inactive variant of AtMC1 (AtMC1C220A) in an atmc1 background triggers severe autoimmunity
          Destination: B2
         Item: 
          Title: The autoimmune phenotype caused by catalytically inactive AtMC1 is partially dependent on SA synthesis and the EDS1-PAD4-ADR1 immune node
          Destination: B3
         Item: 
          Title: Wt AtMC1 alleles suppress the autoimmune phenotype caused by catalytically inactive AtMC1
          Destination: B4
         Item: 
          Title: Catalytically inactive AtMC1 associates with immune-related components involved in PTI and ETI
          Destination: B5
         Item: 
          Title: Individual mutations in NLRs and PTI-related components do not rescue the severe autoimmune phenotype of catalytically inactive AtMC1
          Destination: B6
         Item: 
          Title: Catalytically inactive AtMC1 forms stable condensate-like puncta and may stabilize NLRs and other immune regulators
          Destination: B7
         Item: 
          Title: AtMC1C220A condensate-like puncta are partly degraded through autophagy
          Destination: B8
         Item: 
          Title: Overexpression of SNIPER1 rescues the autoimmune phenotype caused by catalytically inactive AtMC1
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       Item: 
        Title: Discussion
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        Children: 
         Item: 
          Title: AtMC1- and caspase 8-dependent autoimmunity feature striking similarities at the molecular level
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         Item: 
          Title: Catalytically inactive AtMC1 as a docking site of immune-related protein complexes
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         Item: 
          Title: The autoimmune phenotype caused by catalytically inactive AtMC1 is dependent on a salicylic acid-mediated feedback loop and hyperaccumulation of NLRs
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         Item: 
          Title: Stabilization of AtMC1C220A in aberrant condensates may reveal a new proteostatic role for AtMC1 in NLR and other immune regulators clearance mediated by autophagy
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           Item: 
            Title: Final remarks and working model
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       Item: 
        Title: Methods
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          Title: Plant materials and plant growth conditions
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         Item: 
          Title: Plasmid construction and generation of Arabidopsis transgenics
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         Item: 
          Title: Protein extraction and western blotting
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         Item: 
          Title: Fractionation assays
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         Item: 
          Title: Immunoprecipitation and mass spectrometry coupled to liquid chromatography (IP-MS)
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         Item: 
          Title: Transient expression in Nicotiana benthamiana
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         Item: 
          Title: Co-immunoprecipitations (co-IPs)
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         Item: 
          Title: Pseudomonas syringae infection and growth assays
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         Item: 
          Title: Fresh weight experiments
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         Item: 
          Title: Confocal microscopy
          Destination: B23
         Item: 
          Title: Trypan blue staining
          Destination: B24
         Item: 
          Title: Label-free quantification proteomics
          Destination: B25
       Item: 
        Title: Data availability
        Destination: A5
       Item: 
        Title: References
        Destination: A6
        Children: 
         Item: 
          Title: Acknowledgements
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         Item: 
          Title: Author contributions
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       Item: 
        Title: ACKNOWLEDGMENTS
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               <rdf:li xml:lang="x-default">Lack of AtMC1 catalytic activity triggers autoimmunity dependent on NLR stability</rdf:li>
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               <rdf:li>Laia Armengot</rdf:li>
               <rdf:li>Joel Ayet</rdf:li>
               <rdf:li>Nerea Ruiz-Solaní</rdf:li>
               <rdf:li>Svenja C Saile</rdf:li>
               <rdf:li>Marta Salas-Gómez</rdf:li>
               <rdf:li>Esperanza Fernandez</rdf:li>
               <rdf:li>Lode Denolf</rdf:li>
               <rdf:li>Fernando Navarrete</rdf:li>
               <rdf:li>Jenna Krumbach</rdf:li>
               <rdf:li>Markus Kaiser</rdf:li>
               <rdf:li>Simon Stael</rdf:li>
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               <rdf:li>Autophagy</rdf:li>
               <rdf:li>Condensates</rdf:li>
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               <rdf:li>Proteostasis</rdf:li>
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         <prism:copyright>© 2025, The Author(s)</prism:copyright>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
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                  <pdfaSchema:schema>crossmark</pdfaSchema:schema>
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                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
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                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
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                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. 
Comment 
PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. 
Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. 

</pdfaProperty:description>
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                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright </pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. 
If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). 
</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. 
Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. 
</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. 
Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. 

Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” 
</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. 
The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. 
NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. 
</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
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                  </pdfaSchema:property>
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               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
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                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
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   Type: CRC32
  Checksum: 8ca2ee1ea71f4c37bf383e27f7707a07
   Type: MD5
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