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Title:           Exploring a Circulating miRNA Signature for PMM2‐CDG: Initial Insights Toward Diagnosis, Stratification, and Monitoring
Subject:         J of Inher Metab Disea 2025.48:e70104
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     Item: 
      Title: Exploring a Circulating miRNA Signature for PMM2-CDG: Initial Insights Toward Diagnosis, Stratification, and Monitoring
      Children: 
       Item: 
        Title: ABSTRACT
       Item: 
        Title: 1   |   Introduction
       Item: 
        Title: 2   |   Materials and Methods
        Children: 
         Item: 
          Title: 2.1   |   Design and Sample Recruitment
         Item: 
          Title: 2.2   |   Whole Blood Processing
         Item: 
          Title: 2.3   |   miRNA Extraction
         Item: 
          Title: 2.4   |   RNA Quantification and Quality Control
         Item: 
          Title: 2.5   |   Library Preparation
         Item: 
          Title: 2.6   |   Data Processing
         Item: 
          Title: 2.7   |   Differential Gene Expression Analysis (DGEA)
         Item: 
          Title: 2.8   |   Data Normalization, Transformation, and Filtering
         Item: 
          Title: 2.9   |   Machine Learning (ML) Analyses
         Item: 
          Title: 2.10   |   miRNA Tissue of Origin
         Item: 
          Title: 2.11   |   miRNA Targets Pathway Analysis
         Item: 
          Title: 2.12   |   Ethics
       Item: 
        Title: 3   |   Results
        Children: 
         Item: 
          Title: 3.1   |   Sample Recruitment, Demographics, and Clinical Characteristics
         Item: 
          Title: 3.2   |   Differential Gene Expression Analysis
         Item: 
          Title: 3.3   |   Identification of a Plasma miRNA Signature for PMM2-CDG
         Item: 
          Title: 3.4   |   Identification of the Tissue of Origin of the miRNA Biomarkers
         Item: 
          Title: 3.5   |   Analysis of the miRNA-Dysregulated Pathways
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        Title: 4   |   Discussion
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        Title: Author Contributions
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        Title: Acknowledgments
       Item: 
        Title: Ethics Statement
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        Title: Consent
       Item: 
        Title: Conflicts of Interest
       Item: 
        Title: Data Availability Statement
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        Title: References
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