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Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer’s disease risk Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study design Destination: subsection..1.2.1 Item: Title: 2.2 | Clinical assessment Destination: subsection..1.2.2 Item: Title: 2.3 | Statistical analyses Destination: subsection..1.2.3 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Population Destination: subsection..1.3.1 Item: Title: 3.2 | Generational effect on ID level Destination: subsection..1.3.2 Item: Title: 3.3 | Generational effect on schooling, occupation, and bilingualism Destination: subsection..1.3.3 Item: Title: 3.4 | A higher proportion of individuals acquired intellectual milestones and developed day-to-day function Destination: subsection..1.3.4 Item: Title: 3.5 | The age of AD clinical onset in DS is not influenced by ID and has remained stable over decades Destination: subsection..1.3.5 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: CONSENT STATEMENT Destination: section*.8 Item: Title: REFERENCES Destination: section*.10 Item: Title: SUPPORTING INFORMATION Destination: section*.12 Info: Title: Generational effects in Down syndrome: Enriched environment enhances functionality without reducing Alzheimer's disease risk Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sat Sep 27 12:23:00 CEST 2025 ModDate: Sat Sep 27 12:23:38 CEST 2025 ID: 0x9fc3c9184a1c44628f3a29d4d23d3088, 0xa483e00ac3d318917a856c512e3576ed Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: 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