d5657eecc833482daf59448f0e19c138 Efficacy_and_safety_of_efavirenz.pdf 8b0c5b1bbb6bf86728e848d93fd69c50f8e84af8 Efficacy_and_safety_of_efavirenz.pdf 5282c5ca9d2467c8c4dcc03c7669313d75614a86c4b897b12fe104a86ea715a7 Efficacy_and_safety_of_efavirenz.pdf Title: Efficacy and safety of efavirenz in Niemann-Pick disease type C Subject: Neurotherapeutics, 22 (2025) e00706. doi:10.1016/j.neurot.2025.e00706 Author: Jordi Gascón-Bayarri Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Sat Sep 13 13:21:05 2025 CEST ModDate: Sat Sep 13 13:25:45 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1888316 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UPARUZ+CharisSIL CID TrueType Identity-H yes yes yes 1909 0 WDVDIE+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1916 0 HRSSLQ+STIX-Regular Type 1C Custom yes yes yes 1922 0 BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 1913 0 EQLITZ+Univers Type 1C Builtin yes yes yes 1928 0 GMXZGX+CharisSIL-Bold CID TrueType Identity-H yes yes yes 152 0 WTTXDG+CM_Maths_Symbols Type 1C Builtin yes yes yes 153 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 262 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-02-13 03:08:48 CET RepresentationInformation: Efficacy_and_safety_of_efavirenz.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-02-12 18:51:38 CET Size: 1888316 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 1830938 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 2017 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Efficacy and safety of efavirenz in Niemann-Pick disease type C Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Materials and Methods Destination: flink2 Children: Item: Title: Trial design and oversight Destination: slink1 Item: Title: Patients Destination: slink2 Item: Title: Trial procedures Destination: slink3 Item: Title: Outcomes Destination: slink4 Item: Title: Statistical analysis Destination: slink5 Item: Title: Results Destination: flink3 Children: Item: Title: Patients Destination: slink6 Item: Title: Primary efficacy outcome Destination: slink7 Item: Title: Secondary efficacy outcomes Destination: slink8 Children: Item: Title: Secondary neuropsychological outcomes Destination: tlink9 Item: Title: Post hoc analysis Destination: tlink10 Item: Title: Secondary neurological outcomes Destination: tlink11 Item: Title: Secondary biological outcomes Destination: tlink12 Item: Title: Safety outcomes Destination: slink13 Item: Title: Discussion Destination: flink4 Item: Title: Author contributions Destination: flink5 Item: Title: Data access and availability statements Destination: flink6 Item: Title: Additional contributions Destination: flink7 Item: Title: Funding/Support Destination: flink8 Item: Title: Declaration of Competing Interest Destination: creditlink2 Item: Title: Appendix A. Supplementary data Destination: flink9 Item: Title: References Destination: blink1 Info: Title: Efficacy and safety of efavirenz in Niemann-Pick disease type C Author: Jordi Gascón-Bayarri Subject: Neurotherapeutics, 22 (2025) e00706. doi:10.1016/j.neurot.2025.e00706 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Sat Sep 13 13:51:05 CEST 2025 ModDate: Sat Sep 13 13:55:45 CEST 2025 ID: 0x40c870c14d72f301e5bbbda6c608bb38, 0x65bc5caebd913d4e9fac15b80a5c9a69 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 272 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type0: Font: BaseFont: UPARUZ+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: GMXZGX+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: WDVDIE+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: HRSSLQ+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: HRSSLQ+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: EQLITZ+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: EQLITZ+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: BRWWWZ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: BRWWWZ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: WTTXDG+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: WTTXDG+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: UPARUZ+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UPARUZ+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: WDVDIE+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WDVDIE+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: GMXZGX+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GMXZGX+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true XMP: application/pdf doi:10.1016/j.neurot.2025.e00706 Efficacy and safety of efavirenz in Niemann-Pick disease type C Jordi Gascón-Bayarri Inmaculada Rico Cristina Sánchez-Castañeda María Dolores Ledesma Thiago Carnaval Helena Bejr-Kasem Jaume Campdelacreu Anna Ferrer Laura Rodríguez-Bel Mónica Cos Eugenia de Lama Adolfo López de Munain Idoia Rouco Celia Pérez-Sousa María Cerdán Nuria Muelas María Dolores Sevillano Pablo Mir Jesús Villoria Sebastián Videla Clinical trial Dementia Lipid metabolism disorders Lysosomal storage diseases Neurodegenerative diseases Neuropsychological tests Neurotherapeutics, 22 (2025) e00706. doi:10.1016/j.neurot.2025.e00706 The Author(s) journal Neurotherapeutics © 2025 The Author(s). Published by Elsevier Inc. on behalf of American Society for Experimental NeuroTherapeutics. 1878-7479 22 5 September 2025 e00706 e00706 10.1016/j.neurot.2025.e00706 https://doi.org/10.1016/j.neurot.2025.e00706 VoR 7.0.1 10.1016/j.neurot.2025.e00706 noindex PStill version 1.84.42 Elsevier 2025-09-13T16:51:05+05:30 2025-09-13T16:55:45+05:30 2025-09-13T16:55:45+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json PDFlib+PDI 10.0.2p2 (C++/Win64) uuid:15d21888-47e4-49bc-8577-b089278fa378 uuid:b4fe8b87-292f-487f-9bdf-688cdc792e50 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 37, 738, 37, 738 Flags: Print Annotation: Subtype: Link Rect: 138, 588, 142, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 145, 588, 149, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 152, 588, 156, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 159, 588, 163, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 166, 595, 170, 601 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 166, 588, 170, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 257, 588, 261, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 264, 588, 268, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 405, 588, 409, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 412, 588, 416, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 419, 588, 422, 598 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 149, 575, 152, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 237, 575, 242, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 339, 575, 343, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 346, 575, 349, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 458, 575, 463, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 465, 575, 469, 585 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 95, 562, 100, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 204, 562, 207, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 210, 562, 213, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 276, 562, 279, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 282, 562, 285, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 374, 562, 377, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 380, 562, 385, 573 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 155, 549, 157, 560 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 222, 549, 229, 560 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 320, 549, 324, 560 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 396, 549, 401, 560 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 472, 549, 476, 560 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 152, 536, 156, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 210, 536, 214, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 285, 536, 288, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 374, 536, 377, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 380, 536, 384, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 387, 536, 391, 547 Flags: Print Destination: 1863 Annotation: Subtype: Link Rect: 98, 104, 206, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 241, 667, 430, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 187, 94 Flags: Print Annotation: Subtype: Link Rect: 123, 59, 290, 66 Flags: Print Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 351, 698, 557, 705 Flags: Print Annotation: Subtype: Link Rect: 201, 688, 235, 696 Flags: Print Annotation: Subtype: Link Rect: 68, 607, 72, 615 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 231, 596, 244, 604 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 219, 575, 231, 583 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 125, 533, 149, 541 Flags: Print Destination: null Annotation: Subtype: Link Rect: 158, 533, 162, 541 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 165, 533, 169, 541 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 250, 512, 254, 520 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 224, 502, 229, 510 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 146, 471, 151, 479 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 153, 471, 162, 479 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 168, 439, 172, 447 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 174, 439, 183, 447 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 133, 397, 138, 405 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 140, 397, 149, 405 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 135, 356, 144, 364 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 147, 356, 156, 364 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 40, 324, 49, 332 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 143, 272, 152, 280 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 154, 272, 163, 280 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 63, 241, 67, 248 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 101, 230, 105, 238 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 108, 230, 112, 238 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 114, 230, 123, 238 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 69, 220, 74, 228 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 76, 220, 80, 228 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 82, 220, 91, 228 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 162, 199, 167, 207 Flags: Print Destination: 47 Annotation: Subtype: Link Rect: 169, 199, 178, 207 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 201, 178, 210, 186 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 212, 178, 221, 186 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 190, 157, 198, 165 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 40, 136, 49, 144 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 152, 115, 161, 123 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 274, 104, 283, 112 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 248, 84, 256, 92 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 378, 648, 387, 656 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 519, 628, 528, 636 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 476, 617, 497, 625 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 519, 607, 528, 615 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 424, 575, 433, 583 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 543, 554, 552, 562 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 468, 199, 477, 207 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 403, 83, 433, 91 Flags: Print Destination: null Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 257, 605, 283, 613 Flags: Print Destination: null Annotation: Subtype: Link Rect: 250, 573, 259, 581 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 261, 573, 270, 581 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 101, 500, 110, 508 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 194, 165, 275, 173 Flags: Print Destination: null Annotation: Subtype: Link Rect: 367, 447, 391, 455 Flags: Print Destination: null Annotation: Subtype: Link Rect: 418, 374, 427, 382 Flags: Print Destination: 50 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 124, 720, 147, 728 Flags: Print Destination: 7 Annotation: Subtype: Link Rect: 64, 668, 92, 676 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 169, 626, 196, 634 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 40, 479, 60, 487 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 123, 342, 142, 350 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 72, 332, 93, 340 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 40, 279, 61, 287 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 134, 279, 154, 287 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 533, 668, 553, 676 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 411, 636, 432, 644 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 515, 626, 536, 634 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 401, 594, 421, 602 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 309, 573, 329, 581 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 415, 563, 435, 571 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 494, 563, 514, 571 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 316, 553, 336, 561 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 535, 521, 555, 529 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 434, 479, 452, 487 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 412, 469, 432, 477 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 528, 375, 552, 383 Flags: Print Destination: null Annotation: Subtype: Link Rect: 394, 312, 419, 320 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 270, 333, 278 Flags: Print Destination: null Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 40, 391, 67, 399 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 84, 391, 115, 399 Flags: Print Destination: null Annotation: Subtype: Link Rect: 62, 349, 82, 357 Flags: Print Destination: 37 Annotation: Subtype: Link Rect: 68, 328, 90, 336 Flags: Print Destination: 37 Annotation: Subtype: Link Rect: 213, 308, 234, 316 Flags: Print Destination: 37 Annotation: Subtype: Link Rect: 259, 297, 283, 305 Flags: Print Destination: null Annotation: Subtype: Link Rect: 386, 444, 461, 452 Flags: Print Destination: null Annotation: Subtype: Link Rect: 371, 391, 451, 399 Flags: Print Destination: null Annotation: Subtype: Link Rect: 368, 381, 479, 389 Flags: Print Destination: null Annotation: Subtype: Link Rect: 187, 639, 189, 645 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 273, 604, 275, 611 Flags: Print Destination: 17 Annotation: Subtype: Link Rect: 400, 604, 402, 611 Flags: Print Destination: 17 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 396, 193, 405, 201 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 408, 193, 417, 201 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 435, 532, 437, 538 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 515, 437, 521 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 506, 437, 513 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 498, 508, 504 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 489, 509, 496 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 481, 437, 487 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 472, 437, 478 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 472, 508, 478 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 464, 437, 470 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 446, 509, 453 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 438, 437, 444 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 438, 508, 444 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 429, 437, 436 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 412, 437, 419 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 435, 404, 437, 410 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 506, 404, 508, 410 Flags: Print Destination: 27 Annotation: Subtype: Link Rect: 509, 351, 518, 358 Flags: Print Destination: 50 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 161, 699, 183, 707 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 373, 709, 382, 717 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 384, 709, 393, 717 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 396, 709, 405, 717 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 362, 689, 371, 696 Flags: Print Destination: 50 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 274, 584, 283, 592 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 40, 511, 49, 519 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 73, 427, 82, 435 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 84, 427, 93, 435 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 188, 406, 197, 414 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 77, 385, 86, 393 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 88, 385, 97, 393 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 164, 375, 173, 383 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 116, 302, 138, 309 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 138, 228, 147, 236 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 203, 82, 212, 90 Flags: Print Destination: 50 Annotation: Subtype: Link Rect: 516, 195, 557, 203 Flags: Print Annotation: Subtype: Link Rect: 306, 185, 431, 193 Flags: Print Annotation: Subtype: Link Rect: 322, 146, 553, 152 Flags: Print Annotation: Subtype: Link Rect: 322, 138, 548, 144 Flags: Print Annotation: Subtype: Link Rect: 322, 130, 344, 136 Flags: Print Annotation: Subtype: Link Rect: 322, 122, 532, 128 Flags: Print Annotation: Subtype: Link Rect: 322, 114, 555, 120 Flags: Print Annotation: Subtype: Link Rect: 322, 106, 555, 112 Flags: Print Annotation: Subtype: Link Rect: 322, 98, 366, 104 Flags: Print Annotation: Subtype: Link Rect: 322, 90, 540, 96 Flags: Print Annotation: Subtype: Link Rect: 322, 82, 555, 88 Flags: Print Annotation: Subtype: Link Rect: 322, 74, 482, 80 Flags: Print Annotation: Subtype: Link Rect: 322, 66, 532, 73 Flags: Print Annotation: Subtype: Link Rect: 322, 58, 555, 65 Flags: Print Annotation: Subtype: Link Rect: 322, 50, 457, 57 Flags: Print Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 53, 732, 284, 738 Flags: Print Annotation: Subtype: Link Rect: 53, 724, 285, 730 Flags: Print Annotation: Subtype: Link Rect: 53, 716, 281, 722 Flags: Print Annotation: Subtype: Link Rect: 53, 708, 268, 714 Flags: Print Annotation: Subtype: Link Rect: 53, 700, 218, 706 Flags: Print Annotation: Subtype: Link Rect: 53, 692, 275, 698 Flags: Print Annotation: Subtype: Link Rect: 53, 684, 284, 690 Flags: Print Annotation: Subtype: Link Rect: 53, 676, 172, 682 Flags: Print Annotation: Subtype: Link Rect: 53, 668, 285, 674 Flags: Print Annotation: Subtype: Link Rect: 53, 660, 285, 666 Flags: Print Annotation: Subtype: Link Rect: 53, 652, 281, 658 Flags: Print Annotation: Subtype: Link Rect: 53, 644, 107, 651 Flags: Print Annotation: Subtype: Link Rect: 54, 636, 280, 643 Flags: Print Annotation: Subtype: Link Rect: 54, 628, 279, 635 Flags: Print Annotation: Subtype: Link Rect: 54, 620, 131, 627 Flags: Print Annotation: Subtype: Link Rect: 54, 612, 279, 619 Flags: Print Annotation: Subtype: Link Rect: 54, 604, 284, 611 Flags: Print Annotation: Subtype: Link Rect: 54, 596, 285, 603 Flags: Print Annotation: Subtype: Link Rect: 54, 588, 283, 595 Flags: Print Annotation: Subtype: Link Rect: 54, 580, 91, 587 Flags: Print Annotation: Subtype: Link Rect: 54, 572, 282, 579 Flags: Print Annotation: Subtype: Link Rect: 54, 565, 277, 571 Flags: Print Annotation: Subtype: Link Rect: 54, 557, 191, 563 Flags: Print Annotation: Subtype: Link Rect: 54, 549, 284, 555 Flags: Print Annotation: Subtype: Link Rect: 54, 541, 272, 547 Flags: Print Annotation: Subtype: Link Rect: 54, 533, 286, 539 Flags: Print Annotation: Subtype: Link Rect: 54, 525, 285, 531 Flags: Print Annotation: Subtype: Link Rect: 54, 517, 284, 523 Flags: Print Annotation: Subtype: Link Rect: 54, 509, 100, 515 Flags: Print Annotation: Subtype: Link Rect: 54, 501, 268, 507 Flags: Print Annotation: Subtype: Link Rect: 54, 493, 230, 499 Flags: Print Annotation: Subtype: Link Rect: 54, 485, 286, 491 Flags: Print Annotation: Subtype: Link Rect: 54, 477, 262, 483 Flags: Print Annotation: Subtype: Link Rect: 54, 469, 209, 475 Flags: Print Annotation: Subtype: Link Rect: 54, 461, 286, 467 Flags: Print Annotation: Subtype: Link Rect: 54, 453, 145, 459 Flags: Print Annotation: Subtype: Link Rect: 54, 445, 283, 451 Flags: Print Annotation: Subtype: Link Rect: 54, 437, 274, 443 Flags: Print Annotation: Subtype: Link Rect: 54, 429, 286, 435 Flags: Print Annotation: Subtype: Link Rect: 54, 421, 182, 427 Flags: Print Annotation: Subtype: Link Rect: 54, 413, 281, 419 Flags: Print Annotation: Subtype: Link Rect: 54, 405, 222, 411 Flags: Print Annotation: Subtype: Link Rect: 54, 397, 286, 403 Flags: Print Annotation: Subtype: Link Rect: 54, 389, 282, 396 Flags: Print Annotation: Subtype: Link Rect: 54, 381, 278, 388 Flags: Print Annotation: Subtype: Link Rect: 54, 373, 241, 380 Flags: Print Annotation: Subtype: Link Rect: 54, 365, 285, 372 Flags: Print Annotation: Subtype: Link Rect: 54, 357, 286, 364 Flags: Print Annotation: Subtype: Link Rect: 54, 349, 103, 356 Flags: Print Annotation: Subtype: Link Rect: 54, 341, 264, 348 Flags: Print Annotation: Subtype: Link Rect: 54, 333, 261, 340 Flags: Print Annotation: Subtype: Link Rect: 54, 325, 271, 332 Flags: Print Annotation: Subtype: Link Rect: 54, 317, 78, 324 Flags: Print Annotation: Subtype: Link Rect: 54, 309, 280, 316 Flags: Print Annotation: Subtype: Link Rect: 54, 301, 274, 308 Flags: Print Annotation: Subtype: Link Rect: 54, 294, 75, 300 Flags: Print Annotation: Subtype: Link Rect: 54, 286, 268, 292 Flags: Print Annotation: Subtype: Link Rect: 54, 278, 286, 284 Flags: Print Annotation: Subtype: Link Rect: 54, 270, 190, 276 Flags: Print Annotation: Subtype: Link Rect: 54, 262, 286, 268 Flags: Print Annotation: Subtype: Link Rect: 54, 254, 286, 260 Flags: Print Annotation: Subtype: Link Rect: 54, 246, 254, 252 Flags: Print Annotation: Subtype: Link Rect: 54, 238, 286, 244 Flags: Print Annotation: Subtype: Link Rect: 54, 230, 286, 236 Flags: Print Annotation: Subtype: Link Rect: 54, 222, 189, 228 Flags: Print Annotation: Subtype: Link Rect: 323, 732, 541, 738 Flags: Print Annotation: Subtype: Link Rect: 323, 724, 555, 730 Flags: Print Annotation: Subtype: Link Rect: 323, 716, 452, 722 Flags: Print Annotation: Subtype: Link Rect: 323, 708, 554, 714 Flags: Print Annotation: Subtype: Link Rect: 323, 700, 555, 706 Flags: Print Annotation: Subtype: Link Rect: 323, 692, 536, 698 Flags: Print Annotation: Subtype: Link Rect: 323, 684, 452, 690 Flags: Print Annotation: Subtype: Link Rect: 323, 676, 532, 682 Flags: Print Annotation: Subtype: Link Rect: 323, 668, 553, 674 Flags: Print Annotation: Subtype: Link Rect: 323, 660, 413, 666 Flags: Print Annotation: Subtype: Link Rect: 323, 652, 555, 658 Flags: Print Annotation: Subtype: Link Rect: 323, 644, 555, 651 Flags: Print Annotation: Subtype: Link Rect: 323, 636, 549, 643 Flags: Print Annotation: Subtype: Link Rect: 323, 628, 369, 635 Flags: Print Annotation: Subtype: Link Rect: 323, 620, 550, 627 Flags: Print Annotation: Subtype: Link Rect: 323, 612, 555, 619 Flags: Print Annotation: Subtype: Link Rect: 323, 604, 509, 611 Flags: Print Annotation: Subtype: Link Rect: 323, 596, 555, 603 Flags: Print Annotation: Subtype: Link Rect: 323, 588, 555, 595 Flags: Print Annotation: Subtype: Link Rect: 323, 580, 540, 587 Flags: Print Annotation: Subtype: Link Rect: 323, 572, 555, 579 Flags: Print Annotation: Subtype: Link Rect: 323, 565, 555, 571 Flags: Print Annotation: Subtype: Link Rect: 323, 557, 496, 563 Flags: Print Annotation: Subtype: Link Rect: 323, 549, 555, 555 Flags: Print Annotation: Subtype: Link Rect: 323, 541, 550, 547 Flags: Print Annotation: Subtype: Link Rect: 323, 533, 337, 539 Flags: Print Annotation: Subtype: Link Rect: 323, 525, 549, 531 Flags: Print Annotation: Subtype: Link Rect: 323, 517, 555, 523 Flags: Print Annotation: Subtype: Link Rect: 323, 509, 356, 515 Flags: Print Annotation: Subtype: Link Rect: 323, 501, 506, 507 Flags: Print Annotation: Subtype: Link Rect: 323, 493, 537, 499 Flags: Print Annotation: Subtype: Link Rect: 323, 485, 451, 491 Flags: Print Annotation: Subtype: Link Rect: 323, 477, 555, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 469, 505, 475 Flags: Print Annotation: Subtype: Link Rect: 323, 461, 555, 467 Flags: Print Annotation: Subtype: Link Rect: 323, 453, 555, 459 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 456, 451 Flags: Print Annotation: Subtype: Link Rect: 323, 437, 534, 443 Flags: Print Annotation: Subtype: Link Rect: 323, 429, 542, 435 Flags: Print Annotation: Subtype: Link Rect: 323, 421, 427, 427 Flags: Print Annotation: Subtype: Link Rect: 323, 413, 555, 419 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 473, 411 Flags: Print Annotation: Subtype: Link Rect: 323, 397, 543, 403 Flags: Print Annotation: Subtype: Link Rect: 323, 389, 555, 396 Flags: Print Annotation: Subtype: Link Rect: 323, 381, 463, 388 Flags: Print Annotation: Subtype: Link Rect: 323, 373, 543, 380 Flags: Print Annotation: Subtype: Link Rect: 323, 365, 527, 372 Flags: Print Annotation: Subtype: Link Rect: 323, 357, 535, 364 Flags: Print Annotation: Subtype: Link Rect: 323, 349, 552, 356 Flags: Print Annotation: Subtype: Link Rect: 323, 341, 555, 348 Flags: Print Annotation: Subtype: Link Rect: 323, 333, 344, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 552, 332 Flags: Print Annotation: Subtype: Link Rect: 323, 317, 555, 324 Flags: Print Annotation: Subtype: Link Rect: 323, 309, 552, 316 Flags: Print Annotation: Subtype: Link Rect: 323, 301, 479, 308 Flags: Print Annotation: Subtype: Link Rect: 323, 294, 543, 300 Flags: Print Annotation: Subtype: Link Rect: 323, 286, 551, 292 Flags: Print Annotation: Subtype: Link Rect: 323, 278, 555, 284 Flags: Print Annotation: Subtype: Link Rect: 323, 270, 369, 276 Flags: Print Annotation: Subtype: Link Rect: 323, 262, 554, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 555, 260 Flags: Print Annotation: Subtype: Link Rect: 323, 246, 364, 252 Flags: Print Annotation: Subtype: Link Rect: 323, 238, 524, 244 Flags: Print Annotation: Subtype: Link Rect: 323, 230, 555, 236 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 344, 228 Flags: Print Checksum: a208d265 Type: CRC32 Checksum: d5657eecc833482daf59448f0e19c138 Type: MD5 Checksum: 8b0c5b1bbb6bf86728e848d93fd69c50f8e84af8 Type: SHA-1 Checksum: 5282c5ca9d2467c8c4dcc03c7669313d75614a86c4b897b12fe104a86ea715a7 Type: SHA-256