ddc4ffe0305c8ebad73b94d01978d7fc 321332.pdf 9c0e676a1906c1f6f4e624f7211e645c1c132c04 321332.pdf 46559d60622ce4b36e5a724227cf94e1afbaf939e8dd463cd1e7e3771f3a5016 321332.pdf Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Sep 11 06:21:06 2025 CEST ModDate: Thu Sep 11 06:21:06 2025 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2401826 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HBEOFJ+AdvOTd3a5f740 Type 1C WinAnsi yes yes no 710 0 HBEOGK+AdvOTd3a5f740+fb Type 1C Custom yes yes yes 711 0 HBEOGL+AdvOT9b12cd41 Type 1C WinAnsi yes yes no 712 0 HBEOGM+AdvOTd168d80a.I Type 1C WinAnsi yes yes no 713 0 HBEOGN+AdvOT9b12cd41+fb Type 1C Custom yes yes yes 714 0 HBEOHN+AdvOT9b12cd41+20 Type 1C WinAnsi yes yes no 715 0 HBEOHO+AdvOT2c8ce45a Type 1C WinAnsi yes yes no 716 0 HBEOHP+AdvOTc8b77491.I Type 1C WinAnsi yes yes no 717 0 HBEOJA+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 718 0 HBEOJB+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 719 0 HBFBKA+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 729 0 HBFBLB+AdvOT749c1f5a.I Type 1C WinAnsi yes yes no 730 0 HBFBLC+AdvOT1ef757c0+22 Type 1C Custom yes yes no 731 0 HBFBJA+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 732 0 HBFCBB+AdvOT310e2d14 Type 1C WinAnsi yes yes no 733 0 HBFCCB+AdvOT7d6df7ab.I+fb Type 1C Custom yes yes yes 734 0 HBGOMC+AdvOT2c8ce45a+fb Type 1C Custom yes yes yes 739 0 HBHONB+AdvOT310e2d14+21 Type 1C Custom yes yes yes 741 0 HBIJAD+AdvOT310e2d14+03 Type 1C Custom yes yes yes 744 0 HBIMLN+AdvOT1ef757c0+01 Type 1C Custom yes yes no 745 0 HBIMLO+AdvOTd3a5f740+20 Type 1C WinAnsi yes yes no 746 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-02-14 04:22:33 CET RepresentationInformation: 321332.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-02-13 09:42:09 CET Size: 2401826 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 865 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer Destination: titlink1 Children: Item: Title: 1 Introduction Destination: flink1 Item: Title: 2 Materials and methods Destination: flink2 Children: Item: Title: 2.1 In silico clinical trial study Destination: slink1 Children: Item: Title: 2.1.1 Model stimulus and mCRC molecular definition Destination: sslink1 Item: Title: 2.1.2 IDE generation Destination: sslink2 Item: Title: 2.1.3 TPMS modelling Destination: sslink3 Item: Title: 2.1.4 Calibration of in silico signal to clinical outcomes Destination: sslink4 Item: Title: 2.1.5 Individual model construction using TPMS Destination: sslink5 Item: Title: 2.2 Identification of mechanistic and predictive biomarkers Destination: slink2 Item: Title: 2.3 Association between miRNAs and proteins Destination: slink3 Item: Title: 2.4 Assessing the predictive value of mechanistic and predictive biomarkers Destination: slink4 Item: Title: 3 Results Destination: flink3 Children: Item: Title: 3.1 Patient-specific differential expression profiles in elderly mCRC Destination: slink5 Item: Title: 3.2 Simulation of first-line single-agent regorafenib and definition of good and poor responders Destination: slink6 Item: Title: 3.3 Mechanistic and predictive biomarkers identification Destination: slink7 Item: Title: 3.4 Independent cohort validation Destination: slink8 Item: Title: 3.5 Validation of predictive biomarkers through previously identified regorafenib-associated miRNAs Destination: slink9 Item: Title: 3.6 Assessing the predictive value of mechanistic and predictive biomarkers Destination: slink10 Item: Title: 4 Discussion Destination: flink4 Item: Title: Data availability statement Destination: flink5 Item: Title: Ethics statement Destination: flink6 Item: Title: Author contributions Destination: flink7 Item: Title: Funding Destination: flink8 Item: Title: Acknowledgments Destination: slink11 Item: Title: Conflict of interest Destination: flink9 Item: Title: Generative AI statement Destination: flink10 Item: Title: Publisher’s note Destination: flink11 Item: Title: Supplementary material Destination: flink12 Item: Title: References Destination: rlink1 Info: Creator: Arbortext Advanced Print Publisher 9.1.510/W Unicode Producer: Acrobat Distiller 7.0 (Windows) CreationDate: Thu Sep 11 06:51:06 CEST 2025 ModDate: Thu Sep 11 06:51:06 CEST 2025 ID: 0x035218dc330d3d57ee82661515686fa8, 0x31a5ded47442f04b9c7b2975d8346edf Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1966 ImageHeight: 1937 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 927 ImageHeight: 927 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1352 ImageHeight: 721 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1966 ImageHeight: 1142 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1965 ImageHeight: 926 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 927 ImageHeight: 876 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type1: Font: BaseFont: HBGOMC+AdvOT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HBGOMC+AdvOT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBHONB+AdvOT310e2d14+21 FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HBHONB+AdvOT310e2d14+21 Flags: Symbolic FontBBox: 0, -427, 1541, 1062 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBEOFJ+AdvOTd3a5f740 FontSubset: true FirstChar: 42 LastChar: 237 FontDescriptor: FontName: HBEOFJ+AdvOTd3a5f740 Flags: Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOGK+AdvOTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HBEOGK+AdvOTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBEOGL+AdvOT9b12cd41 FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: HBEOGL+AdvOT9b12cd41 Flags: Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBIJAD+AdvOT310e2d14+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HBIJAD+AdvOT310e2d14+03 Flags: Symbolic FontBBox: -437, -427, 1541, 1062 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBEOGM+AdvOTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 121 FontDescriptor: FontName: HBEOGM+AdvOTd168d80a.I Flags: Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBIMLN+AdvOT1ef757c0+01 FontSubset: true FirstChar: 20 LastChar: 20 FontDescriptor: FontName: HBIMLN+AdvOT1ef757c0+01 Flags: Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HBEOGN+AdvOT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HBEOGN+AdvOT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBIMLO+AdvOTd3a5f740+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: HBIMLO+AdvOTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOHN+AdvOT9b12cd41+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: HBEOHN+AdvOT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOHO+AdvOT2c8ce45a FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HBEOHO+AdvOT2c8ce45a Flags: Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOHP+AdvOTc8b77491.I FontSubset: true FirstChar: 73 LastChar: 115 FontDescriptor: FontName: HBEOHP+AdvOTc8b77491.I Flags: Nonsymbolic FontBBox: -145, -208, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOJA+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 250 FontDescriptor: FontName: HBEOJA+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBEOJB+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 151 FontDescriptor: FontName: HBEOJB+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBFBKA+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: HBFBKA+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: HBFBLB+AdvOT749c1f5a.I FontSubset: true FirstChar: 73 LastChar: 115 FontDescriptor: FontName: HBFBLB+AdvOT749c1f5a.I Flags: Nonsymbolic FontBBox: -145, -208, 989, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBFBLC+AdvOT1ef757c0+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: HBFBLC+AdvOT1ef757c0+22 Flags: Nonsymbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: HBFBJA+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: HBFBJA+AdvOT7d6df7ab.I Flags: Serif, Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBFCBB+AdvOT310e2d14 FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: HBFCBB+AdvOT310e2d14 Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1062 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: HBFCCB+AdvOT7d6df7ab.I+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: HBFCCB+AdvOT7d6df7ab.I+fb Flags: Symbolic FontBBox: -156, -250, 802, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 222, 688, 545, 709 Annotation: Subtype: Link Rect: 222, 663, 459, 684 Annotation: Subtype: Link Rect: 222, 638, 524, 659 Annotation: Subtype: Link Rect: 222, 613, 499, 634 Annotation: Subtype: Link Rect: 480, 141, 543, 150 Destination: 29 Annotation: Subtype: Link Rect: 222, 129, 332, 138 Destination: 29 Annotation: Subtype: Link Rect: 355, 69, 438, 78 Destination: 29 Annotation: Subtype: Link Rect: 49, 694, 121, 708 Annotation: Subtype: Link Rect: 49, 543, 53, 547 Annotation: Subtype: Link Rect: 56, 542, 122, 549 Annotation: Subtype: Link Rect: 63, 432, 154, 439 Annotation: Subtype: Link Rect: 160, 391, 186, 398 Annotation: Subtype: Link Rect: 49, 382, 168, 389 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 787, 247, 801 Annotation: Subtype: Link Rect: 442, 800, 455, 805 Annotation: Subtype: Link Rect: 455, 799, 514, 806 Annotation: Subtype: Link Rect: 455, 781, 545, 788 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 163, 739, 246, 748 Destination: 29 Annotation: Subtype: Link Rect: 216, 703, 287, 712 Destination: 29 Annotation: Subtype: Link Rect: 136, 691, 206, 700 Destination: 30 Annotation: Subtype: Link Rect: 103, 679, 190, 688 Destination: 29 Annotation: Subtype: Link Rect: 199, 679, 285, 688 Destination: 30 Annotation: Subtype: Link Rect: 52, 595, 145, 604 Destination: 29 Annotation: Subtype: Link Rect: 152, 595, 234, 604 Destination: 29 Annotation: Subtype: Link Rect: 98, 572, 166, 580 Destination: 29 Annotation: Subtype: Link Rect: 243, 572, 290, 580 Destination: 30 Annotation: Subtype: Link Rect: 49, 560, 66, 569 Destination: 30 Annotation: Subtype: Link Rect: 52, 452, 119, 461 Destination: 29 Annotation: Subtype: Link Rect: 263, 428, 290, 437 Destination: 29 Annotation: Subtype: Link Rect: 49, 416, 87, 425 Destination: 29 Annotation: Subtype: Link Rect: 92, 416, 160, 425 Destination: 29 Annotation: Subtype: Link Rect: 268, 392, 290, 401 Destination: 29 Annotation: Subtype: Link Rect: 49, 380, 89, 389 Destination: 29 Annotation: Subtype: Link Rect: 274, 309, 290, 317 Destination: 29 Annotation: Subtype: Link Rect: 49, 297, 102, 306 Destination: 29 Annotation: Subtype: Link Rect: 99, 237, 170, 246 Destination: 29 Annotation: Subtype: Link Rect: 181, 165, 241, 174 Destination: 29 Annotation: Subtype: Link Rect: 246, 165, 290, 174 Destination: 30 Annotation: Subtype: Link Rect: 49, 153, 94, 162 Destination: 30 Annotation: Subtype: Link Rect: 423, 560, 518, 569 Destination: 30 Annotation: Subtype: Link Rect: 304, 548, 393, 557 Destination: 28 Annotation: Subtype: Link Rect: 441, 524, 505, 533 Destination: 29 Annotation: Subtype: Link Rect: 469, 464, 545, 473 Destination: 28 Annotation: Subtype: Link Rect: 304, 452, 313, 461 Destination: 28 Annotation: Subtype: Link Rect: 342, 404, 409, 413 Destination: 29 Annotation: Subtype: Link Rect: 415, 404, 486, 413 Destination: 29 Annotation: Subtype: Link Rect: 397, 332, 485, 341 Destination: 28 Annotation: Subtype: Link Rect: 377, 309, 474, 317 Destination: 28 Annotation: Subtype: Link Rect: 399, 297, 467, 306 Destination: 29 Annotation: Subtype: Link Rect: 314, 141, 383, 150 Destination: 29 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 83, 691, 142, 700 Destination: 29 Annotation: Subtype: Link Rect: 88, 572, 147, 580 Destination: 29 Annotation: Subtype: Link Rect: 151, 572, 255, 580 Destination: 29 Annotation: Subtype: Link Rect: 205, 464, 285, 473 Destination: 29 Annotation: Subtype: Link Rect: 102, 452, 169, 461 Destination: 29 Annotation: Subtype: Link Rect: 210, 452, 285, 461 Destination: 29 Annotation: Subtype: Link Rect: 91, 440, 170, 449 Destination: 29 Annotation: Subtype: Link Rect: 209, 440, 268, 449 Destination: 29 Annotation: Subtype: Link Rect: 87, 428, 143, 437 Destination: 29 Annotation: Subtype: Link Rect: 348, 285, 413, 294 Destination: 30 Annotation: Subtype: Link Rect: 469, 285, 540, 294 Destination: 29 Annotation: Subtype: Link Rect: 355, 273, 442, 282 Destination: 29 Annotation: Subtype: Link Rect: 498, 273, 545, 282 Destination: 29 Annotation: Subtype: Link Rect: 304, 261, 346, 270 Destination: 29 Annotation: Subtype: Link Rect: 414, 261, 477, 270 Destination: 29 Annotation: Subtype: Link Rect: 378, 225, 472, 234 Destination: 30 Annotation: Subtype: Link Rect: 479, 225, 542, 234 Destination: 29 Annotation: Subtype: Link Rect: 321, 177, 409, 186 Destination: 28 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 126, 727, 222, 736 Destination: 28 Annotation: Subtype: Link Rect: 173, 703, 266, 712 Destination: 28 Annotation: Subtype: Link Rect: 52, 583, 118, 592 Destination: 29 Annotation: Subtype: Link Rect: 490, 619, 545, 628 Destination: 29 Annotation: Subtype: Link Rect: 304, 607, 321, 616 Destination: 29 Annotation: Subtype: Link Rect: 396, 607, 463, 616 Destination: 29 Annotation: Subtype: Link Rect: 412, 524, 489, 533 Destination: 29 Annotation: Subtype: Link Rect: 461, 512, 514, 521 Destination: 30 Annotation: Subtype: Link Rect: 409, 380, 473, 389 Destination: 29 Annotation: Subtype: Link Rect: 475, 368, 545, 377 Destination: 29 Annotation: Subtype: Link Rect: 304, 356, 321, 365 Destination: 29 Annotation: Subtype: Link Rect: 419, 332, 496, 341 Destination: 29 Annotation: Subtype: Link Rect: 307, 320, 379, 329 Destination: 30 Annotation: Subtype: Link Rect: 464, 320, 540, 329 Destination: 30 Annotation: Subtype: Link Rect: 346, 297, 426, 306 Destination: 29 Annotation: Subtype: Link Rect: 461, 297, 540, 306 Destination: 29 Annotation: Subtype: Link Rect: 356, 285, 448, 294 Destination: 29 Annotation: Subtype: Link Rect: 497, 285, 545, 294 Destination: 30 Annotation: Subtype: Link Rect: 304, 273, 359, 282 Destination: 30 Annotation: Subtype: Link Rect: 446, 273, 540, 282 Destination: 29 Annotation: Subtype: Link Rect: 371, 69, 442, 78 Destination: 29 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 246, 177, 275, 186 Destination: 22 Annotation: Subtype: Link Rect: 61, 282, 533, 747 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 120, 727, 205, 736 Destination: 28 Annotation: Subtype: Link Rect: 103, 548, 186, 557 Destination: 28 Annotation: Subtype: Link Rect: 105, 309, 197, 317 Destination: 28 Annotation: Subtype: Link Rect: 202, 273, 230, 282 Destination: 23 Annotation: Subtype: Link Rect: 152, 153, 179, 162 Destination: 24 Annotation: Subtype: Link Rect: 388, 333, 484, 342 Destination: 28 Annotation: Subtype: Link Rect: 508, 285, 540, 294 Destination: 24 Annotation: Subtype: Link Rect: 304, 189, 393, 198 Destination: 28 Annotation: Subtype: Link Rect: 463, 141, 545, 150 Destination: 28 Annotation: Subtype: Link Rect: 304, 129, 318, 138 Destination: 28 Annotation: Subtype: Link Rect: 314, 525, 536, 747 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 49, 285, 149, 294 Destination: 28 Annotation: Subtype: Link Rect: 181, 201, 219, 210 Destination: 25 Annotation: Subtype: Link Rect: 66, 153, 102, 162 Destination: 25 Annotation: Subtype: Link Rect: 108, 70, 144, 79 Destination: 25 Annotation: Subtype: Link Rect: 488, 237, 517, 246 Destination: 26 Annotation: Subtype: Link Rect: 352, 201, 445, 210 Destination: 28 Annotation: Subtype: Link Rect: 454, 93, 482, 102 Destination: 26 Annotation: Subtype: Link Rect: 489, 70, 545, 79 Destination: 28 Annotation: Subtype: Link Rect: 135, 368, 459, 541 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 49, 367, 88, 376 Destination: 28 Annotation: Subtype: Link Rect: 142, 343, 243, 352 Destination: 28 Annotation: Subtype: Link Rect: 158, 319, 263, 328 Destination: 28 Annotation: Subtype: Link Rect: 99, 283, 195, 292 Destination: 28 Annotation: Subtype: Link Rect: 212, 176, 250, 184 Destination: 26 Annotation: Subtype: Link Rect: 349, 367, 427, 376 Destination: 29 Annotation: Subtype: Link Rect: 304, 259, 404, 268 Destination: 28 Annotation: Subtype: Link Rect: 328, 152, 364, 161 Destination: 26 Annotation: Subtype: Link Rect: 61, 473, 533, 747 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 94, 111, 130, 120 Destination: 25 Annotation: Subtype: Link Rect: 321, 195, 351, 204 Destination: 27 Annotation: Subtype: Link Rect: 61, 325, 533, 547 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 52, 274, 114, 283 Destination: 29 Annotation: Subtype: Link Rect: 119, 274, 207, 283 Destination: 30 Annotation: Subtype: Link Rect: 176, 130, 243, 139 Destination: 30 Annotation: Subtype: Link Rect: 87, 118, 165, 127 Destination: 29 Annotation: Subtype: Link Rect: 170, 118, 234, 127 Destination: 30 Annotation: Subtype: Link Rect: 124, 106, 193, 115 Destination: 29 Annotation: Subtype: Link Rect: 199, 106, 285, 115 Destination: 29 Annotation: Subtype: Link Rect: 483, 739, 545, 748 Destination: 29 Annotation: Subtype: Link Rect: 304, 727, 353, 736 Destination: 29 Annotation: Subtype: Link Rect: 339, 619, 416, 628 Destination: 29 Annotation: Subtype: Link Rect: 446, 237, 498, 246 Destination: 29 Annotation: Subtype: Link Rect: 526, 237, 545, 246 Destination: 29 Annotation: Subtype: Link Rect: 304, 225, 342, 234 Destination: 29 Annotation: Subtype: Link Rect: 395, 225, 457, 234 Destination: 30 Annotation: Subtype: Link Rect: 535, 189, 545, 198 Destination: 30 Annotation: Subtype: Link Rect: 304, 177, 344, 186 Destination: 30 Annotation: Subtype: Link Rect: 389, 153, 457, 162 Destination: 30 Annotation: Subtype: Link Rect: 58, 537, 281, 747 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 129, 476, 222, 485 Annotation: Subtype: Link Rect: 474, 583, 545, 592 Annotation: Subtype: Link Rect: 304, 572, 334, 580 Annotation: Subtype: Link Rect: 317, 141, 545, 150 Annotation: Subtype: Link Rect: 304, 129, 403, 138 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 155, 716, 225, 723 Annotation: Subtype: Link Rect: 100, 681, 172, 688 Annotation: Subtype: Link Rect: 87, 653, 150, 660 Annotation: Subtype: Link Rect: 138, 625, 196, 632 Annotation: Subtype: Link Rect: 176, 597, 258, 604 Annotation: Subtype: Link Rect: 60, 561, 114, 568 Annotation: Subtype: Link Rect: 181, 533, 268, 540 Annotation: Subtype: Link Rect: 232, 497, 290, 504 Annotation: Subtype: Link Rect: 49, 489, 68, 496 Annotation: Subtype: Link Rect: 113, 461, 194, 468 Annotation: Subtype: Link Rect: 108, 426, 180, 433 Annotation: Subtype: Link Rect: 266, 398, 290, 405 Annotation: Subtype: Link Rect: 49, 390, 108, 397 Annotation: Subtype: Link Rect: 128, 354, 208, 361 Annotation: Subtype: Link Rect: 281, 318, 290, 325 Annotation: Subtype: Link Rect: 49, 310, 136, 317 Annotation: Subtype: Link Rect: 175, 282, 237, 289 Annotation: Subtype: Link Rect: 87, 254, 146, 261 Annotation: Subtype: Link Rect: 224, 234, 290, 241 Annotation: Subtype: Link Rect: 79, 206, 290, 213 Annotation: Subtype: Link Rect: 49, 198, 290, 205 Annotation: Subtype: Link Rect: 49, 190, 78, 197 Annotation: Subtype: Link Rect: 182, 163, 274, 170 Annotation: Subtype: Link Rect: 84, 127, 157, 134 Annotation: Subtype: Link Rect: 60, 99, 112, 106 Annotation: Subtype: Link Rect: 146, 71, 210, 78 Annotation: Subtype: Link Rect: 521, 705, 545, 712 Annotation: Subtype: Link Rect: 304, 697, 363, 704 Annotation: Subtype: Link Rect: 468, 669, 530, 676 Annotation: Subtype: Link Rect: 537, 641, 545, 648 Annotation: Subtype: Link Rect: 304, 633, 380, 640 Annotation: Subtype: Link Rect: 315, 605, 404, 612 Annotation: Subtype: Link Rect: 426, 577, 487, 584 Annotation: Subtype: Link Rect: 390, 549, 448, 556 Annotation: Subtype: Link Rect: 537, 529, 545, 536 Annotation: Subtype: Link Rect: 304, 521, 340, 528 Annotation: Subtype: Link Rect: 500, 501, 545, 508 Annotation: Subtype: Link Rect: 304, 493, 339, 500 Annotation: Subtype: Link Rect: 459, 465, 539, 472 Annotation: Subtype: Link Rect: 537, 446, 545, 452 Annotation: Subtype: Link Rect: 304, 438, 379, 444 Annotation: Subtype: Link Rect: 521, 418, 545, 425 Annotation: Subtype: Link Rect: 304, 410, 358, 417 Annotation: Subtype: Link Rect: 344, 370, 412, 377 Annotation: Subtype: Link Rect: 537, 350, 545, 357 Annotation: Subtype: Link Rect: 304, 342, 358, 349 Annotation: Subtype: Link Rect: 487, 314, 535, 321 Annotation: Subtype: Link Rect: 347, 278, 419, 285 Annotation: Subtype: Link Rect: 521, 258, 545, 265 Annotation: Subtype: Link Rect: 304, 250, 336, 257 Annotation: Subtype: Link Rect: 537, 222, 545, 229 Annotation: Subtype: Link Rect: 304, 214, 352, 221 Annotation: Subtype: Link Rect: 537, 175, 545, 181 Annotation: Subtype: Link Rect: 304, 167, 354, 174 Annotation: Subtype: Link Rect: 408, 139, 480, 146 Annotation: Subtype: Link Rect: 444, 119, 524, 126 Annotation: Subtype: Link Rect: 400, 91, 454, 98 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 60, 745, 122, 752 Annotation: Subtype: Link Rect: 218, 710, 290, 716 Annotation: Subtype: Link Rect: 49, 702, 67, 709 Annotation: Subtype: Link Rect: 87, 666, 160, 673 Annotation: Subtype: Link Rect: 232, 638, 290, 645 Annotation: Subtype: Link Rect: 49, 630, 73, 637 Annotation: Subtype: Link Rect: 87, 602, 167, 609 Annotation: Subtype: Link Rect: 135, 566, 216, 573 Annotation: Subtype: Link Rect: 225, 546, 290, 553 Annotation: Subtype: Link Rect: 49, 538, 69, 545 Annotation: Subtype: Link Rect: 232, 510, 290, 517 Annotation: Subtype: Link Rect: 49, 502, 69, 509 Annotation: Subtype: Link Rect: 373, 737, 459, 744 Annotation: Subtype: Link Rect: 354, 710, 436, 716 Annotation: Subtype: Link Rect: 435, 682, 517, 689 Annotation: Subtype: Link Rect: 500, 654, 545, 661 Annotation: Subtype: Link Rect: 304, 646, 339, 653 Annotation: Subtype: Link Rect: 383, 618, 442, 625 Annotation: Subtype: Link Rect: 352, 590, 408, 597 Annotation: Subtype: Link Rect: 487, 570, 545, 577 Annotation: Subtype: Link Rect: 304, 562, 326, 569 Annotation: Subtype: Link Rect: 368, 534, 449, 541 Annotation: Subtype: Link Rect: 401, 506, 465, 513 Annotation: Subtype: Link Rect: 49, 33, 141, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 453, 799, 545, 806 Thumb: true Checksum: b4df96bb Type: CRC32 Checksum: ddc4ffe0305c8ebad73b94d01978d7fc Type: MD5 Checksum: 9c0e676a1906c1f6f4e624f7211e645c1c132c04 Type: SHA-1 Checksum: 46559d60622ce4b36e5a724227cf94e1afbaf939e8dd463cd1e7e3771f3a5016 Type: SHA-256