05905b45a5b593a3a7b6b77f6a3a27b5 321336.pdf 54ee6b83ba303d87380405cb78f8bf8519c88cf4 321336.pdf 3bd2b29cd0c5fb794361a4477692a788600a7e27814b7f014f38003cc17a740f 321336.pdf Title: Comprehensive Assessment of Left Atrial Function: The Emerging Role of Cardiac Magnetic Resonance Feature Tracking Subject: Traditional volumetric parameters fall short of capturing the complex, phasic nature of atrial function. In contrast, atrial strain has become recognized as a sensitive, non-invasive imaging marker that enables earlier detection of myocardial dysfunction, refined risk stratification, and individualized therapeutic decision-making across a wide range of cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) has emerged as a robust imaging technique for evaluating atrial strain, offering high spatial resolution, high reproducibility, and independence from acoustic window limitations. Despite its promise, the routine clinical adoption of CMR-FT atrial strain remains limited. Key barriers include intervendor variability in strain values, the absence of standardized post-processing protocols, the lengthy acquisition times inherent to CMR studies, and the time required for post-processing atrial strain analysis. Overcoming these barriers is crucial to facilitate the integration of atrial strain assessment into routine clinical CMR protocols, particularly in patients with heart failure, valvular disease, or cardiomyopathy who undergo imaging for diagnostic or prognostic evaluation. Keywords: left atrial strain; cardiovascular magnetic resonance; feature tracking;risk stratification; valvular heart disease; cardiomyopathy Author: Javier Solsona-Caravaca, Alessandro Giustiniani, Eduard Ródenas-Alesina, Laura Galian-Gay, Ruperto Oliveró, Filipa Valente, Guillem Casas, Gisela Teixidó-Turà, Nuria Vallejo, Rubén Fernández-Galera, Víctor González-Fernández, Pablo Escribano-Escribano, Axel Hernández-Pineda, Ignacio Ferreira-González and José Fernando Rodríguez-Palomares Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Thu Sep 4 04:29:40 2025 CEST ModDate: Thu Sep 4 04:42:19 2025 CEST Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 20 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2506356 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 174 0 MNBCIK+VnURWPalladioL Type 1 Custom yes yes yes 175 0 JUILIR+URWPalladioL-Ital Type 1 Custom yes yes yes 176 0 GIFUJN+URWPalladioL-Bold Type 1 Custom yes yes yes 177 0 MBQWKY+URWPalladioL-Roma Type 1 Custom yes yes yes 178 0 VDITSV+CMSY10 Type 1 Builtin yes yes yes 223 0 PAFKDD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 218 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 219 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 384 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 379 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 412 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 445 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 456 0 PAGEON+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 457 0 PAFKDF+PalatinoLinotype TrueType WinAnsi yes yes no 498 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-02-14 04:21:59 CET RepresentationInformation: 321336.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-02-13 14:28:51 CET Size: 2506356 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 722 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Left Atrial Dynamics in the Cardiac Cycle: Physiology and Imaging Assessment Children: Item: Title: Understanding the Physiological Role of Left Atrial Function Item: Title: From Physiology to Imaging: Assessment of LA Function Item: Title: Clinical and Hemodynamic Determinants of LAS Item: Title: Technological Innovations in LA Strain Assessment: CMR-FT as a Novel Tool Children: Item: Title: Comparative Evaluation of LA Function: TTE Versus CMR—Strengths and Limitations of CMR Item: Title: LAS Analysis Using CMR-FT Item: Title: Reference Values for LAS Using CMR-FT Item: Title: LA Strain Assessment by CMR-FT: Diagnostic Value and Prognostic Implications Children: Item: Title: Identifying Patients at Risk of Cardiovascular Disease Item: Title: Atrial Fibrillation Item: Title: Heart Failure with Preserved Ejection Fraction Item: Title: Heart Failure with Reduced Ejection Fraction Children: Item: Title: Dilated Cardiomyopathy Item: Title: Takotsubo Syndrome Item: Title: Cardiomyopathies Children: Item: Title: Excessive Trabeculation of the Left Ventricle Item: Title: Hypertrophic Cardiomyopathy Item: Title: Cardiac Amyloidosis Item: Title: Anderson–Fabry Disease Item: Title: Systemic Sclerosis Item: Title: Myocarditis Item: Title: Ischemic Heart Disease and Myocardial Infarction Item: Title: Valvular Heart Disease: Aortic Stenosis Item: Title: Congenital Diseases Item: Title: Future Directions Item: Title: Conclusions Item: Title: References Info: Title: Comprehensive Assessment of Left Atrial Function: The Emerging Role of Cardiac Magnetic Resonance Feature Tracking Author: Javier Solsona-Caravaca, Alessandro Giustiniani, Eduard Ródenas-Alesina, Laura Galian-Gay, Ruperto Oliveró, Filipa Valente, Guillem Casas, Gisela Teixidó-Turà, Nuria Vallejo, Rubén Fernández-Galera, Víctor González-Fernández, Pablo Escribano-Escribano, Axel Hernández-Pineda, Ignacio Ferreira-González and José Fernando Rodríguez-Palomares Subject: Traditional volumetric parameters fall short of capturing the complex, phasic nature of atrial function. In contrast, atrial strain has become recognized as a sensitive, non-invasive imaging marker that enables earlier detection of myocardial dysfunction, refined risk stratification, and individualized therapeutic decision-making across a wide range of cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) has emerged as a robust imaging technique for evaluating atrial strain, offering high spatial resolution, high reproducibility, and independence from acoustic window limitations. Despite its promise, the routine clinical adoption of CMR-FT atrial strain remains limited. Key barriers include intervendor variability in strain values, the absence of standardized post-processing protocols, the lengthy acquisition times inherent to CMR studies, and the time required for post-processing atrial strain analysis. Overcoming these barriers is crucial to facilitate the integration of atrial strain assessment into routine clinical CMR protocols, particularly in patients with heart failure, valvular disease, or cardiomyopathy who undergo imaging for diagnostic or prognostic evaluation. 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