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Title:           HTGAnalyzer: An accessible R package with a web interface for enhanced transcriptomic analysis in precision medicine
Subject:         Computers in Biology and Medicine, 196 (2025) 110772. doi:10.1016/j.compbiomed.2025.110772
Keywords:        Transcriptomics,HTG,RNA-seq,Molecular pathology,Precision medicine,Clinical analysis
Author:          Laia Díez-Ahijado
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      Title: HTGAnalyzer: An accessible R package with a web interface for enhanced transcriptomic analysis in precision medicine
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 Patient data and tumor classification
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          Title: 2.2 HTG transcriptome panel
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          Title: 2.3 Datasets
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          Title: 2.4 Overview of the HTGAnalyzer package
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          Title: 2.5 HTGAnalyzer Shiny Application
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        Title: 3 Results
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          Title: 3.1 HTGAnalyzer allows easy data importing and QC assessment
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          Title: 3.2 The HTG_Analysis function: HTG_DEA and HTG_GSEA subfunctions identify critical pathways and differential gene expressio ...
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          Title: 3.3 The HTG_Analysis function: HTG_TME and HTG_survival subfunctions integrate transcriptomic profiling and tumor microenvi ...
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          Title: 3.4 Application of HTGAnalyzer to TCGA RNA-seq data
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          Title: 3.5 Performance and resource usage
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        Title: 4 Discussion
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       Item: 
        Title: CRediT authorship contribution statement
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       Item: 
        Title: Data availability
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        Title: Ethics compliance statement
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        Title: Funding sources
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        Title: Declaration of competing interest
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        Title: Acknowledgments
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        Title: Abbreviations
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        Title: Appendix A Supplementary data
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       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 230, 547, 236
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 222, 555, 228
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 214, 367, 220
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 206, 548, 212
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 198, 555, 204
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 190, 356, 196
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 182, 537, 188
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 174, 547, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 166, 553, 172
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 323, 158, 378, 164
       Flags: Print
  Checksum: 5ebf9575
   Type: CRC32
  Checksum: 65ade5083045fb9c6af457662697acf0
   Type: MD5
  Checksum: 00417cfe10a53f916351ed69c412568d6844a96f
   Type: SHA-1
  Checksum: 7a43a07ce48b462257886dca1473f9c1c1815a3c303e0f8a4ce40f4b017d2b69
   Type: SHA-256