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FontDescriptor: FontName: PZZLIK+LMRoman9-Regular Flags: Serif, Symbolic FontBBox: -443, -292, 1454, 1128 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZZROSQ+LMMathExtension10-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: ZZROSQ+LMMathExtension10-Regular Flags: Serif, Symbolic FontBBox: -24, -2960, 1454, 772 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+LMMathItalic9-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: PZZLIK+LMMathItalic9-Regular Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KCKHQU+LMMathItalic6-Regular FontSubset: true FirstChar: 17 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic 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FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic FontBBox: 0, -250, 1241, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+LMMathItalic9-Regular FontSubset: true FirstChar: 24 LastChar: 31 FontDescriptor: FontName: PZZLIK+LMMathItalic9-Regular Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+LMMathItalic9-Regular FontSubset: true FirstChar: 27 LastChar: 31 FontDescriptor: FontName: PZZLIK+LMMathItalic9-Regular Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+SFRM0900 FontSubset: true FirstChar: 28 LastChar: 31 FontDescriptor: FontName: PZZLIK+SFRM0900 Flags: Serif, Symbolic 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FirstChar: 30 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic FontBBox: 0, -250, 1241, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KCKHQU+LMMathItalic6-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic FontBBox: 0, -250, 1241, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+LMMathItalic9-Regular FontSubset: true FirstChar: 27 LastChar: 31 FontDescriptor: FontName: PZZLIK+LMMathItalic9-Regular Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ZZROSQ+LMMathExtension10-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: 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EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KCKHQU+LMMathItalic6-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic FontBBox: 0, -250, 1241, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PZZLIK+LMMathItalic9-Regular FontSubset: true FirstChar: 28 LastChar: 31 FontDescriptor: FontName: PZZLIK+LMMathItalic9-Regular Flags: Serif, Symbolic, Italic FontBBox: -29, -250, 1075, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: KCKHQU+LMMathItalic6-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: KCKHQU+LMMathItalic6-Regular Flags: Serif, Symbolic, Italic FontBBox: 0, -250, 1241, 750 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true 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converted uuid:5bb0f69e-195f-4081-80e7-1dd5422a3f90 converted to PDF/A-2b pdfToolbox 2025-04-30T05:18:29+02:00 journal 10.1038/s41598-025-94815-3 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1038/s41598-025-94815-3 springer.com springerlink.com VoR application/pdf Adobe PDF Library 17.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) False 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://ns.adobe.com/pdfx/1.3/ pdfx pdfx internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains Seq Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text internal Mirrors crossmark:DOI doi Text http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://crossref.org/crossmark/1.0/ crossmark crossmark internal CrossMarkDomains CrossMarkDomains Seq Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Usual same as prism:doi DOI Text external The date when a publication was published. MajorVersionDate Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 224, 266, 227, 254 Flags: Print AppearanceDictionary: true Destination: 776 Annotation: Subtype: Link Rect: 266, 246, 269, 234 Flags: Print AppearanceDictionary: true Destination: 776 Annotation: Subtype: Link Rect: 270, 246, 273, 234 Flags: Print AppearanceDictionary: true Destination: 776 Annotation: Subtype: Link Rect: 488, 236, 491, 224 Flags: Print AppearanceDictionary: true 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