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SinglePage PageMode: UseOutlines Outlines: Item: Title: Nerve growth factor precursor alterations in neuron-derived extracellular vesicles from individuals with Down syndrome along the Alzheimer’s disease continuum Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study population Destination: subsection..1.2.1 Item: Title: 2.2 | Apolipoprotein E genotyping Destination: subsection..1.2.2 Item: Title: 2.3 | Isolation of NDEVs Destination: subsection..1.2.3 Item: Title: 2.4 | Nanoparticle tracking analysis Destination: subsection..1.2.4 Item: Title: 2.5 | Cryo-electron microscopy Destination: subsection..1.2.5 Item: Title: 2.6 | Analysis of L1CAM, neurofilament light chain, and phosphorylated tau181 in NDEVs Destination: subsection..1.2.6 Item: Title: 2.7 | Analysis of vesicular and contamination markers Destination: subsection..1.2.7 Item: Title: 2.8 | Analysis of proNGF and CD81 Destination: subsection..1.2.8 Item: Title: 2.9 | Analysis of CSF and plasma biomarkers Destination: subsection..1.2.9 Item: Title: 2.10 | Image acquisition and processing of basal forebrain volume Destination: subsection..1.2.10 Item: Title: 2.11 | Statistical analyses Destination: subsection..1.2.11 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Demographics Destination: subsection..1.3.1 Item: Title: 3.2 | Validation of neuronal EV enrichment protocol Destination: subsection..1.3.2 Item: Title: 3.3 | proNGF levels in NDEVs increase with age and along the AD continuum in DS Destination: subsection..1.3.3 Item: Title: 3.4 | Association between proNGF and AT(N) biomarkers in both CSF and plasma Destination: subsection..1.3.4 Item: Title: 3.5 | Association between proNGF and cognitive decline Destination: subsection..1.3.5 Item: Title: 3.6 | Association between proNGF and basal forebrain volume Destination: subsection..1.3.6 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: AUTHOR CONTRIBUTIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Item: Title: CONSENT STATEMENT Destination: section*.10 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.12 Item: Title: REFERENCES Destination: section*.14 Item: Title: SUPPORTING INFORMATION Destination: section*.16 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 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