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Aging Neurosci. 17:1522434. doi: 10.3389/fnagi.2025.1522434 Author: Laura Del Hoyo Soriano Creator: Adobe InDesign 14.0 (Windows) Producer: Adobe PDF Library 15.0 CreationDate: Thu Feb 27 11:48:47 2025 CET ModDate: Thu Feb 27 11:48:59 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 4213958 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XKAUXY+MuseoSans-500 Type 1C Custom yes yes yes 1659 0 VHWIVC+MuseoSans-300 Type 1C Custom yes yes yes 1666 0 TEXWTG+MuseoSans-300Italic Type 1C WinAnsi yes yes yes 1667 0 SANQFI+MuseoSans-700 Type 1C Custom yes yes yes 1674 0 RBYKRK+MuseoSans-700Italic Type 1C WinAnsi yes yes yes 1675 0 QXJEDM+MinionPro-Regular Type 1C Custom yes yes yes 1676 0 NQAMNS+STIXGeneral-Italic Type 1C Custom yes yes yes 176 0 MRLBZU+STIXGeneral-Regular Type 1C Custom yes yes yes 219 0 KOMPXY+MinionPro-It Type 1C Custom yes yes yes 167 0 ILNDVC+MuseoSans-500Italic Type 1C WinAnsi yes yes yes 529 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-15 04:25:02 CET RepresentationInformation: 321754.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-14 08:11:27 CET Size: 4213958 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1733 FreeObjects: 803 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-GB Outlines: Item: Title: Sex-related differences in genetically determined Alzheimer’s disease Children: Item: Title: 1 Introduction Item: Title: 2 Sex-related differences in ADAD Item: Title: 3 Sex-related differences in DSAD Item: Title: 4 Sex-related differences in APOE4 homozygotes Item: Title: 5 Concluding remarks Item: Title: 6 Priority areas for future research Item: Title: References Info: Title: Sex-related differences in genetically determined Alzheimer’s disease Author: Laura Del Hoyo Soriano Subject: Del Hoyo Soriano L, Wagemann O, Bejanin A, Levin J and Fortea J (2025) Sex-related differences in genetically determined Alzheimer’s disease. Front. 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Front. Aging Neurosci. 17:1522434. doi: 10.3389/fnagi.2025.1522434 genetically determined Alzheimer’s disease autosomal dominant Alzheimer’s disease (ADAD) down syndrome-associated Alzheimer’s disease (DS-AD) apolipoprotein E epsilon 4 (APOE4) homozygosity sex differences in Alzheimer’s disease disease penetrance in Alzheimer’s disease symptom onset in Alzheimer’s disease AT(N) biomarker trajectories in Alzheimer’s disease (amyloid tau and neurodegeneration biomarkers) Copyright © 2025 Del Hoyo Soriano, Wagemann, Bejanin, Levin and Fortea. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 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