a63a61a1f39a155f007e664d16b0f7e0 321764.pdf a3b9647316cf0d6008dfcb007d3b1910eeae732f 321764.pdf ebb2d3e3ce52d6e514248d1279907ad74a8e04ff9b710e6e42c20fe764231fab 321764.pdf Title: When should the nephrologist think about genetics in patients with glomerular diseases? Subject: DOI: 10.1093/ckj/sfaf044 Clinical Kidney Journal, 18, 3, 13-02-2025. Abstract: This review discusses the significance of genetics in diagnosing glomerular diseases. Advances in genetic testing, particularly next-generation sequencing, have improved the accessibility and accuracy of diagnosing monogenic diseases, allowing for targeted gene panels and whole-exome/genome sequencing to identify genetic variants associated with glomerular diseases. Key indicators for considering a genetic cause include the age of onset, extrarenal features, family history, and inconclusive kidney biopsy results. Early-onset diseases, for instance, have a higher likelihood of being genetically caused, while extrarenal manifestations can also suggest an underlying genetic condition. A thorough family history can reveal patterns of inheritance that point to monogenic causes, although complexities like incomplete penetrance, skewed X inactivation and mosaicism can complicate the assessment. Also, autosomal recessive conditions imply asymptomatic parents, making genetic suspicion less likely, while de novo mutations can occur without any family history, further obscuring genetic assessment. Focal segmental glomerulosclerosis (FSGS) is characterized by podocyte injury and depletion, presenting in various forms, including primary, genetic, and secondary FSGS. Accurate classification of FSGS patients based on clinical and histological features is essential for guiding treatment decisions, optimizing therapeutic plans, avoiding unnecessary immunosuppression, and predicting relapse risk after kidney transplantation. Overall, a clinicopathological approach, enriched by genetic testing, offers a precise framework for diagnosis and management in glomerular diseases. Future directions for research and clinical practice include potential advancements in genetic testing and personalized medicine, which could further improve diagnostic precision and individualized treatment strategies. Keywords: FSGS, genetic, genetic testing, glomerular, proteinuric Author: Torra Roser, Barros Xoana, Díaz-Encarnación Montserrat, Fayos Leonor, Furlano Mónica, Pilco Melissa, Pybus Marc, Shabaka Amir, Viera Elizabeth, Ars Elisabet Creator: OUP Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Mar 20 01:55:33 2025 CET ModDate: Thu Mar 20 01:56:12 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 612.284 x 790.866 pts Page rot: 0 File size: 858239 bytes Optimized: yes PDF version: 1.3 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- PILHOE+CaeciliaLTStd-Bold Type 1C Custom yes yes yes 2830 0 PILKKE+CaeciliaLTStd-Heavy Type 1C WinAnsi yes yes no 2835 0 PILHNB+CaeciliaLTStd-Italic Type 1C WinAnsi yes yes no 2838 0 PILHOD+CaeciliaLTStd-Roman Type 1C Custom yes yes yes 2841 0 PILHNC+dummy-space Type 1C WinAnsi yes yes no 2846 0 PILLKP+ArialMT Type 1C WinAnsi yes yes no 7 0 PIMCEH+CaeciliaLTStd-BoldItalic Type 1C WinAnsi yes yes no 464 0 PIMCPE+RMTMI Type 1C Custom yes yes yes 467 0 PIMELK+MTSY Type 1C Custom yes yes yes 142 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-15 04:24:35 CET RepresentationInformation: 321764.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-14 13:00:15 CET Size: 858239 Format: PDF Version: 1.3 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 2908 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: OneColumn PageMode: UseOutlines Language: English Outlines: Item: Title: INTRODUCTION Destination: section*.2 Item: Title: FEATURES SUGGESTING A GLOMERULAR DISEASE OF GENETIC ORIGIN Destination: section*.4 Item: Title: Age of onset Destination: section*.6 Item: Title: Extrarenal features Destination: section*.8 Item: Title: Family history Destination: section*.10 Item: Title: Kidney biopsy Destination: section*.12 Item: Title: Focal segmental glomerulosclerosis Destination: section*.14 Item: Title: Recurrence in kidney transplantation Destination: section*.16 Item: Title: POSSIBLE RESULTS OF GENETIC TESTING Destination: section*.18 Item: Title: Benefits of genetic testing Destination: section*.20 Item: Title: CONCLUSION Destination: section*.22 Item: Title: DATA AVAILABILITY STATEMENT Destination: section*.24 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.26 Item: Title: FUNDING Destination: section*.28 Item: Title: REFERENCES Destination: section*.30 Info: Title: When should the nephrologist think about genetics in patients with glomerular diseases? Author: Torra Roser, Barros Xoana, Díaz-Encarnación Montserrat, Fayos Leonor, Furlano Mónica, Pilco Melissa, Pybus Marc, Shabaka Amir, Viera Elizabeth, Ars Elisabet Subject: DOI: 10.1093/ckj/sfaf044 Clinical Kidney Journal, 18, 3, 13-02-2025. Abstract: This review discusses the significance of genetics in diagnosing glomerular diseases. Advances in genetic testing, particularly next-generation sequencing, have improved the accessibility and accuracy of diagnosing monogenic diseases, allowing for targeted gene panels and whole-exome/genome sequencing to identify genetic variants associated with glomerular diseases. Key indicators for considering a genetic cause include the age of onset, extrarenal features, family history, and inconclusive kidney biopsy results. Early-onset diseases, for instance, have a higher likelihood of being genetically caused, while extrarenal manifestations can also suggest an underlying genetic condition. A thorough family history can reveal patterns of inheritance that point to monogenic causes, although complexities like incomplete penetrance, skewed X inactivation and mosaicism can complicate the assessment. Also, autosomal recessive conditions imply asymptomatic parents, making genetic suspicion less likely, while de novo mutations can occur without any family history, further obscuring genetic assessment. Focal segmental glomerulosclerosis (FSGS) is characterized by podocyte injury and depletion, presenting in various forms, including primary, genetic, and secondary FSGS. Accurate classification of FSGS patients based on clinical and histological features is essential for guiding treatment decisions, optimizing therapeutic plans, avoiding unnecessary immunosuppression, and predicting relapse risk after kidney transplantation. Overall, a clinicopathological approach, enriched by genetic testing, offers a precise framework for diagnosis and management in glomerular diseases. Future directions for research and clinical practice include potential advancements in genetic testing and personalized medicine, which could further improve diagnostic precision and individualized treatment strategies. Keywords: FSGS, genetic, genetic testing, glomerular, proteinuric Creator: OUP Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Mar 20 02:25:33 CET 2025 ModDate: Thu Mar 20 02:26:12 CET 2025 ID: 0x6925905339cb4a85b75b2a8487404aac, 0xbed5348f48af3bb6e7a0967d94ab29ab Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 143 ImageHeight: 151 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1157 ImageHeight: 262 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: PIMCEH+CaeciliaLTStd-BoldItalic FontSubset: true FirstChar: 83 LastChar: 121 FontDescriptor: FontName: PIMCEH+CaeciliaLTStd-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -169, -273, 1082, 932 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PILKKE+CaeciliaLTStd-Heavy FontSubset: true FirstChar: 48 LastChar: 89 FontDescriptor: FontName: PILKKE+CaeciliaLTStd-Heavy Flags: Nonsymbolic, ForceBold FontBBox: -170, -277, 1146, 970 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PIMCPE+RMTMI FontSubset: true FirstChar: 2 LastChar: 62 FontDescriptor: FontName: PIMCPE+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PILHNB+CaeciliaLTStd-Italic FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: PILHNB+CaeciliaLTStd-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -166, -270, 1053, 915 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PILLKP+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PILLKP+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1006 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PILHOD+CaeciliaLTStd-Roman FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: PILHOD+CaeciliaLTStd-Roman Flags: Serif, Symbolic FontBBox: -167, -270, 1136, 926 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PILHNC+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: PILHNC+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PILHOE+CaeciliaLTStd-Bold FontSubset: true FirstChar: 2 LastChar: 133 FontDescriptor: FontName: PILHOE+CaeciliaLTStd-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -166, -273, 1141, 938 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: PIMELK+MTSY FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: PIMELK+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: 2025-03-20T06:25:33+05:30 2025-03-20T06:26:12+05:30 2025-03-20T06:26:12+05:30 OUP Acrobat Distiller 10.0.0 (Windows) FSGS, genetic, genetic testing, glomerular, proteinuric VoR 10.1093/ckj/sfaf044 2048-8513 Clinical Kidney Journal journal 18 10.1093/ckj/sfaf044 https://doi.org/10.1093/ckj/sfaf044 © The Author(s) 2025. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. All Rights Reserved application/pdf doi:10.1093/ckj/sfaf044 © The Author(s) 2025. Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Torra Roser Barros Xoana Díaz-Encarnación Montserrat Fayos Leonor Furlano Mónica Pilco Melissa Pybus Marc Shabaka Amir Viera Elizabeth Ars Elisabet Oxford University Press DOI: 10.1093/ckj/sfaf044 Clinical Kidney Journal, 18, 3, 13-02-2025. Abstract: This review discusses the significance of genetics in diagnosing glomerular diseases. Advances in genetic testing, particularly next-generation sequencing, have improved the accessibility and accuracy of diagnosing monogenic diseases, allowing for targeted gene panels and whole-exome/genome sequencing to identify genetic variants associated with glomerular diseases. Key indicators for considering a genetic cause include the age of onset, extrarenal features, family history, and inconclusive kidney biopsy results. Early-onset diseases, for instance, have a higher likelihood of being genetically caused, while extrarenal manifestations can also suggest an underlying genetic condition. A thorough family history can reveal patterns of inheritance that point to monogenic causes, although complexities like incomplete penetrance, skewed X inactivation and mosaicism can complicate the assessment. Also, autosomal recessive conditions imply asymptomatic parents, making genetic suspicion less likely, while de novo mutations can occur without any family history, further obscuring genetic assessment. Focal segmental glomerulosclerosis (FSGS) is characterized by podocyte injury and depletion, presenting in various forms, including primary, genetic, and secondary FSGS. Accurate classification of FSGS patients based on clinical and histological features is essential for guiding treatment decisions, optimizing therapeutic plans, avoiding unnecessary immunosuppression, and predicting relapse risk after kidney transplantation. Overall, a clinicopathological approach, enriched by genetic testing, offers a precise framework for diagnosis and management in glomerular diseases. Future directions for research and clinical practice include potential advancements in genetic testing and personalized medicine, which could further improve diagnostic precision and individualized treatment strategies. FSGS genetic genetic testing glomerular proteinuric When should the nephrologist think about genetics in patients with glomerular diseases? Torra Roser, Barros Xoana, Díaz-Encarnación Montserrat, Fayos Leonor, Furlano Mónica, Pilco Melissa, Pybus Marc, Shabaka Amir, Viera Elizabeth, Ars Elisabet uuid:d7ec40c9-89a5-3f27-818f-21fee04c8bab uuid:b88d75f2-cf66-46d3-97de-106963117f77 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 62, 683, 116, 694 Annotation: Subtype: Link Rect: 314, 709, 424, 719 Annotation: Subtype: Link Rect: 137, 543, 151, 560 Annotation: Subtype: Link Rect: 149, 549, 156, 561 Destination: 2813 Annotation: Subtype: Link Rect: 246, 549, 253, 561 Destination: 2813 Annotation: Subtype: Link Rect: 448, 543, 462, 560 Annotation: Subtype: Link Rect: 460, 549, 467, 561 Destination: 2813 Annotation: Subtype: Link Rect: 145, 531, 152, 543 Destination: 2813 Annotation: Subtype: Link Rect: 259, 525, 273, 542 Annotation: Subtype: Link Rect: 271, 531, 278, 543 Destination: 2813 Annotation: Subtype: Link Rect: 367, 525, 381, 542 Annotation: Subtype: Link Rect: 379, 531, 386, 543 Destination: 2813 Annotation: Subtype: Link Rect: 467, 525, 480, 542 Annotation: Subtype: Link Rect: 479, 531, 486, 543 Destination: 2813 Annotation: Subtype: Link Rect: 154, 507, 168, 524 Annotation: Subtype: Link Rect: 166, 513, 173, 525 Destination: 2813 Annotation: Subtype: Link Rect: 274, 513, 281, 525 Destination: 2813 Annotation: Subtype: Link Rect: 388, 507, 402, 524 Annotation: Subtype: Link Rect: 400, 513, 407, 525 Destination: 2813 Annotation: Subtype: Link Rect: 190, 433, 282, 443 Annotation: Subtype: Link Rect: 190, 71, 335, 80 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 231, 595, 237, 605 Destination: 187 Annotation: Subtype: Link Rect: 169, 248, 175, 259 Destination: 187 Annotation: Subtype: Link Rect: 272, 217, 279, 227 Destination: 1 Annotation: Subtype: Link Rect: 470, 528, 476, 539 Destination: 187 Annotation: Subtype: Link Rect: 396, 465, 403, 476 Destination: 187 Annotation: Subtype: Link Rect: 406, 465, 412, 476 Destination: 187 Annotation: Subtype: Link Rect: 372, 423, 378, 434 Destination: 187 Annotation: Subtype: Link Rect: 380, 423, 386, 434 Destination: 187 Annotation: Subtype: Link Rect: 394, 350, 400, 360 Destination: 210 Annotation: Subtype: Link Rect: 402, 350, 412, 360 Destination: 210 Annotation: Subtype: Link Rect: 438, 318, 444, 329 Destination: 210 Annotation: Subtype: Link Rect: 446, 318, 457, 329 Destination: 210 Annotation: Subtype: Link Rect: 443, 224, 454, 234 Destination: 210 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 86, 706, 96, 717 Destination: 210 Annotation: Subtype: Link Rect: 129, 622, 135, 633 Destination: 187 Annotation: Subtype: Link Rect: 137, 622, 143, 633 Destination: 210 Annotation: Subtype: Link Rect: 193, 580, 199, 591 Destination: 187 Annotation: Subtype: Link Rect: 147, 392, 154, 403 Destination: 40 Annotation: Subtype: Link Rect: 270, 193, 281, 203 Destination: 210 Annotation: Subtype: Link Rect: 283, 193, 293, 203 Destination: 210 Annotation: Subtype: Link Rect: 220, 161, 230, 172 Destination: 210 Annotation: Subtype: Link Rect: 232, 161, 243, 172 Destination: 210 Annotation: Subtype: Link Rect: 185, 98, 195, 109 Destination: 210 Annotation: Subtype: Link Rect: 197, 98, 207, 109 Destination: 210 Annotation: Subtype: Link Rect: 327, 685, 337, 696 Destination: 210 Annotation: Subtype: Link Rect: 339, 685, 349, 696 Destination: 210 Annotation: Subtype: Link Rect: 472, 539, 483, 550 Destination: 210 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 121, 99, 131, 109 Destination: 274 Annotation: Subtype: Link Rect: 111, 203, 121, 212 Destination: 274 Annotation: Subtype: Link Rect: 111, 214, 121, 224 Destination: 274 Annotation: Subtype: Link Rect: 151, 634, 161, 644 Destination: 274 Annotation: Subtype: Link Rect: 151, 646, 161, 656 Destination: 274 Annotation: Subtype: Link Rect: 161, 203, 171, 213 Destination: 274 Annotation: Subtype: Link Rect: 161, 214, 171, 224 Destination: 274 Annotation: Subtype: Link Rect: 181, 634, 191, 644 Destination: 210 Annotation: Subtype: Link Rect: 191, 256, 201, 266 Destination: 274 Annotation: Subtype: Link Rect: 201, 143, 211, 152 Destination: 274 Annotation: Subtype: Link Rect: 261, 255, 271, 264 Destination: 274 Annotation: Subtype: Link Rect: 271, 143, 281, 152 Destination: 274 Annotation: Subtype: Link Rect: 301, 163, 311, 173 Destination: 274 Annotation: Subtype: Link Rect: 350, 153, 360, 163 Destination: 274 Annotation: Subtype: Link Rect: 350, 164, 360, 174 Destination: 274 Annotation: Subtype: Link Rect: 384, 116, 394, 125 Destination: 274 Annotation: Subtype: Link Rect: 374, 184, 384, 193 Destination: 274 Annotation: Subtype: Link Rect: 394, 212, 404, 222 Destination: 274 Annotation: Subtype: Link Rect: 394, 224, 404, 234 Destination: 274 Annotation: Subtype: Link Rect: 394, 637, 404, 646 Destination: 274 Annotation: Subtype: Link Rect: 434, 264, 444, 274 Destination: 274 Annotation: Subtype: Link Rect: 444, 257, 454, 267 Destination: 274 Annotation: Subtype: Link Rect: 484, 213, 494, 223 Destination: 274 Annotation: Subtype: Link Rect: 524, 199, 534, 209 Destination: 274 Annotation: Subtype: Link Rect: 524, 210, 534, 220 Destination: 274 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 126, 107, 136, 116 Destination: 274 Annotation: Subtype: Link Rect: 116, 196, 126, 206 Destination: 274 Annotation: Subtype: Link Rect: 116, 208, 126, 218 Destination: 338 Annotation: Subtype: Link Rect: 136, 202, 146, 212 Destination: 338 Annotation: Subtype: Link Rect: 156, 201, 166, 211 Destination: 338 Annotation: Subtype: Link Rect: 156, 213, 166, 223 Destination: 338 Annotation: Subtype: Link Rect: 196, 209, 206, 219 Destination: 338 Annotation: Subtype: Link Rect: 196, 221, 206, 231 Destination: 338 Annotation: Subtype: Link Rect: 256, 236, 266, 246 Destination: 338 Annotation: Subtype: Link Rect: 256, 247, 266, 257 Destination: 338 Annotation: Subtype: Link Rect: 276, 220, 286, 230 Destination: 338 Annotation: Subtype: Link Rect: 276, 231, 286, 241 Destination: 338 Annotation: Subtype: Link Rect: 296, 188, 306, 198 Destination: 338 Annotation: Subtype: Link Rect: 296, 199, 306, 209 Destination: 338 Annotation: Subtype: Link Rect: 346, 96, 355, 106 Destination: 274 Annotation: Subtype: Link Rect: 336, 152, 346, 162 Destination: 338 Annotation: Subtype: Link Rect: 336, 163, 346, 173 Destination: 338 Annotation: Subtype: Link Rect: 391, 115, 401, 125 Destination: 338 Annotation: Subtype: Link Rect: 421, 207, 431, 216 Destination: 338 Annotation: Subtype: Link Rect: 421, 218, 431, 228 Destination: 338 Annotation: Subtype: Link Rect: 441, 191, 451, 201 Destination: 338 Annotation: Subtype: Link Rect: 487, 107, 497, 116 Destination: 274 Annotation: Subtype: Link Rect: 477, 195, 487, 204 Destination: 338 Annotation: Subtype: Link Rect: 477, 206, 487, 216 Destination: 338 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 120, 235, 130, 245 Destination: 338 Annotation: Subtype: Link Rect: 169, 218, 179, 228 Destination: 338 Annotation: Subtype: Link Rect: 215, 88, 225, 98 Destination: 274 Annotation: Subtype: Link Rect: 225, 169, 235, 178 Destination: 338 Annotation: Subtype: Link Rect: 225, 180, 235, 190 Destination: 338 Annotation: Subtype: Link Rect: 245, 230, 255, 240 Destination: 338 Annotation: Subtype: Link Rect: 245, 242, 255, 251 Destination: 338 Annotation: Subtype: Link Rect: 305, 178, 315, 188 Destination: 338 Annotation: Subtype: Link Rect: 305, 190, 315, 199 Destination: 338 Annotation: Subtype: Link Rect: 325, 207, 335, 216 Destination: 338 Annotation: Subtype: Link Rect: 325, 218, 335, 228 Destination: 338 Annotation: Subtype: Link Rect: 371, 94, 381, 103 Destination: 274 Annotation: Subtype: Link Rect: 361, 213, 371, 223 Destination: 338 Annotation: Subtype: Link Rect: 361, 224, 371, 238 Destination: 338 Annotation: Subtype: Link Rect: 448, 117, 458, 126 Destination: 274 Annotation: Subtype: Link Rect: 448, 170, 458, 184 Destination: 338 Annotation: Subtype: Link Rect: 448, 186, 458, 199 Destination: 338 Annotation: Subtype: Link Rect: 493, 210, 503, 224 Destination: 403 Annotation: Subtype: Link Rect: 513, 184, 523, 197 Destination: 403 Annotation: Subtype: Link Rect: 513, 199, 523, 213 Destination: 403 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 124, 203, 134, 217 Destination: 403 Annotation: Subtype: Link Rect: 124, 218, 134, 232 Destination: 403 Annotation: Subtype: Link Rect: 184, 181, 194, 194 Destination: 403 Annotation: Subtype: Link Rect: 210, 180, 220, 190 Destination: 210 Annotation: Subtype: Link Rect: 210, 192, 220, 205 Destination: 403 Annotation: Subtype: Link Rect: 300, 584, 310, 597 Destination: 403 Annotation: Subtype: Link Rect: 310, 210, 320, 216 Destination: 187 Annotation: Subtype: Link Rect: 310, 218, 320, 231 Destination: 403 Annotation: Subtype: Link Rect: 369, 624, 379, 638 Destination: 403 Annotation: Subtype: Link Rect: 369, 640, 379, 653 Destination: 403 Annotation: Subtype: Link Rect: 379, 236, 389, 250 Destination: 403 Annotation: Subtype: Link Rect: 439, 152, 449, 166 Destination: 403 Annotation: Subtype: Link Rect: 439, 167, 449, 181 Destination: 403 Annotation: Subtype: Link Rect: 479, 178, 489, 192 Destination: 403 Annotation: Subtype: Link Rect: 479, 194, 489, 207 Destination: 403 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 232, 166, 242, 179 Destination: 403 Annotation: Subtype: Link Rect: 232, 181, 242, 195 Destination: 403 Annotation: Subtype: Link Rect: 381, 607, 391, 621 Destination: 403 Annotation: Subtype: Link Rect: 411, 226, 421, 235 Destination: 210 Annotation: Subtype: Link Rect: 421, 230, 431, 244 Destination: 403 Annotation: Subtype: Link Rect: 431, 140, 441, 154 Destination: 403 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 154, 244, 164, 258 Destination: 403 Annotation: Subtype: Link Rect: 164, 159, 174, 169 Destination: 210 Annotation: Subtype: Link Rect: 253, 607, 263, 621 Destination: 403 Annotation: Subtype: Link Rect: 353, 226, 363, 240 Destination: 403 Annotation: Subtype: Link Rect: 353, 242, 363, 255 Destination: 403 Annotation: Subtype: Link Rect: 363, 229, 373, 243 Destination: 403 Annotation: Subtype: Link Rect: 363, 244, 373, 258 Destination: 403 Annotation: Subtype: Link Rect: 413, 181, 423, 187 Destination: 187 Annotation: Subtype: Link Rect: 488, 279, 497, 291 Destination: 403 Thumb: true Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 95, 580, 106, 590 Destination: 210 Annotation: Subtype: Link Rect: 108, 580, 118, 590 Destination: 210 Annotation: Subtype: Link Rect: 162, 517, 172, 527 Destination: 210 Annotation: Subtype: Link Rect: 175, 517, 185, 527 Destination: 210 Annotation: Subtype: Link Rect: 218, 454, 229, 464 Destination: 210 Annotation: Subtype: Link Rect: 231, 454, 241, 464 Destination: 210 Annotation: Subtype: Link Rect: 119, 412, 125, 422 Destination: 40 Annotation: Subtype: Link Rect: 65, 359, 76, 370 Destination: 210 Annotation: Subtype: Link Rect: 271, 296, 281, 307 Destination: 210 Annotation: Subtype: Link Rect: 166, 191, 176, 202 Destination: 210 Annotation: Subtype: Link Rect: 151, 107, 161, 118 Destination: 210 Annotation: Subtype: Link Rect: 352, 706, 363, 717 Destination: 210 Annotation: Subtype: Link Rect: 497, 675, 508, 685 Destination: 210 Annotation: Subtype: Link Rect: 416, 664, 427, 675 Destination: 210 Annotation: Subtype: Link Rect: 510, 633, 521, 643 Destination: 210 Annotation: Subtype: Link Rect: 517, 412, 527, 423 Destination: 210 Annotation: Subtype: Link Rect: 463, 181, 469, 192 Destination: 178 Annotation: Subtype: Link Rect: 474, 181, 485, 192 Destination: 210 Annotation: Subtype: Link Rect: 365, 118, 371, 129 Destination: 210 Annotation: Subtype: Link Rect: 400, 55, 410, 66 Destination: 210 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 243, 511, 253, 522 Destination: 210 Annotation: Subtype: Link Rect: 238, 480, 249, 490 Destination: 210 Annotation: Subtype: Link Rect: 250, 480, 261, 490 Destination: 210 Annotation: Subtype: Link Rect: 116, 427, 126, 438 Destination: 210 Annotation: Subtype: Link Rect: 128, 427, 138, 438 Destination: 274 Annotation: Subtype: Link Rect: 200, 211, 210, 221 Destination: 274 Annotation: Subtype: Link Rect: 408, 349, 418, 360 Destination: 210 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 284, 454, 294, 464 Destination: 210 Annotation: Subtype: Link Rect: 160, 412, 170, 422 Destination: 274 Annotation: Subtype: Link Rect: 172, 412, 182, 422 Destination: 274 Annotation: Subtype: Link Rect: 258, 401, 268, 412 Destination: 274 Annotation: Subtype: Link Rect: 85, 349, 91, 359 Destination: 187 Annotation: Subtype: Link Rect: 314, 390, 322, 400 Destination: 1 Annotation: Subtype: Link Rect: 333, 347, 570, 370 Annotation: Subtype: Link Rect: 314, 337, 322, 348 Destination: 1 Annotation: Subtype: Link Rect: 333, 315, 570, 338 Annotation: Subtype: Link Rect: 314, 306, 322, 316 Destination: 1 Annotation: Subtype: Link Rect: 333, 273, 570, 296 Annotation: Subtype: Link Rect: 314, 264, 322, 275 Destination: 1 Annotation: Subtype: Link Rect: 334, 233, 470, 243 Annotation: Subtype: Link Rect: 314, 222, 322, 233 Destination: 1 Annotation: Subtype: Link Rect: 392, 191, 523, 201 Annotation: Subtype: Link Rect: 314, 180, 322, 191 Destination: 1 Annotation: Subtype: Link Rect: 333, 148, 570, 171 Annotation: Subtype: Link Rect: 314, 138, 322, 149 Destination: 1 Annotation: Subtype: Link Rect: 333, 106, 570, 129 Annotation: Subtype: Link Rect: 314, 97, 322, 107 Destination: 1 Annotation: Subtype: Link Rect: 334, 55, 470, 65 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 62, 717, 70, 727 Destination: 1 Annotation: Subtype: Link Rect: 51, 684, 298, 707 Annotation: Subtype: Link Rect: 62, 675, 74, 685 Destination: 1 Annotation: Subtype: Link Rect: 51, 642, 298, 665 Annotation: Subtype: Link Rect: 62, 633, 74, 643 Destination: 1 Annotation: Subtype: Link Rect: 94, 601, 266, 612 Annotation: Subtype: Link Rect: 62, 591, 74, 602 Destination: 24 Annotation: Subtype: Link Rect: 51, 548, 298, 571 Annotation: Subtype: Link Rect: 62, 539, 74, 549 Destination: 24 Annotation: Subtype: Link Rect: 51, 506, 298, 529 Annotation: Subtype: Link Rect: 62, 497, 74, 507 Destination: 24 Annotation: Subtype: Link Rect: 51, 454, 298, 477 Annotation: Subtype: Link Rect: 62, 445, 74, 455 Destination: 24 Annotation: Subtype: Link Rect: 82, 413, 228, 424 Annotation: Subtype: Link Rect: 62, 403, 74, 413 Destination: 24 Annotation: Subtype: Link Rect: 51, 370, 298, 393 Annotation: Subtype: Link Rect: 62, 361, 74, 371 Destination: 24 Annotation: Subtype: Link Rect: 51, 329, 298, 351 Annotation: Subtype: Link Rect: 62, 319, 74, 330 Destination: 24 Annotation: Subtype: Link Rect: 51, 287, 298, 310 Annotation: Subtype: Link Rect: 62, 277, 74, 288 Destination: 24 Annotation: Subtype: Link Rect: 51, 245, 298, 268 Annotation: Subtype: Link Rect: 62, 235, 74, 246 Destination: 24 Annotation: Subtype: Link Rect: 51, 203, 299, 226 Annotation: Subtype: Link Rect: 62, 194, 74, 204 Destination: 24 Annotation: Subtype: Link Rect: 82, 162, 206, 173 Annotation: Subtype: Link Rect: 62, 152, 74, 162 Destination: 156 Annotation: Subtype: Link Rect: 51, 119, 298, 142 Annotation: Subtype: Link Rect: 62, 110, 74, 120 Destination: 156 Annotation: Subtype: Link Rect: 51, 77, 298, 100 Annotation: Subtype: Link Rect: 62, 68, 74, 79 Destination: 156 Annotation: Subtype: Link Rect: 51, 46, 299, 69 Annotation: Subtype: Link Rect: 313, 717, 325, 727 Destination: 156 Annotation: Subtype: Link Rect: 345, 675, 492, 685 Annotation: Subtype: Link Rect: 313, 664, 325, 675 Destination: 156 Annotation: Subtype: Link Rect: 332, 632, 569, 655 Annotation: Subtype: Link Rect: 313, 622, 325, 633 Destination: 156 Annotation: Subtype: Link Rect: 395, 591, 529, 602 Annotation: Subtype: Link Rect: 313, 581, 325, 591 Destination: 40 Annotation: Subtype: Link Rect: 332, 548, 569, 571 Annotation: Subtype: Link Rect: 313, 539, 325, 549 Destination: 156 Annotation: Subtype: Link Rect: 332, 517, 569, 540 Annotation: Subtype: Link Rect: 313, 507, 325, 518 Destination: 156 Annotation: Subtype: Link Rect: 332, 464, 569, 487 Annotation: Subtype: Link Rect: 313, 455, 325, 466 Destination: 156 Annotation: Subtype: Link Rect: 332, 412, 569, 435 Annotation: Subtype: Link Rect: 313, 403, 325, 413 Destination: 156 Annotation: Subtype: Link Rect: 332, 349, 569, 372 Annotation: Subtype: Link Rect: 313, 340, 325, 351 Destination: 156 Annotation: Subtype: Link Rect: 332, 308, 569, 331 Annotation: Subtype: Link Rect: 313, 298, 325, 309 Destination: 156 Annotation: Subtype: Link Rect: 332, 266, 569, 289 Annotation: Subtype: Link Rect: 313, 256, 325, 267 Destination: 156 Annotation: Subtype: Link Rect: 350, 235, 485, 246 Annotation: Subtype: Link Rect: 313, 225, 325, 235 Destination: 178 Annotation: Subtype: Link Rect: 345, 194, 508, 204 Annotation: Subtype: Link Rect: 313, 183, 325, 194 Destination: 132 Annotation: Subtype: Link Rect: 332, 151, 569, 174 Annotation: Subtype: Link Rect: 313, 141, 325, 152 Destination: 178 Annotation: Subtype: Link Rect: 332, 88, 569, 111 Annotation: Subtype: Link Rect: 313, 78, 325, 89 Destination: 178 Annotation: Subtype: Link Rect: 333, 47, 480, 58 Thumb: true Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 63, 717, 75, 727 Destination: 178 Annotation: Subtype: Link Rect: 52, 684, 299, 707 Annotation: Subtype: Link Rect: 63, 675, 75, 685 Destination: 178 Annotation: Subtype: Link Rect: 52, 632, 299, 655 Annotation: Subtype: Link Rect: 63, 622, 75, 633 Destination: 178 Annotation: Subtype: Link Rect: 52, 580, 299, 603 Annotation: Subtype: Link Rect: 63, 570, 75, 581 Destination: 187 Annotation: Subtype: Link Rect: 52, 527, 299, 550 Annotation: Subtype: Link Rect: 63, 518, 75, 528 Destination: 187 Annotation: Subtype: Link Rect: 137, 486, 293, 497 Annotation: Subtype: Link Rect: 63, 476, 75, 486 Destination: 187 Annotation: Subtype: Link Rect: 52, 444, 299, 467 Annotation: Subtype: Link Rect: 63, 434, 75, 445 Destination: 40 Annotation: Subtype: Link Rect: 52, 412, 299, 435 Annotation: Subtype: Link Rect: 63, 403, 75, 413 Destination: 40 Annotation: Subtype: Link Rect: 52, 370, 299, 393 Annotation: Subtype: Link Rect: 63, 361, 75, 371 Destination: 40 Annotation: Subtype: Link Rect: 52, 318, 299, 341 Annotation: Subtype: Link Rect: 63, 309, 75, 319 Destination: 40 Annotation: Subtype: Link Rect: 52, 266, 299, 289 Annotation: Subtype: Link Rect: 63, 256, 75, 267 Destination: 40 Annotation: Subtype: Link Rect: 52, 213, 299, 236 Annotation: Subtype: Link Rect: 63, 204, 75, 215 Destination: 40 Annotation: Subtype: Link Rect: 141, 173, 275, 183 Annotation: Subtype: Link Rect: 63, 162, 75, 173 Destination: 40 Annotation: Subtype: Link Rect: 141, 131, 249, 141 Annotation: Subtype: Link Rect: 63, 120, 75, 131 Destination: 40 Annotation: Subtype: Link Rect: 83, 99, 226, 110 Annotation: Subtype: Link Rect: 63, 89, 75, 99 Destination: 40 Annotation: Subtype: Link Rect: 52, 57, 299, 80 Annotation: Subtype: Link Rect: 314, 717, 326, 727 Destination: 40 Annotation: Subtype: Link Rect: 333, 684, 570, 707 Annotation: Subtype: Link Rect: 314, 675, 326, 685 Destination: 40 Annotation: Subtype: Link Rect: 333, 642, 570, 665 Annotation: Subtype: Link Rect: 314, 633, 326, 643 Destination: 40 Annotation: Subtype: Link Rect: 333, 600, 570, 623 Annotation: Subtype: Link Rect: 314, 591, 326, 602 Destination: 40 Annotation: Subtype: Link Rect: 384, 570, 527, 581 Annotation: Subtype: Link Rect: 314, 560, 326, 570 Destination: 40 Annotation: Subtype: Link Rect: 333, 538, 570, 561 Annotation: Subtype: Link Rect: 314, 528, 326, 539 Destination: 40 Annotation: Subtype: Link Rect: 333, 485, 570, 508 Annotation: Subtype: Link Rect: 314, 476, 326, 486 Destination: 40 Annotation: Subtype: Link Rect: 417, 445, 534, 455 Annotation: Subtype: Link Rect: 314, 434, 326, 445 Destination: 40 Annotation: Subtype: Link Rect: 333, 402, 570, 425 Annotation: Subtype: Link Rect: 314, 392, 326, 403 Destination: 40 Annotation: Subtype: Link Rect: 342, 371, 521, 382 Annotation: Subtype: Link Rect: 314, 361, 326, 371 Destination: 40 Annotation: Subtype: Link Rect: 334, 319, 471, 330 Annotation: Subtype: Link Rect: 314, 309, 326, 319 Destination: 40 Annotation: Subtype: Link Rect: 401, 288, 519, 298 Annotation: Subtype: Link Rect: 314, 277, 326, 288 Destination: 40 Annotation: Subtype: Link Rect: 333, 245, 570, 268 Annotation: Subtype: Link Rect: 314, 235, 326, 246 Destination: 40 Annotation: Subtype: Link Rect: 346, 204, 518, 215 Annotation: Subtype: Link Rect: 314, 194, 326, 204 Destination: 40 Annotation: Subtype: Link Rect: 333, 151, 570, 174 Annotation: Subtype: Link Rect: 314, 141, 326, 152 Destination: 40 Annotation: Subtype: Link Rect: 333, 98, 570, 121 Annotation: Subtype: Link Rect: 314, 89, 326, 99 Destination: 67 Annotation: Subtype: Link Rect: 333, 57, 570, 80 Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 62, 717, 74, 727 Destination: 67 Annotation: Subtype: Link Rect: 51, 684, 298, 707 Annotation: Subtype: Link Rect: 62, 675, 74, 685 Destination: 67 Annotation: Subtype: Link Rect: 51, 642, 298, 665 Annotation: Subtype: Link Rect: 62, 633, 74, 643 Destination: 67 Annotation: Subtype: Link Rect: 82, 612, 229, 622 Annotation: Subtype: Link Rect: 62, 601, 74, 612 Destination: 67 Annotation: Subtype: Link Rect: 51, 569, 298, 592 Annotation: Subtype: Link Rect: 62, 560, 74, 570 Destination: 67 Annotation: Subtype: Link Rect: 51, 527, 298, 550 Annotation: Subtype: Link Rect: 62, 518, 74, 528 Destination: 67 Annotation: Subtype: Link Rect: 51, 496, 298, 519 Annotation: Subtype: Link Rect: 62, 486, 74, 497 Destination: 67 Annotation: Subtype: Link Rect: 51, 454, 298, 477 Annotation: Subtype: Link Rect: 62, 445, 74, 455 Destination: 67 Annotation: Subtype: Link Rect: 149, 424, 295, 434 Annotation: Subtype: Link Rect: 62, 413, 74, 424 Destination: 67 Annotation: Subtype: Link Rect: 51, 381, 298, 404 Annotation: Subtype: Link Rect: 62, 371, 74, 382 Destination: 67 Annotation: Subtype: Link Rect: 51, 329, 298, 351 Annotation: Subtype: Link Rect: 62, 319, 74, 330 Destination: 67 Annotation: Subtype: Link Rect: 170, 288, 285, 298 Annotation: Subtype: Link Rect: 62, 277, 74, 288 Destination: 67 Annotation: Subtype: Link Rect: 51, 245, 298, 268 Annotation: Subtype: Link Rect: 62, 235, 74, 246 Destination: 67 Annotation: Subtype: Link Rect: 51, 193, 298, 216 Annotation: Subtype: Link Rect: 62, 183, 74, 194 Destination: 67 Annotation: Subtype: Link Rect: 145, 162, 282, 173 Annotation: Subtype: Link Rect: 62, 152, 74, 162 Destination: 67 Annotation: Subtype: Link Rect: 51, 119, 298, 142 Annotation: Subtype: Link Rect: 62, 110, 74, 120 Destination: 67 Annotation: Subtype: Link Rect: 94, 89, 256, 99 Annotation: Subtype: Link Rect: 62, 78, 74, 89 Destination: 67 Annotation: Subtype: Link Rect: 332, 705, 569, 728 Annotation: Subtype: Link Rect: 313, 696, 325, 706 Destination: 67 Annotation: Subtype: Link Rect: 391, 664, 545, 675 Annotation: Subtype: Link Rect: 313, 654, 325, 664 Destination: 93 Annotation: Subtype: Link Rect: 332, 621, 569, 644 Annotation: Subtype: Link Rect: 313, 612, 325, 622 Destination: 93 Annotation: Subtype: Link Rect: 431, 581, 543, 591 Annotation: Subtype: Link Rect: 313, 570, 325, 581 Destination: 93 Annotation: Subtype: Link Rect: 333, 539, 450, 549 Annotation: Subtype: Link Rect: 313, 528, 325, 539 Destination: 93 Annotation: Subtype: Link Rect: 332, 496, 569, 519 Annotation: Subtype: Link Rect: 313, 486, 325, 497 Destination: 93 Annotation: Subtype: Link Rect: 332, 454, 569, 477 Annotation: Subtype: Link Rect: 313, 445, 325, 455 Destination: 93 Annotation: Subtype: Link Rect: 332, 412, 569, 435 Annotation: Subtype: Link Rect: 313, 403, 325, 413 Destination: 93 Annotation: Subtype: Link Rect: 332, 360, 569, 383 Annotation: Subtype: Link Rect: 313, 350, 325, 361 Destination: 93 Annotation: Subtype: Link Rect: 333, 319, 508, 330 Annotation: Subtype: Link Rect: 313, 309, 325, 319 Destination: 93 Annotation: Subtype: Link Rect: 333, 277, 469, 288 Annotation: Subtype: Link Rect: 313, 267, 325, 277 Destination: 93 Annotation: Subtype: Link Rect: 332, 234, 569, 257 Annotation: Subtype: Link Rect: 313, 225, 325, 235 Destination: 93 Annotation: Subtype: Link Rect: 345, 194, 511, 204 Annotation: Subtype: Link Rect: 313, 183, 330, 194 Destination: 93 Annotation: Subtype: Link Rect: 313, 141, 330, 152 Destination: 93 Annotation: Subtype: Link Rect: 396, 110, 514, 120 Annotation: Subtype: Link Rect: 313, 99, 330, 110 Destination: 93 Annotation: Subtype: Link Rect: 332, 57, 569, 80 Thumb: true Page: Label: 16 Annotations: Annotation: Subtype: Link Rect: 63, 717, 79, 727 Destination: 93 Annotation: Subtype: Link Rect: 52, 684, 299, 707 Annotation: Subtype: Link Rect: 63, 675, 79, 685 Destination: 93 Annotation: Subtype: Link Rect: 52, 642, 299, 665 Annotation: Subtype: Link Rect: 63, 633, 79, 643 Destination: 93 Annotation: Subtype: Link Rect: 52, 600, 299, 623 Annotation: Subtype: Link Rect: 63, 591, 79, 602 Destination: 115 Annotation: Subtype: Link Rect: 145, 560, 283, 570 Annotation: Subtype: Link Rect: 63, 549, 79, 560 Destination: 115 Annotation: Subtype: Link Rect: 52, 517, 299, 540 Annotation: Subtype: Link Rect: 63, 507, 79, 518 Destination: 115 Annotation: Subtype: Link Rect: 52, 475, 299, 498 Annotation: Subtype: Link Rect: 63, 465, 79, 476 Destination: 115 Annotation: Subtype: Link Rect: 52, 433, 299, 456 Annotation: Subtype: Link Rect: 63, 424, 79, 434 Destination: 115 Annotation: Subtype: Link Rect: 52, 391, 299, 414 Annotation: Subtype: Link Rect: 63, 382, 79, 392 Destination: 115 Annotation: Subtype: Link Rect: 83, 361, 234, 371 Annotation: Subtype: Link Rect: 63, 350, 79, 361 Destination: 115 Annotation: Subtype: Link Rect: 52, 318, 299, 341 Annotation: Subtype: Link Rect: 63, 309, 79, 319 Destination: 115 Annotation: Subtype: Link Rect: 141, 288, 298, 298 Annotation: Subtype: Link Rect: 63, 277, 79, 288 Destination: 115 Annotation: Subtype: Link Rect: 95, 256, 242, 267 Annotation: Subtype: Link Rect: 63, 246, 79, 256 Destination: 115 Annotation: Subtype: Link Rect: 141, 214, 293, 225 Annotation: Subtype: Link Rect: 63, 204, 79, 215 Destination: 115 Annotation: Subtype: Link Rect: 146, 183, 290, 194 Annotation: Subtype: Link Rect: 63, 173, 79, 183 Destination: 115 Annotation: Subtype: Link Rect: 52, 140, 299, 163 Annotation: Subtype: Link Rect: 314, 717, 330, 727 Destination: 115 Annotation: Subtype: Link Rect: 333, 684, 570, 707 Annotation: Subtype: Link Rect: 314, 675, 330, 685 Destination: 132 Annotation: Subtype: Link Rect: 333, 632, 570, 655 Annotation: Subtype: Link Rect: 314, 622, 330, 633 Destination: 132 Annotation: Subtype: Link Rect: 333, 590, 570, 613 Annotation: Subtype: Link Rect: 314, 581, 330, 591 Destination: 132 Annotation: Subtype: Link Rect: 333, 538, 570, 561 Annotation: Subtype: Link Rect: 314, 528, 330, 539 Destination: 132 Annotation: Subtype: Link Rect: 388, 507, 539, 518 Annotation: Subtype: Link Rect: 314, 497, 330, 507 Destination: 132 Annotation: Subtype: Link Rect: 333, 464, 570, 487 Annotation: Subtype: Link Rect: 314, 455, 330, 466 Destination: 132 Annotation: Subtype: Link Rect: 333, 423, 570, 446 Annotation: Subtype: Link Rect: 314, 413, 330, 424 Destination: 140 Annotation: Subtype: Link Rect: 333, 360, 570, 383 Annotation: Subtype: Link Rect: 314, 350, 330, 361 Destination: 140 Annotation: Subtype: Link Rect: 342, 329, 493, 340 Annotation: Subtype: Link Rect: 314, 319, 330, 330 Destination: 140 Annotation: Subtype: Link Rect: 333, 287, 570, 310 Annotation: Subtype: Link Rect: 314, 277, 330, 288 Destination: 140 Annotation: Subtype: Link Rect: 333, 245, 570, 268 Annotation: Subtype: Link Rect: 314, 235, 330, 246 Destination: 140 Annotation: Subtype: Link Rect: 334, 214, 490, 225 Annotation: Subtype: Link Rect: 314, 204, 330, 215 Destination: 140 Annotation: Subtype: Link Rect: 346, 183, 509, 194 Annotation: Subtype: Link Rect: 314, 173, 330, 183 Destination: 140 Annotation: Subtype: Link Rect: 333, 140, 570, 163 Annotation: Subtype: Link Rect: 191, 37, 336, 46 Thumb: true Checksum: e0432338 Type: CRC32 Checksum: a63a61a1f39a155f007e664d16b0f7e0 Type: MD5 Checksum: a3b9647316cf0d6008dfcb007d3b1910eeae732f Type: SHA-1 Checksum: ebb2d3e3ce52d6e514248d1279907ad74a8e04ff9b710e6e42c20fe764231fab Type: SHA-256