0ff251043dda1b6b0050c5896c9b3fc6 321773.pdf e87d7297072aecd3c5bc6013caae0ce2d2fef56e 321773.pdf 82907ae191de9b91b3cfd2ca0e7b53fe917dc2a827cabdcd8d092ed257f17199 321773.pdf Title: Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans Subject: Circulation 2025.151:847-862 Author: Bo Sun Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT CreationDate: Sat Mar 15 10:02:04 2025 CET ModDate: Tue Nov 25 08:58:58 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 585 x 783 pts Page rot: 0 File size: 13530887 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AkzidenzGrotesk-LightItalic Type 1C WinAnsi yes no yes 60 0 AkzidenzGroteskBE-BoldCn Type 1C WinAnsi yes no yes 257 0 AkzidenzGroteskBE-Light Type 1C Custom yes no yes 59 0 CZFMLK+GandhariUnicode-Roman Type 1C Custom yes yes yes 70 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 430 0 Times-Roman Type 1 WinAnsi no no no 5 0 AkzidenzGrotesk-LightItalic Type 1C WinAnsi yes no yes 432 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 434 0 AkzidenzGroteskBE-Regular Type 1C Custom yes no yes 61 0 AkzidenzGroteskBE-Bold Type 1C Custom yes no yes 62 0 AkzidenzGroteskBE-Md Type 1C Custom yes no yes 63 0 AkzidenzGroteskBE-BoldCn Type 1C WinAnsi yes no yes 219 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 218 0 PDRHLK+SymbolMT CID TrueType Identity-H yes yes yes 69 0 AkzidenzGroteskBE-BoldCn Type 1C WinAnsi yes no yes 231 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 234 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 236 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 237 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 239 0 AkzidenzGroteskBE-Light Type 1C WinAnsi yes no yes 241 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-26 04:28:36 CET RepresentationInformation: 321773.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-25 08:59:53 CET Size: 13530887 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2374 ImageHeight: 2639 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1971 ImageHeight: 855 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1970 ImageHeight: 1088 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2207 ImageHeight: 2698 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1970 ImageHeight: 1373 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1970 ImageHeight: 1471 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1501 ImageHeight: 1945 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2392 ImageHeight: 2343 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: PDRHLK+SymbolMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: AkzidenzGroteskBE-BoldCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGroteskBE-BoldCn Flags: Nonsymbolic FontBBox: -101, -250, 974, 919 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: CZFMLK+GandhariUnicode-Roman FontSubset: true FirstChar: 26 LastChar: 31 FontDescriptor: FontName: CZFMLK+GandhariUnicode-Roman Flags: Serif, Nonsymbolic FontBBox: -752, -250, 1779, 944 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AkzidenzGroteskBE-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGroteskBE-Light Flags: Nonsymbolic FontBBox: -131, -256, 1219, 907 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AkzidenzGrotesk-LightItalic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGrotesk-LightItalic Flags: Nonsymbolic, Italic FontBBox: -169, -248, 1159, 931 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: AkzidenzGroteskBE-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AkzidenzGroteskBE-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGroteskBE-Bold Flags: Nonsymbolic FontBBox: -166, -250, 1222, 927 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AkzidenzGroteskBE-Md FirstChar: 0 LastChar: 255 FontDescriptor: FontName: AkzidenzGroteskBE-Md Flags: Nonsymbolic FontBBox: -145, -250, 1225, 963 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: PDRHLK+SymbolMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PDRHLK+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile2: true XMP: application/pdfdoi:10.1161/CIRCULATIONAHA.124.070563 10.1161/CIRCULATIONAHA.124.070563https://doi.org/10.1161/CIRCULATIONAHA.124.070563 2024-12-10truewww.ahajournals.org10.1161/CIRCULATIONAHA.124.070563 www.ahajournals.orgtrue10.1161/CIRCULATIONAHA.124.0705632024-12-10 Pages: Page: Label: 847 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 367, 143, 428, 134 Annotation: Subtype: Link Rect: 255, 134, 317, 125 Annotation: Subtype: Link Rect: 179, 125, 254, 116 Annotation: Subtype: Link Rect: 49, 107, 49, 98 Annotation: Subtype: Link Rect: 157, 107, 400, 98 Annotation: Subtype: Link Rect: 98, 80, 266, 71 Annotation: Subtype: Link Rect: 75, 570, 87, 557 Annotation: Subtype: Link Rect: 149, 570, 162, 557 Annotation: Subtype: Link Rect: 216, 570, 229, 557 Annotation: Subtype: Link Rect: 265, 568, 265, 557 Annotation: Subtype: Link Rect: 330, 570, 343, 557 Annotation: Subtype: Link Rect: 361, 568, 361, 557 Annotation: Subtype: Link Rect: 401, 570, 413, 557 Annotation: Subtype: Link Rect: 431, 568, 431, 557 Annotation: Subtype: Link Rect: 518, 568, 518, 557 Annotation: Subtype: Link Rect: 93, 558, 106, 545 Annotation: Subtype: Link Rect: 124, 556, 124, 545 Annotation: Subtype: Link Rect: 198, 556, 198, 545 Annotation: Subtype: Link Rect: 264, 556, 264, 545 Annotation: Subtype: Link Rect: 337, 556, 337, 545 Annotation: Subtype: Link Rect: 380, 558, 393, 545 Annotation: Subtype: Link Rect: 411, 556, 411, 545 Annotation: Subtype: Link Rect: 492, 556, 492, 545 Annotation: Subtype: Link Rect: 137, 544, 137, 533 Annotation: Subtype: Link Rect: 186, 546, 198, 533 Annotation: Subtype: Link Rect: 217, 544, 217, 533 Annotation: Subtype: Link Rect: 307, 546, 319, 533 Annotation: Subtype: Link Rect: 338, 544, 338, 533 Annotation: Subtype: Link Rect: 397, 546, 409, 533 Annotation: Subtype: Link Rect: 428, 544, 428, 533 Annotation: Subtype: Link Rect: 498, 546, 511, 533 Annotation: Subtype: Link Rect: 529, 544, 529, 533 Annotation: Subtype: Link Rect: 113, 532, 113, 521 Annotation: Subtype: Link Rect: 196, 534, 208, 521 Annotation: Subtype: Link Rect: 226, 532, 226, 521 Annotation: Subtype: Link Rect: 276, 534, 289, 521 Annotation: Subtype: Link Rect: 307, 532, 307, 521 Annotation: Subtype: Link Rect: 379, 534, 391, 521 Annotation: Subtype: Link Rect: 410, 532, 410, 521 Annotation: Subtype: Link Rect: 499, 534, 511, 521 Annotation: Subtype: Link Rect: 110, 522, 122, 509 Annotation: Subtype: Link Rect: 138, 520, 138, 509 Annotation: Subtype: Link Rect: 172, 522, 184, 509 Annotation: Subtype: Link Rect: 203, 520, 203, 509 Annotation: Subtype: Link Rect: 282, 522, 294, 509 Annotation: Subtype: Link Rect: 310, 520, 310, 509 Annotation: Subtype: Link Rect: 377, 522, 390, 509 Annotation: Subtype: Link Rect: 426, 520, 426, 509 Annotation: Subtype: Link Rect: 470, 522, 482, 509 Annotation: Subtype: Link Rect: 501, 520, 501, 509 Annotation: Subtype: Link Rect: 136, 510, 149, 497 Annotation: Subtype: Link Rect: 185, 508, 185, 497 Annotation: Subtype: Link Rect: 248, 510, 260, 497 Annotation: Subtype: Link Rect: 345, 510, 358, 497 Annotation: Subtype: Link Rect: 483, 770, 583, 748 Page: Label: 848 Sequence: 2 Page: Label: 849 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 49, 254, 133, 243 Annotation: Subtype: Link Rect: 504, 577, 535, 565 Annotation: Subtype: Link Rect: 301, 565, 419, 553 Annotation: Subtype: Link Rect: 354, 541, 391, 529 Annotation: Subtype: Link Rect: 461, 433, 496, 421 Annotation: Subtype: Link Rect: 381, 385, 416, 373 Annotation: Subtype: Link Rect: 420, 385, 460, 373 Annotation: Subtype: Link Rect: 489, 313, 530, 301 Annotation: Subtype: Link Rect: 431, 121, 468, 109 Page: Label: 850 Sequence: 4 Page: Label: 851 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 49, 336, 87, 324 Annotation: Subtype: Link Rect: 152, 312, 189, 300 Annotation: Subtype: Link Rect: 101, 276, 142, 264 Annotation: Subtype: Link Rect: 68, 180, 105, 168 Annotation: Subtype: Link Rect: 508, 120, 535, 108 Annotation: Subtype: Link Rect: 301, 108, 405, 96 Annotation: Subtype: Link Rect: 420, 72, 530, 60 Page: Label: 852 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 174, 264, 278, 253 Annotation: Subtype: Link Rect: 518, 336, 535, 325 Annotation: Subtype: Link Rect: 301, 324, 330, 313 Page: Label: 853 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 83, 69, 126, 57 Annotation: Subtype: Link Rect: 384, 69, 459, 57 Page: Label: 854 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 142, 128, 226, 116 Annotation: Subtype: Link Rect: 117, 80, 204, 68 Annotation: Subtype: Link Rect: 301, 236, 388, 224 Annotation: Subtype: Link Rect: 335, 224, 382, 212 Page: Label: 855 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 70, 700, 158, 689 Annotation: Subtype: Link Rect: 482, 664, 530, 653 Page: Label: 856 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 404, 616, 441, 605 Annotation: Subtype: Link Rect: 507, 268, 535, 257 Annotation: Subtype: Link Rect: 301, 256, 472, 245 Annotation: Subtype: Link Rect: 514, 196, 535, 185 Annotation: Subtype: Link Rect: 301, 184, 313, 173 Page: Label: 857 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 210, 82, 251, 71 Page: Label: 858 Sequence: 12 Page: Label: 859 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 188, 424, 283, 413 Annotation: Subtype: Link Rect: 49, 412, 100, 401 Annotation: Subtype: Link Rect: 151, 412, 283, 401 Annotation: Subtype: Link Rect: 49, 400, 122, 389 Annotation: Subtype: Link Rect: 159, 328, 198, 317 Annotation: Subtype: Link Rect: 140, 280, 178, 269 Page: Label: 860 Sequence: 14 Page: Label: 861 Sequence: 15 Page: Label: 862 Sequence: 16 Checksum: bfd2ab29 Type: CRC32 Checksum: 0ff251043dda1b6b0050c5896c9b3fc6 Type: MD5 Checksum: e87d7297072aecd3c5bc6013caae0ce2d2fef56e Type: SHA-1 Checksum: 82907ae191de9b91b3cfd2ca0e7b53fe917dc2a827cabdcd8d092ed257f17199 Type: SHA-256