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Oncol. 15:1552908. doi: 10.3389/fonc.2025.1552908 Keywords: cardiotoxicity; coronary artery calcium; planning CT; breast cancer; radiotherapy Author: Eugenia Otero-Pla CreationDate: Fri Mar 7 02:08:16 2025 CET ModDate: Fri Mar 7 02:08:16 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 365629 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NPGANA+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 761 0 NPGANB+AdvPSA18C Type 1C WinAnsi yes yes no 762 0 NPGAOB+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 763 0 NPGAOC+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 764 0 NPGAOD+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 765 0 NPGAOE+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 771 0 NPGBHC+AdvPSA323 Type 1C WinAnsi yes yes no 773 0 NPGBHD+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 774 0 NPGBHE+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 775 0 NPGBMF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 168 0 NPGBMD+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 169 0 NPGBME+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 166 0 NPGBOF+AdvOT3f84ef53 Type 1C WinAnsi yes yes no 172 0 NPGBPG+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 173 0 NPGCEF+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 179 0 NPGCEG+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 178 0 NPHDHN+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 184 0 NPHDIO+AdvTT58d178b9+03 Type 1C Custom yes yes yes 183 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-27 04:05:21 CET RepresentationInformation: 321778.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-26 13:09:00 CET Size: 365629 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 835 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Mapping clinical and imaging factors that might predict cardiac events in breast cancer patients Destination: bmark_890867625 Children: Item: Title: 1 Introduction Destination: s1 Item: Title: 2 Methods Destination: s2 Children: Item: Title: 2.1 Clinical data Destination: s2_1 Item: Title: 2.2 Radiotherapy treatment Destination: s2_2 Item: Title: 2.3 CAC scoring Destination: s2_3 Item: Title: 2.4 Statistical analysis Destination: s2_4 Item: Title: 3 Results Destination: s3 Children: Item: Title: 3.1 Deep inspiration breath hold and radiotherapy technique Destination: s3_1 Item: Title: 3.2 Coronary arterial calcium Destination: s3_2 Item: Title: 4 Discussion Destination: s4 Item: Title: 5 Conclusion Destination: s5 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Title: Mapping clinical and imaging factors that might predict cardiac events in breast cancer patients Author: Eugenia Otero-Pla Subject: Otero-Pla E, Fuentes Raspall MJ, Gallego Franco P, Fernández Martínez J, Gich Saladich I, Jornet Sala N, Lizondo Gisbert M, Rojas Cordero J, Isern Verdum J and Sancho-Pardo G (2025) Mapping clinical and imaging factors that might predict cardiac events in breast cancer patients. Front. 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Martínez Ignasi Gich Saladich Nuria Jornet Sala Maria Lizondo Gisbert Jady Rojas Cordero Josep Isern Verdum Gemma Sancho-Pardo Otero-Pla E, Fuentes Raspall MJ, Gallego Franco P, Fernández Martínez J, Gich Saladich I, Jornet Sala N, Lizondo Gisbert M, Rojas Cordero J, Isern Verdum J and Sancho-Pardo G (2025) Mapping clinical and imaging factors that might predict cardiac events in breast cancer patients. Front. Oncol. 15:1552908. doi: 10.3389/fonc.2025.1552908 Copyright © 2025 Otero-Pla, Fuentes Raspall, Gallego Franco, Fernández Martínez, Gich Saladich, Jornet Sala, Lizondo Gisbert, Rojas Cordero, Isern Verdum and Sancho-Pardo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 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