1c5aea70417169e48c0b087d180e044a 321784.pdf add221a412e139dbdd499763cf351749238869d4 321784.pdf 26236ad5f911af0b6ff069ee27d109bd12ca9794a837349b37587a97d5324bcc 321784.pdf Title: Improving HCV Screening in Addiction Care Centers with Plasma Separation Cards Subject: Globally, 50 million people are infected with hepatitis C virus (HCV), many of whom are people who inject drugs. These individuals face healthcare barriers, necessitating innovative diagnostic tools. This study evaluated the impact of cobas plasma separation cards (PSCs) for dry plasma collection in Barcelona’s outpatient drug addiction centers (CAS). From February to December 2021, nine CASs were invited to implement PSC for HCV screening; three centers participated, allowing for the assessment of its impact on HCV detection. Of the 679 clients screened, 54 (8%) provided finger-prick blood samples via PSC due to their refusal or inability to undergo venipuncture. Overall, 100 (14.7%) clients tested positive for HCV antibodies, with 24 (24%) confirmed as HCV-RNA positive. Among venipuncture clients, 9.1% had positive antibodies, with 15.8% showing active infection. In contrast, 79.6% of PSC clients had positive antibodies and 34.9% had detectable HCV RNA, contributing to 62.5% of the active infections detected. The odds ratio was 26.3, indicating that refusal or inability to undergo venipuncture correlated with a significantly higher burden of active HCV infection. The findings highlight PSC as a valuable alternative for diagnosing HCV in people with substance use disorders, addressing accessibility barriers and improving linkage to care in high-risk populations.36pt Keywords: hepatitis c infection; intravenous drug users; finger prick Author: Fernando Velásquez Orozco, David Tabernero, María Gabriela Barbaglia, Lara Treviño, Begoña Trujillo, Andrés Marco, Miguel Ángel Carrillo, Gerard Ruiz Salinas, Francesc Xavier Majo Roca, Joan Colom Farran, María Buti, Tomas Pumarola-Sunyer, Francisco Rodriguez-Frias and Ariadna Rando-Segura Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Sat Mar 1 10:51:40 2025 CET ModDate: Sat Mar 1 10:55:46 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 537869 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DMTLJA+VnURWPalladioL Type 1 Custom yes yes yes 10 0 LFFJJD+URWPalladioL-Roma Type 1 Custom yes yes yes 16 0 BTWVYU+URWPalladioL-Bold Type 1 Custom yes yes yes 22 0 CZNYMV+URWPalladioL-Ital Type 1 Custom yes yes yes 27 0 DVCMRV+CMSY10 Type 1 Builtin yes yes yes 56 0 JHYTSG+CMR10 Type 1 Builtin yes yes yes 61 0 MGALFD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 82 0 MGALFE+PalatinoLinotype CID TrueType Identity-H yes yes yes 85 0 MGALFF+PalatinoLinotype TrueType WinAnsi yes yes no 91 0 MGALFH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 94 0 MGALMH+PalatinoLinotype TrueType MacRoman yes yes no 97 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-27 04:05:01 CET RepresentationInformation: 321784.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-26 13:45:15 CET Size: 537869 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 192 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Material and Methods Destination: section.2 Children: Item: Title: Clinical Setting Destination: subsection.2.1 Item: Title: Intervention Destination: subsection.2.2 Item: Title: DPS Samples Destination: subsection.2.3 Item: Title: Data Inclusion Criteria Destination: subsection.2.4 Item: Title: Statistical Analysis Destination: subsection.2.5 Item: Title: AI-Assisted Writing Destination: subsection.2.6 Item: Title: Ethical Considerations Destination: subsection.2.7 Item: Title: Results Destination: section.3 Children: Item: Title: Hepatitis C Infection Destination: subsection.3.1 Item: Title: Hepatitis C Cascade of Care Destination: subsection.3.2 Item: Title: Discussion Destination: section.4 Item: Title: Conclusions Destination: section.5 Item: Title: References Destination: section.6 Info: Title: Improving HCV Screening in Addiction Care Centers with Plasma Separation Cards Author: Fernando Velásquez Orozco, David Tabernero, María Gabriela Barbaglia, Lara Treviño, Begoña Trujillo, Andrés Marco, Miguel Ángel Carrillo, Gerard Ruiz Salinas, Francesc Xavier Majo Roca, Joan Colom Farran, María Buti, Tomas Pumarola-Sunyer, Francisco Rodriguez-Frias and Ariadna Rando-Segura Subject: Globally, 50 million people are infected with hepatitis C virus (HCV), many of whom are people who inject drugs. These individuals face healthcare barriers, necessitating innovative diagnostic tools. This study evaluated the impact of cobas plasma separation cards (PSCs) for dry plasma collection in Barcelona’s outpatient drug addiction centers (CAS). From February to December 2021, nine CASs were invited to implement PSC for HCV screening; three centers participated, allowing for the assessment of its impact on HCV detection. Of the 679 clients screened, 54 (8%) provided finger-prick blood samples via PSC due to their refusal or inability to undergo venipuncture. Overall, 100 (14.7%) clients tested positive for HCV antibodies, with 24 (24%) confirmed as HCV-RNA positive. Among venipuncture clients, 9.1% had positive antibodies, with 15.8% showing active infection. In contrast, 79.6% of PSC clients had positive antibodies and 34.9% had detectable HCV RNA, contributing to 62.5% of the active infections detected. The odds ratio was 26.3, indicating that refusal or inability to undergo venipuncture correlated with a significantly higher burden of active HCV infection. 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