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Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Results & discussion Destination: mk:H1_2 Children: Item: Title: 2.1 Simulation set-up Destination: mk:H2_1 Item: Title: 2.2 Depletion-enrichment of lipids around each TRPV Destination: mk:H2_2 Item: Title: 2.3 Lipid residence time and binding events as a proxy for binding affinity Destination: mk:H2_3 Item: Title: 2.4 Characterization of the bioactive paralipidome Destination: mk:H2_4 Item: Title: 2.5 Molecular determinants of lipid binding Destination: mk:H2_5 Children: Item: Title: 2.5.1 Residue nature Destination: mk:H3_6 Item: Title: 2.5.2 Characterization of lipid binding sites Destination: mk:H3_7 Children: Item: Title: 2.5.2.1 Phosphatidylinositols Destination: mk:H4_8 Item: Title: 2.5.2.2 Cholesterol Destination: mk:H4_9 Item: Title: 2.5.2.3 Phosphatidic acid Destination: mk:H4_10 Item: Title: 2.5.2.4 Other lipids Destination: mk:H4_11 Item: Title: 2.5.3 Residue conservation Destination: mk:H3_12 Item: Title: 2.5.4 Comparison of lipid and drug binding to TRPVs Destination: mk:H3_13 Children: Item: Title: 2.5.4.1 Known lipid-drug binding sites Destination: mk:H4_14 Item: Title: 2.5.4.2 Drug-only binding sites Destination: mk:H4_15 Item: Title: 2.5.4.3 “Orphan” lipid binding sites Destination: mk:H4_16 Item: Title: 3 Conclusions Destination: mk:H1_3 Item: Title: 4 Methods Destination: mk:H1_4 Children: Item: Title: 4.1 Simulation details Destination: mk:H2_17 Children: Item: Title: 4.1.1 System setup Destination: mk:H3_18 Item: Title: 4.1.2 Simulation setup Destination: mk:H3_19 Item: Title: 4.2 Data analysis Destination: mk:H2_20 Children: Item: Title: 4.2.1 Trajectory analysis Destination: mk:H3_21 Item: Title: 4.2.2 Initial vs final lipid microenvironment Destination: mk:H3_22 Item: Title: 4.2.3 Lipid occupancy and residence time and prediction of binding events Destination: mk:H3_23 Item: Title: 4.2.4 Weighted GRAVY score binding region analysis Destination: mk:H3_24 Item: Title: 4.2.5 Residue conservation Destination: mk:H3_25 Item: Title: 4.2.6 Molecular representation Destination: mk:H3_26 Item: Title: CRediT authorship contribution statement Destination: mk:H1_5 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Acknowledgements Destination: mk:HH1_3 Item: Title: Appendix A Supplementary data Destination: mk:H1_6 Item: Title: Data availability Destination: datalink4 Item: Title: References Destination: mk:HH2_1 Info: Title: Computational insights into the lipid code of transient receptor potential vanilloid channels reveal overlap with drug binding sites Author: Mario Lopez-Martin Subject: International Journal of Biological Macromolecules, 330 (2025) 148108. doi:10.1016/j.ijbiomac.2025.148108 Keywords: Biomembranes,Ion channels,TRP channels,Lipid-protein interactions,Paralipidome,Martini force field,Bioactive lipids Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: 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