940dfad8c466439ce0f6ab322d3fc58b VED_a2025v36p723.pdf 5eb54186b3bab160937bbccbe2aa04d7c8927201 VED_a2025v36p723.pdf c7956d846188bf4dcc89ddb3f0e4c0868b0c2f63356bff20da34aec293a60ea4 VED_a2025v36p723.pdf Title: World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis Subject: Veterinary Dermatology 2025.36:723-787 Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Fri Oct 24 12:40:39 2025 CEST ModDate: Thu Nov 20 14:19:13 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 65 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 4689786 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- 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0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence-Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis Children: Item: Title: ABSTRACT Item: Title: ZUSAMMENFASSUNG Item: Title: 摘要 Item: Title: RÉSUMÉ Item: Title: 要約 Item: Title: RESUMO Item: Title: RESUMEN Item: Title: 1   |   Introduction Children: Item: Title: 1.1   |   Aetiology Item: Title: 1.2   |   Epidemiology Item: Title: 2   |   Pathogenesis and Immunology of Canine Leishmaniosis Item: Title: 3   |   Non-Cutaneous Manifestations of Canine Leishmaniosis Children: Item: Title: 3.1   |   History and Common Clinical Manifestations Item: Title: 3.2   |   Clinicopathologic Abnormalities Item: Title: 4   |   Cutaneous Manifestations of Canine Leishmaniosis Children: Item: Title: 4.1   |   Exfoliative Dermatitis Item: Title: 4.2   |   Ulcerative Dermatitis Children: Item: Title: 4.2.1   |   Ulcerative Dermatitis on Sites Subjected to Trauma Item: Title: 4.2.2   |   Ulcerative Dermatitis on Body Extremities Item: Title: 4.2.3   |   Ulcerative Dermatitis of the Nasal Planum and/or Mucocutaneous Junctions Item: Title: 4.3   |   Papular Dermatitis Item: Title: 4.4   |   Cutaneous and Mucocutaneous Nodular Dermatitis Item: Title: 4.5   |   Pustular Dermatitis Item: Title: 4.6   |   Footpad and/or Nasal Hyperkeratosis Item: Title: 4.7   |   Onychogryphosis Item: Title: 5   |   Diagnosis of Canine Leishmaniosis Children: Item: Title: 5.1   |   Microscopy and Histopathology Item: Title: 5.2   |   Serology Item: Title: 5.3   |   Molecular Tests [Polymerase Chain Reaction] Children: Item: Title: 5.3.1   |   Consensus Statement Item: Title: 5.4   |   Staging of Canine Leishmaniosis Item: Title: 6   |   Diagnostic Approach to the Skin Lesions of Dogs With Leishmaniosis Children: Item: Title: 6.1   |   Case Example 1 Item: Title: 6.2   |   Case Example 2 Item: Title: 6.3   |   Case Example 3 Item: Title: 7   |   Systematic Review on Treatment and Prevention of Canine Leishmaniosis Children: Item: Title: 7.1   |   Evaluation of Quality of Randomised Controlled Trials Item: Title: 7.2   |   Evaluation of Level of Evidence and Consistency Among Studies Item: Title: 7.3   |   Strength of Recommendation Item: Title: 7.4   |   Eligible Randomised Controlled Trials Item: Title: 8   |   Treatment of Canine Leishmaniosis Children: Item: Title: 8.1   |   Indications for Euthanasia (Instead of Treatment) Item: Title: 8.2   |   Indications and Aims of Treatment Item: Title: 8.3   |   Drugs With Direct Anti-Leishmania Activity Children: Item: Title: 8.3.1   |   Meglumine Antimoniate Item: Title: 8.3.2   |   Miltefosine Item: Title: 8.3.3   |   Allopurinol Item: Title: 8.3.4   |   Aminosidine (Paromomycin) Item: Title: 8.3.5   |   Marbofloxacin Item: Title: 8.3.6   |   Metronidazole Item: Title: 8.3.7   |   O-Alkyl-Hydroxamate (MTC-305) Item: Title: 8.3.8   |   (−)-α-Bisabolol Item: Title: 8.3.9   |   Artesunate Item: Title: 8.3.10   |   Combinations of Drugs With Direct Anti-Leishmania Activity Children: Item: Title: 8.3.10.1   |   Meglumine Antimoniate–Allopurinol Combination. Item: Title: 8.3.10.2   |   Meglumine Antimoniate–Aminosidine Combination. Item: Title: 8.3.10.3   |   Meglumine Antimoniate–Metronidazole Combination. Item: Title: 8.3.10.4   |   Meglumine Antimoniate​–O-Alkyl-​Hydroxamate (MTC-305) Combination. Item: Title: 8.3.10.5   |   Miltefosine–Allopurinol Combination. Item: Title: 8.3.10.6   |   Allopurinol–Aminosidine Combination. Item: Title: 8.4   |   Immunomodulators Children: Item: Title: 8.4.1   |   Domperidone Item: Title: 8.4.2   |   Nutritional Supplements Item: Title: 8.4.3   |   Monoclonal Antibody Against Canine IL-10 Receptor Item: Title: 8.4.4   |   Vaccines Item: Title: 8.5   |   Combinations of Drugs With Direct Anti-Leishmania Activity and Immunomodulators Children: Item: Title: 8.5.1   |   Meglumine Antimoniate-Nutritional Supplement Combination Item: Title: 8.5.2   |   Meglumine Antimoniate-Vaccines Combination Item: Title: 8.5.3   |   Meglumine Antimoniate–Allopurinol–Domperidone Combination Item: Title: 8.5.4   |   Meglumine Antimoniate–Allopurinol–Deslorelin Combination Item: Title: 8.5.5   |   Allopurinol–Metronidazole–Ketoconazole-n-3 Fatty Acid–B Vitamin Combination Item: Title: 8.5.6   |   Allopurinol–Vaccine Combination Item: Title: 8.6   |   Symptomatic Treatment Item: Title: 8.7   |   Treatment of Concurrent Diseases Item: Title: 8.8   |   Measures Against Sand Fly Bites Item: Title: 8.9   |   Treatment Monitoring Item: Title: 8.10   |   Treatment Discontinuation and Follow-Up Children: Item: Title: 8.10.1   |   Summary of Recommendations for the Treatment of CanL due to L. infantum Item: Title: 9   |   Prevention of Canine Leishmaniosis Children: Item: Title: 9.1   |   Insect Repellents Children: Item: Title: 9.1.1   |   Deltamethrin 4% Collar Item: Title: 9.1.2   |   Flumethrin 4.5% Plus Imidacloprid 10% Collar Item: Title: 9.1.3   |   Permethrin 50% Plus Imidacloprid 10% Spot-On Item: Title: 9.2   |   Environmental Insecticides Item: Title: 9.3   |   Indoor Confinement and Use of Fine Mesh Nets Item: Title: 9.4   |   Not Using Infected Dogs as Blood Donors Item: Title: 9.5   |   Not Using Infected Dogs as Breeding Animals Item: Title: 9.6   |   Vaccines Children: Item: Title: 9.6.1   |   Autoclaved L. major Promastigote Vaccine Item: Title: 9.6.2   |   Excreted–Secreted Proteins (Antigens) From Amastigotes of L. infantum Item: Title: 9.6.3   |   Fucose-Mannose Ligand (FML) of L. donovani Item: Title: 9.6.4   |   LiF2 L. infantum Promastigote Fraction Item: Title: 9.6.5   |   Live Gentamycin-Attenuated L. infantum (H Line) Item: Title: 9.6.6   |   Protein A2 Vaccine Item: Title: 9.6.7   |   Protein Leish111f or MML) Item: Title: 9.6.8   |   Protein Q Vaccine Item: Title: 9.7   |   Immunomodulators Children: Item: Title: 9.7.1   |   Domperidone Item: Title: 9.7.2   |   Nutritional Supplements Item: Title: 9.8   |   Miscellaneous Children: Item: Title: 9.8.1   |   Summary of Recommendations for the Prevention of CanL due to L. infantum Item: Title: 10   |   Canine Leishmaniosis due to Species Other Than L. infantum Item: Title: 11   |   Future Trends Item: Title: Author Contributions Item: Title: Acknowledgements Item: Title: Disclosure Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: 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