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Title:           Sleep-related changes in astrocytic biomarkers are modulated by APOE ε4 genotype in cognitively unimpaired adults
Subject:         DOI: 10.1093/braincomms/fcaf437; Brain Communications, 7, 6, 2025-11-07.; Abstract: Astrocytes are key regulators of sleep and neuroinflammatory responses. However, the relationship between objective sleep parameters and astrocytic fluid biomarkers in cognitively unimpaired individuals remains unclear. We examined how sleep architecture relates to astrocytic, neuroaxonal and Alzheimer’s disease-related fluid biomarkers in cognitively unimpaired adults and whether age, sex and APOE ε4 moderate these associations. This cross-sectional study included 51 cognitively unimpaired participants from the Sant Pau Initiative on Neurodegeneration cohort. One-night in-lab polysomnography was used to quantify sleep architecture, fragmentation, slow-wave activity and respiratory parameters. CSF biomarkers included glial fibrillary acidic protein (GFAP), chitinase-like-3 protein 1 (YKL-40), Aβ42, Aβ40, pTau181 and tTau; plasma biomarkers included GFAP and neurofilament light chain (NfL). Association
Keywords:        astrocytes; Alzheimer’s disease-related proteins; polysomnography; apolipoprotein ε4; cognitively unimpaired individual
Author:          Nuole Zhu
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     Item: 
      Title: Sleep-related changes in astrocytic biomarkers are modulated by APOE ε4 genotype in cognitively unimpaired adults
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       Item: 
        Title: Introduction
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       Item: 
        Title: Materials and methods
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        Children: 
         Item: 
          Title: Ethics approval and consent to participate
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         Item: 
          Title: Participants and study design
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         Item: 
          Title: Polysomnography
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         Item: 
          Title: Blood and CSF collection and analysis
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          Title: APOE status determination
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         Item: 
          Title: Statistical analyses
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Participants characteristics
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         Item: 
          Title: Bivariate associations between sleep parameters and fluid biomarkers
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         Item: 
          Title: Multivariate associations between sleep parameters and astrocytic-neuroaxonal fluid biomarkers
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         Item: 
          Title: Multivariate associations between sleep parameters and CSF Alzheimer’s disease-related proteins
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         Item: 
          Title: Moderating effects of APOE ε4, age and sex on the associations between sleep parameters and fluid biomarkers
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        Title: Discussion
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         Item: 
          Title: Strengths and limitations
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       Item: 
        Title: Conclusion
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       Item: 
        Title: Competing interests
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
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    Title: Sleep-related changes in astrocytic biomarkers are modulated by APOE ε4 genotype in cognitively unimpaired adults
    Author: Nuole Zhu
    Subject: DOI: 10.1093/braincomms/fcaf437; Brain Communications, 7, 6, 2025-11-07.; Abstract: Astrocytes are key regulators of sleep and neuroinflammatory responses. However, the relationship between objective sleep parameters and astrocytic fluid biomarkers in cognitively unimpaired individuals remains unclear. We examined how sleep architecture relates to astrocytic, neuroaxonal and Alzheimer’s disease-related fluid biomarkers in cognitively unimpaired adults and whether age, sex and APOE ε4 moderate these associations. This cross-sectional study included 51 cognitively unimpaired participants from the Sant Pau Initiative on Neurodegeneration cohort. One-night in-lab polysomnography was used to quantify sleep architecture, fragmentation, slow-wave activity and respiratory parameters. CSF biomarkers included glial fibrillary acidic protein (GFAP), chitinase-like-3 protein 1 (YKL-40), Aβ42, Aβ40, pTau181 and tTau; plasma biomarkers included GFAP and neurofilament light chain (NfL). Association
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  Checksum: d3d59282
   Type: CRC32
  Checksum: 756ecc2bb7e85ae1f520b6c677e2cc74
   Type: MD5
  Checksum: f65096f740038f4f98b621650e02337ecb10708c
   Type: SHA-1
  Checksum: 1b1395489646396e70a35e288afbe94039dc098dd7761ccb92d3f483b1ec30c2
   Type: SHA-256