612e4ade2613ae3804a7853484e50ad2 jcm-14-07771-v3.pdf 67ea47cf098aeb06e39b62b2013321cbf8243938 jcm-14-07771-v3.pdf 0b57b6b2c2162e4c8268b69fb93e402bdc167a955814c91c258eb7df7c0e2798 jcm-14-07771-v3.pdf Title: Efficacy of Autologous Conditioned Serum on the Dorsal Root Ganglion in Patients with Chronic Radicular Pain: Prospective Randomized Placebo-Controlled Double Blind Clinical Trial (RADISAC Trial) Subject: Background: Pulsed radiofrequency (PRF) applied to the dorsal root ganglion (DRG) has been proposed as an effective neuromodulator treatment for persistent radicular pain. Autologous conditioned serum (ACS) therapy, derived from the patient’s own blood, offers a conservative approach. This study aims to evaluate the efficacy of ACS applied to the DRG as an adjunct in treating lower limb radicular pain (LLRP). Methods: A prospective, randomized, double-blind, placebo-controlled clinical trial was conducted comparing PRF combined with ACS versus PRF with physiological saline (PhS) on the DRG. Seventy patients (35 per group) with radicular pain lasting 6 months and refractory to previous treatments were enrolled. The primary outcome measure was the Numeric Pain Rating Scale (NPRS); secondary measures included the Oswestry Disability Index (ODI), Mood Assessment Scale (MOAS), SF-12 quality of life questionnaire, and DN4 neuropathic pain scale. Assessments occurred at baseline, 1 month, 3 months, 6 months, and 12 months post-intervention. Results: A total of 70 patients were included. The ACS group showed a significant reduction in pain compared to controls at 30 days (p < 0.05). Additionally, neuropathic symptoms such as tingling, numbness, stubbing, and burning decreased significantly in the ACS group during this period (p < 0.05). While both groups experienced pain reduction over time, no significant differences persisted at 6 months. No adverse effects were reported. Conclusions: The addition of ACS to PRF provides a short-term, statistically significant reduction in radicular pain at 30 days, suggesting it is a safe and effective adjunct therapy for lower limb radicular pain. Keywords: lower limb radicular pain; lumbar radicular pain; autologous conditioned serum; pulsed radiofrequency; dorsal root ganglion Author: Marta Homs, Raimon Milà, Jordi Recasens, Diego Delgado, Rosa Maria Borràs, Ricard Valdés and David Parés Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25; modified using OpenPDF 1.4.2 CreationDate: Wed Nov 5 02:53:04 2025 CET ModDate: Wed Nov 5 03:08:22 2025 CET Custom Metadata: yes Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1288034 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HQBQWV+VnURWPalladioL Type 1 Custom yes yes yes 124 0 FFDGWE+CMSY10 Type 1 Builtin yes yes yes 125 0 GSAWPE+URWPalladioL-Roma Type 1 Custom yes yes yes 126 0 ADHSVO+URWPalladioL-Ital Type 1 Custom yes yes yes 127 0 ADQKWX+URWPalladioL-Bold Type 1 Custom yes yes yes 128 0 WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 129 0 HGDCFI+PalatinoLinotype TrueType WinAnsi yes yes no 218 0 HGDCFI+PalatinoLinotype TrueType WinAnsi yes yes no 225 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes yes 271 0 HGDCGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 287 0 HGDCFI+PalatinoLinotype TrueType WinAnsi yes yes no 288 0 HGDCFG+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 289 0 HGDEMO+PalatinoLinotype,BoldItalic TrueType WinAnsi yes yes no 290 0 HGDCGJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 313 0 HGDCFI+PalatinoLinotype TrueType WinAnsi yes yes no 314 0 LWLIVD+EURM10 Type 1 Builtin yes yes yes 359 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-26 03:10:55 CET RepresentationInformation: jcm-14-07771-v3.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-25 10:43:16 CET Size: 1288034 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 560 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Study Design Item: Title: Study Population Item: Title: Preparation of ACS Item: Title: Treatment Administration Item: Title: Clinical Outcomes Item: Title: Safety Outcomes Item: Title: Sample Size Calculation Item: Title: Statistical Analysis Item: Title: Results Children: Item: Title: Patient Characteristics Item: Title: Clinical Evaluation Item: Title: Safety Evaluation Item: Title: Discussion Item: Title: Conclusions Item: Title: References Info: Title: Efficacy of Autologous Conditioned Serum on the Dorsal Root Ganglion in Patients with Chronic Radicular Pain: Prospective Randomized Placebo-Controlled Double Blind Clinical Trial (RADISAC Trial) Author: Marta Homs, Raimon Milà, Jordi Recasens, Diego Delgado, Rosa Maria Borràs, Ricard Valdés and David Parés Subject: Background: Pulsed radiofrequency (PRF) applied to the dorsal root ganglion (DRG) has been proposed as an effective neuromodulator treatment for persistent radicular pain. Autologous conditioned serum (ACS) therapy, derived from the patient’s own blood, offers a conservative approach. This study aims to evaluate the efficacy of ACS applied to the DRG as an adjunct in treating lower limb radicular pain (LLRP). Methods: A prospective, randomized, double-blind, placebo-controlled clinical trial was conducted comparing PRF combined with ACS versus PRF with physiological saline (PhS) on the DRG. Seventy patients (35 per group) with radicular pain lasting 6 months and refractory to previous treatments were enrolled. The primary outcome measure was the Numeric Pain Rating Scale (NPRS); secondary measures included the Oswestry Disability Index (ODI), Mood Assessment Scale (MOAS), SF-12 quality of life questionnaire, and DN4 neuropathic pain scale. Assessments occurred at baseline, 1 month, 3 months, 6 months, and 12 months post-intervention. Results: A total of 70 patients were included. The ACS group showed a significant reduction in pain compared to controls at 30 days (p < 0.05). Additionally, neuropathic symptoms such as tingling, numbness, stubbing, and burning decreased significantly in the ACS group during this period (p < 0.05). While both groups experienced pain reduction over time, no significant differences persisted at 6 months. No adverse effects were reported. Conclusions: The addition of ACS to PRF provides a short-term, statistically significant reduction in radicular pain at 30 days, suggesting it is a safe and effective adjunct therapy for lower limb radicular pain. 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