23d6a4ed3821628c0f5e2a32ed2c97b7 322583.pdf db8cc4ce759063c2ed3f64e36fd8b39c53b0ffec 322583.pdf d22c67948f1bb689a187d4b2463fd1d770029184876e2f9c3ec3e280473af4f6 322583.pdf Title: HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome Subject: Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia—characterized by altered levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)—plays a crucial role in the disorder’s progression. This review aims to elucidate the intricate interplay between HDL-C and TG within the context of lipid metabolism and cardiovascular health, while also addressing the detrimental impact of various cardiovascular risk factors and associated comorbidities. The dynamics of HDL-C and TG are explored, highlighting their reciprocal relationship and respective contributions to the pathophysiology of MetS. Elevated levels of TGs are consistently associated with reduced concentrations of HDL-C, resulting in a lipid profile that promotes the development of vascular disease. Specifically, as TG levels rise, the protective cardiovascular effects of HDL-C are diminished, leading to the increased accumulation of pro-atherogenic TG-rich lipoproteins and low-density lipoprotein particles within the vascular wall, contributing to the progression of atheromas, which can ultimately result in significant ischemic cardiovascular events. Ultimately, this paper underscores the significance of HDL and TG as essential targets for therapeutic intervention, emphasizing their potential in effectively managing MetS and reducing cardiovascular risk. Keywords: triglycerides; HDL; metabolic syndrome; lipid metabolism; reverse cholesterol transport; antioxidant activity; insulin resistance; atherosclerosis; cardiovascular disease Author: Sebastià Alcover, Lisaidy Ramos-Regalado, Gabriela Girón, Natàlia Muñoz-García and Gemma Vilahur Creator: LaTeX with hyperref Producer: MiKTeX pdfTeX-1.40.24 CreationDate: Thu Apr 3 15:16:47 2025 CEST ModDate: Thu Apr 3 16:36:30 2025 CEST Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2668863 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes yes 10 0 MGZXEQ+VnURWPalladioL Type 1 Custom yes yes yes 16 0 KLSFDR+URWPalladioL-Roma Type 1 Custom yes yes yes 21 0 HKVSUU+URWPalladioL-Bold Type 1 Custom yes yes yes 27 0 OSSDNK+URWPalladioL-Ital Type 1 Custom yes yes yes 32 0 KDEBLH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 71 0 KDEBLI+PalatinoLinotype CID TrueType Identity-H yes yes yes 74 0 KDEBLJ+PalatinoLinotype TrueType WinAnsi yes yes no 80 0 KDEBML+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 83 0 KDECBK+PalatinoLinotype TrueType MacRoman yes yes no 86 0 GOCQIR+EURM10 Type 1 Builtin yes yes yes 94 0 KDEBLH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 109 0 KDEBLI+PalatinoLinotype CID TrueType Identity-H yes yes yes 112 0 KDEBLJ+PalatinoLinotype TrueType WinAnsi yes yes no 118 0 KDEBML+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 121 0 KDECBK+PalatinoLinotype TrueType MacRoman yes yes no 124 0 TNHTZS+CMSY10 Type 1 Builtin yes yes yes 137 0 KDEBLH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 152 0 KDEBLI+PalatinoLinotype CID TrueType Identity-H yes yes yes 155 0 KDEBLJ+PalatinoLinotype TrueType WinAnsi yes yes no 161 0 KDEBML+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 164 0 KDECBK+PalatinoLinotype TrueType MacRoman yes yes no 167 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-11-28 04:33:13 CET RepresentationInformation: 322583.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-11-27 08:30:29 CET Size: 2668863 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 816 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: The Metabolic Syndrome: Epidemiology and Introduction Destination: section.1 Item: Title: TG and HDL Biogenesis Destination: section.2 Item: Title: Understanding HDL: Insights into Functional and Dysfunctional Particles Destination: section.3 Children: Item: Title: HDL Particles: Structure and Composition Destination: subsection.3.1 Item: Title: Functional HDL Particles Destination: subsection.3.2 Children: Item: Title: Antioxidant Properties Destination: subsubsection.3.2.1 Item: Title: Vasodilatory and Antithrombotic Properties Destination: subsubsection.3.2.2 Item: Title: Glucose Metabolism Destination: subsubsection.3.2.3 Item: Title: Others Destination: subsubsection.3.2.4 Item: Title: HDL Adverse Remodelling: The Impact of Cardiovascular Risk Factors and Comorbid Conditions in HDL Functionality Destination: subsection.3.3 Item: Title: The Role of TG and FFAA in Metabolic and Cardiovascular Risk Destination: section.4 Children: Item: Title: FFAA and Lipid Metabolism: TG-Rich Lipoproteins and Remnant Lipoprotein Particles Destination: subsection.4.1 Item: Title: FFAA and Glucose Control Destination: subsection.4.2 Item: Title: FFAA Levels and the Vascular Tone Destination: subsection.4.3 Item: Title: The TG/HDL-C Ratio Destination: section.5 Item: Title: Therapeutic Management to Target TG and HDL-C Levels Destination: section.6 Children: Item: Title: Lifestyle Changes Destination: subsection.6.1 Item: Title: Drug Therapy Destination: subsection.6.2 Children: Item: Title: Effort to Improve Primary Cardiovascular Endpoints by Increasing HDL-C Levels or HDL-Mimetics Destination: subsubsection.6.2.1 Item: Title: Others Therapeutic Strategies Destination: subsubsection.6.2.2 Item: Title: Future Perspectives and Directions Destination: section.7 Item: Title: References Destination: section.8 Info: Title: HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome Author: Sebastià Alcover, Lisaidy Ramos-Regalado, Gabriela Girón, Natàlia Muñoz-García and Gemma Vilahur Subject: Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic disorders that significantly elevate the risk of cardiovascular disease, making it a pressing public health concern worldwide. Among the key features of MetS, dyslipidemia characterized by altered levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) plays a crucial role in the disorder’s progression. This review aims to elucidate the intricate interplay between HDL-C and TG within the context of lipid metabolism and cardiovascular health, while also addressing the detrimental impact of various cardiovascular risk factors and associated comorbidities. The dynamics of HDL-C and TG are explored, highlighting their reciprocal relationship and respective contributions to the pathophysiology of MetS. Elevated levels of TGs are consistently associated with reduced concentrations of HDL-C, resulting in a lipid profile that promotes the development of vascular disease. Specifically, as TG levels rise, the protective cardiovascular effects of HDL-C are diminished, leading to the increased accumulation of pro-atherogenic TG-rich lipoproteins and low-density lipoprotein particles within the vascular wall, contributing to the progression of atheromas, which can ultimately result in significant ischemic cardiovascular events. Ultimately, this paper underscores the significance of HDL and TG as essential targets for therapeutic intervention, emphasizing their potential in effectively managing MetS and reducing cardiovascular risk. 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