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Title:           Whole Genome Sequencing Analysis of Klebsiella pneumoniae Isolates from Health Care–Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study
Subject:         DOI: 10.1093/ofid/ofaf164; Open Forum Infectious Diseases, 12, 4, 2025-03-15.; Abstract:  Background: The objective of this study was to assess the microbiological and clinical features of Klebsiella pneumoniae health care–associated bacteremia of urinary origin (HCA-BUO) in Spain, with a focus on third-generation cephalosporin-(3GCR-Kp) and carbapenem-resistant K pneumoniae (CR-Kp) isolates. Methods: A total of 96 (21.4%, 96/449) K pneumoniae blood isolates were prospectively collected from patients with HCA-BUO (n = 443) from 12 tertiary care hospitals in Spain (2017–2019). Antimicrobial susceptibility was determined (standard broth microdilution), and extended-spectrum β-lactamase, AmpC, and carbapenemase production was screened. A subset of 55 K pneumoniae isolates was analyzed by whole genome sequencing (Illumina) to determine population structure, resistome, and virulome. Additionally, 13 of these isolates were subjected to long-read sequencing (Nanopore) for plasmid characteri
Keywords:        carbapenemase-producing Enterobacterales; extended-spectrum β-lactamases; health care–associated infections; Klebsiella pneumoniae; ST307 clone
Author:          Federico Becerra-Aparicio
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      Title: Whole Genome Sequencing Analysis of Klebsiella pneumoniae Isolates from Health Care Associated Bacteremia of Urinary Origin in Spain: Findings from the Multicenter ITUBRAS-2 Cohort Study
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        Title: METHODS
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          Title: Study Design and Bacterial Isolates
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          Title: Bacterial Identification and Antimicrobial Susceptibility Testing
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          Title: Detection of β-Lactamase Enzymes
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          Title: WGS and Bioinformatic Analysis
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          Title: Clinical Features and Definitions
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          Title: Statistical Analysis
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        Title: RESULTS
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          Title: K pneumoniae Prevalence, Antimicrobial Susceptibility, and β-Lactamase Production
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          Title: WGS, Population Structure, and HiRCs
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          Title: Antibiotic Resistance Determinants
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          Title: Characterization of Plasmids Carrying ESBLs and Carbapenemase Genes
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          Title: Virulence Gene Content
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          Title: Clinical Variables Associated With K pneumoniae Episodes
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        Title: DISCUSSION
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  Checksum: ee1a95cb
   Type: CRC32
  Checksum: 10e0dbf3cbc5611ded053da2adc316b0
   Type: MD5
  Checksum: da35e77cc2b7b7cc215b23b45eb324029f9b93d1
   Type: SHA-1
  Checksum: ce842d0a54a793ec39d540eb0ab27e8cea3cfac5446fbde73e137509d8ddbc5d
   Type: SHA-256