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Linearized PDF PDFMetadata: Objects: 477 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer’s disease Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study design and participants Destination: subsection..1.2.1 Item: Title: 2.2 | Biomarker measurements Destination: subsection..1.2.2 Item: Title: 2.3 | Statistical analysis Destination: subsection..1.2.3 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Cohort characteristics Destination: subsection..1.3.1 Item: Title: 3.2 | Correlations with biomarkers and cognition Destination: subsection..1.3.2 Item: Title: 3.3 | Plasma p-tau212 levels are increased in asymptomatic Down syndrome Destination: subsection..1.3.3 Item: Title: 3.4 | Plasma and CSF p-tau212 increase along the AD continuum in DSAD and sporadic AD Destination: subsection..1.3.4 Item: Title: 3.5 | Plasma p-tau212 has greater diagnostic accuracy than p-tau181 Destination: subsection..1.3.5 Item: Title: 3.6 | Plasma p-tau212 increases approximately parallel to amyloid PET positivity and has great accuracy in discriminating between Ab+ and Ab− participants Destination: subsection..1.3.6 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: ETHICS STATEMENT Destination: section*.8 Item: Title: ORCID Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Info: Title: Plasma p‐tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease Author: Subject: Keywords: Creator: LaTeX with hyperref package 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