c4193a1ba534ab702550d96a77d02d50 322725.pdf e3025cb28b487cb5fcd12d6ab1543ee873e462c4 322725.pdf af7b2e434b882354d55c03537c7084e3d5ac303c622c5c4beeecb7cd81b7130d 322725.pdf Title: Managing Preoperative Anxiety and Thromboprophylaxis in Children Undergoing Urological Procedures: An Update of the European Association of Urology/European Society for Paediatric Urology Guidelines on Paediatric Urology Subject: European Urology Open Science, 75 (2025) doi:10.1016/j.euros.2025.02.006 Keywords: Premedication,Midazolam,Clonidine,Analgesia,Anaesthesia,Antithrombotic prophylaxis,Thromboembolism,Catheter-associated thrombosis Author: Michele Gnech Creator: Elsevier Producer: Acrobat DC CreationDate: Tue Apr 15 03:17:57 2025 CEST ModDate: Tue Apr 15 16:29:49 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 310223 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DDJKKB+AdvGulliv-R Type 1C Custom yes yes no 993 0 DDJKMD+AdvPSHEL-B Type 1C WinAnsi yes yes no 995 0 DDJKIO+AdvGulliv-B Type 1C WinAnsi yes yes no 997 0 DDJKIP+AdvP4DF612 Type 1C WinAnsi yes yes no 999 0 DDJKJA+AdvP4DF611 Type 1C WinAnsi yes yes no 1001 0 DDJKKC+AdvGulliv-I Type 1C Custom yes yes no 1003 0 DDJKKD+AdvPSSym Type 1C Custom yes yes yes 1006 0 DDJLFB+AdvPSMP13 Type 1C WinAnsi yes yes no 44 0 DDKBOK+AdvGulli-BI Type 1C WinAnsi yes yes no 47 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-12-11 04:12:20 CET RepresentationInformation: 322725.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-12-10 09:47:34 CET Size: 310223 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'Linknote_t0010' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'Linknote_t0005' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Linknote_t0010' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'Linknote_t0005' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para2' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found ID: PDF-HUL-122 Offset: 299655 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found ID: PDF-HUL-122 Offset: 299655 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN-US Outlines: Item: Title: Managing Preoperative Anxiety and Thromboprophylaxis in Children Undergoing Urological Procedures: An Update of the European Association of Urology/European Society for Paediatric Urology Guidelines on Paediatric Urology Destination: 1 Children: Item: Title: 1 Introduction Destination: 1 Item: Title: 2 Methods Destination: 1 Item: Title: 3 Evidence synthesis Destination: 1 Children: Item: Title: 3.1 Preventative measures against anxiety Destination: 1 Children: Item: Title: 3.1.1 Nonmedical preventative measures Destination: 1 Item: Title: 3.1.2 Premedication Destination: 1 Children: Item: Title: 3.1.2.1 Midazolam Destination: 1 Item: Title: 3.1.2.2 Clonidine Destination: 1 Item: Title: 3.1.2.3 Dexmedetomidine Destination: 1 Item: Title: 3.1.2.4 Ketamine Destination: 1 Item: Title: 3.1.2.5 Melatonin Destination: 1 Item: Title: 3.1.2.6 Topical analgesia Destination: 1 Item: Title: 3.1.2.7 Children with “special needs” Destination: 1 Item: Title: 3.2 Antithrombotic prophylaxis Destination: 1 Children: Item: Title: 3.2.1 Diagnostic evaluation Destination: 1 Item: Title: 3.2.2 Laboratory evaluation before surgery Destination: 1 Item: Title: 3.2.3 Perioperative antithrombotic prophylaxis Destination: 1 Children: Item: Title: 3.2.3.1 Physical interventions Destination: 1 Item: Title: 3.2.3.2 Pharmacological methods Destination: 1 Item: Title: 3.2.3.3 Identification of patients with indication for pharmacological antithrombotic prophylaxis Destination: 1 Item: Title: 4 Conclusions Destination: 1 Item: Title: Appendix A Supplementary material Destination: 1 Item: Title: References Destination: 1 Filters: FilterPipeline: FlateDecode FilterPipeline: CCITTFaxDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/tiff CompressionScheme: CCITT Group 4 ImageWidth: 1651 ImageHeight: 466 BitsPerSample: 1 BitsPerSampleUnit: integer ImageMask: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 296 ImageHeight: 373 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 65 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 1000 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 65 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 37 ImageHeight: 65 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1000 ImageHeight: 1000 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DDJKKB+AdvGulliv-R FontSubset: true FirstChar: 28 LastChar: 252 FontDescriptor: FontName: DDJKKB+AdvGulliv-R Flags: Serif, Nonsymbolic FontBBox: -104, -250, 1041, 979 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DDJKMD+AdvPSHEL-B FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: DDJKMD+AdvPSHEL-B Flags: Nonsymbolic FontBBox: -166, -218, 1000, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DDJKIO+AdvGulliv-B FontSubset: true FirstChar: 46 LastChar: 150 FontDescriptor: FontName: DDJKIO+AdvGulliv-B Flags: Serif, Nonsymbolic FontBBox: -145, -239, 1125, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DDJKIP+AdvP4DF612 FontSubset: true FirstChar: 44 LastChar: 168 FontDescriptor: FontName: DDJKIP+AdvP4DF612 Flags: Serif, Nonsymbolic FontBBox: -145, -229, 1083, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DDJKJA+AdvP4DF611 FontSubset: true FirstChar: 42 LastChar: 44 FontDescriptor: FontName: DDJKJA+AdvP4DF611 Flags: Nonsymbolic FontBBox: -125, -239, 1052, 822 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DDJKKC+AdvGulliv-I FontSubset: true FirstChar: 30 LastChar: 243 FontDescriptor: FontName: DDJKKC+AdvGulliv-I Flags: Serif, Nonsymbolic FontBBox: -135, -229, 1052, 968 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DDJLFB+AdvPSMP13 FontSubset: true FirstChar: 108 LastChar: 108 FontDescriptor: FontName: DDJLFB+AdvPSMP13 Flags: Serif, Nonsymbolic FontBBox: 0, -302, 958, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DDJKKD+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DDJKKD+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DDKBOK+AdvGulli-BI FontSubset: true FirstChar: 47 LastChar: 117 FontDescriptor: FontName: DDKBOK+AdvGulli-BI Flags: Serif, Nonsymbolic FontBBox: -166, -239, 1135, 989 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.euros.2025.02.006 The Author(s) European Urology Open Science, 75 (2025) doi:10.1016/j.euros.2025.02.006 Premedication Midazolam Clonidine Analgesia Anaesthesia Antithrombotic prophylaxis Thromboembolism Catheter-associated thrombosis Managing Preoperative Anxiety and Thromboprophylaxis in Children Undergoing Urological Procedures: An Update of the European Association of Urology/European Society for Paediatric Urology Guidelines on Paediatric Urology Michele Gnech Lisette ’t Hoen Martin Skott Guy Bogaert Marco Castagnetti Fardod O’Kelly Josine Quaedackers Yazan F. Rawashdeh Uchenna Kennedy Allon van Uitert Yuhong Yuan Marco Capecchi Andrea Artoni Gülhan Karaöz-Bulut Niklas Pakkasjärvi Berk Burgu Anna Bujons Mesrur Selcuk Silay Christian Radmayr journal European Urology Open Science © 2025 The Author(s). Published by Elsevier B.V. on behalf of European Association of Urology. 2666-1683 75 May 2025 10.1016/j.euros.2025.02.006 https://doi.org/10.1016/j.euros.2025.02.006 2010-04-23 true 10.1016/j.euros.2025.02.006 elsevier.com sciencedirect.com VoR 10.1016/j.euros.2025.02.006 noindex 2010-04-23 true 7.0.1 sciencedirect.com elsevier.com sciencedirect.com elsevier.com Elsevier 2025-04-15T06:47:57+05:30 2025-04-15T19:59:49+05:30 2025-04-15T19:59:49+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json Acrobat DC False Premedication,Midazolam,Clonidine,Analgesia,Anaesthesia,Antithrombotic prophylaxis,Thromboembolism,Catheter-associated thrombosis uuid:ef5d99b0-7bc9-409a-997f-1f86884346e9 uuid:c77b92a2-0810-4923-9a82-625cd172cfe3 1 http://creativecommons.org/licenses/by-nc-nd/4.0/ Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: Link Rect: 126, 490, 131, 501 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 138, 487, 143, 500 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 223, 490, 228, 501 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 306, 490, 310, 501 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 380, 490, 385, 501 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 486, 490, 490, 501 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 127, 476, 130, 487 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 132, 476, 136, 487 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 242, 476, 247, 487 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 359, 476, 362, 487 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 461, 476, 464, 487 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 134, 461, 137, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 213, 461, 217, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 219, 461, 222, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 309, 461, 317, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 319, 461, 324, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 403, 461, 408, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 524, 461, 528, 472 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 148, 447, 153, 458 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 154, 447, 159, 458 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 224, 447, 228, 458 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 300, 447, 304, 458 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 411, 447, 414, 458 Destination: 931 Annotation: Subtype: Link Contents: Link Rect: 518, 447, 523, 458 Destination: 931 Annotation: Subtype: Link Rect: 51, 424, 51, 431 Destination: null Annotation: Subtype: Link Rect: 408, 424, 408, 431 Destination: null Annotation: Subtype: Link Rect: 206, 414, 206, 421 Destination: null Annotation: Subtype: Link Rect: 51, 404, 51, 411 Destination: null Annotation: Subtype: Link Rect: 255, 404, 255, 411 Destination: null Annotation: Subtype: Link Rect: 94, 394, 94, 401 Destination: null Annotation: Subtype: Link Rect: 327, 394, 327, 401 Destination: null Annotation: Subtype: Link Rect: 468, 394, 468, 401 Destination: null Annotation: Subtype: Link Rect: 279, 384, 280, 391 Destination: null Annotation: Subtype: Link Rect: 94, 374, 94, 381 Destination: null Annotation: Subtype: Link Rect: 387, 374, 387, 381 Destination: null Annotation: Subtype: Link Rect: 159, 364, 159, 371 Destination: null Annotation: Subtype: Link Rect: 401, 364, 401, 371 Destination: null Annotation: Subtype: Link Rect: 156, 354, 156, 361 Destination: null Annotation: Subtype: Link Rect: 91, 344, 91, 351 Destination: null Annotation: Subtype: Link Rect: 392, 344, 392, 351 Destination: null Annotation: Subtype: Link Rect: 228, 334, 228, 341 Destination: null Annotation: Subtype: Link Rect: 51, 324, 51, 331 Destination: null Annotation: Subtype: Link Rect: 347, 324, 347, 331 Destination: null Annotation: Subtype: Link Rect: 252, 314, 252, 321 Destination: null Annotation: Subtype: Link Rect: 51, 304, 51, 311 Destination: null Annotation: Subtype: Link Contents: Link Rect: 51, 58, 196, 65 Annotation: Subtype: Link Contents: Link Rect: 159, 40, 326, 47 Annotation: Subtype: Link Contents: Link Rect: 518, 39, 546, 67 Annotation: Subtype: Link Contents: Link Rect: 270, 84, 375, 91 Annotation: Subtype: Link Rect: 183, 752, 332, 759 Annotation: Subtype: Link Contents: Link Rect: 183, 752, 332, 759 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Contents: Link Rect: 486, 468, 543, 475 Annotation: Subtype: Link Contents: Link Rect: 402, 458, 538, 465 Annotation: Subtype: Link Contents: Link Rect: 485, 175, 490, 184 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 437, 40, 442, 48 Destination: 15 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Contents: Link Rect: 178, 694, 183, 702 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 55, 614, 60, 622 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 155, 261, 160, 269 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 162, 261, 167, 269 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 97, 215, 102, 223 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 104, 215, 109, 223 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 128, 123, 148, 132 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 226, 43, 231, 51 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 350, 637, 360, 645 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 532, 467, 542, 475 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 491, 364, 520, 372 Destination: 5 Annotation: Subtype: Link Contents: Link Rect: 520, 364, 520, 372 Destination: null Annotation: Subtype: Link Contents: Link Rect: 342, 329, 347, 338 Destination: 15 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Contents: Link Rect: 189, 542, 194, 550 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 155, 360, 160, 369 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 162, 360, 173, 369 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 184, 213, 194, 222 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 196, 213, 206, 222 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 140, 89, 145, 97 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 147, 89, 158, 97 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 372, 475, 377, 483 Destination: 15 Annotation: Subtype: Link Contents: Link Rect: 470, 282, 480, 290 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 474, 139, 503, 148 Destination: 11 Annotation: Subtype: Link Contents: Link Rect: 503, 139, 503, 148 Destination: null Annotation: Subtype: Link Contents: Link Rect: 403, 71, 413, 79 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 415, 71, 425, 79 Destination: 19 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Contents: Link Rect: 265, 579, 275, 588 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 121, 545, 131, 553 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 275, 487, 285, 496 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 260, 442, 270, 450 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 236, 407, 246, 416 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 85, 373, 95, 381 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 97, 373, 107, 381 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 188, 316, 198, 324 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 200, 316, 211, 324 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 312, 281, 322, 290 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 444, 155, 455, 164 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 465, 66, 475, 74 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 477, 66, 487, 74 Destination: 19 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Contents: Link Rect: 50, 625, 60, 634 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 70, 273, 80, 281 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 50, 227, 60, 235 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 98, 112, 108, 121 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 340, 637, 350, 645 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 391, 330, 401, 339 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 481, 273, 491, 281 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 528, 216, 538, 224 Destination: 19 Annotation: Subtype: Link Contents: Link Rect: 435, 112, 446, 121 Destination: 19 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Contents: Link Rect: 308, 383, 483, 391 Annotation: Subtype: Link Contents: Link Rect: 325, 325, 547, 332 Annotation: Subtype: Link Contents: Link Rect: 325, 316, 547, 323 Annotation: Subtype: Link Contents: Link Rect: 325, 307, 547, 314 Annotation: Subtype: Link Contents: Link Rect: 325, 298, 380, 305 Annotation: Subtype: Link Contents: Link Rect: 325, 289, 547, 296 Annotation: Subtype: Link Contents: Link Rect: 325, 280, 547, 287 Annotation: Subtype: Link Contents: Link Rect: 325, 271, 545, 278 Annotation: Subtype: Link Contents: Link Rect: 325, 262, 547, 269 Annotation: Subtype: Link Contents: Link Rect: 325, 253, 468, 260 Annotation: Subtype: Link Contents: Link Rect: 325, 244, 547, 251 Annotation: Subtype: Link Contents: Link Rect: 325, 235, 547, 242 Annotation: Subtype: Link Contents: Link Rect: 325, 226, 547, 233 Annotation: Subtype: Link Contents: Link Rect: 325, 218, 392, 225 Annotation: Subtype: Link Contents: Link Rect: 325, 209, 547, 216 Annotation: Subtype: Link Contents: Link Rect: 325, 200, 547, 207 Annotation: Subtype: Link Contents: Link Rect: 325, 191, 447, 198 Annotation: Subtype: Link Contents: Link Rect: 325, 182, 547, 189 Annotation: Subtype: Link Contents: Link Rect: 325, 173, 547, 180 Annotation: Subtype: Link Contents: Link Rect: 325, 164, 388, 171 Annotation: Subtype: Link Contents: Link Rect: 325, 155, 547, 162 Annotation: Subtype: Link Contents: Link Rect: 325, 146, 547, 153 Annotation: Subtype: Link Contents: Link Rect: 325, 137, 435, 144 Annotation: Subtype: Link Contents: Link Rect: 325, 128, 547, 135 Annotation: Subtype: Link Contents: Link Rect: 325, 119, 547, 126 Annotation: Subtype: Link Contents: Link Rect: 325, 110, 547, 117 Annotation: Subtype: Link Contents: Link Rect: 325, 101, 399, 108 Annotation: Subtype: Link Contents: Link Rect: 325, 92, 547, 99 Annotation: Subtype: Link Contents: Link Rect: 325, 83, 547, 90 Annotation: Subtype: Link Contents: Link Rect: 325, 74, 547, 81 Annotation: Subtype: Link Contents: Link Rect: 325, 65, 547, 72 Annotation: Subtype: Link Contents: Link Rect: 325, 56, 384, 63 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Contents: Link Rect: 64, 718, 286, 725 Annotation: Subtype: Link Contents: Link Rect: 64, 709, 286, 716 Annotation: Subtype: Link Contents: Link Rect: 64, 700, 174, 707 Annotation: Subtype: Link Contents: Link Rect: 64, 691, 286, 698 Annotation: Subtype: Link Contents: Link Rect: 64, 683, 286, 690 Annotation: Subtype: Link Contents: Link Rect: 64, 674, 286, 681 Annotation: Subtype: Link Contents: Link Rect: 64, 665, 182, 672 Annotation: Subtype: Link Contents: Link Rect: 64, 656, 286, 663 Annotation: Subtype: Link Contents: Link Rect: 64, 647, 286, 654 Annotation: Subtype: Link Contents: Link Rect: 64, 638, 238, 645 Annotation: Subtype: Link Contents: Link Rect: 64, 629, 286, 636 Annotation: Subtype: Link Contents: Link Rect: 64, 620, 286, 627 Annotation: Subtype: Link Contents: Link Rect: 64, 611, 159, 618 Annotation: Subtype: Link Contents: Link Rect: 64, 602, 286, 609 Annotation: Subtype: Link Contents: Link Rect: 64, 593, 286, 600 Annotation: Subtype: Link Contents: Link Rect: 64, 584, 286, 591 Annotation: Subtype: Link Contents: Link Rect: 64, 575, 127, 582 Annotation: Subtype: Link Contents: Link Rect: 64, 566, 286, 573 Annotation: Subtype: Link Contents: Link Rect: 64, 557, 286, 564 Annotation: Subtype: Link Contents: Link Rect: 64, 548, 286, 555 Annotation: Subtype: Link Contents: Link Rect: 64, 539, 115, 546 Annotation: Subtype: Link Contents: Link Rect: 64, 530, 286, 537 Annotation: Subtype: Link Contents: Link Rect: 64, 521, 286, 528 Annotation: Subtype: Link Contents: Link Rect: 64, 512, 119, 519 Annotation: Subtype: Link Contents: Link Rect: 64, 503, 286, 510 Annotation: Subtype: Link Contents: Link Rect: 64, 494, 286, 501 Annotation: Subtype: Link Contents: Link Rect: 64, 485, 286, 492 Annotation: Subtype: Link Contents: Link Rect: 64, 476, 238, 483 Annotation: Subtype: Link Contents: Link Rect: 64, 467, 286, 474 Annotation: Subtype: Link Contents: Link Rect: 64, 458, 286, 465 Annotation: Subtype: Link Contents: Link Rect: 64, 449, 115, 456 Annotation: Subtype: Link Contents: Link Rect: 320, 718, 543, 725 Annotation: Subtype: Link Contents: Link Rect: 320, 709, 543, 716 Annotation: Subtype: Link Contents: Link Rect: 320, 700, 458, 707 Annotation: Subtype: Link Contents: Link Rect: 321, 691, 543, 698 Annotation: Subtype: Link Contents: Link Rect: 321, 683, 543, 690 Annotation: Subtype: Link Contents: Link Rect: 321, 674, 522, 681 Annotation: Subtype: Link Contents: Link Rect: 321, 665, 543, 672 Annotation: Subtype: Link Contents: Link Rect: 321, 656, 543, 663 Annotation: Subtype: Link Contents: Link Rect: 321, 647, 477, 654 Annotation: Subtype: Link Contents: Link Rect: 321, 638, 543, 645 Annotation: Subtype: Link Contents: Link Rect: 321, 629, 486, 636 Annotation: Subtype: Link Contents: Link Rect: 321, 575, 543, 582 Annotation: Subtype: Link Contents: Link Rect: 321, 566, 543, 573 Annotation: Subtype: Link Contents: Link Rect: 321, 557, 543, 564 Annotation: Subtype: Link Contents: Link Rect: 321, 548, 384, 555 Annotation: Subtype: Link Contents: Link Rect: 321, 539, 543, 546 Annotation: Subtype: Link Contents: Link Rect: 321, 530, 543, 537 Annotation: Subtype: Link Contents: Link Rect: 321, 521, 543, 528 Annotation: Subtype: Link Contents: Link Rect: 321, 512, 456, 519 Annotation: Subtype: Link Contents: Link Rect: 321, 503, 543, 510 Annotation: Subtype: Link Contents: Link Rect: 321, 494, 538, 501 Annotation: Subtype: Link Contents: Link Rect: 321, 485, 543, 492 Annotation: Subtype: Link Contents: Link Rect: 321, 476, 543, 483 Annotation: Subtype: Link Contents: Link Rect: 321, 467, 376, 474 Annotation: Subtype: Link Contents: Link Rect: 321, 458, 543, 465 Annotation: Subtype: Link Contents: Link Rect: 321, 449, 543, 456 Annotation: Subtype: Link Contents: Link Rect: 321, 440, 543, 447 Annotation: Subtype: Link Contents: Link Rect: 321, 431, 376, 438 Checksum: 772a7bac Type: CRC32 Checksum: c4193a1ba534ab702550d96a77d02d50 Type: MD5 Checksum: e3025cb28b487cb5fcd12d6ab1543ee873e462c4 Type: SHA-1 Checksum: af7b2e434b882354d55c03537c7084e3d5ac303c622c5c4beeecb7cd81b7130d Type: SHA-256