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Introduction Destination: mk:H1_1 Item: Title: 2 Experimental procedures Destination: mk:H1_2 Children: Item: Title: 2.1 Study design Destination: mk:H2_1 Item: Title: 2.2 Subjects Destination: mk:H2_2 Item: Title: 2.3 Clinical assessment Destination: mk:H2_3 Item: Title: 2.4 Cognitive assessment Destination: mk:H2_4 Item: Title: 2.5 Relapse definition Destination: mk:H2_5 Item: Title: 2.6 Biological samples Destination: mk:H2_6 Item: Title: 2.7 Methylation data collection Destination: mk:H2_7 Item: Title: 2.8 Methylation profile score calculation Destination: mk:H2_8 Item: Title: 2.9 Statistical analysis Destination: mk:H2_9 Item: Title: 3 Results Destination: mk:H1_3 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Author disclosure Destination: mk:H1_5 Children: Item: Title: Role of funding source Destination: mk:H2_10 Item: Title: Author contributions Destination: mk:H1_6 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: Acknowledgements 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10.1016/j.euroneuro.2025.02.003 Elsevier B.V. European Neuropsychopharmacology, 94 (2025) 4-15. doi:10.1016/j.euroneuro.2025.02.003 Schizophrenia Relapse Epigenetics Early stressful life events DNA methylation Methylation profile scores Methylation profile scores of environmental exposures and risk of relapse after a first episode of schizophrenia 2 Alex-González Segura Llucia Prohens Laura Julià Silvia Amoretti Maria RIbero Laura Pino-Camacho Guillermo Cano-Escalera Anna Mane Roberto Rodriguez-Jimenez Alexandra Roldan Salvador Sarró Angela Ibañez Judith Usall Antonio Lobo Clemente Garcia-Rizo Manuel Jesus Cuesta Mara Parellada Ana González-Pinto Esther Berrocoso Miquel Bernardo Sergi Mas Natalia Rodríguez Anaid Perez-Ramos Sergi Salmeron Javier González-Peñas Xaquín Gurriarán Adriana Farré Esther Pousa Iñaki Zorrilla Lorea Mar-Barrutia Amira Trabsa Laura Martinez Ángeles Sánchez-Cabezudo Estela Jiménez-López Edith Pomarol-Clotet Raymond Salvador Anna Butjosa Rubio-Abadal Elena Lucía Moreno-Izco Ana M. Sánchez Torres Jeronimo Saiz Leticia León-Quismondo Olga Rivero Leticia González-Blanco Concepción De-la-Cámara VoR 9th May 2025 Acrobat Distiller 8.1.0 (Windows) Schizophrenia,Relapse,Epigenetics,Early stressful life events,DNA methylation,Methylation profile scores 9th May 2025 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.euroneuro.2025.02.003 noindex journal © 2025 The Authors. 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