3d5d33fbed39267e7aed39f377fa11a7 322752.pdf 79dbe306e0625a7641cf79df7496d274d9d71fc9 322752.pdf dd8e2186c7451680ae5a89da724fc831759f416fa75cb5845d3e826d61f19ee2 322752.pdf Title: Current advances and unmet needs in Alzheimer's disease trials for individuals with Down syndrome: Navigating new therapeutic frontiers Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Tue Jun 17 12:11:29 2025 CEST ModDate: Tue Jun 17 12:12:12 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 891492 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- OLEDJM+STIXTwoMath Type 1C Custom yes yes yes 289 0 OLDMGI+Lato-Regular Type 1C WinAnsi yes yes no 294 0 OLEDHK+Lato-Bold 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Children: Item: Title: 1.1 | Recent advances in AD therapies Destination: subsection..1.1.1 Item: Title: 1.2 | Current state of clinical trials in AD and DS Destination: subsection..1.1.2 Children: Item: Title: 1.2.1 | TRC-DS Destination: subsubsection..1.1.2.1 Item: Title: 1.2.2 | ABATE Destination: subsubsection..1.1.2.2 Item: Title: 1.2.3 | HERO Destination: subsubsection..1.1.2.3 Item: Title: 1.2.4 | ALADDIN Destination: subsubsection..1.1.2.4 Item: Title: 1.2.5 | LESS-AD Destination: subsubsection..1.1.2.5 Item: Title: 1.3 | Main challenges in conducting trials Destination: subsection..1.1.3 Item: Title: 1.4 | Emerging trends and innovative approaches Destination: subsection..1.1.4 Item: Title: 1.5 | Future directions Destination: subsection..1.1.5 Item: Title: 2 | CONCLUSIONS Destination: section..1.2 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: REFERENCES Destination: section*.8 Item: Title: 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