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INTRODUCTION Destination: section..1.1 Item: Title: 2 | HISTORICAL BACKGROUND OF DS Destination: section..1.2 Children: Item: Title: 2.1 | An integral part of humanity since its origins Destination: subsection..1.2.1 Item: Title: 2.2 | The identification of DS as a specific form of ID Destination: subsection..1.2.2 Item: Title: 3 | HOW DS CONTRIBUTED TO THE CHARACTERIZATION OF AD Destination: section..1.3 Children: Item: Title: 3.1 | Pathological and histochemical similarities Destination: subsection..1.3.1 Item: Title: 3.2 | Clinical picture: the natural history of DSAD Destination: subsection..1.3.2 Item: Title: 3.3 | The impact of advocacy and deinstitutionalization in DS Destination: subsection..1.3.3 Item: Title: 4 | SHIFTING THE LENS: THE EVOLUTION OF APPROACHES TO MEDICAL RESEARCH IN DS Destination: section..1.4 Children: Item: Title: 4.1 | From pioneers to international consortia: overcoming barriers to inclusion Destination: subsection..1.4.1 Item: Title: 4.2 | Bridging the gap in DSAD research Destination: subsection..1.4.2 Item: Title: 4.3 | Clinical trials in DS: an opportunity we have yet to fully leverage Destination: subsection..1.4.3 Item: Title: 5 | CONCLUSION: A PATH FORWARD FOR DSAD Destination: section..1.5 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: CONSENT STATEMENT Destination: section*.8 Item: Title: ORCID Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Info: Title: The history of Down syndrome–associated Alzheimer's disease; past, present, and future Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Jun 04 11:29:51 CEST 2025 ModDate: Wed Jun 04 11:30:21 CEST 2025 ID: 0x0e822bbbe03bc85950f0ccd8a0d05c59, 0xa50db3ad81c13207eed2079a046d4c57 Filters: FilterPipeline: FlateDecode FilterPipeline: 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