c20350735adc91f91b7322237cc32fe3 322778.pdf b2e3c2d5e7b79ea46d5b099bb1c07280706b3012 322778.pdf 3c9cfb074718f494958f5fce8b3c5eb6ee4d4ab2950ade50e2830d0fba8c37bb 322778.pdf Title: Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Mon Jun 16 08:37:22 2025 CEST ModDate: Mon Jun 16 08:37:50 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1839257 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AAPLII+STIXTwoMath Type 1C Custom yes yes yes 458 0 AAPLIG+STIXMath-Regular Type 1C WinAnsi yes yes no 463 0 AAPLIH+STIXTwoText-Italic 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shows progression of dementia in individuals with Down syndrome Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | MATERIAL AND METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study participants Destination: subsection..1.2.1 Item: Title: 2.2 | Isolation of NDEVs from human plasma Destination: subsection..1.2.2 Item: Title: 2.3 | NDEV characterization Destination: subsection..1.2.3 Item: Title: 2.4 | Biomarker analysis Destination: subsection..1.2.4 Item: Title: 2.5 | Statistical analysis Destination: subsection..1.2.5 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Participants demographics Destination: subsection..1.3.1 Item: Title: 3.2 | Characterization of NDEVs Destination: subsection..1.3.2 Item: Title: 3.3 | AD biomarker levels in NDEVs Destination: subsection..1.3.3 Item: Title: 3.4 | Effects of biological sex on NDEV biomarker levels Destination: subsection..1.3.4 Item: Title: 3.5 | NDEV biomarker levels correlate with CSF and blood biomarkers Destination: subsection..1.3.5 Item: Title: 3.6 | Relationships between NDEV biomarker levels and cognitive measures Destination: subsection..1.3.6 Item: Title: 3.7 | Onset of dementia in DS is predicted by age and increase in NDEV biomarker levels Destination: subsection..1.3.7 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: CONSENT STATEMENT Destination: section*.8 Item: Title: ORCID Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Info: Title: Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat 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