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Title:           Prospective evaluation of plasma pTau
Subject:         Alzheimer's Research & Therapy, https://doi.org/10.1186/s13195-025-01779-7
Keywords:        Stability;Plasma;Biomarkers;Alzheimer;Blood;Amyloid;Tau
Author:           Javier Arranz 
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     Item: 
      Title: Prospective evaluation of plasma pTau217 stability for the detection of Alzheimer’s disease in a tertiary memory clinic
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Aims 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study participants and clinical classification
         Item: 
          Title: Sample collection and analysis
          Children: 
           Item: 
            Title: Blood and CSF protocols
         Item: 
          Title: Stability of samples and batch-to-batch variability (fridge vs freezer; lot-to-lot variability)
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Study participants
         Item: 
          Title: Accuracy, PPV and NPV of historical cutoffs and AUC of pTau217 in the prospective clinical cohort
         Item: 
          Title: Cutoffs calculated in the prospective evaluation
         Item: 
          Title: Variations in PPV, NPV, and global accuracy across different cutoff combinations in clinical scenarios with varying prevalence of amyloid pathology
         Item: 
          Title: Performance of historical cutoffs in the subset without CSF
         Item: 
          Title: Effect of chronic kidney disease on plasma pTau217 accuracy
         Item: 
          Title: Pre-analytical variability
          Children: 
           Item: 
            Title: Short-term storage conditions
         Item: 
          Title: Clinical vs. research protocol
         Item: 
          Title: Analytical variability: lot-to-lot variability
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
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