c6a4b67375856e01124b5cedd379b9ae  41467_2025_Article_65882.pdf
84ff197c6da352b99768518daa040a653e0fbd23  41467_2025_Article_65882.pdf
1ac7956b0f37ce21ecdaadecff738986636abb24323f5b67894e72d1672e40c1  41467_2025_Article_65882.pdf

Title:           Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome
Subject:         Nature Communications, doi:10.1038/s41467-025-65882-x
Keywords:        
Author:          Hanna Huber
Creator:         Springer
Producer:        iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Fri Nov  7 15:40:39 2025 CET
ModDate:         Mon Nov 10 16:53:03 2025 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           8
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       856573 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OIDFMN+AdvOT13119950                 Type 1C           WinAnsi          yes yes no      37  0
OIDILF+AdvOT0c200bf0                 Type 1C           WinAnsi          yes yes no      38  0
OIDILG+AdvOT0c200bf0+fb              Type 1C           Custom           yes yes yes     39  0
OIDIOG+AdvOT511ca30e.B               Type 1C           WinAnsi          yes yes no      40  0
OIDFMO+AdvOT89719618                 Type 1C           WinAnsi          yes yes no      48  0
OIDFMP+AdvOTa2fa4214.B               Type 1C           WinAnsi          yes yes no     491  0
OIDFNA+AdvOTa2fa4214.B+20            Type 1C           WinAnsi          yes yes no     492  0
OIDIHB+AdvOTdd63dae3                 Type 1C           WinAnsi          yes yes no      49  0
OIDIHC+AdvOTdd63dae3+20              Type 1C           WinAnsi          yes yes no      50  0
OIDIHD+AdvOTcc1f6510.I               Type 1C           WinAnsi          yes yes no      51  0
OIDIIE+AdvOTdd63dae3+03              Type 1C           Custom           yes yes yes     52  0
OIDIIF+AdvOTdd63dae3+fb              Type 1C           Custom           yes yes yes     53  0
OIDIPG+AdvOT3d287b35.B               Type 1C           WinAnsi          yes yes no      41  0
OIDIPH+AdvOT70e1938e                 Type 1C           WinAnsi          yes yes no      42  0
OIDIPI+AdvOT70e1938e+03              Type 1C           Custom           yes yes yes     43  0
OIDJAJ+AdvOT0c200bf0+03              Type 1C           Custom           yes yes yes     44  0
OIDJAK+AdvOT23e3f5cb.I               Type 1C           WinAnsi          yes yes no      45  0
OIDJAL+AdvOT23e3f5cb.I+03            Type 1C           Custom           yes yes yes     46  0
OIDJBM+AdvOT0c200bf0+20              Type 1C           WinAnsi          yes yes no      47  0
OIDJCM+AdvOTdd63dae3+22              Type 1C           Custom           yes yes yes     71  0
OIDKJF+Helvetica                     Type 1C           Custom           yes yes yes     72  0
OIDLDC+Helvetica-Bold                Type 1C           WinAnsi          yes yes no      73  0
OIDLIB+AdvOT13119950+fb              Type 1C           Custom           yes yes yes    134  0
OIDLMA+AdvOT23e3f5cb.I+20            Type 1C           WinAnsi          yes yes no     174  0
OIDLNB+AdvOT0c200bf0+01              Type 1C           Custom           yes yes no     175  0
OIDLPB+AdvOT13119950+20              Type 1C           WinAnsi          yes yes no     195  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-01-10 03:11:28 CET
 RepresentationInformation: 41467_2025_Article_65882.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-01-09 19:12:05 CET
  Size: 856573
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 631
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome
      Destination: title_link
      Children: 
       Item: 
        Title: Results
        Destination: A1
        Children: 
         Item: 
          Title: Participant characteristics
          Destination: B1
         Item: 
          Title: Plasma p-tau217 levels by clinical diagnosis and accuracy in discriminating diagnostic groups
          Destination: B2
         Item: 
          Title: Plasma p-tau217 levels by amyloid status and accuracy in discriminating abnormal Aβ
          Destination: B3
         Item: 
          Title: Plasma p-tau217 compared to p-tau181, p-tau231, NfL and GFAP
          Destination: B4
       Item: 
        Title: Discussion
        Destination: A2
       Item: 
        Title: Methods
        Destination: A3
        Children: 
         Item: 
          Title: Participants
          Destination: B5
         Item: 
          Title: Plasma, CSF, and imaging biomarkers
          Destination: B6
         Item: 
          Title: Statistics and reproducibility
          Destination: B7
         Item: 
          Title: Reporting summary
          Destination: B8
       Item: 
        Title: Data availability
        Destination: M1
       Item: 
        Title: References
        Destination: A4
       Item: 
        Title: Acknowledgements
        Destination: A5
       Item: 
        Title: Author contributions
        Destination: A6
       Item: 
        Title: Funding
        Destination: A7
       Item: 
        Title: Competing interests
        Destination: A8
       Item: 
        Title: Additional information
        Destination: M3
   Info: 
    Title: Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome
    Author: Hanna Huber
    Subject: Nature Communications, doi:10.1038/s41467-025-65882-x
    Keywords: 
    Creator: Springer
    Producer: iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Fri Nov 07 16:10:39 CET 2025
    ModDate: Mon Nov 10 16:53:03 CET 2025
   ID: 0x6bb5dc4c343555498f9cf1ab66fbb253, 0xc3005c05e006b03d48ebe5d809c7cae2
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 46
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1850
      ImageHeight: 972
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OIDLPB+AdvOT13119950+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OIDLPB+AdvOT13119950+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1156, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDLIB+AdvOT13119950+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OIDLIB+AdvOT13119950+fb
       Flags: Symbolic
       FontBBox: 9, 0, 666, 760
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDJCM+AdvOTdd63dae3+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: OIDJCM+AdvOTdd63dae3+22
       Flags: Symbolic
       FontBBox: -62, -250, 1083, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDKJF+Helvetica
      FontSubset: true
      FirstChar: 2
      LastChar: 118
      FontDescriptor: 
       FontName: OIDKJF+Helvetica
       Flags: Symbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDLDC+Helvetica-Bold
      FontSubset: true
      FirstChar: 65
      LastChar: 71
      FontDescriptor: 
       FontName: OIDLDC+Helvetica-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDFMN+AdvOT13119950
      FontSubset: true
      FirstChar: 37
      LastChar: 243
      FontDescriptor: 
       FontName: OIDFMN+AdvOT13119950
       Flags: Nonsymbolic
       FontBBox: -31, -218, 947, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDILF+AdvOT0c200bf0
      FontSubset: true
      FirstChar: 37
      LastChar: 246
      FontDescriptor: 
       FontName: OIDILF+AdvOT0c200bf0
       Flags: Nonsymbolic
       FontBBox: -10, -208, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDILG+AdvOT0c200bf0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OIDILG+AdvOT0c200bf0+fb
       Flags: Symbolic
       FontBBox: 19, 0, 604, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDIOG+AdvOT511ca30e.B
      FontSubset: true
      FirstChar: 49
      LastChar: 56
      FontDescriptor: 
       FontName: OIDIOG+AdvOT511ca30e.B
       Flags: Nonsymbolic
       FontBBox: -41, -218, 979, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIPG+AdvOT3d287b35.B
      FontSubset: true
      FirstChar: 45
      LastChar: 124
      FontDescriptor: 
       FontName: OIDIPG+AdvOT3d287b35.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 1000, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIPH+AdvOT70e1938e
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: OIDIPH+AdvOT70e1938e
       Flags: Serif, Nonsymbolic
       FontBBox: -114, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDFMP+AdvOTa2fa4214.B
      FontSubset: true
      FirstChar: 45
      LastChar: 122
      FontDescriptor: 
       FontName: OIDFMP+AdvOTa2fa4214.B
       Flags: Serif, Nonsymbolic
       FontBBox: -125, -218, 989, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIPI+AdvOT70e1938e+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OIDIPI+AdvOT70e1938e+03
       Flags: Symbolic
       FontBBox: -187, -197, 864, 906
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDFNA+AdvOTa2fa4214.B+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OIDFNA+AdvOTa2fa4214.B+20
       Flags: Nonsymbolic
       FontBBox: -187, -145, 1385, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDJAJ+AdvOT0c200bf0+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OIDJAJ+AdvOT0c200bf0+03
       Flags: Symbolic
       FontBBox: -156, -177, 802, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDJAK+AdvOT23e3f5cb.I
      FontSubset: true
      FirstChar: 39
      LastChar: 122
      FontDescriptor: 
       FontName: OIDJAK+AdvOT23e3f5cb.I
       Flags: Nonsymbolic
       FontBBox: -62, -208, 947, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDJAL+AdvOT23e3f5cb.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OIDJAL+AdvOT23e3f5cb.I+03
       Flags: Symbolic
       FontBBox: -125, -177, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDLMA+AdvOT23e3f5cb.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: OIDLMA+AdvOT23e3f5cb.I+20
       Flags: Nonsymbolic
       FontBBox: -260, -104, 1062, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDJBM+AdvOT0c200bf0+20
      FontSubset: true
      FirstChar: 146
      LastChar: 150
      FontDescriptor: 
       FontName: OIDJBM+AdvOT0c200bf0+20
       Flags: Nonsymbolic
       FontBBox: -229, -104, 1083, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDLNB+AdvOT0c200bf0+01
      FontSubset: true
      FirstChar: 20
      LastChar: 20
      FontDescriptor: 
       FontName: OIDLNB+AdvOT0c200bf0+01
       Flags: Nonsymbolic
       FontBBox: -41, -218, 947, 1104
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OIDFMO+AdvOT89719618
      FontSubset: true
      FirstChar: 35
      LastChar: 124
      FontDescriptor: 
       FontName: OIDFMO+AdvOT89719618
       Flags: Nonsymbolic
       FontBBox: -20, -218, 927, 968
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIHB+AdvOTdd63dae3
      FontSubset: true
      FirstChar: 37
      LastChar: 215
      FontDescriptor: 
       FontName: OIDIHB+AdvOTdd63dae3
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -218, 979, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIHC+AdvOTdd63dae3+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: OIDIHC+AdvOTdd63dae3+20
       Flags: Nonsymbolic
       FontBBox: -197, -125, 1322, 822
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIHD+AdvOTcc1f6510.I
      FontSubset: true
      FirstChar: 41
      LastChar: 110
      FontDescriptor: 
       FontName: OIDIHD+AdvOTcc1f6510.I
       Flags: Nonsymbolic
       FontBBox: -218, -218, 1020, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OIDIIE+AdvOTdd63dae3+03
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OIDIIE+AdvOTdd63dae3+03
       Flags: Symbolic
       FontBBox: -156, -197, 833, 885
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OIDIIF+AdvOTdd63dae3+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OIDIIF+AdvOTdd63dae3+fb
       Flags: Symbolic
       FontBBox: 19, 0, 812, 781
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
        xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
        xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#"
      dc:format="application/pdf"
      dc:identifier="doi:10.1038/s41467-025-65882-x"
      prism:doi="10.1038/s41467-025-65882-x"
      prism:url="http://dx.doi.org/10.1038/s41467-025-65882-x"
      prism:aggregationType="journal"
      prism:publicationName="Nature Communications"
      prism:copyright="© 2025, The Author(s)"
      prism:issn="2041-1723"
      pdfx:doi="10.1038/s41467-025-65882-x"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="True"
      crossmark:DOI="10.1038/s41467-025-65882-x"
      xmp:CreatorTool="Springer"
      xmp:ModifyDate="2025-11-10T16:53:03+01:00"
      xmp:CreateDate="2025-11-07T20:10:39+05:30"
      xmp:MetadataDate="2025-11-10T16:53:03+01:00"
      xmpRights:Marked="True"
      pdf:Keywords=""
      pdf:Producer="iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      jav:journal_article_version="VoR"
      xmpMM:DocumentID="uuid:7e4a6962-dbad-4794-9463-dc94d178532e"
      xmpMM:InstanceID="uuid:d52094ba-f1dc-4336-9696-a33293e8af19"
      xmpMM:RenditionClass="default"
      xmpMM:VersionID="1"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li>Hanna Huber</rdf:li>
          <rdf:li>Javier Arranz</rdf:li>
          <rdf:li>Burak Arslan</rdf:li>
          <rdf:li>Antoine Leuzy</rdf:li>
          <rdf:li>Oscar Kittel</rdf:li>
          <rdf:li>Guglielmo Molfetta</rdf:li>
          <rdf:li>Bessy Benejam</rdf:li>
          <rdf:li>Laura Videla</rdf:li>
          <rdf:li>Isabel Barroeta</rdf:li>
          <rdf:li>Laura del Hoyo Soriano</rdf:li>
          <rdf:li>Lucía Maure-Blesa</rdf:li>
          <rdf:li>Íñigo Rodríguez-Baz</rdf:li>
          <rdf:li>José Enrique Arriola Infante</rdf:li>
          <rdf:li>Ignacio Illán-Gala</rdf:li>
          <rdf:li>Alexandre Bejanin</rdf:li>
          <rdf:li>Laia Montoliu-Gaya</rdf:li>
          <rdf:li>Alberto Lleó</rdf:li>
          <rdf:li>María Carmona-Iragui</rdf:li>
          <rdf:li>Daniel Alcolea</rdf:li>
          <rdf:li>Kaj Blennow</rdf:li>
          <rdf:li>Henrik Zetterberg</rdf:li>
          <rdf:li>Juan Fortea</rdf:li>
          <rdf:li>Nicholas J. Ashton</rdf:li>
        </rdf:Seq>
      </dc:creator>
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Springer US</rdf:li>
        </rdf:Bag>
      </dc:publisher>
      <dc:subject>
        <rdf:Bag/>
      </dc:subject>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Nature Communications, doi:10.1038/s41467-025-65882-x</rdf:li>
        </rdf:Alt>
      </dc:description>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:26eec94a-51d0-40c2-973b-addf88cf0e4c"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-11-07T20:11:56+05:30"/>
        </rdf:Seq>
      </xmpMM:History>
      <sn:authorInfo>
        <rdf:Bag>
          <rdf:li
            author:name="Hanna Huber"
            author:orcid="http://orcid.org/0009-0004-3080-6870"/>
          <rdf:li
            author:name="Javier Arranz"
            author:orcid="http://orcid.org/0000-0003-0891-1215"/>
          <rdf:li
            author:name="Guglielmo Molfetta"
            author:orcid="http://orcid.org/0009-0001-5339-933X"/>
          <rdf:li
            author:name="Laura Videla"
            author:orcid="http://orcid.org/0000-0002-9748-8465"/>
          <rdf:li
            author:name="Lucía Maure-Blesa"
            author:orcid="http://orcid.org/0000-0001-5643-7971"/>
          <rdf:li
            author:name="Íñigo Rodríguez-Baz"
            author:orcid="http://orcid.org/0000-0003-3039-9115"/>
          <rdf:li
            author:name="Alexandre Bejanin"
            author:orcid="http://orcid.org/0000-0002-9958-0951"/>
          <rdf:li
            author:name="Laia Montoliu-Gaya"
            author:orcid="http://orcid.org/0000-0001-7684-6318"/>
          <rdf:li
            author:name="Alberto Lleó"
            author:orcid="http://orcid.org/0000-0002-2568-5478"/>
          <rdf:li
            author:name="Daniel Alcolea"
            author:orcid="http://orcid.org/0000-0002-3819-3245"/>
          <rdf:li
            author:name="Kaj Blennow"
            author:orcid="http://orcid.org/0000-0002-1890-4193"/>
          <rdf:li
            author:name="Henrik Zetterberg"
            author:orcid="http://orcid.org/0000-0003-3930-4354"/>
          <rdf:li
            author:name="Juan Fortea"
            author:orcid="http://orcid.org/0000-0002-1340-638X"/>
          <rdf:li
            author:name="Nicholas J. Ashton"
            author:orcid="http://orcid.org/0000-0002-3579-8804"/>
        </rdf:Bag>
      </sn:authorInfo>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A structure containing the characteristics of a font used in a document"
                  pdfaProperty:name="Fonts"
                  pdfaProperty:valueType="Bag Font"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="A structure containing the characteristics of a font used in a document."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Font#"
                  pdfaType:prefix="stFnt"
                  pdfaType:type="Font"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright "
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. &#xA;If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). &#xA;"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. &#xA;Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. See prism:issn. &#xA;"
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. &#xA;Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. &#xA;&#xA;Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” &#xA;"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. &#xA;The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. &#xA;NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. &#xA;"
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn"
              pdfaSchema:schema="Springer Nature ORCID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."
                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li>
                  <rdf:Description
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author."
                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:type="AuthorInformation">
                  <pdfaType:field>
                    <rdf:Seq>
                      <rdf:li
                        pdfaField:description="Gives the name of an author."
                        pdfaField:name="name"
                        pdfaField:valueType="Text"/>
                      <rdf:li
                        pdfaField:description="Gives the ORCID of an author."
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"/>
                    </rdf:Seq>
                  </pdfaType:field>
                  </rdf:Description>
                </rdf:li>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 273, 552, 275, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 273, 552, 275, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 282, 550, 283, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 274, 550, 282, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 282, 550, 284, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 552, 354, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 552, 354, 561
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 362, 550, 363, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 353, 550, 362, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 362, 550, 363, 560
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 369, 539, 370, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 369, 539, 370, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 538, 379, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 369, 538, 378, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 538, 379, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 519, 539, 521, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 519, 539, 521, 548
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 538, 529, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 538, 528, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 528, 538, 530, 547
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 527, 485, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 527, 485, 536
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 525, 494, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 484, 525, 493, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 493, 525, 494, 534
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 514, 304, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 514, 304, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 311, 512, 312, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 303, 512, 311, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 311, 512, 313, 522
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 501, 296, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 501, 296, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 500, 305, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 295, 500, 304, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 500, 305, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 501, 404, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 501, 404, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 411, 500, 412, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 402, 500, 411, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 411, 500, 412, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 473, 501, 475, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 473, 501, 475, 510
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 500, 483, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 473, 500, 482, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 500, 483, 509
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 488, 383, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 488, 383, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 487, 391, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 487, 390, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 487, 391, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 488, 461, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 488, 461, 498
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 487, 469, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 459, 487, 468, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 468, 487, 469, 496
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 476, 295, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 476, 295, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 474, 303, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 293, 474, 302, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 302, 474, 303, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 476, 402, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 476, 402, 485
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 410, 474, 411, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 401, 474, 410, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 410, 474, 411, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 463, 297, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 463, 297, 472
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 462, 306, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 296, 462, 305, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 305, 462, 306, 471
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 147, 137, 149, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 151, 137, 154, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 59, 116, 62, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 63, 116, 66, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 143, 84, 146, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 417, 169, 419, 174
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 406, 127, 409, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 500, 105, 503, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: -2, 479, 50, 511
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 486, 50, 518
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 38, 490, 40, 500
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 48, 343, 55
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 209, 737, 211, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 213, 737, 218, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 220, 737, 225, 742
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 120, 694, 125, 699
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 253, 651, 255, 656
       Flags: Print
       AppearanceDictionary: true
       Destination: 138
      Annotation: 
       Subtype: Link
       Rect: 59, 587, 63, 592
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 241, 433, 245, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 126, 390, 130, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 370, 583, 374, 591
       Flags: Print
       AppearanceDictionary: true
       Destination: 56
      Annotation: 
       Subtype: Link
       Rect: 415, 583, 420, 591
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 366, 486, 370, 495
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 369, 433, 374, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 156, 165, 159, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 56
      Annotation: 
       Subtype: Link
       Rect: 199, 165, 203, 173
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 171, 127, 176, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 177, 127, 183, 132
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 250, 95, 254, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 256, 95, 261, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 133, 73, 138, 78
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 248, 62, 253, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 482, 459, 487, 464
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 426, 427, 431, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 432, 427, 438, 431
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 319, 384, 323, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 349, 384, 353, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 406, 384, 411, 389
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 502, 362, 507, 367
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 510, 352, 515, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 378, 309, 383, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 455, 266, 460, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 461, 266, 467, 271
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 421, 180, 427, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 428, 180, 433, 185
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 335, 159, 340, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 458, 84, 464, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 465, 84, 471, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 455, 62, 459, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 462, 62, 467, 67
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 218, 437, 223, 442
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 189, 394, 191, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 193, 394, 198, 399
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 62, 352, 67, 356
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 77, 244, 80, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 81, 244, 85, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 87, 244, 92, 249
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 167, 116, 172, 121
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 211, 95, 217, 99
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 341, 705, 347, 710
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 337, 684, 342, 688
       Flags: Print
       AppearanceDictionary: true
       Destination: 168
      Annotation: 
       Subtype: Link
       Rect: 376, 433, 380, 441
       Flags: Print
       AppearanceDictionary: true
       Destination: 84
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 306, 465, 465, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 358, 421, 366
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 456, 187, 561, 195
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 176, 365, 184
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 74, 679, 152, 687
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 39, 18, 128, 26
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: caf728bd
   Type: CRC32
  Checksum: c6a4b67375856e01124b5cedd379b9ae
   Type: MD5
  Checksum: 84ff197c6da352b99768518daa040a653e0fbd23
   Type: SHA-1
  Checksum: 1ac7956b0f37ce21ecdaadecff738986636abb24323f5b67894e72d1672e40c1
   Type: SHA-256