d543d7bdba36da92a3c3d67bab1990e7 schbul_a2025v00n00p1iENG.pdf 81f582a7916bc68e96f876cf8eb04f81dae63e58 schbul_a2025v00n00p1iENG.pdf e8a0ba93b1f651ce6e0e3514ac770456ce8d33b9e909ce3d246e263c350457e3 schbul_a2025v00n00p1iENG.pdf Title: Gray Matter Volume Abnormalities and the Association with the Trajectory of Symptoms and Functioning in Individuals at Clinical High Risk of Psychosis Subject: DOI: 10.1093/schbul/sbaf231, Schizophrenia Bulletin, 00, 00, 00 00 0000. Abstract: Background: Brain volume alterations in those at clinical high risk (CHR) of psychosis have been reported in many studies. However, the association between these alterations and the longitudinal trajectory of changes in symptoms and functioning remains unexplored. Study Design: T1-weighted magnetic resonance imaging (MRI) scans were acquired from 226 CHR and 65 healthy controls (HC) recruited from the EU-GEI high-risk study. Five a priori regions of interest were examined and segmented using FreeSurfer: total gray matter (GM) volume, anterior cingulate cortex (ACC), hippocampus, fusiform gyri, and insula. Brain volumes in the CHR and HC groups were compared at baseline. In the CHR group, linear mixed models were used to investigate the association between baseline brain volume and longitudinal changes in positive symptoms, negative symptoms, and functioning over a 2-year follow-up period. We also compared CHR participants who later transitioned to psychosis (CHR-T, n = 48) and those who did not (CHR-NT, n = 178) in terms of their trajectory of symptoms and functioning. Study Results: Compared with HC, CHR participants had lower total GM and fusiform volume at baseline. Lower total GM and hippocampus volume at baseline were associated with higher levels of positive symptoms at baseline and follow-up in CHR individuals, and lower baseline hippocampus volume also predicted future transition. CHR-T and CHR-NT individuals demonstrated distinct symptoms and functioning trajectories over time. Conclusion: Our findings suggest that CHR individuals show baseline differences in brain structure compared to HC, which may also predict changes in positive symptoms over the subsequent 2 years. Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 23.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Sat Dec 13 14:12:18 2025 CET ModDate: Wed Feb 4 11:04:14 2026 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 593.98 x 782.863 pts Page rot: 0 File size: 722753 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NIFLDL+TimesNewRomanMTStd Type 1C Custom yes yes yes 51 0 NIFLEM+TimesNewRomanMTStd-Bold Type 1C Custom yes yes yes 52 0 NIFNBC+TimesNewRomanMTStd-BoldIt Type 1C Custom yes yes yes 117 0 NIFNBD+MTSYN Type 1C Custom yes yes yes 118 0 YDSJNH+ArialMT TrueType WinAnsi yes yes no 1 0 NIFNCD+TimesNewRomanMTStd-Italic Type 1C Custom yes yes yes 53 0 NIFNLB+MTMI Type 1C Custom yes yes yes 84 0 NIFOJM+MTGU Type 1C Custom yes yes yes 119 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-02-05 03:08:39 CET RepresentationInformation: schbul_a2025v00n00p1iENG.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-02-04 16:50:15 CET Size: 722753 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'reciaff2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'myrefsref17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'myrefsref18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tblfn1a' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'myrefsref7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'myrefsref28' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tblfn1a' cannot be found ID: PDF-HUL-122 Offset: 213521 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'myrefsref28' cannot be found ID: PDF-HUL-122 Offset: 213521 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'reciaff2' cannot be found ID: PDF-HUL-122 Offset: 213521 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'myrefsref17' cannot be found ID: PDF-HUL-122 Offset: 213521 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'myrefsref7' cannot be found ID: PDF-HUL-122 Offset: 213521 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'myrefsref18' cannot be found ID: PDF-HUL-122 Offset: 213521 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2926 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Gray Matter Volume Abnormalities and the Association with the Trajectory of Symptoms and Functioning in Individuals at Clinical High Risk of Psychosis Destination: toc.chapter Children: Item: Title: Introduction Destination: section.47.1.1 Item: Title: Methods Destination: section.48.1.2 Item: Title: Results Destination: section.53.1.3 Item: Title: Discussion Destination: section.67.1.4 Item: Title: Supplementary Material Destination: section.72.1.5 Item: Title: Funding Destination: section.73.1.6 Item: Title: Conflict of Interest Destination: section.74.1.7 Item: Title: EU-GEI High Risk Study Group Authors Destination: section.75.1.8 Item: Title: References Destination: section*.76.1.9 Info: Title: Gray Matter Volume Abnormalities and the Association with the Trajectory of Symptoms and Functioning in Individuals at Clinical High Risk of Psychosis Author: Subject: DOI: 10.1093/schbul/sbaf231, Schizophrenia Bulletin, 00, 00, 00 00 0000. Abstract: Background: Brain volume alterations in those at clinical high risk (CHR) of psychosis have been reported in many studies. However, the association between these alterations and the longitudinal trajectory of changes in symptoms and functioning remains unexplored. Study Design: T1-weighted magnetic resonance imaging (MRI) scans were acquired from 226 CHR and 65 healthy controls (HC) recruited from the EU-GEI high-risk study. Five a priori regions of interest were examined and segmented using FreeSurfer: total gray matter (GM) volume, anterior cingulate cortex (ACC), hippocampus, fusiform gyri, and insula. Brain volumes in the CHR and HC groups were compared at baseline. In the CHR group, linear mixed models were used to investigate the association between baseline brain volume and longitudinal changes in positive symptoms, negative symptoms, and functioning over a 2-year follow-up period. We also compared CHR participants who later transitioned to psychosis (CHR-T, n = 48) and those who did not (CHR-NT, n = 178) in terms of their trajectory of symptoms and functioning. Study Results: Compared with HC, CHR participants had lower total GM and fusiform volume at baseline. Lower total GM and hippocampus volume at baseline were associated with higher levels of positive symptoms at baseline and follow-up in CHR individuals, and lower baseline hippocampus volume also predicted future transition. CHR-T and CHR-NT individuals demonstrated distinct symptoms and functioning trajectories over time. Conclusion: Our findings suggest that CHR individuals show baseline differences in brain structure compared to HC, which may also predict changes in positive symptoms over the subsequent 2 years. Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 23.0 (Windows); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Sat Dec 13 14:42:18 CET 2025 ModDate: Wed Feb 04 11:04:14 CET 2026 ID: 0x489e11da110e6d2daf8f4ce17b3ed09f, 0x58eff73290e68d7cfee0c734d3915821 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 975 ImageHeight: 1755 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: NIFLDL+TimesNewRomanMTStd FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: NIFLDL+TimesNewRomanMTStd Flags: Serif, Symbolic FontBBox: -94, -241, 1006, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFLEM+TimesNewRomanMTStd-Bold FontSubset: true FirstChar: 2 LastChar: 248 FontDescriptor: FontName: NIFLEM+TimesNewRomanMTStd-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -191, -241, 1065, 957 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFNLB+MTMI FontSubset: true FirstChar: 60 LastChar: 60 FontDescriptor: FontName: NIFNLB+MTMI Flags: Serif, Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFNBC+TimesNewRomanMTStd-BoldIt FontSubset: true FirstChar: 37 LastChar: 121 FontDescriptor: FontName: NIFNBC+TimesNewRomanMTStd-BoldIt Flags: Serif, Symbolic, Italic, ForceBold FontBBox: -266, -259, 1076, 942 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFNCD+TimesNewRomanMTStd-Italic FontSubset: true FirstChar: 38 LastChar: 122 FontDescriptor: FontName: NIFNCD+TimesNewRomanMTStd-Italic Flags: Serif, Symbolic, Italic FontBBox: -271, -246, 1100, 904 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFNBD+MTSYN FontSubset: true FirstChar: 2 LastChar: 215 FontDescriptor: FontName: NIFNBD+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NIFOJM+MTGU FontSubset: true FirstChar: 2 LastChar: 2 FontDescriptor: FontName: NIFOJM+MTGU Flags: Symbolic FontBBox: 24, -213, 839, 683 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true TrueType: Font: BaseFont: YDSJNH+ArialMT FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: YDSJNH+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf Gray Matter Volume Abnormalities and the Association with the Trajectory of Symptoms and Functioning in Individuals at Clinical High Risk of Psychosis Si ShuqingSee CherylHedges Emily P.Tognin StefaniaModinos Gemmade Haan Lieuwevan der Gaag MarkNelson BarnabyPantelis ChristosRiecher-Rössler AnitaBressan RodrigoBarrantes-Vidal NeusKrebs Marie-OdileGlenthøj BirteRuhrmann StephanSachs GabrieleRutten Bart P.van Os JimBarker Gareth J.James AnthonyValmaggia LuciaMcGuire PhilipKempton Matthew J. DOI: 10.1093/schbul/sbaf231, Schizophrenia Bulletin, 00, 00, 00 00 0000. Abstract: Background: Brain volume alterations in those at clinical high risk (CHR) of psychosis have been reported in many studies. However, the association between these alterations and the longitudinal trajectory of changes in symptoms and functioning remains unexplored. Study Design: T1-weighted magnetic resonance imaging (MRI) scans were acquired from 226 CHR and 65 healthy controls (HC) recruited from the EU-GEI high-risk study. Five a priori regions of interest were examined and segmented using FreeSurfer: total gray matter (GM) volume, anterior cingulate cortex (ACC), hippocampus, fusiform gyri, and insula. Brain volumes in the CHR and HC groups were compared at baseline. In the CHR group, linear mixed models were used to investigate the association between baseline brain volume and longitudinal changes in positive symptoms, negative symptoms, and functioning over a 2-year follow-up period. We also compared CHR participants who later transitioned to psychosis (CHR-T, n = 48) and those who did not (CHR-NT, n = 178) in terms of their trajectory of symptoms and functioning. Study Results: Compared with HC, CHR participants had lower total GM and fusiform volume at baseline. Lower total GM and hippocampus volume at baseline were associated with higher levels of positive symptoms at baseline and follow-up in CHR individuals, and lower baseline hippocampus volume also predicted future transition. CHR-T and CHR-NT individuals demonstrated distinct symptoms and functioning trajectories over time. Conclusion: Our findings suggest that CHR individuals show baseline differences in brain structure compared to HC, which may also predict changes in positive symptoms over the subsequent 2 years. sMRI; psychosis; clinical high risk; gray matter volume © The Author(s) 2025. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 88, 601, 91, 605 Destination: 495 Annotation: Subtype: Link Rect: 93, 597, 99, 604 Destination: 495 Annotation: Subtype: Link Rect: 153, 595, 161, 603 Annotation: Subtype: Link Rect: 161, 601, 164, 605 Destination: 495 Annotation: Subtype: Link Rect: 243, 595, 251, 603 Annotation: Subtype: Link Rect: 251, 601, 254, 605 Destination: 495 Annotation: Subtype: Link Rect: 331, 595, 339, 603 Annotation: Subtype: Link Rect: 339, 601, 342, 605 Destination: 495 Annotation: Subtype: Link Rect: 424, 595, 432, 603 Annotation: Subtype: Link Rect: 432, 601, 436, 605 Destination: null Annotation: Subtype: Link Rect: 512, 601, 515, 605 Destination: 495 Annotation: Subtype: Link Rect: 518, 601, 521, 605 Destination: 495 Annotation: Subtype: Link Rect: 126, 589, 129, 593 Destination: 495 Annotation: Subtype: Link Rect: 132, 589, 135, 593 Destination: 495 Annotation: Subtype: Link Rect: 211, 589, 214, 593 Destination: 495 Annotation: Subtype: Link Rect: 296, 583, 304, 591 Annotation: Subtype: Link Rect: 304, 589, 307, 593 Destination: 495 Annotation: Subtype: Link Rect: 410, 583, 419, 591 Annotation: Subtype: Link Rect: 419, 589, 422, 593 Destination: 495 Annotation: Subtype: Link Rect: 499, 589, 505, 593 Destination: 495 Annotation: Subtype: Link Rect: 136, 571, 144, 579 Annotation: Subtype: Link Rect: 144, 577, 150, 581 Destination: 495 Annotation: Subtype: Link Rect: 239, 577, 245, 581 Destination: 495 Annotation: Subtype: Link Rect: 313, 577, 319, 581 Destination: 495 Annotation: Subtype: Link Rect: 409, 577, 415, 581 Destination: 495 Annotation: Subtype: Link Rect: 488, 571, 496, 579 Annotation: Subtype: Link Rect: 496, 577, 503, 581 Destination: 495 Annotation: Subtype: Link Rect: 103, 565, 109, 569 Destination: 495 Annotation: Subtype: Link Rect: 166, 559, 174, 567 Annotation: Subtype: Link Rect: 174, 565, 177, 569 Destination: 495 Annotation: Subtype: Link Rect: 180, 565, 186, 569 Destination: 495 Annotation: Subtype: Link Rect: 266, 565, 272, 569 Destination: 495 Annotation: Subtype: Link Rect: 345, 565, 351, 569 Destination: 495 Annotation: Subtype: Link Rect: 354, 565, 360, 569 Destination: 495 Annotation: Subtype: Link Rect: 479, 560, 482, 568 Destination: 495 Annotation: Subtype: Link Rect: 482, 561, 482, 561 Destination: 495 Annotation: Subtype: Link Rect: 115, 553, 118, 557 Destination: 495 Annotation: Subtype: Link Rect: 120, 553, 126, 557 Destination: 495 Annotation: Subtype: Link Rect: 201, 553, 207, 557 Destination: 495 Annotation: Subtype: Link Rect: 209, 548, 213, 556 Destination: 495 Annotation: Subtype: Link Rect: 310, 553, 313, 557 Destination: 495 Annotation: Subtype: Link Rect: 315, 548, 319, 556 Destination: 495 Annotation: Subtype: Link Rect: 40, 539, 44, 544 Destination: 495 Annotation: Subtype: Link Rect: 111, 529, 114, 534 Destination: 495 Annotation: Subtype: Link Rect: 184, 519, 187, 524 Destination: 495 Annotation: Subtype: Link Rect: 159, 510, 162, 514 Destination: 495 Annotation: Subtype: Link Rect: 346, 509, 349, 514 Destination: 495 Annotation: Subtype: Link Rect: 496, 499, 499, 504 Destination: 495 Annotation: Subtype: Link Rect: 463, 490, 467, 494 Destination: 495 Annotation: Subtype: Link Rect: 462, 480, 465, 484 Destination: 495 Annotation: Subtype: Link Rect: 477, 470, 480, 474 Destination: 495 Annotation: Subtype: Link Rect: 115, 460, 122, 464 Destination: 495 Annotation: Subtype: Link Rect: 176, 450, 182, 454 Destination: 495 Annotation: Subtype: Link Rect: 232, 440, 238, 444 Destination: 495 Annotation: Subtype: Link Rect: 385, 430, 391, 434 Destination: 495 Annotation: Subtype: Link Rect: 266, 410, 272, 414 Destination: 495 Annotation: Subtype: Link Rect: 288, 400, 294, 404 Destination: 495 Annotation: Subtype: Link Rect: 134, 390, 140, 394 Destination: 495 Annotation: Subtype: Link Rect: 374, 380, 380, 384 Destination: 495 Annotation: Subtype: Link Rect: 432, 370, 438, 374 Destination: 495 Annotation: Subtype: Link Rect: 228, 360, 234, 364 Destination: 495 Annotation: Subtype: Link Rect: 479, 360, 485, 364 Destination: 495 Annotation: Subtype: Link Rect: 40, 333, 45, 339 Destination: 495 Annotation: Subtype: Link Rect: 334, 321, 416, 329 Annotation: Subtype: Link Rect: 334, 321, 367, 329 Annotation: Subtype: Link Rect: 367, 321, 395, 329 Annotation: Subtype: Link Rect: 395, 321, 406, 329 Annotation: Subtype: Link Rect: 406, 321, 416, 329 Annotation: Subtype: Link Rect: 40, 305, 44, 313 Destination: 495 Annotation: Subtype: Link Rect: 40, 295, 44, 303 Destination: 495 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 273, 574, 277, 583 Destination: 179 Annotation: Subtype: Link Rect: 279, 574, 283, 583 Destination: 179 Annotation: Subtype: Link Rect: 129, 527, 133, 535 Destination: 179 Annotation: Subtype: Link Rect: 158, 503, 161, 511 Destination: 179 Annotation: Subtype: Link Rect: 44, 431, 53, 439 Destination: 179 Annotation: Subtype: Link Rect: 119, 347, 123, 355 Destination: 179 Annotation: Subtype: Link Rect: 243, 323, 247, 331 Destination: 179 Annotation: Subtype: Link Rect: 213, 288, 216, 296 Destination: 179 Annotation: Subtype: Link Rect: 86, 276, 90, 284 Destination: 179 Annotation: Subtype: Link Rect: 98, 180, 104, 188 Destination: 179 Annotation: Subtype: Link Rect: 91, 72, 98, 80 Destination: 179 Annotation: Subtype: Link Rect: 335, 628, 342, 636 Destination: 179 Annotation: Subtype: Link Rect: 412, 568, 418, 576 Destination: 233 Annotation: Subtype: Link Rect: 420, 568, 427, 576 Destination: 233 Annotation: Subtype: Link Rect: 546, 556, 553, 564 Destination: 233 Annotation: Subtype: Link Rect: 538, 532, 553, 540 Destination: 233 Annotation: Subtype: Link Rect: 477, 192, 484, 200 Destination: 233 Annotation: Subtype: Link Rect: 500, 48, 507, 57 Destination: 233 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 168, 240, 174, 248 Destination: 233 Annotation: Subtype: Link Rect: 72, 156, 79, 164 Destination: 233 Annotation: Subtype: Link Rect: 256, 84, 263, 92 Destination: 233 Annotation: Subtype: Link Rect: 286, 72, 292, 80 Destination: 233 Annotation: Subtype: Link Rect: 368, 604, 406, 611 Annotation: Subtype: Link Rect: 413, 556, 420, 564 Destination: 233 Annotation: Subtype: Link Rect: 520, 544, 558, 552 Annotation: Subtype: Link Rect: 463, 494, 494, 504 Annotation: Subtype: Link Rect: 494, 494, 539, 504 Annotation: Subtype: Link Rect: 539, 494, 556, 504 Annotation: Subtype: Link Rect: 517, 472, 524, 480 Destination: 233 Annotation: Subtype: Link Rect: 483, 446, 510, 456 Annotation: Subtype: Link Rect: 510, 446, 545, 456 Annotation: Subtype: Link Rect: 545, 446, 562, 456 Annotation: Subtype: Link Rect: 310, 434, 327, 444 Annotation: Subtype: Link Rect: 456, 398, 500, 408 Annotation: Subtype: Link Rect: 425, 341, 439, 349 Destination: 233 Annotation: Subtype: Link Rect: 453, 317, 459, 325 Destination: 233 Annotation: Subtype: Link Rect: 462, 317, 476, 325 Destination: 233 Annotation: Subtype: Link Rect: 547, 317, 554, 325 Destination: 233 Annotation: Subtype: Link Rect: 556, 317, 562, 325 Destination: 233 Annotation: Subtype: Link Rect: 337, 305, 344, 313 Destination: 233 Annotation: Subtype: Link Rect: 346, 305, 352, 313 Destination: 233 Annotation: Subtype: Link Rect: 437, 305, 440, 313 Destination: 179 Annotation: Subtype: Link Rect: 442, 305, 449, 313 Destination: 233 Annotation: Subtype: Link Rect: 451, 305, 458, 313 Destination: 233 Annotation: Subtype: Link Rect: 464, 48, 502, 56 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 113, 616, 119, 624 Destination: 233 Annotation: Subtype: Link Rect: 79, 412, 86, 421 Destination: 233 Annotation: Subtype: Link Rect: 153, 84, 160, 92 Destination: 233 Annotation: Subtype: Link Rect: 162, 84, 168, 92 Destination: 233 Annotation: Subtype: Link Rect: 398, 687, 404, 696 Destination: 233 Annotation: Subtype: Link Rect: 330, 346, 362, 354 Destination: 100 Annotation: Subtype: Link Rect: 301, 334, 338, 342 Annotation: Subtype: Link Rect: 377, 274, 409, 282 Destination: 100 Annotation: Subtype: Link Rect: 434, 274, 472, 282 Annotation: Subtype: Link Rect: 414, 190, 452, 198 Annotation: Subtype: Link Rect: 444, 113, 476, 121 Destination: 100 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 111, 639, 115, 645 Destination: null Annotation: Subtype: Link Rect: 207, 619, 211, 627 Destination: null Annotation: Subtype: Link Rect: 60, 609, 63, 615 Destination: null Annotation: Subtype: Link Rect: 145, 598, 149, 606 Destination: null Annotation: Subtype: Link Rect: 133, 588, 136, 594 Destination: null Annotation: Subtype: Link Rect: 99, 577, 102, 585 Destination: null Annotation: Subtype: Link Rect: 147, 567, 151, 574 Destination: null Annotation: Subtype: Link Rect: 132, 557, 136, 564 Destination: null Annotation: Subtype: Link Rect: 546, 394, 555, 400 Destination: 100 Annotation: Subtype: Link Rect: 92, 200, 124, 208 Destination: 125 Annotation: Subtype: Link Rect: 128, 198, 171, 208 Annotation: Subtype: Link Rect: 236, 104, 273, 112 Annotation: Subtype: Link Rect: 124, 92, 161, 100 Annotation: Subtype: Link Rect: 314, 248, 346, 255 Destination: 125 Annotation: Subtype: Link Rect: 351, 126, 394, 136 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 541, 619, 550, 627 Destination: 125 Annotation: Subtype: Link Rect: 541, 608, 550, 616 Destination: 125 Annotation: Subtype: Link Rect: 305, 597, 313, 603 Destination: 125 Annotation: Subtype: Link Rect: 541, 597, 550, 605 Destination: 125 Annotation: Subtype: Link Rect: 541, 586, 550, 594 Destination: 125 Annotation: Subtype: Link Rect: 541, 576, 550, 583 Destination: 125 Annotation: Subtype: Link Rect: 223, 259, 260, 268 Destination: 142 Annotation: Subtype: Link Rect: 31, 249, 68, 256 Annotation: Subtype: Link Rect: 116, 140, 154, 148 Annotation: Subtype: Link Rect: 457, 309, 495, 316 Annotation: Subtype: Link Rect: 407, 285, 449, 292 Annotation: Subtype: Link Rect: 471, 285, 487, 292 Annotation: Subtype: Link Rect: 325, 261, 368, 268 Annotation: Subtype: Link Rect: 439, 225, 482, 233 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 497, 699, 540, 707 Annotation: Subtype: Link Rect: 310, 685, 353, 695 Annotation: Subtype: Link Rect: 383, 204, 390, 212 Destination: 233 Annotation: Subtype: Link Rect: 334, 192, 341, 200 Destination: 233 Annotation: Subtype: Link Rect: 528, 168, 532, 176 Destination: 179 Annotation: Subtype: Link Rect: 437, 84, 443, 92 Destination: 233 Annotation: Subtype: Link Rect: 526, 84, 532, 92 Destination: 233 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 253, 540, 259, 548 Destination: 398 Annotation: Subtype: Link Rect: 276, 492, 283, 500 Destination: 398 Annotation: Subtype: Link Rect: 182, 456, 188, 464 Destination: 398 Annotation: Subtype: Link Rect: 126, 205, 132, 213 Destination: 398 Annotation: Subtype: Link Rect: 181, 146, 184, 154 Destination: 179 Annotation: Subtype: Link Rect: 186, 146, 193, 154 Destination: 398 Annotation: Subtype: Link Rect: 136, 98, 142, 106 Destination: 398 Annotation: Subtype: Link Rect: 367, 524, 374, 532 Destination: 398 Annotation: Subtype: Link Rect: 423, 489, 429, 497 Destination: 398 Annotation: Subtype: Link Rect: 368, 429, 375, 437 Destination: 398 Annotation: Subtype: Link Rect: 503, 381, 510, 389 Destination: 398 Annotation: Subtype: Link Rect: 323, 357, 330, 365 Destination: 398 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 173, 616, 180, 624 Destination: 398 Annotation: Subtype: Link Rect: 131, 604, 137, 612 Destination: 398 Annotation: Subtype: Link Rect: 40, 103, 147, 112 Annotation: Subtype: Link Rect: 217, 103, 248, 112 Annotation: Subtype: Link Rect: 248, 103, 292, 112 Annotation: Subtype: Link Rect: 40, 91, 60, 100 Annotation: Subtype: Link Rect: 60, 91, 82, 100 Annotation: Subtype: Link Rect: 82, 91, 177, 100 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 305, 542, 312, 549 Destination: 29 Annotation: Subtype: Link Rect: 317, 511, 343, 519 Annotation: Subtype: Link Rect: 343, 511, 358, 519 Annotation: Subtype: Link Rect: 358, 511, 405, 519 Annotation: Subtype: Link Rect: 405, 511, 503, 519 Annotation: Subtype: Link Rect: 305, 501, 312, 507 Destination: 29 Annotation: Subtype: Link Rect: 511, 479, 538, 487 Annotation: Subtype: Link Rect: 538, 479, 553, 487 Annotation: Subtype: Link Rect: 317, 469, 364, 477 Annotation: Subtype: Link Rect: 364, 469, 473, 477 Annotation: Subtype: Link Rect: 305, 459, 312, 465 Destination: 29 Annotation: Subtype: Link Rect: 526, 437, 553, 445 Annotation: Subtype: Link Rect: 317, 427, 331, 435 Annotation: Subtype: Link Rect: 331, 427, 379, 435 Annotation: Subtype: Link Rect: 379, 427, 383, 435 Annotation: Subtype: Link Rect: 383, 427, 470, 435 Annotation: Subtype: Link Rect: 305, 417, 312, 423 Destination: 29 Annotation: Subtype: Link Rect: 412, 395, 598, 404 Annotation: Subtype: Link Rect: 305, 375, 312, 381 Destination: 29 Annotation: Subtype: Link Rect: 317, 333, 503, 342 Annotation: Subtype: Link Rect: 305, 323, 312, 330 Destination: 55 Annotation: Subtype: Link Rect: 464, 292, 491, 300 Annotation: Subtype: Link Rect: 491, 292, 505, 300 Annotation: Subtype: Link Rect: 505, 292, 553, 300 Annotation: Subtype: Link Rect: 317, 282, 321, 290 Annotation: Subtype: Link Rect: 321, 282, 395, 290 Annotation: Subtype: Link Rect: 305, 271, 312, 278 Destination: null Annotation: Subtype: Link Rect: 459, 230, 486, 238 Annotation: Subtype: Link Rect: 486, 230, 501, 238 Annotation: Subtype: Link Rect: 501, 230, 548, 238 Annotation: Subtype: Link Rect: 548, 230, 553, 238 Annotation: Subtype: Link Rect: 317, 220, 391, 228 Annotation: Subtype: Link Rect: 305, 210, 312, 216 Destination: 29 Annotation: Subtype: Link Rect: 335, 188, 362, 196 Annotation: Subtype: Link Rect: 362, 188, 376, 196 Annotation: Subtype: Link Rect: 376, 188, 424, 196 Annotation: Subtype: Link Rect: 424, 188, 501, 196 Annotation: Subtype: Link Rect: 305, 178, 312, 184 Destination: 29 Annotation: Subtype: Link Rect: 388, 156, 552, 164 Annotation: Subtype: Link Rect: 301, 146, 312, 152 Destination: 29 Annotation: Subtype: Link Rect: 526, 124, 553, 133 Annotation: Subtype: Link Rect: 317, 114, 331, 123 Annotation: Subtype: Link Rect: 331, 114, 379, 123 Annotation: Subtype: Link Rect: 379, 114, 394, 123 Annotation: Subtype: Link Rect: 394, 114, 426, 123 Annotation: Subtype: Link Rect: 301, 104, 312, 110 Destination: 29 Annotation: Subtype: Link Rect: 526, 72, 553, 81 Annotation: Subtype: Link Rect: 317, 62, 331, 71 Annotation: Subtype: Link Rect: 331, 62, 379, 71 Annotation: Subtype: Link Rect: 379, 62, 383, 71 Annotation: Subtype: Link Rect: 383, 62, 454, 71 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 40, 712, 52, 719 Destination: 29 Annotation: Subtype: Link Rect: 203, 681, 230, 689 Annotation: Subtype: Link Rect: 230, 681, 245, 689 Annotation: Subtype: Link Rect: 245, 681, 292, 689 Annotation: Subtype: Link Rect: 56, 671, 111, 679 Annotation: Subtype: Link Rect: 111, 671, 141, 679 Annotation: Subtype: Link Rect: 40, 661, 52, 667 Destination: 29 Annotation: Subtype: Link Rect: 203, 629, 230, 637 Annotation: Subtype: Link Rect: 230, 629, 245, 637 Annotation: Subtype: Link Rect: 245, 629, 292, 637 Annotation: Subtype: Link Rect: 56, 619, 148, 627 Annotation: Subtype: Link Rect: 148, 619, 153, 627 Annotation: Subtype: Link Rect: 40, 609, 52, 615 Destination: 29 Annotation: Subtype: Link Rect: 74, 577, 101, 585 Annotation: Subtype: Link Rect: 101, 577, 116, 585 Annotation: Subtype: Link Rect: 116, 577, 163, 585 Annotation: Subtype: Link Rect: 163, 577, 196, 585 Annotation: Subtype: Link Rect: 196, 577, 222, 585 Annotation: Subtype: Link Rect: 40, 567, 52, 573 Destination: 29 Annotation: Subtype: Link Rect: 251, 555, 278, 564 Annotation: Subtype: Link Rect: 278, 555, 292, 564 Annotation: Subtype: Link Rect: 56, 545, 103, 554 Annotation: Subtype: Link Rect: 103, 545, 108, 554 Annotation: Subtype: Link Rect: 108, 545, 171, 554 Annotation: Subtype: Link Rect: 40, 535, 52, 541 Destination: 29 Annotation: Subtype: Link Rect: 251, 513, 278, 522 Annotation: Subtype: Link Rect: 278, 513, 292, 522 Annotation: Subtype: Link Rect: 56, 503, 103, 512 Annotation: Subtype: Link Rect: 103, 503, 145, 512 Annotation: Subtype: Link Rect: 40, 493, 52, 500 Destination: null Annotation: Subtype: Link Rect: 199, 461, 225, 470 Annotation: Subtype: Link Rect: 225, 461, 240, 470 Annotation: Subtype: Link Rect: 240, 461, 288, 470 Annotation: Subtype: Link Rect: 288, 461, 292, 470 Annotation: Subtype: Link Rect: 56, 452, 121, 460 Annotation: Subtype: Link Rect: 40, 441, 52, 448 Destination: null Annotation: Subtype: Link Rect: 199, 430, 225, 438 Annotation: Subtype: Link Rect: 225, 430, 240, 438 Annotation: Subtype: Link Rect: 240, 430, 288, 438 Annotation: Subtype: Link Rect: 288, 430, 292, 438 Annotation: Subtype: Link Rect: 56, 420, 127, 428 Annotation: Subtype: Link Rect: 40, 409, 52, 416 Destination: 29 Annotation: Subtype: Link Rect: 265, 388, 292, 396 Annotation: Subtype: Link Rect: 56, 378, 71, 386 Annotation: Subtype: Link Rect: 71, 378, 118, 386 Annotation: Subtype: Link Rect: 118, 378, 145, 386 Annotation: Subtype: Link Rect: 145, 378, 172, 386 Annotation: Subtype: Link Rect: 40, 368, 52, 374 Destination: 29 Annotation: Subtype: Link Rect: 203, 336, 230, 344 Annotation: Subtype: Link Rect: 230, 336, 245, 344 Annotation: Subtype: Link Rect: 245, 336, 292, 344 Annotation: Subtype: Link Rect: 56, 326, 148, 334 Annotation: Subtype: Link Rect: 148, 326, 153, 334 Annotation: Subtype: Link Rect: 40, 316, 52, 322 Destination: 55 Annotation: Subtype: Link Rect: 40, 294, 52, 300 Destination: 55 Annotation: Subtype: Link Rect: 203, 272, 230, 281 Annotation: Subtype: Link Rect: 230, 272, 245, 281 Annotation: Subtype: Link Rect: 245, 272, 292, 281 Annotation: Subtype: Link Rect: 56, 262, 133, 271 Annotation: Subtype: Link Rect: 40, 252, 52, 258 Destination: 55 Annotation: Subtype: Link Rect: 203, 240, 230, 249 Annotation: Subtype: Link Rect: 230, 240, 245, 249 Annotation: Subtype: Link Rect: 245, 240, 292, 249 Annotation: Subtype: Link Rect: 56, 230, 101, 239 Annotation: Subtype: Link Rect: 101, 230, 113, 239 Annotation: Subtype: Link Rect: 113, 230, 146, 239 Annotation: Subtype: Link Rect: 40, 220, 52, 227 Destination: 55 Annotation: Subtype: Link Rect: 199, 189, 225, 197 Annotation: Subtype: Link Rect: 225, 189, 240, 197 Annotation: Subtype: Link Rect: 240, 189, 288, 197 Annotation: Subtype: Link Rect: 288, 189, 292, 197 Annotation: Subtype: Link Rect: 56, 179, 123, 187 Annotation: Subtype: Link Rect: 40, 168, 52, 175 Destination: 55 Annotation: Subtype: Link Rect: 56, 137, 83, 145 Annotation: Subtype: Link Rect: 83, 137, 98, 145 Annotation: Subtype: Link Rect: 98, 137, 145, 145 Annotation: Subtype: Link Rect: 145, 137, 150, 145 Annotation: Subtype: Link Rect: 150, 137, 211, 145 Annotation: Subtype: Link Rect: 40, 127, 52, 133 Destination: 55 Annotation: Subtype: Link Rect: 265, 95, 292, 103 Annotation: Subtype: Link Rect: 56, 85, 71, 93 Annotation: Subtype: Link Rect: 71, 85, 118, 93 Annotation: Subtype: Link Rect: 118, 85, 123, 93 Annotation: Subtype: Link Rect: 123, 85, 217, 93 Annotation: Subtype: Link Rect: 40, 75, 52, 81 Destination: 55 Annotation: Subtype: Link Rect: 446, 711, 588, 719 Annotation: Subtype: Link Rect: 310, 690, 322, 697 Destination: null Annotation: Subtype: Link Rect: 390, 659, 417, 667 Annotation: Subtype: Link Rect: 417, 659, 432, 667 Annotation: Subtype: Link Rect: 432, 659, 479, 667 Annotation: Subtype: Link Rect: 479, 659, 523, 667 Annotation: Subtype: Link Rect: 310, 649, 322, 655 Destination: 55 Annotation: Subtype: Link Rect: 393, 617, 420, 625 Annotation: Subtype: Link Rect: 420, 617, 435, 625 Annotation: Subtype: Link Rect: 435, 617, 482, 625 Annotation: Subtype: Link Rect: 482, 617, 559, 625 Annotation: Subtype: Link Rect: 310, 607, 322, 613 Destination: 55 Annotation: Subtype: Link Rect: 473, 565, 500, 573 Annotation: Subtype: Link Rect: 500, 565, 515, 573 Annotation: Subtype: Link Rect: 515, 565, 562, 573 Annotation: Subtype: Link Rect: 326, 555, 403, 564 Annotation: Subtype: Link Rect: 310, 545, 322, 551 Destination: 55 Annotation: Subtype: Link Rect: 473, 503, 616, 512 Annotation: Subtype: Link Rect: 310, 483, 322, 490 Destination: 55 Annotation: Subtype: Link Rect: 469, 452, 495, 460 Annotation: Subtype: Link Rect: 495, 452, 510, 460 Annotation: Subtype: Link Rect: 510, 452, 557, 460 Annotation: Subtype: Link Rect: 557, 452, 562, 460 Annotation: Subtype: Link Rect: 326, 442, 397, 450 Annotation: Subtype: Link Rect: 310, 431, 322, 438 Destination: 55 Annotation: Subtype: Link Rect: 521, 410, 548, 418 Annotation: Subtype: Link Rect: 548, 410, 562, 418 Annotation: Subtype: Link Rect: 326, 400, 373, 408 Annotation: Subtype: Link Rect: 373, 400, 378, 408 Annotation: Subtype: Link Rect: 378, 400, 463, 408 Annotation: Subtype: Link Rect: 310, 390, 322, 396 Destination: 55 Annotation: Subtype: Link Rect: 521, 358, 548, 366 Annotation: Subtype: Link Rect: 548, 358, 562, 366 Annotation: Subtype: Link Rect: 326, 348, 373, 356 Annotation: Subtype: Link Rect: 373, 348, 417, 356 Annotation: Subtype: Link Rect: 310, 338, 322, 344 Destination: 86 Annotation: Subtype: Link Rect: 521, 326, 548, 334 Annotation: Subtype: Link Rect: 548, 326, 562, 334 Annotation: Subtype: Link Rect: 326, 316, 373, 324 Annotation: Subtype: Link Rect: 373, 316, 438, 324 Annotation: Subtype: Link Rect: 310, 306, 322, 312 Destination: 86 Annotation: Subtype: Link Rect: 473, 284, 500, 293 Annotation: Subtype: Link Rect: 500, 284, 515, 293 Annotation: Subtype: Link Rect: 515, 284, 562, 293 Annotation: Subtype: Link Rect: 326, 274, 331, 283 Annotation: Subtype: Link Rect: 331, 274, 410, 283 Annotation: Subtype: Link Rect: 310, 264, 322, 270 Destination: 86 Annotation: Subtype: Link Rect: 473, 242, 500, 251 Annotation: Subtype: Link Rect: 500, 242, 515, 251 Annotation: Subtype: Link Rect: 515, 242, 562, 251 Annotation: Subtype: Link Rect: 326, 232, 403, 241 Annotation: Subtype: Link Rect: 310, 222, 322, 229 Destination: 86 Annotation: Subtype: Link Rect: 326, 181, 353, 189 Annotation: Subtype: Link Rect: 353, 181, 368, 189 Annotation: Subtype: Link Rect: 368, 181, 415, 189 Annotation: Subtype: Link Rect: 415, 181, 420, 189 Annotation: Subtype: Link Rect: 420, 181, 505, 189 Annotation: Subtype: Link Rect: 310, 170, 322, 177 Destination: 86 Annotation: Subtype: Link Rect: 344, 139, 371, 147 Annotation: Subtype: Link Rect: 371, 139, 386, 147 Annotation: Subtype: Link Rect: 386, 139, 433, 147 Annotation: Subtype: Link Rect: 433, 139, 476, 147 Annotation: Subtype: Link Rect: 476, 139, 488, 147 Annotation: Subtype: Link Rect: 488, 139, 522, 147 Annotation: Subtype: Link Rect: 310, 129, 322, 135 Destination: 142 Annotation: Subtype: Link Rect: 535, 107, 562, 115 Annotation: Subtype: Link Rect: 326, 97, 341, 105 Annotation: Subtype: Link Rect: 341, 97, 388, 105 Annotation: Subtype: Link Rect: 388, 97, 393, 105 Annotation: Subtype: Link Rect: 393, 97, 457, 105 Annotation: Subtype: Link Rect: 310, 87, 322, 93 Destination: 142 Annotation: Subtype: Link Rect: 340, 55, 367, 63 Annotation: Subtype: Link Rect: 367, 55, 382, 63 Annotation: Subtype: Link Rect: 382, 55, 429, 63 Annotation: Subtype: Link Rect: 429, 55, 448, 63 Annotation: Subtype: Link Rect: 448, 55, 518, 63 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 31, 712, 42, 719 Destination: 142 Annotation: Subtype: Link Rect: 162, 681, 321, 689 Annotation: Subtype: Link Rect: 31, 661, 42, 667 Destination: 153 Annotation: Subtype: Link Rect: 69, 619, 96, 627 Annotation: Subtype: Link Rect: 96, 619, 111, 627 Annotation: Subtype: Link Rect: 111, 619, 158, 627 Annotation: Subtype: Link Rect: 158, 619, 200, 627 Annotation: Subtype: Link Rect: 31, 609, 42, 615 Destination: 153 Annotation: Subtype: Link Rect: 241, 587, 268, 595 Annotation: Subtype: Link Rect: 268, 587, 283, 595 Annotation: Subtype: Link Rect: 47, 577, 94, 585 Annotation: Subtype: Link Rect: 94, 577, 121, 585 Annotation: Subtype: Link Rect: 121, 577, 152, 585 Annotation: Subtype: Link Rect: 31, 567, 42, 573 Destination: 153 Annotation: Subtype: Link Rect: 241, 535, 268, 544 Annotation: Subtype: Link Rect: 268, 535, 283, 544 Annotation: Subtype: Link Rect: 47, 525, 94, 534 Annotation: Subtype: Link Rect: 94, 525, 121, 534 Annotation: Subtype: Link Rect: 121, 525, 148, 534 Annotation: Subtype: Link Rect: 31, 515, 42, 521 Destination: 153 Annotation: Subtype: Link Rect: 47, 463, 73, 472 Annotation: Subtype: Link Rect: 73, 463, 88, 472 Annotation: Subtype: Link Rect: 88, 463, 135, 472 Annotation: Subtype: Link Rect: 135, 463, 163, 472 Annotation: Subtype: Link Rect: 163, 463, 193, 472 Annotation: Subtype: Link Rect: 31, 453, 42, 460 Destination: 153 Annotation: Subtype: Link Rect: 189, 422, 216, 430 Annotation: Subtype: Link Rect: 216, 422, 231, 430 Annotation: Subtype: Link Rect: 231, 422, 278, 430 Annotation: Subtype: Link Rect: 278, 422, 283, 430 Annotation: Subtype: Link Rect: 47, 412, 117, 420 Annotation: Subtype: Link Rect: 31, 401, 42, 408 Destination: 153 Annotation: Subtype: Link Rect: 189, 370, 216, 378 Annotation: Subtype: Link Rect: 216, 370, 231, 378 Annotation: Subtype: Link Rect: 231, 370, 278, 378 Annotation: Subtype: Link Rect: 278, 370, 283, 378 Annotation: Subtype: Link Rect: 47, 360, 132, 368 Annotation: Subtype: Link Rect: 301, 712, 312, 719 Destination: 153 Annotation: Subtype: Link Rect: 464, 681, 491, 689 Annotation: Subtype: Link Rect: 491, 681, 505, 689 Annotation: Subtype: Link Rect: 505, 681, 553, 689 Annotation: Subtype: Link Rect: 317, 671, 409, 679 Annotation: Subtype: Link Rect: 409, 671, 413, 679 Annotation: Subtype: Link Rect: 301, 661, 312, 667 Destination: 153 Annotation: Subtype: Link Rect: 464, 629, 491, 637 Annotation: Subtype: Link Rect: 491, 629, 505, 637 Annotation: Subtype: Link Rect: 505, 629, 553, 637 Annotation: Subtype: Link Rect: 317, 619, 394, 627 Annotation: Subtype: Link Rect: 301, 609, 312, 615 Destination: 153 Annotation: Subtype: Link Rect: 317, 567, 343, 575 Annotation: Subtype: Link Rect: 343, 567, 358, 575 Annotation: Subtype: Link Rect: 358, 567, 405, 575 Annotation: Subtype: Link Rect: 405, 567, 410, 575 Annotation: Subtype: Link Rect: 410, 567, 475, 575 Annotation: Subtype: Link Rect: 301, 557, 312, 563 Destination: 153 Annotation: Subtype: Link Rect: 511, 505, 538, 514 Annotation: Subtype: Link Rect: 538, 505, 553, 514 Annotation: Subtype: Link Rect: 317, 495, 364, 504 Annotation: Subtype: Link Rect: 364, 495, 369, 504 Annotation: Subtype: Link Rect: 369, 495, 439, 504 Annotation: Subtype: Link Rect: 301, 485, 312, 492 Destination: 153 Annotation: Subtype: Link Rect: 464, 454, 491, 462 Annotation: Subtype: Link Rect: 491, 454, 505, 462 Annotation: Subtype: Link Rect: 505, 454, 553, 462 Annotation: Subtype: Link Rect: 317, 444, 371, 452 Annotation: Subtype: Link Rect: 371, 444, 402, 452 Annotation: Subtype: Link Rect: 301, 433, 312, 440 Destination: 168 Annotation: Subtype: Link Rect: 335, 412, 362, 420 Annotation: Subtype: Link Rect: 362, 412, 376, 420 Annotation: Subtype: Link Rect: 376, 412, 424, 420 Annotation: Subtype: Link Rect: 424, 412, 463, 420 Annotation: Subtype: Link Rect: 463, 412, 493, 420 Annotation: Subtype: Link Rect: 493, 412, 526, 420 Annotation: Subtype: Link Rect: 526, 412, 531, 420 Annotation: Subtype: Link Rect: 301, 401, 312, 408 Destination: 168 Annotation: Subtype: Link Rect: 526, 370, 553, 378 Annotation: Subtype: Link Rect: 317, 360, 331, 368 Annotation: Subtype: Link Rect: 331, 360, 379, 368 Annotation: Subtype: Link Rect: 379, 360, 414, 368 Annotation: Subtype: Link Rect: 408, 52, 420, 56 Annotation: Subtype: Link Rect: 420, 52, 450, 56 Annotation: Subtype: Link Rect: 450, 52, 457, 56 Annotation: Subtype: Link Rect: 457, 52, 471, 56 Annotation: Subtype: Link Rect: 471, 52, 482, 56 Annotation: Subtype: Link Rect: 31, 39, 95, 43 Checksum: 42182268 Type: CRC32 Checksum: d543d7bdba36da92a3c3d67bab1990e7 Type: MD5 Checksum: 81f582a7916bc68e96f876cf8eb04f81dae63e58 Type: SHA-1 Checksum: e8a0ba93b1f651ce6e0e3514ac770456ce8d33b9e909ce3d246e263c350457e3 Type: SHA-256