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Title:           Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia
Subject:         Irigoien I, Mas-Bermejo P, Papiol S, Barrantes-Vidal N, Rosa A and Arenas C (2025) Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia. Front. Psychiatry 16:1621972. doi: 10.3389/fpsyt.2025.1621972
Keywords:        polygenic risk score; statistical analysis; covariates; schizophrenia; psychotic-like experiences
Author:          Itziar Irigoien
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      Title: Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia
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        Title: 1 Introduction
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       Item: 
        Title: 2 Guidelines for the association analysis
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         Item: 
          Title: 2.1 Which full model should be considered?
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         Item: 
          Title: 2.2 When and how to make a PRS ranking?
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         Item: 
          Title: 2.3 Which model among all the possible ones is the most appropriate?
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         Item: 
          Title: 2.4 For a continuous trait, what steps should be followed for a correct analysis?
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            Title: 2.4.1 How is the candidate model validated?
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            Title: 2.4.2 What can be done if any validation condition fails?
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            Title: 2.4.3 How is a possible association established?
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          Title: 2.5 For a binary trait, what steps should be followed for a correct analysis?
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          Title: 2.6 Is it necessary to consider all the steps mentioned above?
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        Title: 3 Analysing a real data set
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          Title: 3.1 CAPE negative as the trait
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          Title: 3.2 CAPE positive as the trait
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        Title: 4 Concluding remarks
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        Title: Data availability statement
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        Title: Ethics statement
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        Title: Funding
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        Title: Conflict of interest
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        Title: Generative AI statement
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       Item: 
        Title: Publisher’s note
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       Item: 
        Title: References
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    Author: Itziar Irigoien
    Subject: Irigoien I, Mas-Bermejo P, Papiol S, Barrantes-Vidal N, Rosa A and Arenas C (2025) Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia. Front. Psychiatry 16:1621972. doi: 10.3389/fpsyt.2025.1621972
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  Checksum: db1ad818
   Type: CRC32
  Checksum: d246b0df6a11e0385f2847ada088b10c
   Type: MD5
  Checksum: 02ea8083593da3dc257c8296ded553dd202828e6
   Type: SHA-1
  Checksum: f268a01ef2a3c9c27ccb9581c7a09d1ed1ef11c197f511a32cf42a0dc0861cf0
   Type: SHA-256