52f55ae98885a9e13b7c8fd2b550abf3  VETSC_a2025v12p1162.pdf
ffca3ea32baa6e9d6f00a2e421e06227e260674c  VETSC_a2025v12p1162.pdf
4d9061c814252bfc6a38448ec4a4765485fa8de18c9e6c2c673b6dd965b83bca  VETSC_a2025v12p1162.pdf

Title:           Bilateral Cranial Cruciate Ligament Rupture Treatment in a Dog Affected by Classical Ehlers–Danlos Syndrome
Subject:         Ehlers–Danlos syndrome (EDS) is a congenital disorder affecting connective tissue. Patients diagnosed with EDS may present with joint instability, and in human medicine, an increased risk of cranial cruciate rupture has been described. A few therapeutic options for these patients have been described, with no evident superiority of one technique due to small study groups. Cranial cruciate rupture has never been described in a dog with EDS. This is a case report of an 11-month-old Maltese diagnosed with bilateral cruciate ligament rupture and classical EDS with a previously undescribed heterozygous COL5A1 missense variant that underwent stifle stabilization.
Keywords:        Canis lupus familiaris; surgery; orthopedics; dermatology; genetics; collagen; skin; whole genome sequencing; hereditary; inherited
Author:          Núria Vizcaíno-Revés, Stefan J. Rietmann, Elisabet Domínguez, Dolors Fondevila, Vidhya Jagannathan, Tosso Leeb and Mar Bardagí
Creator:         LaTeX with hyperref
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    Title: Bilateral Cranial Cruciate Ligament Rupture Treatment in a Dog Affected by Classical Ehlers–Danlos Syndrome
    Author: Núria Vizcaíno-Revés, Stefan J. Rietmann, Elisabet Domínguez, Dolors Fondevila, Vidhya Jagannathan, Tosso Leeb and Mar Bardagí
    Subject: Ehlers–Danlos syndrome (EDS) is a congenital disorder affecting connective tissue. Patients diagnosed with EDS may present with joint instability, and in human medicine, an increased risk of cranial cruciate rupture has been described. A few therapeutic options for these patients have been described, with no evident superiority of one technique due to small study groups. Cranial cruciate rupture has never been described in a dog with EDS. This is a case report of an 11-month-old Maltese diagnosed with bilateral cruciate ligament rupture and classical EDS with a previously undescribed heterozygous COL5A1 missense variant that underwent stifle stabilization.
    Keywords: Canis lupus familiaris; surgery; orthopedics; dermatology; genetics; collagen; skin; whole genome sequencing; hereditary; inherited
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